HRP970419A2 - Medically beneficial preparation for outer use containing amino acids - Google Patents
Medically beneficial preparation for outer use containing amino acidsInfo
- Publication number
- HRP970419A2 HRP970419A2 HRP9602024A HRP970419A HRP970419A2 HR P970419 A2 HRP970419 A2 HR P970419A2 HR P9602024 A HRP9602024 A HR P9602024A HR P970419 A HRP970419 A HR P970419A HR P970419 A2 HRP970419 A2 HR P970419A2
- Authority
- HR
- Croatia
- Prior art keywords
- amino acids
- interferon
- antiviral
- fact
- pct
- Prior art date
Links
- 150000001413 amino acids Chemical class 0.000 title claims abstract description 25
- 238000002360 preparation method Methods 0.000 title claims abstract description 14
- 230000009286 beneficial effect Effects 0.000 title abstract 2
- 102000014150 Interferons Human genes 0.000 claims abstract description 24
- 108010050904 Interferons Proteins 0.000 claims abstract description 24
- 230000000840 anti-viral effect Effects 0.000 claims abstract description 22
- 229940079322 interferon Drugs 0.000 claims abstract description 20
- 208000024891 symptom Diseases 0.000 claims abstract description 8
- 230000003602 anti-herpes Effects 0.000 claims abstract description 6
- 230000003110 anti-inflammatory effect Effects 0.000 claims abstract description 6
- 229940024606 amino acid Drugs 0.000 claims description 23
- 235000001014 amino acid Nutrition 0.000 claims description 23
- CKLJMWTZIZZHCS-UWTATZPHSA-N D-aspartic acid Chemical compound OC(=O)[C@H](N)CC(O)=O CKLJMWTZIZZHCS-UWTATZPHSA-N 0.000 claims description 9
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims description 8
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims description 6
- 150000001875 compounds Chemical class 0.000 claims description 6
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 5
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims description 5
- 201000004681 Psoriasis Diseases 0.000 claims description 5
- IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 claims description 5
- -1 oxyproline Chemical compound 0.000 claims description 5
- CKLJMWTZIZZHCS-UHFFFAOYSA-N D-OH-Asp Natural products OC(=O)C(N)CC(O)=O CKLJMWTZIZZHCS-UHFFFAOYSA-N 0.000 claims description 4
- 230000003389 potentiating effect Effects 0.000 claims description 4
- DWRXFEITVBNRMK-UHFFFAOYSA-N Beta-D-1-Arabinofuranosylthymine Natural products O=C1NC(=O)C(C)=CN1C1C(O)C(O)C(CO)O1 DWRXFEITVBNRMK-UHFFFAOYSA-N 0.000 claims description 3
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims description 3
- IQFYYKKMVGJFEH-UHFFFAOYSA-N beta-L-thymidine Natural products O=C1NC(=O)C(C)=CN1C1OC(CO)C(O)C1 IQFYYKKMVGJFEH-UHFFFAOYSA-N 0.000 claims description 3
- 239000003883 ointment base Substances 0.000 claims description 3
- 229940104230 thymidine Drugs 0.000 claims description 3
- LEVWYRKDKASIDU-QWWZWVQMSA-N D-cystine Chemical compound OC(=O)[C@H](N)CSSC[C@@H](N)C(O)=O LEVWYRKDKASIDU-QWWZWVQMSA-N 0.000 claims description 2
- 239000004471 Glycine Substances 0.000 claims description 2
- DRTQHJPVMGBUCF-XVFCMESISA-N Uridine Chemical class O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-XVFCMESISA-N 0.000 claims description 2
- 229960005261 aspartic acid Drugs 0.000 claims description 2
- 235000018417 cysteine Nutrition 0.000 claims description 2
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims description 2
- 229960002433 cysteine Drugs 0.000 claims description 2
- 229960003067 cystine Drugs 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims description 2
- 239000003085 diluting agent Substances 0.000 claims 1
- 230000002349 favourable effect Effects 0.000 claims 1
- 229960002449 glycine Drugs 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000003755 preservative agent Substances 0.000 claims 1
- 230000002335 preservative effect Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 abstract description 4
- 208000029433 Herpesviridae infectious disease Diseases 0.000 abstract description 3
- 229940079593 drug Drugs 0.000 abstract description 3
- 230000003190 augmentative effect Effects 0.000 abstract 1
- 230000001185 psoriatic effect Effects 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 description 10
- 241000700605 Viruses Species 0.000 description 7
- 230000000694 effects Effects 0.000 description 7
- 239000000243 solution Substances 0.000 description 7
- 230000001225 therapeutic effect Effects 0.000 description 7
- 238000005259 measurement Methods 0.000 description 6
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 description 4
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 4
- 229930006000 Sucrose Natural products 0.000 description 4
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 4
- 239000007864 aqueous solution Substances 0.000 description 4
- 208000015181 infectious disease Diseases 0.000 description 4
- 229940047124 interferons Drugs 0.000 description 4
- 239000005720 sucrose Substances 0.000 description 4
- 206010028980 Neoplasm Diseases 0.000 description 3
- 241000711975 Vesicular stomatitis virus Species 0.000 description 3
- 201000011510 cancer Diseases 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- DWBZEJHQQIURML-IMJSIDKUSA-N Asp-Ser Chemical compound OC(=O)C[C@H](N)C(=O)N[C@@H](CO)C(O)=O DWBZEJHQQIURML-IMJSIDKUSA-N 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 239000012298 atmosphere Substances 0.000 description 2
- 230000004071 biological effect Effects 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 239000002674 ointment Substances 0.000 description 2
- 229960001153 serine Drugs 0.000 description 2
- 239000002356 single layer Substances 0.000 description 2
- 238000011287 therapeutic dose Methods 0.000 description 2
- 241001529453 unidentified herpesvirus Species 0.000 description 2
- 230000009385 viral infection Effects 0.000 description 2
- MXHRCPNRJAMMIM-SHYZEUOFSA-N 2'-deoxyuridine Chemical class C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C=C1 MXHRCPNRJAMMIM-SHYZEUOFSA-N 0.000 description 1
- FRYULLIZUDQONW-IMJSIDKUSA-N Asp-Asp Chemical compound OC(=O)C[C@H](N)C(=O)N[C@@H](CC(O)=O)C(O)=O FRYULLIZUDQONW-IMJSIDKUSA-N 0.000 description 1
- FKBFDTRILNZGAI-IMJSIDKUSA-N Asp-Cys Chemical compound OC(=O)C[C@H](N)C(=O)N[C@@H](CS)C(O)=O FKBFDTRILNZGAI-IMJSIDKUSA-N 0.000 description 1
- OABOXRPGTFRBFZ-IMJSIDKUSA-N Cys-Cys Chemical compound SC[C@H](N)C(=O)N[C@@H](CS)C(O)=O OABOXRPGTFRBFZ-IMJSIDKUSA-N 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 208000007514 Herpes zoster Diseases 0.000 description 1
- 101000599940 Homo sapiens Interferon gamma Proteins 0.000 description 1
- 241000700588 Human alphaherpesvirus 1 Species 0.000 description 1
- 206010020843 Hyperthermia Diseases 0.000 description 1
- 102000006992 Interferon-alpha Human genes 0.000 description 1
- 108010047761 Interferon-alpha Proteins 0.000 description 1
- NHUHCSRWZMLRLA-UHFFFAOYSA-N Sulfisoxazole Chemical compound CC1=NOC(NS(=O)(=O)C=2C=CC(N)=CC=2)=C1C NHUHCSRWZMLRLA-UHFFFAOYSA-N 0.000 description 1
- JAQGKXUEKGKTKX-HOTGVXAUSA-N Tyr-Tyr Chemical compound C([C@H](N)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(O)=O)C1=CC=C(O)C=C1 JAQGKXUEKGKTKX-HOTGVXAUSA-N 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 210000001691 amnion Anatomy 0.000 description 1
- 239000003443 antiviral agent Substances 0.000 description 1
- 108010040443 aspartyl-aspartic acid Proteins 0.000 description 1
- 230000031018 biological processes and functions Effects 0.000 description 1
- 230000032823 cell division Effects 0.000 description 1
- 230000006037 cell lysis Effects 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 238000002648 combination therapy Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 108010004073 cysteinylcysteine Proteins 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- MXHRCPNRJAMMIM-UHFFFAOYSA-N desoxyuridine Natural products C1C(O)C(CO)OC1N1C(=O)NC(=O)C=C1 MXHRCPNRJAMMIM-UHFFFAOYSA-N 0.000 description 1
- 239000000890 drug combination Substances 0.000 description 1
- XACKNLSZYYIACO-DJLDLDEBSA-N edoxudine Chemical compound O=C1NC(=O)C(CC)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 XACKNLSZYYIACO-DJLDLDEBSA-N 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 239000012737 fresh medium Substances 0.000 description 1
- 230000003284 homeostatic effect Effects 0.000 description 1
- 102000043557 human IFNG Human genes 0.000 description 1
- 230000036031 hyperthermia Effects 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 239000003607 modifier Substances 0.000 description 1
- 230000000644 propagated effect Effects 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 108010003137 tyrosyltyrosine Proteins 0.000 description 1
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/212—IFN-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/217—IFN-gamma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU9602024A HUP9602024A3 (en) | 1996-07-25 | 1996-07-25 | Pharmaceutical composition containing aminoacid for external use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP970419A2 true HRP970419A2 (en) | 1998-08-31 |
Family
ID=89994154
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP9602024A HRP970419A2 (en) | 1996-07-25 | 1997-07-24 | Medically beneficial preparation for outer use containing amino acids |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6048843A (fr) |
| EP (1) | EP0855915B1 (fr) |
| AT (1) | ATE297752T1 (fr) |
| AU (1) | AU3354997A (fr) |
| CA (1) | CA2232710A1 (fr) |
| DE (1) | DE69733539D1 (fr) |
| HR (1) | HRP970419A2 (fr) |
| HU (1) | HUP9602024A3 (fr) |
| WO (1) | WO1998004280A2 (fr) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69706657T2 (de) * | 1996-02-28 | 2002-06-20 | Unihart Corp., Dublin | Natürliches menschliches alpha interferon enthaltende pharmazeutische zusammensetzungen |
| US7396526B1 (en) | 1998-11-12 | 2008-07-08 | Johnson & Johnson Consumer Companies, Inc. | Skin care composition |
| IL150109A0 (en) | 1999-12-09 | 2002-12-01 | Chiron Corp | Method for administering a cytokine to the central nervous system and the lymphatic system |
| US6415797B1 (en) * | 2000-07-07 | 2002-07-09 | First Circle Medical, Inc. | Treatment of human herpesviruses using hyperthermia |
| KR20020027198A (ko) * | 2000-10-02 | 2002-04-13 | 차알스 제이. 메츠 | 염증과 홍반의 완화방법 |
| US6328987B1 (en) * | 2000-11-03 | 2001-12-11 | Jan Marini Skin Research, Inc. | Cosmetic skin care compositions containing alpha interferon |
| DE10112924A1 (de) * | 2001-03-13 | 2002-10-02 | Erich Eigenbrodt | 1-Butansäurederivate, pharmazeutische Zusammensetzungen enthaltend solche Derivate und Verwendungen solcher Derivate |
| CA2441088A1 (fr) * | 2001-03-13 | 2002-09-19 | Protagen Ag | Derives de l'acide butyrique et leur application |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4710376A (en) * | 1985-02-01 | 1987-12-01 | Interferon Sciences, Inc. | Topical therapeutic composition containing oxidation inhibitor system |
| HU196038B (en) * | 1987-08-07 | 1988-09-28 | Mta Koezponti Kemiai Kutato In | Process for producing antiherpetic pharmaceutics for external use, containing 5-isopropyl-2'-beta-deoxy-uridine |
| ES2058351T3 (es) * | 1988-01-29 | 1994-11-01 | Sumitomo Pharma | Un procedimiento para producir una formulacion de liberacion sostenida que es adecuada para el uso humano y veterinario. |
| CA1339256C (fr) * | 1989-01-26 | 1997-08-12 | Wulf Droge | Traitement de maladies associees aux infections par le vih |
-
1996
- 1996-07-25 HU HU9602024A patent/HUP9602024A3/hu unknown
-
1997
- 1997-07-03 DE DE69733539T patent/DE69733539D1/de not_active Expired - Fee Related
- 1997-07-03 EP EP97929442A patent/EP0855915B1/fr not_active Expired - Lifetime
- 1997-07-03 US US09/043,657 patent/US6048843A/en not_active Expired - Fee Related
- 1997-07-03 AU AU33549/97A patent/AU3354997A/en not_active Abandoned
- 1997-07-03 WO PCT/HU1997/000035 patent/WO1998004280A2/fr active IP Right Grant
- 1997-07-03 AT AT97929442T patent/ATE297752T1/de not_active IP Right Cessation
- 1997-07-03 CA CA002232710A patent/CA2232710A1/fr not_active Abandoned
- 1997-07-24 HR HRP9602024A patent/HRP970419A2/hr not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0855915A2 (fr) | 1998-08-05 |
| HU9602024D0 (en) | 1996-09-30 |
| EP0855915B1 (fr) | 2005-06-15 |
| CA2232710A1 (fr) | 1998-02-05 |
| ATE297752T1 (de) | 2005-07-15 |
| HUP9602024A3 (en) | 1999-05-28 |
| DE69733539D1 (de) | 2005-07-21 |
| AU3354997A (en) | 1998-02-20 |
| HUP9602024A2 (hu) | 1998-03-30 |
| US6048843A (en) | 2000-04-11 |
| WO1998004280A2 (fr) | 1998-02-05 |
| WO1998004280A3 (fr) | 1998-03-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Han et al. | Antioxidants, cytokines, and influenza infection in aged mice and elderly humans | |
| US20090304628A1 (en) | Stabilized pharmaceutical formulations that contain the interferons gamma and alpha in synergistic proportions | |
| AU2788892A (en) | Stabilization of human interferon | |
| US20150374759A1 (en) | Method for Treatment of Sores and Lesions of the Skin | |
| ES2186714T3 (es) | Uso de sustipo simple alpha 8 en la preparacion de medicamentos para el tratamiento de infecciones virales del higado. | |
| EP2298350A3 (fr) | Compositions contenant un agent inducteur ainsi qu'un agent antiviral et destinees au traitement de troubles viraux | |
| JP6898706B2 (ja) | 肝疾患を治療するための間葉系幹細胞 | |
| HRP970419A2 (en) | Medically beneficial preparation for outer use containing amino acids | |
| Balzarini et al. | Potentiating effect of ribavirin on the in vitro and in vivo antiretrovirus activities of 2', 3'-dideoxyinosine and 2', 3'-dideoxy-2, 6-diaminopurine riboside | |
| CN111671886B (zh) | 一种预防高危易感人群感染冠状病毒或发生冠状病毒感染疾病的药物组合及其用途 | |
| Müller-Löbnitz et al. | Review of the clinical efficacy of the multicomponent combination medication Traumeel and its components. | |
| JP2023123440A (ja) | 合成リジンアナログ及び模倣物の抗ウイルス用途のための方法及び組成物 | |
| Rush et al. | Immunomodulation in horses | |
| RU2738719C1 (ru) | Средство для лечения коронавирусных, ретровирусных инфекций и гепатита с | |
| CN105816857A (zh) | 干扰素的水溶液制剂 | |
| DE102011003478A1 (de) | Antivirales Mittel enthaltend rekombinante Mistellektine | |
| Pluta et al. | The use of interferon in medicine | |
| WO1984003043A1 (fr) | Composition antivirale et son procede d'administration | |
| Lee et al. | Clinical trials of interferon-gamma in treating warts | |
| RU2819719C2 (ru) | Средство для наружного применения с противовирусным действием | |
| Matsumori et al. | Animal models for therapeutic trials of viral myocarditis: effect of ribavirin and alpha interferon on coxsackievirus B3 and encephalomyocarditis virus myocarditis | |
| RU2380405C2 (ru) | Способ получения рекомбинантного альфа 16-интерферона человека и фармацевтическая композиция для лечения вирусных заболеваний на основе рекомбинантного альфа 16-интерферона человека | |
| Cerruti et al. | Synergistic interaction between interferon-α and acyclovir in the treatment of herpes simplex virus type 1 infection in mice | |
| Jose et al. | Levamisole in patients with recurrent herpes infection | |
| RU2359664C1 (ru) | Фармацевтическая инъекционная композиция на основе тилорона для лечения гнойно-деструктивных процессов с признаками иммунной недостаточности |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A1OB | Publication of a patent application | ||
| AIPI | Request for the grant of a patent on the basis of a substantive examination of a patent application | ||
| ODRP | Renewal fee for the maintenance of a patent |
Payment date: 20050712 Year of fee payment: 9 |
|
| ODBI | Application refused |