HU9700595D0 - Fluoro-alkyl- and fluoro-alkoxy-substituted heterocyclic bradiquinine-antagonists, process for producing them and their use - Google Patents
Fluoro-alkyl- and fluoro-alkoxy-substituted heterocyclic bradiquinine-antagonists, process for producing them and their useInfo
- Publication number
- HU9700595D0 HU9700595D0 HU9700595A HUP9700595A HU9700595D0 HU 9700595 D0 HU9700595 D0 HU 9700595D0 HU 9700595 A HU9700595 A HU 9700595A HU P9700595 A HUP9700595 A HU P9700595A HU 9700595 D0 HU9700595 D0 HU 9700595D0
- Authority
- HU
- Hungary
- Prior art keywords
- fluoro
- bradiquinine
- antagonists
- alkoxy
- alkyl
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title 1
- 125000000623 heterocyclic group Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/24—Oxygen atoms attached in position 8
- C07D215/26—Alcohols; Ethers thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/40—Benzopyrazines
- C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/08—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/10—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C07D257/12—Six-membered rings having four nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19610784A DE19610784A1 (de) | 1996-03-19 | 1996-03-19 | Fluoralkyl- und Fluoralkoxysubstituierte heterocyclische Bradykinin-Antagonisten, Verfahren zu ihrer Herstellung und ihre Verwendung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HU9700595D0 true HU9700595D0 (en) | 1997-05-28 |
| HUP9700595A1 HUP9700595A1 (hu) | 2000-08-28 |
Family
ID=7788755
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9700595A HUP9700595A1 (hu) | 1996-03-19 | 1997-03-17 | Fluor-alkil- és fluor-alkoxicsoporttal helyettesített heterociklikus bradikinin-antagonisták, eljárás ezek előállítására, valamint ezek alkalmazása |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US5859025A (hu) |
| EP (1) | EP0796848B1 (hu) |
| JP (1) | JP4199315B2 (hu) |
| KR (1) | KR970065522A (hu) |
| AR (1) | AR006261A1 (hu) |
| AT (1) | ATE242215T1 (hu) |
| AU (1) | AU1628397A (hu) |
| BR (1) | BR9701332A (hu) |
| CA (1) | CA2199925A1 (hu) |
| CZ (1) | CZ81097A3 (hu) |
| DE (2) | DE19610784A1 (hu) |
| DK (1) | DK0796848T3 (hu) |
| ES (1) | ES2196207T3 (hu) |
| HR (1) | HRP970155A2 (hu) |
| HU (1) | HUP9700595A1 (hu) |
| ID (1) | ID16274A (hu) |
| IL (1) | IL120477A0 (hu) |
| NO (1) | NO971238L (hu) |
| PL (1) | PL318924A1 (hu) |
| PT (1) | PT796848E (hu) |
| SI (1) | SI0796848T1 (hu) |
| SK (1) | SK34897A3 (hu) |
| TR (1) | TR199700206A2 (hu) |
| ZA (1) | ZA972328B (hu) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19712960A1 (de) * | 1997-03-27 | 1998-10-01 | Hoechst Ag | Benzyloxy-substituierte, anellierte N-Heterocyclen, Verfahren zu ihrer Herstellung und ihre Verwendung als Bradykininrezeptorantagonisten |
| TR200400220T4 (tr) * | 1999-12-10 | 2004-02-23 | Pfizer Inc. | Bradikinin antagonistleri olarak, 5 üyeli heteroaril ile ikame edilmiş 1,4-dihidropiridin bileşikleri. |
| JP2005525398A (ja) | 2002-04-10 | 2005-08-25 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | ブラジキニン受容体モジュレーターとして有用な新規なヘテロアリールアルキルアミド誘導体 |
| EP1914236A1 (en) | 2002-04-10 | 2008-04-23 | Ortho-McNeil Pharmaceutical, Inc. | Novel heteroaryl alkylamide derivatives useful as bradykinin receptor modulators |
| ITMI20021247A1 (it) * | 2002-06-07 | 2003-12-09 | Menarini Ricerche Spa | Antagonisti basici non peptidici della bradichinina e loro impiego informulazioni farmaceutiche |
| US7256207B2 (en) | 2003-08-20 | 2007-08-14 | Irm Llc | Inhibitors of cathepsin S |
| AU2006218661A1 (en) | 2005-03-01 | 2006-09-08 | Wyeth | Cinnoline compounds and their use as liver X receptor modilators |
| TWI407960B (zh) | 2007-03-23 | 2013-09-11 | Jerini Ag | 小分子緩激肽ｂ２受體調節劑 |
| AR085073A1 (es) * | 2012-01-11 | 2013-09-11 | Richmond Sa Com Ind Y Financiera Lab | Compuestos con actividad antibacteriana, un procedimiento para su obtencion y composiciones farmaceuticas que los comprenden |
| CN111433196B (zh) | 2017-11-24 | 2023-06-06 | 法瓦里斯荷兰有限责任公司 | 缓激肽b2受体拮抗剂及其用途 |
| AR118983A1 (es) | 2019-05-23 | 2021-11-17 | Pharvaris Gmbh | Antagonistas cíclicos del receptor b2 de bradiquinina |
| UY38706A (es) | 2019-05-23 | 2020-12-31 | Pharvaris Gmbh | Antagonistas cíclicos del receptor b2 de bradiquinina |
| WO2023012322A1 (en) | 2021-08-05 | 2023-02-09 | Pharvaris Gmbh | Lipid-based composition for oral administration of bradykinin b2-receptor antagonists |
| WO2023180575A1 (en) | 2022-03-25 | 2023-09-28 | Pharvaris Gmbh | Solid composition comprising solubilised bradykinin b2-receptor antagonists |
| WO2023180577A1 (en) | 2022-03-25 | 2023-09-28 | Pharvaris Gmbh | Therapeutic uses of bradykinin b2-receptor antagonists |
| TW202345810A (zh) | 2022-03-25 | 2023-12-01 | 瑞士商帕法瑞斯有限責任公司 | 包含緩激肽ｂ２受體拮抗劑之固態延長釋放組成物 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5212182A (en) * | 1990-10-03 | 1993-05-18 | American Home Products Corpooration | Substituted quinolinyl- and naphthalenylbenzamides or benzylamines and related compounds useful as analgesics |
| US5216165A (en) * | 1990-10-03 | 1993-06-01 | American Home Products Corporation | N-substituted aminoquinolines as analgesic agents |
| US5438064A (en) * | 1991-12-23 | 1995-08-01 | American Home Products Corporation | Derivatives of 4-anilinoquinoline-3-carboxamide as analgesic agents |
| AU680870B2 (en) * | 1993-04-28 | 1997-08-14 | Astellas Pharma Inc. | New heterocyclic compounds |
| WO1996005202A1 (fr) * | 1994-08-17 | 1996-02-22 | Nippon Hypox Laboratories Inc. | Derive de l'imidazoquinoleine |
| DE69533174T2 (de) * | 1994-10-27 | 2004-11-18 | Fujisawa Pharmaceutical Co., Ltd. | Pyridopyrimidinone, chinoline und anellierte n-heterozyklen als bradykinin-antagonisten |
-
1996
- 1996-03-19 DE DE19610784A patent/DE19610784A1/de not_active Withdrawn
-
1997
- 1997-03-05 ES ES97103611T patent/ES2196207T3/es not_active Expired - Lifetime
- 1997-03-05 EP EP97103611A patent/EP0796848B1/de not_active Expired - Lifetime
- 1997-03-05 AT AT97103611T patent/ATE242215T1/de not_active IP Right Cessation
- 1997-03-05 PT PT97103611T patent/PT796848E/pt unknown
- 1997-03-05 DE DE59710191T patent/DE59710191D1/de not_active Expired - Lifetime
- 1997-03-05 DK DK97103611T patent/DK0796848T3/da active
- 1997-03-05 SI SI9730572T patent/SI0796848T1/xx unknown
- 1997-03-12 PL PL97318924A patent/PL318924A1/xx unknown
- 1997-03-13 CA CA002199925A patent/CA2199925A1/en not_active Abandoned
- 1997-03-17 TR TR97/00206A patent/TR199700206A2/xx unknown
- 1997-03-17 AU AU16283/97A patent/AU1628397A/en not_active Abandoned
- 1997-03-17 AR ARP970101058A patent/AR006261A1/es unknown
- 1997-03-17 HU HU9700595A patent/HUP9700595A1/hu unknown
- 1997-03-17 CZ CZ97810A patent/CZ81097A3/cs unknown
- 1997-03-17 SK SK348-97A patent/SK34897A3/sk unknown
- 1997-03-17 ID IDP970863A patent/ID16274A/id unknown
- 1997-03-17 KR KR1019970008899A patent/KR970065522A/ko not_active Application Discontinuation
- 1997-03-18 IL IL12047797A patent/IL120477A0/xx unknown
- 1997-03-18 NO NO971238A patent/NO971238L/no unknown
- 1997-03-18 JP JP06474897A patent/JP4199315B2/ja not_active Expired - Lifetime
- 1997-03-18 US US08/819,351 patent/US5859025A/en not_active Expired - Lifetime
- 1997-03-18 HR HR19610784.9A patent/HRP970155A2/xx not_active Application Discontinuation
- 1997-03-18 BR BR9701332A patent/BR9701332A/pt not_active Application Discontinuation
- 1997-03-18 ZA ZA9702328A patent/ZA972328B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL120477A0 (en) | 1997-07-13 |
| US5859025A (en) | 1999-01-12 |
| EP0796848B1 (de) | 2003-06-04 |
| AU1628397A (en) | 1997-09-25 |
| HRP970155A2 (en) | 1998-04-30 |
| MX9702028A (es) | 1997-09-30 |
| CA2199925A1 (en) | 1997-09-19 |
| DK0796848T3 (da) | 2003-09-22 |
| NO971238L (no) | 1997-09-22 |
| KR970065522A (ko) | 1997-10-13 |
| ES2196207T3 (es) | 2003-12-16 |
| TR199700206A2 (xx) | 1997-10-21 |
| PL318924A1 (en) | 1997-09-29 |
| PT796848E (pt) | 2003-08-29 |
| BR9701332A (pt) | 1998-08-18 |
| ATE242215T1 (de) | 2003-06-15 |
| HUP9700595A1 (hu) | 2000-08-28 |
| DE19610784A1 (de) | 1997-09-25 |
| ZA972328B (en) | 1997-09-19 |
| EP0796848A1 (de) | 1997-09-24 |
| ID16274A (id) | 1997-09-18 |
| JPH107656A (ja) | 1998-01-13 |
| SK34897A3 (en) | 1998-01-14 |
| AR006261A1 (es) | 1999-08-11 |
| DE59710191D1 (de) | 2003-07-10 |
| CZ81097A3 (en) | 1997-10-15 |
| JP4199315B2 (ja) | 2008-12-17 |
| SI0796848T1 (en) | 2003-12-31 |
| NO971238D0 (no) | 1997-03-18 |
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