HU231057B1 - Gyógyászatilag hatékony aril-szubsztituált pirazolo[1,5-a]pirimidin származékok - Google Patents
Gyógyászatilag hatékony aril-szubsztituált pirazolo[1,5-a]pirimidin származékok Download PDFInfo
- Publication number
- HU231057B1 HU231057B1 HU1700107A HUP1700107A HU231057B1 HU 231057 B1 HU231057 B1 HU 231057B1 HU 1700107 A HU1700107 A HU 1700107A HU P1700107 A HUP1700107 A HU P1700107A HU 231057 B1 HU231057 B1 HU 231057B1
- Authority
- HU
- Hungary
- Prior art keywords
- formula
- pyrazolo
- methyl
- propan
- carboxylic acid
- Prior art date
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- LDIJKUBTLZTFRG-UHFFFAOYSA-N pyrazolo[1,5-a]pyrimidine Chemical class N1=CC=CN2N=CC=C21 LDIJKUBTLZTFRG-UHFFFAOYSA-N 0.000 title claims description 7
- 239000000203 mixture Substances 0.000 claims description 85
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 54
- -1 racemates Chemical class 0.000 claims description 50
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- 238000000034 method Methods 0.000 claims description 35
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- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 32
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 31
- 125000000217 alkyl group Chemical group 0.000 claims description 29
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- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims description 7
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- C—CHEMISTRY; METALLURGY
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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Landscapes
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Priority Applications (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU1700107A HU231057B1 (hu) | 2017-03-13 | 2017-03-13 | Gyógyászatilag hatékony aril-szubsztituált pirazolo[1,5-a]pirimidin származékok |
| EP18713015.8A EP3596079B1 (en) | 2017-03-13 | 2018-03-12 | Pharmacologically active aryl-substituted pyrazolo[1,5-a]pyrimidine derivatives |
| JP2019549365A JP7153661B2 (ja) | 2017-03-13 | 2018-03-12 | 薬理学的に活性なアリール置換ピラゾロ［１，５－ａ］ピリミジン誘導体 |
| PCT/IB2018/051598 WO2018167629A1 (en) | 2017-03-13 | 2018-03-12 | PHARMACOLOGICALLY ACTIVE ARYL-SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES |
| HUE18713015A HUE056561T2 (hu) | 2017-03-13 | 2018-03-12 | Gyógyászatilag hatékony aril-szubsztituált pirazolo[1,5-a]pirimidin származékok |
| US16/493,018 US10960007B2 (en) | 2017-03-13 | 2018-03-12 | Pharmacologically active aryl-substituted pyrazolo[1,5-a]pyrimidine derivatives |
| ARP180100581A AR111272A1 (es) | 2017-03-13 | 2018-03-13 | Derivados pirazol[1,5-a]pirimidina sustituidos con arilo farmacológicamente activos |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU1700107A HU231057B1 (hu) | 2017-03-13 | 2017-03-13 | Gyógyászatilag hatékony aril-szubsztituált pirazolo[1,5-a]pirimidin származékok |
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|---|---|
| HUP1700107A2 HUP1700107A2 (en) | 2018-09-28 |
| HU231057B1 true HU231057B1 (hu) | 2020-04-28 |
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| HU1700107A HU231057B1 (hu) | 2017-03-13 | 2017-03-13 | Gyógyászatilag hatékony aril-szubsztituált pirazolo[1,5-a]pirimidin származékok |
| HUE18713015A HUE056561T2 (hu) | 2017-03-13 | 2018-03-12 | Gyógyászatilag hatékony aril-szubsztituált pirazolo[1,5-a]pirimidin származékok |
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| HUE18713015A HUE056561T2 (hu) | 2017-03-13 | 2018-03-12 | Gyógyászatilag hatékony aril-szubsztituált pirazolo[1,5-a]pirimidin származékok |
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| US (1) | US10960007B2 (enExample) |
| EP (1) | EP3596079B1 (enExample) |
| JP (1) | JP7153661B2 (enExample) |
| AR (1) | AR111272A1 (enExample) |
| HU (2) | HU231057B1 (enExample) |
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| HU231058B1 (hu) | 2017-03-13 | 2020-04-28 | Richter Gedeon Nyrt. | Gyógyászatilag hatékony aliciklusos-szubsztituált pirazolo[1,5-a]pirimidin származékok |
| US12649738B2 (en) | 2020-03-26 | 2026-06-09 | Richter Gedeon Nyrt. | 1,3-dihydro-2H-pyrrolo[3,4-c]pyridine derivatives as GABAA α5 receptor modulators |
| TWI901650B (zh) | 2020-03-26 | 2025-10-21 | 匈牙利商羅特格登公司 | 啶及吡啶并〔３，４－ｃ〕嗒衍生物 |
| CN111514149B (zh) * | 2020-06-16 | 2021-02-23 | 中国人民解放军空军军医大学 | Xav939在制备治疗孤独症谱系障碍的药物中的应用 |
| TWI907472B (zh) * | 2020-08-05 | 2025-12-11 | 匈牙利商羅特格登公司 | 具藥理活性之經雜環取代的吡唑并〔１，５－ａ〕嘧啶衍生物 |
| HU231691B1 (hu) | 2021-09-29 | 2025-10-28 | Richter Gedeon Nyrt | GABAA ALFA5 receptor modulátor hatású biciklusos aminszármazékok |
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| WO2009123986A1 (en) * | 2008-03-31 | 2009-10-08 | Takeda Pharmaceutical Company Limited | Apoptosis signal-regulating kinase 1 inhibitors |
| WO2016169995A1 (en) * | 2015-04-20 | 2016-10-27 | AbbVie Deutschland GmbH & Co. KG | Substituted pyrazolopyrimidines and method of use |
| HU231058B1 (hu) | 2017-03-13 | 2020-04-28 | Richter Gedeon Nyrt. | Gyógyászatilag hatékony aliciklusos-szubsztituált pirazolo[1,5-a]pirimidin származékok |
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2017
- 2017-03-13 HU HU1700107A patent/HU231057B1/hu not_active IP Right Cessation
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2018
- 2018-03-12 US US16/493,018 patent/US10960007B2/en active Active
- 2018-03-12 WO PCT/IB2018/051598 patent/WO2018167629A1/en not_active Ceased
- 2018-03-12 EP EP18713015.8A patent/EP3596079B1/en active Active
- 2018-03-12 JP JP2019549365A patent/JP7153661B2/ja active Active
- 2018-03-12 HU HUE18713015A patent/HUE056561T2/hu unknown
- 2018-03-13 AR ARP180100581A patent/AR111272A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP7153661B2 (ja) | 2022-10-14 |
| AR111272A1 (es) | 2019-06-26 |
| HUP1700107A2 (en) | 2018-09-28 |
| JP2020514341A (ja) | 2020-05-21 |
| EP3596079B1 (en) | 2021-09-01 |
| US10960007B2 (en) | 2021-03-30 |
| EP3596079A1 (en) | 2020-01-22 |
| US20200061068A1 (en) | 2020-02-27 |
| WO2018167629A1 (en) | 2018-09-20 |
| HUE056561T2 (hu) | 2022-02-28 |
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