HRP920741A2 - Process for the production of chamomile extract rich with flavone - Google Patents
Process for the production of chamomile extract rich with flavone Download PDFInfo
- Publication number
- HRP920741A2 HRP920741A2 HR920741A HRP920741A HRP920741A2 HR P920741 A2 HRP920741 A2 HR P920741A2 HR 920741 A HR920741 A HR 920741A HR P920741 A HRP920741 A HR P920741A HR P920741 A2 HRP920741 A2 HR P920741A2
- Authority
- HR
- Croatia
- Prior art keywords
- chamomile
- extraction
- mixture
- extract
- flowers
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 18
- 235000020221 chamomile extract Nutrition 0.000 title claims description 10
- 235000011949 flavones Nutrition 0.000 title claims description 8
- 229930003944 flavone Natural products 0.000 title claims description 7
- 238000004519 manufacturing process Methods 0.000 title claims description 6
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 title claims description 6
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 title claims description 5
- 150000002212 flavone derivatives Chemical class 0.000 title claims description 5
- 229940119217 chamomile extract Drugs 0.000 title claims description 3
- 239000000203 mixture Substances 0.000 claims description 37
- 235000007866 Chamaemelum nobile Nutrition 0.000 claims description 30
- 235000007232 Matricaria chamomilla Nutrition 0.000 claims description 30
- 238000000605 extraction Methods 0.000 claims description 23
- 239000000341 volatile oil Substances 0.000 claims description 19
- 239000000284 extract Substances 0.000 claims description 17
- 239000002904 solvent Substances 0.000 claims description 11
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 10
- 229940070641 chamomile flowers Drugs 0.000 claims description 9
- RNVYQYLELCKWAN-UHFFFAOYSA-N solketal Chemical compound CC1(C)OCC(CO)O1 RNVYQYLELCKWAN-UHFFFAOYSA-N 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 claims 1
- 240000003538 Chamaemelum nobile Species 0.000 claims 1
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims 1
- 244000042664 Matricaria chamomilla Species 0.000 description 30
- CUFNKYGDVFVPHO-UHFFFAOYSA-N azulene Chemical compound C1=CC=CC2=CC=CC2=C1 CUFNKYGDVFVPHO-UHFFFAOYSA-N 0.000 description 26
- XADJWCRESPGUTB-UHFFFAOYSA-N apigenin Natural products C1=CC(O)=CC=C1C1=CC(=O)C2=CC(O)=C(O)C=C2O1 XADJWCRESPGUTB-UHFFFAOYSA-N 0.000 description 11
- 235000008714 apigenin Nutrition 0.000 description 11
- 229940117893 apigenin Drugs 0.000 description 11
- KZNIFHPLKGYRTM-UHFFFAOYSA-N apigenin Chemical compound C1=CC(O)=CC=C1C1=CC(=O)C2=C(O)C=C(O)C=C2O1 KZNIFHPLKGYRTM-UHFFFAOYSA-N 0.000 description 10
- 239000000463 material Substances 0.000 description 7
- 239000013543 active substance Substances 0.000 description 5
- 229930182478 glucoside Natural products 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 238000001035 drying Methods 0.000 description 4
- 150000008131 glucosides Chemical class 0.000 description 4
- 241001164374 Calyx Species 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- -1 apigenin glycosides Chemical class 0.000 description 3
- 229930182470 glycoside Natural products 0.000 description 3
- 230000002093 peripheral effect Effects 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 241000020115 Heterosperma pinnatum Species 0.000 description 2
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 2
- 150000001298 alcohols Chemical class 0.000 description 2
- 125000001931 aliphatic group Chemical group 0.000 description 2
- 125000004432 carbon atom Chemical group C* 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 150000002213 flavones Chemical class 0.000 description 2
- 150000002338 glycosides Chemical class 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 230000002048 spasmolytic effect Effects 0.000 description 2
- 210000002105 tongue Anatomy 0.000 description 2
- WTVHAMTYZJGJLJ-UHFFFAOYSA-N (+)-(4S,8R)-8-epi-beta-bisabolol Natural products CC(C)=CCCC(C)C1(O)CCC(C)=CC1 WTVHAMTYZJGJLJ-UHFFFAOYSA-N 0.000 description 1
- RGZSQWQPBWRIAQ-CABCVRRESA-N (-)-alpha-Bisabolol Chemical compound CC(C)=CCC[C@](C)(O)[C@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-CABCVRRESA-N 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 208000035199 Tetraploidy Diseases 0.000 description 1
- RGZSQWQPBWRIAQ-LSDHHAIUSA-N alpha-Bisabolol Natural products CC(C)=CCC[C@@](C)(O)[C@@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-LSDHHAIUSA-N 0.000 description 1
- 229940036350 bisabolol Drugs 0.000 description 1
- HHGZABIIYIWLGA-UHFFFAOYSA-N bisabolol Natural products CC1CCC(C(C)(O)CCC=C(C)C)CC1 HHGZABIIYIWLGA-UHFFFAOYSA-N 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 235000020346 chamomile tea Nutrition 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- 239000008240 homogeneous mixture Substances 0.000 description 1
- 230000003170 musculotropic effect Effects 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Landscapes
- Cosmetics (AREA)
Description
Područje tehnike The field of technology
Izum je iz područja proizvodnje ekstrakata kamilice koji se primjenjuju u farmakologiji i kozmetici (MKP A 61 K 35/78; B 01 D 11/02). The invention is from the field of production of chamomile extracts used in pharmacology and cosmetics (MKP A 61 K 35/78; B 01 D 11/02).
Tehnički problem Technical problem
Tehnički problem koji se rješava ovim izumom je kako proizvesti ekstrakte kamilice koji bi imali relativno visok sadržaj flavona i njegovih glikozida, a da se pri tome ne smanji bitno sadržaj eteričnih ulja u tako proizvedenom ekstraktu. The technical problem solved by this invention is how to produce chamomile extracts that would have a relatively high content of flavones and its glycosides, without significantly reducing the content of essential oils in the thus produced extract.
Stanje tehnike State of the art
Za proizvodnju ekstrakata kamilice obično se koristi tzv čista ljekovita smjesa cvjetova kamilice. Ona se sastoji od osušenih glavica cvjetova uključujući i ostatak peteljke. Glavice cvjetova sastoje se od osnove cvijeta sa čašicom omotača, 12-20 jezičaca i mnogobrojnih cjevastih cvjetića. Udio jezičaca u čistoj ljekovitoj smjesi je oko 5 do 6%, udio cjevastih cvjetića 67 do 69%, a ostatak otpada na osnovu cvjetova sa čašicom omotača i peteljkom cvjetova. For the production of chamomile extracts, the so-called pure medicinal mixture of chamomile flowers is usually used. It consists of dried flower heads including the rest of the stem. The flower heads consist of the base of the flower with a calyx, 12-20 tabs and numerous tubular florets. The proportion of tongues in the pure medicinal mixture is about 5 to 6%, the proportion of tubular flowers is 67 to 69%, and the rest is based on flowers with a calyx and flower stalk.
Već prema zrelosti glavica cvjetova prilikom branja, načinu sušenja, preradi, pakiranju i skladištenju ljekovite smjese, jedan dio čiste ljekovite smjese se razlaže na pojedinačne sastavne djelove pri čemu se drobež kamilice uglavnom sastoji iz cjevastih cvjetova i krilnih listića jezičaca cvjetova. Ovi krilne listići i drobež kamilice se općenito prosijavaju prilikom dobivanja ljekovite smjese. Already according to the maturity of the flower heads during picking, the method of drying, processing, packaging and storage of the medicinal mixture, one part of the pure medicinal mixture is broken down into individual components, whereby chamomile debris mainly consists of tubular flowers and wing petals of flower tongues. These winged leaves and chamomile crumbs are generally sifted when obtaining the medicinal mixture.
Drobež kamilice i krilni listići se u mješavini s fino sjeckanom kamilicom (to je samljevena stabljika kamilice) primjenjuju za punjenje vrecica sa čajem kamilice. Drobež kamilice se osim toga primjenjuje i za dobivanje sjemena kamilice. Chamomile powder and wing leaves mixed with finely chopped chamomile (that is ground chamomile stem) are used to fill bags with chamomile tea. Chamomile pulp is also used to obtain chamomile seeds.
Za proizvodnju ekstrakata kamilice uobičajeno je da se koristi čista ljekovita smjesa kamilice iz koje su uklonjeni drobež i krilni listići kamilice. U takovoj ljekovitoj smjesi, tj. čistoj čistoj ljekovitoj smjesi kamilice, najvažniji sastojak Flavon Aplgenin i njegovi glikozidi više nisu prisutni ili su prisutni u neznatnoj mjeri, s obzirom da se ovi sastojci uglavnom nalaze u krilnim listićima. Na osnovu izrazito muskulotropnog spazmolitičkog djelovanja apigenina, a također i spazmolitičkog djelovanja apigenin glikozida, ekstrakti s visokim sadržajem ovog flavona su sa terapeutskog stanovišta posebno zanimljivi. For the production of chamomile extracts, it is usual to use a pure medicinal mixture of chamomile, from which the pulp and winged leaves of the chamomile have been removed. In such a medicinal mixture, i.e. a pure pure chamomile medicinal mixture, the most important ingredient Flavon Aplgenin and its glycosides are no longer present or are present to an insignificant extent, considering that these ingredients are mainly found in the leaflets. Based on the extremely musculotropic spasmolytic action of apigenin, and also the spasmolytic action of apigenin glycosides, extracts with a high content of this flavone are particularly interesting from a therapeutic point of view.
S obzirom da ovi krilni listići imaju mali sadržaj eteričnih ulja u odnosu na cjevaste cvjetiće, odnosno na neokrnjene glavice cvjetova, oni se do sada nisu koristili za ekstrakciju kamilice u cilju proizvodnje ekstrakata kamilice. Given that these petals have a low content of essential oils compared to tubular flowers, i.e. intact flower heads, they have not been used for chamomile extraction in order to produce chamomile extracts.
Opis rješenja tehničkog problema s primjerima izvođenja Description of the solution to the technical problem with implementation examples
Navedeni tehnički problem rješava se novim postupkom za proizvodnju ekstrakata kamilice bogatih flavonom, koji se od poznatih postupaka te vrste razlikuje po tome što se vrši ekstrakcija listića kamilice i ljekovite smjese kamilice pri temperaturi između 10 i 50°C primjenom alifatskih jedno-ili viševalentnih alkohola ravnog ili razgranatog lanca s 1 do 6 atoma ugljika, solketala ili mješavine tih otapala, pri čemu je udio sušenih latica od 5 do 30 masenih dijelova u odnosu na 100 masenih dijelova ljekovite smjese, a ekstrakcija traje od 15 do 180 minuta. The mentioned technical problem is solved by a new process for the production of flavone-rich chamomile extracts, which differs from known processes of this type in that the extraction of chamomile leaves and medicinal chamomile mixture is performed at a temperature between 10 and 50°C using aliphatic mono- or polyvalent alcohols of equal or a branched chain with 1 to 6 carbon atoms, solketal or a mixture of these solvents, where the proportion of dried petals is from 5 to 30 parts by mass in relation to 100 parts by mass of the medicinal mixture, and the extraction lasts from 15 to 180 minutes.
Umjesto sušenih mogu se pripremiti i svježi listići u odgovarajućoj količini. Instead of dried, fresh leaves can be prepared in the appropriate amount.
Po postupku prema izumu koristi se gore opisana čista ljekovita smjesa kamilice (bez drobeži i krilnih listića) ili uobičajena ljekovita smjesa kamilice iz koje nisu uklonjeni djelomično otpali cjevasti cvjetići i krilni listići. Kamilica koja se frakcionira (npr. cvjetovi kamilice, sve vrste Matricaria recutita) po mogućnosti ne smije se ukladištavati pod uobičajenim uvjetima više od godine dana, jer tada dolazi do velikog gubitka eteričnih ulja i njihovih sastojaka. Kamilica se mora sušiti na uobičajen način, npr. umjetnim uvođenjem zraka, ali se sušenje također može provesti i na suncu (temperatura pri sušenju je npr. 30 do 70°C, a u datom slučaju također i do 100°C. Uputno je sušenje obaviti odmah nakon žetve kamilice i to u tankim slojevima (npr. debljine 5-25 cm), a pri temperaturi zraka ne većoj od 50°C uz sprječavanje izravnog utjecaja sunca. Općenito ljekovita smjesa kamilice koja se ekstrahira sadrži 3 - 15% vlage, a naročito 8 - 10%. According to the procedure according to the invention, the pure medicinal mixture of chamomile described above (without crumbs and wing leaves) or the usual medicinal mixture of chamomile from which the partially fallen tubular flowers and wing leaves have not been removed is used. Chamomile that is fractionated (eg chamomile flowers, all Matricaria recutita species) should preferably not be stored under normal conditions for more than a year, because then there is a large loss of essential oils and their constituents. Chamomile must be dried in the usual way, e.g. by artificially introducing air, but drying can also be carried out in the sun (temperature during drying is e.g. 30 to 70°C, and in the given case also up to 100°C. It is advisable to carry out the drying immediately after harvesting chamomile, in thin layers (e.g. 5-25 cm thick), and at an air temperature not higher than 50°C, while preventing direct exposure to the sun. In general, the medicinal mixture of chamomile that is extracted contains 3 - 15% moisture, and especially 8 - 10%.
Za postupak u skladu s izumom pogodna je ljekovita smjesa kamilice (ekstrakcijski materijal) sa sadržajem eteričnih ulja od najmanje 750 mg%, npr. 750 - 1000 mg%, sadržajem azulena od najmanje 50 mg%, npr. 50 - 250 mg% i sadržajem bisabolola od najmanje 150 mg%, npr 150 - 300 mg%. Kod kamilice može se raditi bilo o diploidnoj ili tetraploidnoj kamilici. Naročito je pogodna za postupak prema izumu ljekovita smjesa kamilice prema njemačkom patentnom spisu 24 02 802 kao i prema patentnim prijavama P 34 23 207 i P 34 46 216. For the procedure according to the invention, a medicinal mixture of chamomile (extraction material) with an essential oil content of at least 750 mg%, e.g. 750 - 1000 mg%, an azulene content of at least 50 mg%, e.g. 50 - 250 mg% and a content of bisabolol of at least 150 mg%, eg 150 - 300 mg%. Chamomile can be either diploid or tetraploid. Especially suitable for the procedure according to the invention is the medicinal mixture of chamomile according to German patent file 24 02 802 as well as according to patent applications P 34 23 207 and P 34 46 216.
Korištene latice mogu potjecati od iste kamilice iz koje se proizvodi ljekovita smjesa. No međutim, razumljivo je, krilni listići mogu potjecati također i od neke druge kamilice, iz drugog područja. The petals used can come from the same chamomile from which the medicinal mixture is produced. However, it is understandable, the leaflets can also come from another chamomile, from another area.
Krilni listići kamilice mogu se upotrijebiti kao svježi ili kao osušeni. Pod svježim krilnim listićima kamilice podrazumijevaju se takovi koji se u roku od 24 sata nakon branja ekstrahiraju ili se u tom roku zamrznu. Chamomile leaves can be used fresh or dried. Fresh chamomile leaves are those that are extracted within 24 hours after picking or are frozen within that period.
Udio krilnih listića koji se dodaju ljekovitoj smjesi kamilice je u području između 5 i 30, prvenstveno 10 do 20 masenih dijelova suhih listića u odnosu na 100 masenih dijelova upotrijebljenog materijala ljekovite smjese(ljekovita smjesa s uobičajenim udjelom krilnih listića od 5 do 6 masenih % ili ljekovita smjesa iz koje su krilni listići uklonjeni prosijavanjem). The proportion of wing leaves that are added to the medicinal mixture of chamomile is in the range between 5 and 30, primarily 10 to 20 parts by mass of dry leaves in relation to 100 parts by mass of the used material of the medicinal mixture (medicinal mixture with the usual proportion of wing leaves of 5 to 6 mass % or medicinal mixture from which the wing leaflets have been removed by sieving).
Odnos između dodatih osušenih krilnih listića prema osušenim glavicama cvjetova kamilice (cjevasti cvjetići na osnovnom cvijetu sa čašicom i peteljkom cvijeta) iznosi npr. 1:9 do 1:2,3, a prvenstveno 1:4 težinskih dijelova. U slučaju da se koriste krilni listići u obliku svježih krilnih listića, onda treba dodati odgovarajuću veču količinu krilnih listića (što znači količinu koja odgovara ekvivalentu ljekovite smjese). U općem slučaju kod svježih krilnih listića uzima se trostruka do peterostruka, a naročito četverostruka do peterostruka količina u odnosu na slučaj kad se koriste osušeni krilni listići. The ratio between added dried wing petals to dried chamomile flower heads (tubular florets on the basic flower with calyx and flower stalk) is, for example, 1:9 to 1:2.3, and preferably 1:4 parts by weight. In the event that wing leaflets are used in the form of fresh wing leaflets, then a correspondingly larger amount of wing leaflets should be added (which means an amount corresponding to the equivalent of the medicinal mixture). In the general case, with fresh wing leaflets, three times to five times, and especially four to five times the amount is taken compared to the case when dried wing leaflets are used.
Krilni listići (jezičci) sadrže samo oko 12% eteričnih ulja koja se nalaze u cvjetovima kamilice. The petals contain only about 12% of the essential oils found in chamomile flowers.
Cvjetovi kamilice i krilni listići mogu biti usitnjeni. Međutim kod upotrebe cvjetova ipak je povoljnije ako se oni po mogućnosti koriste kao neusitnjeni. Krilni listići mogu se prije ekstrakcije homogeno izmiješati sa ljekovitom smjesom kamilice. U slučaju da se ekstrakcija vrši primjenom mješalice, onda se dobije homogena mješavina krilnih listića sa upotrijebljenom ljekovitom smjesom već tijekom odvijanja same ekstrakcije; u tom slučaju jedno prethodno miješanje listića i ljekovite smjese nije više potrebno. Međutim moguće je ljekovitu smjesu kamilice i krilne listiće ekstrahirati odvojeno s navedenim sredstvom za ekstrakciju, a nakon toga se ovi ekstrakti sjedine, tj . pomiješaju, pri čemu se ekstrakt krilnih listića svrhovito pod posebnim uvjetima (npr. u vakuumu) zgušnjava. Chamomile flowers and petals can be chopped. However, when using flowers, it is still more advantageous if they are preferably used unchopped. The wing leaves can be homogenously mixed with the medicinal chamomile mixture before extraction. In the event that the extraction is performed using a mixer, then a homogeneous mixture of wing leaves with the used medicinal mixture is obtained already during the extraction itself; in that case, a preliminary mixing of the leaves and medicinal mixture is no longer necessary. However, it is possible to extract the medicinal mixture of chamomile and wing leaves separately with the specified extraction agent, and then these extracts are combined, i.e. are mixed, whereby the extract of the wing leaflets is purposefully thickened under special conditions (e.g. in a vacuum).
Za izvođenja postupka prema izumu mogu se koristiti postrojenja za miješanje kao što su to npr. koritaste mješalice, prekolatori i drugi prikladni uređaji za ekstrakciju. Temperatura tijekom ekstrakcije je npr. 10 do 50°C. Hlađenje nije nužno. Mixing plants such as trough mixers, precolators and other suitable extraction devices can be used to carry out the process according to the invention. The temperature during extraction is, for example, 10 to 50°C. Cooling is not necessary.
Ako se ekstrakcija vrši pomoću mješalice onda broj okretaja mješalice treba tako podesiti da obodna brzina jedne točke na periferiji mješalice bude u području od 2,8 i 1,4 m/sek, pri čemu vrijeme ekstrakcije iznosi prvenstveno između 15 minuta i 3 sata, a naročito 30 do 120 minuta. If the extraction is carried out using a mixer, then the number of revolutions of the mixer should be adjusted so that the peripheral speed of one point on the periphery of the mixer is in the range of 2.8 and 1.4 m/sec, with the extraction time being primarily between 15 minutes and 3 hours, and especially 30 to 120 minutes.
Za mješalicu radiusa od 55 cm povoljna je npr. obodna brzina od 50 do 250 okretaja u minuti, pri čemu vrijeme ekstrakcije iznosi npr. 15 minuta do 3 sata.Prvenstveno se pri izboru mješalice njena brzina tj . obodna brzina bira tako da ona iznosi 50 do 250 okretaja u minuti, pri čemu vrijeme ekstrakcije od 15 do 120 minuta potpuno zadovoljava. For a mixer with a radius of 55 cm, for example, a peripheral speed of 50 to 250 revolutions per minute is favorable, whereby the extraction time is, for example, 15 minutes to 3 hours. he chooses the peripheral speed so that it amounts to 50 to 250 revolutions per minute, whereby the extraction time of 15 to 120 minutes is completely satisfactory.
Kao otapala dolaze u obzir naročito alifatski jedno-ili viševalentni alkoholi ravnog ili razgranatog lanca s 1-6 ugljikovih atoma, kao što su npr. metanol, etanol, propanol-(2), butanol, glicerin, solketal(2-dimetil-4-oksimetil-1,3-dioksolan i slični, kao i mješavine ovih otapala s vodom. Particularly suitable solvents are aliphatic mono- or polyvalent alcohols with a straight or branched chain with 1-6 carbon atoms, such as, for example, methanol, ethanol, propanol-(2), butanol, glycerin, solketal (2-dimethyl-4- oxymethyl-1,3-dioxolane and the like, as well as mixtures of these solvents with water.
Međutim mogu se koristiti i mješavine ovih otapala. However, mixtures of these solvents can also be used.
Najmanja količina otapala iznosi 2 dijela otapala na 1 dio ljekovite smjese. U općem slučaju koristi se 2 do 20 dijelova otapala na 1 dio ljekovite smjese, a naročito 3 do 10 dijelova otapala na jedan dio ljekovite smjese. The minimum amount of solvent is 2 parts of solvent to 1 part of medicinal mixture. In the general case, 2 to 20 parts of solvent are used for 1 part of medicinal mixture, and especially 3 to 10 parts of solvent for one part of medicinal mixture.
Ekstrakti kamilice dobiveni postupkom prema izumu sadrže najmanje 80, a prvenstveno 90-170 mg% prirodnih flavona, pri čemu se ovdje naročito radi o apigeninu i apigenin-glukozidu (obračunato kao apigenin). Chamomile extracts obtained by the process according to the invention contain at least 80, and primarily 90-170 mg% of natural flavones, where it is particularly apigenin and apigenin-glucoside (calculated as apigenin).
Sadržaj eteričnog ulja u ekstraktu kamilice prema izumu je najmanje 80, a prvenstveno 120 - 150 mg%. Sadržaj azulena u ekstraktima proizvedenim postupkom prema izumu je npr. 3 mg%, a prvenstveno 3-15 mg%. The content of essential oil in the chamomile extract according to the invention is at least 80, and primarily 120 - 150 mg%. The azulene content in the extracts produced by the process according to the invention is, for example, 3 mg%, preferably 3-15 mg%.
Primjer 1 Example 1
Mješavina koja se sastoji od 320 g cvjetova kamilice (eterična ulja 750 mg%, azulen 42 mg%) i 80 g krilnih listića (eterično ulje 196 mg%, azulen 0,4 mg%) ekstrahira se sa 2100 g etanola (40 masenih %) u koritastoj mješalici sa 65 okretaja u minuti. Nakon 90 minuta ekstakcijski materijal preša se i ekstrakt filtrira. Na poznat način utvrđuje se sadržaj aktivnih tvari u ekstraktu i dobije se: A mixture consisting of 320 g of chamomile flowers (essential oils 750 mg%, azulene 42 mg%) and 80 g of winged leaves (essential oil 196 mg%, azulene 0.4 mg%) is extracted with 2100 g of ethanol (40% by weight ) in a trough mixer at 65 revolutions per minute. After 90 minutes, the extraction material is pressed and the extract is filtered. The content of active substances in the extract is determined in a known way and the following is obtained:
azulen: 10,4 mg% azulene: 10.4 mg%
eterično ulje: 98,6 mg% essential oil: 98.6 mg%
apigenim i apigenim glukozid (obračunato kao apigenin): 141,0 mg% apigenim and apigenim glucoside (calculated as apigenin): 141.0 mg%
ekstraktivne tvari: 6,85% extractive substances: 6.85%
Usporedbeni primjer (poznati postupak) Comparative example (known procedure)
400 grama cvjetova kamilice (kao što je gore naznačeno) ekstrahira se sa 2100 g etanola (40 masenih %) u koritastoj mješalici sa 65 okretaja u minuti. Nakon 90 minuta ekstrakcijski materijal se preša i ekstrakt filtrira. Na poznati način utvrdi se sadržaj aktivnih tvari u ekstraktu. Dobije se: 400 grams of chamomile flowers (as indicated above) were extracted with 2100 g of ethanol (40% by weight) in a trough mixer at 65 rpm. After 90 minutes, the extraction material is pressed and the extract is filtered. The content of active substances in the extract is determined in a known way. It is obtained:
azulen: 11,2 mg% azulene: 11.2 mg%
eterično ulje: 101,3 mg% essential oil: 101.3 mg%
apigenim i apigenlni glukozid (obračunato kao apigenin): 65,3 mg% apigenim and apigenl glucoside (calculated as apigenin): 65.3 mg%
ekstraktivne tvari: 6,53% extractive substances: 6.53%
Primjer 2 Example 2
Mješavina koja se sastoji od 240 g cvjetova kamilice (eterično ulje 750 mg%, azulen 42 mg%) i 60 g krilnih listića (eterično ulje 196 mg%, azulen 0,4 mg%) ekstrahira se sa 2100 grama propanola-(2) (33 masenih %) u koritastoj mješalici sa 65 okretaja u minuti. Nakon 90 minuta ekstrakcijski materijal se preša i ekstrakt filtrira. Na poznat način utvrdi se sadržaj aktivnih tvari u ekstraktu. Dobije se: A mixture consisting of 240 g of chamomile flowers (essential oil 750 mg%, azulene 42 mg%) and 60 g of winged leaves (essential oil 196 mg%, azulene 0.4 mg%) is extracted with 2100 grams of propanol-(2) (33 mass %) in a trough mixer with 65 revolutions per minute. After 90 minutes, the extraction material is pressed and the extract is filtered. The content of active substances in the extract is determined in a known way. It is obtained:
azulen: 4,9 mg% azulene: 4.9 mg%
eterično ulje: 87,6 mg% essential oil: 87.6 mg%
apigenim i apigenim glukozid (obračunato kao apigenin): 106,4 mg% apigenim and apigenim glucoside (calculated as apigenin): 106.4 mg%
ekstraktivne tvari: 7,09% extractive substances: 7.09%
Usporedbeni primjer (poznati postupak) Comparative example (known procedure)
300 grama cvjetova kamilice (kao što je gore naznačeno) ekstrahira se sa 2100 grama propanola-(2) (33 težinska %) u koritastoj mješalici sa 65 okretaja u minuti. Nakon 90 minuta taj se ekstrakcijski materijal preša i ekstrakt filtrira. Na poznat način utvrdi se sadržaj aktivnih tvari u ekstraktu. Dobije se: 300 grams of chamomile flowers (as indicated above) are extracted with 2100 grams of propanol-(2) (33% by weight) in a trough mixer at 65 revolutions per minute. After 90 minutes, the extraction material is pressed and the extract is filtered. The content of active substances in the extract is determined in a known way. It is obtained:
azulen: 6,7 mg% azulene: 6.7 mg%
eterično ulje: 82,1 mg% essential oil: 82.1 mg%
apigenim i apigenim glukozid (obračunato kao apigenin): 53,0 mg% apigenim and apigenim glucoside (calculated as apigenin): 53.0 mg%
ekstraktivne tvari: 6,6% extractive substances: 6.6%
Navod o najboljem načinu privredne upotrebe izuma Statement on the best way of economic use of the invention
Za primjenu postupka prema izumu nisu potrebna neka posebna znanja i iskustva, već su dovoljna ona kojima raspolaže prosječan stručnjak za ovu granu tehnike, a koji izum može primijeniti na osnovu priloženog opisa. The application of the procedure according to the invention does not require any special knowledge and experience, but rather those available to an average expert in this branch of technology, who can apply the invention based on the attached description, are sufficient.
Najsvrhovitija varijanta postupka prema izumu je slijedeća; The most expedient variant of the procedure according to the invention is the following;
Mješavina koja se sastoji od 320 g cvjetova (eterična ulja 750 mg%, azulen 42%) i 80 g krilnih listića kamilice (eterična ulja 196 mg%, azulen 0,4 mg%) ekstrahira se sa 2100 g etanola (40 masenih %) u koritastoj mješalici sa 65 okretaja u minuti. Nakon 90 minuta ekstrakcijski materijal se preša i ekstrakt filtrira. A mixture consisting of 320 g of flowers (essential oils 750 mg%, azulene 42%) and 80 g of camomile petals (essential oils 196 mg%, azulene 0.4 mg%) is extracted with 2100 g of ethanol (40% by weight). in a trough mixer at 65 revolutions per minute. After 90 minutes, the extraction material is pressed and the extract is filtered.
Sadržaj aktivnih tvari u tako dobivenom ekstraktu je: 10 mg% azulena, 98,6 mg% eteričnog ulja, 141,0 mg% apigenina i apigenin glukozida (obračunato kao apigenin, 6,85 % estraktivnih tvari. The content of active substances in the thus obtained extract is: 10 mg% of azulene, 98.6 mg% of essential oil, 141.0 mg% of apigenin and apigenin glucoside (calculated as apigenin, 6.85% of extractable substances.
Claims (4)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HR920741A HRP920741B1 (en) | 1985-08-29 | 1992-10-01 | A process for the preparation of chamomile extracts rich with flavone |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| YU136285A YU45739B (en) | 1985-08-29 | 1985-08-29 | PROCEDURE FOR THE PRODUCTION OF CAMOMILE EXTRACTS RICH IN FLAVON |
| HR920741A HRP920741B1 (en) | 1985-08-29 | 1992-10-01 | A process for the preparation of chamomile extracts rich with flavone |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HRP920741A2 true HRP920741A2 (en) | 1994-10-31 |
| HRP920741B1 HRP920741B1 (en) | 2001-06-30 |
Family
ID=26316824
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR920741A HRP920741B1 (en) | 1985-08-29 | 1992-10-01 | A process for the preparation of chamomile extracts rich with flavone |
Country Status (1)
| Country | Link |
|---|---|
| HR (1) | HRP920741B1 (en) |
-
1992
- 1992-10-01 HR HR920741A patent/HRP920741B1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| HRP920741B1 (en) | 2001-06-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Field | Elephant ecology in the Queen Elizabeth National Park, Uganda | |
| Ramachandran et al. | Drumstick (Moringa oleifera): a multipurpose Indian vegetable | |
| Little | Southwestern trees: a guide to the native species of New Mexico and Arizona | |
| JP4912411B2 (en) | Hair growth promoter and method for producing the same | |
| Christophers | Mosquito repellents: being a report of the work of the mosquito repellent inquiry, Cambridge 1943–5 | |
| SE444499B (en) | Suppose, by means of molecular molecule distillation, to produce a fraction containing antioxidant substances | |
| JPH07501082A (en) | organic insecticide | |
| HU196559B (en) | Process for production of capsules of big stability from mild gelatine for medical purpuses containing as active substance of oils of natural origin | |
| US4786498A (en) | Process for the production of camomile extracts rich in flavones | |
| JP3647054B2 (en) | Antioxidant | |
| KR101488764B1 (en) | Cosmetic Composition for Skin Moisturizing Comprising the Seven Flowers Extract as Active Ingredient | |
| JP2003113031A (en) | Skin care preparation | |
| Stern | Comparative anatomy and systematics of woody Saxifragaceae. Hydrangea | |
| HRP920741A2 (en) | Process for the production of chamomile extract rich with flavone | |
| Merrill | Emergency food plants and poisonous plants of the islands of the Pacific | |
| Gülz et al. | Seasonal variations in epicuticular wax ultrastructures of Quercus robur leaves | |
| Silva | Leaf anatomy and epicuticular waxes composition of Clusia fluminensis Planch. & Triana (Clusiaceae) | |
| EP0330240A1 (en) | Camomile drug and its use in the preparation of camomile extracts, camomile oil and pharmaceutical agents | |
| Rao | The insecticidal property of petals of several common plants of India | |
| Wells | The southern Appalachian grass bald problem | |
| Henkel | American medicinal leaves and herbs | |
| RU2071340C1 (en) | Method of matricary extract preparing | |
| Baldwin et al. | Foliar and floral pyrethrins of Chrysanthemum cinerariaefolium are not induced by leaf damage | |
| CN107496241A (en) | A kind of preparation method of the facial mask containing shiny-leaved yellowhorn bioactive ingredients | |
| CS276343B6 (en) | Process for preparing chamomile extracts rich in flavone |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A1OB | Publication of a patent application | ||
| AIPI | Request for the grant of a patent on the basis of a substantive examination of a patent application | ||
| B1PR | Patent granted | ||
| PNAN | Change of the applicant name, address/residence |
Owner name: VIATRIS GMBH & CO.KG, DE |
|
| PPPP | Transfer of rights |
Owner name: ASTA MEDICA AKTIENGESELLSCHAFT, DE Owner name: ASTA MEDICA HEALTH PRODUCTS GMBH & CO. KG, DE |
|
| ODRP | Renewal fee for the maintenance of a patent |
Payment date: 20040721 Year of fee payment: 20 |
|
| PNAN | Change of the applicant name, address/residence |
Owner name: VIATRIS GMBH & CO.KG, DE |
|
| PB20 | Patent expired after termination of 20 years |
Effective date: 20050830 |