HRP20250166T1 - Mini tablete melatonina i način proizvodnje istih - Google Patents

Mini tablete melatonina i način proizvodnje istih Download PDF

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Publication number
HRP20250166T1
HRP20250166T1 HRP20250166TT HRP20250166T HRP20250166T1 HR P20250166 T1 HRP20250166 T1 HR P20250166T1 HR P20250166T T HRP20250166T T HR P20250166TT HR P20250166 T HRP20250166 T HR P20250166T HR P20250166 T1 HRP20250166 T1 HR P20250166T1
Authority
HR
Croatia
Prior art keywords
tablet
mini
melatonin
sustained
coating
Prior art date
Application number
HRP20250166TT
Other languages
English (en)
Croatian (hr)
Inventor
Moshe Laudon
Nava Zisapel
Original Assignee
Neurim Pharmaceuticals Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=57482481&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP20250166(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Neurim Pharmaceuticals Ltd. filed Critical Neurim Pharmaceuticals Ltd.
Publication of HRP20250166T1 publication Critical patent/HRP20250166T1/hr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Neurology (AREA)
  • Anesthesiology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
HRP20250166TT 2016-10-31 2016-11-29 Mini tablete melatonina i način proizvodnje istih HRP20250166T1 (hr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662415014P 2016-10-31 2016-10-31
EP20195788.3A EP3777842B1 (en) 2016-10-31 2016-11-29 Melatonin mini-tablets and method of manufacturing the same

Publications (1)

Publication Number Publication Date
HRP20250166T1 true HRP20250166T1 (hr) 2025-05-09

Family

ID=57482481

Family Applications (2)

Application Number Title Priority Date Filing Date
HRP20250166TT HRP20250166T1 (hr) 2016-10-31 2016-11-29 Mini tablete melatonina i način proizvodnje istih
HRP20201722TT HRP20201722T1 (hr) 2016-10-31 2016-11-29 Minitablete melatonina i postupak njihove proizvodnje

Family Applications After (1)

Application Number Title Priority Date Filing Date
HRP20201722TT HRP20201722T1 (hr) 2016-10-31 2016-11-29 Minitablete melatonina i postupak njihove proizvodnje

Country Status (25)

Country Link
US (2) US10722494B2 (enExample)
EP (3) EP3777842B1 (enExample)
JP (1) JP6830156B2 (enExample)
KR (1) KR102167190B1 (enExample)
CN (1) CN109922795B (enExample)
AU (6) AU2016426598C1 (enExample)
CA (1) CA3040027C (enExample)
CY (1) CY1123449T1 (enExample)
DK (2) DK3337462T3 (enExample)
ES (2) ES2828034T3 (enExample)
FI (1) FI3777842T3 (enExample)
HR (2) HRP20250166T1 (enExample)
HU (2) HUE051362T2 (enExample)
IL (1) IL262537B (enExample)
LT (2) LT3777842T (enExample)
MX (1) MX386987B (enExample)
NZ (1) NZ747702A (enExample)
PL (2) PL3777842T3 (enExample)
PT (2) PT3337462T (enExample)
RS (2) RS66471B1 (enExample)
SG (1) SG11201903829PA (enExample)
SI (2) SI3777842T1 (enExample)
SM (2) SMT202500046T1 (enExample)
TW (1) TWI787164B (enExample)
WO (1) WO2018078429A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12636255B2 (en) * 2020-10-23 2026-05-26 Atoz Pharmaceuticals Pvt Ltd Nongranulated compressed tablets of mesalamine, and process of preparation thereof
WO2022092767A1 (ko) * 2020-10-26 2022-05-05 일동제약(주) 옥수수불검화추출물을 포함하는 소형화된 경구투여 제제의 제조방법 및 이에 따라 제조된 소형화 제제
JP2025533153A (ja) 2022-10-14 2025-10-03 ソシエテ・デ・プロデュイ・ネスレ・エス・アー 持続放出性メラトニン組成物
CN117281909A (zh) * 2023-07-27 2023-12-26 上海长征医院 一种野外条件下诱导快速入睡的组合物及制备方法

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4600723A (en) 1983-05-18 1986-07-15 Monash University Method for minimizing disturbances in circadian rhythms of bodily performance and function
DE69229490T2 (de) 1991-05-09 2000-02-17 Neurim Pharmaceuticals (1991) Ltd., Tel Aviv Melatonin enthaltende Arzneimittel
DK0565296T3 (da) 1992-04-07 1996-12-09 Neurim Pharma 1991 Anvendelse af melatonin til fremstilling af et lægemiddel til behandling af godartet prostatahyperplasi
US5449683A (en) 1992-10-01 1995-09-12 Massachussetts Institute Of Technology Methods of inducing sleep using melatonin
WO1995003043A1 (en) * 1993-07-26 1995-02-02 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University Sustained release oral compositions containing melatonin
MD1716C2 (ro) * 1995-02-01 2002-02-28 Neurim Pharmaceuticals (1991) Ltd. Utilizare a melatoninei pentru tratamentul pacienţilor dependenţi de benzodiazepine
US6469044B1 (en) * 1995-02-01 2002-10-22 Neurim Pharmaceuticals (1991) Ltd. Method for treating patients suffering from drug dependencies which lead to plasma melationin deficiencies
FR2762513B1 (fr) * 1997-04-23 2003-08-22 Permatec Pharma Ag Comprimes bioadhesifs
AU6283299A (en) 1998-10-01 2000-04-17 Elan Pharma International Limited Controlled release nanoparticulate compositions
EP1064938A1 (en) * 1999-06-28 2001-01-03 Sanofi-Synthelabo Pharmaceutical dosage forms for controlled release producing at least a timed pulse
IL150190A0 (en) 2000-01-05 2002-12-01 Neurim Pharma 1991 Method and formulation for treating resistance to antihypertensives and related conditions
US6458384B2 (en) * 2000-02-23 2002-10-01 Impetus Ag Pharmaceutical with predetermined activity profile
IL144900A (en) 2001-08-14 2013-12-31 Neurim Pharma 1991 Melatonin and drugs containing it for use in the treatment of primary insomnia, and the manufacture of those drugs
IL149377A (en) * 2002-04-28 2012-10-31 Neurim Pharma 1991 Pharmaceutical formulation comprising melatonin for the potentiation of the effect of hypnotic compounds
KR20030016215A (ko) * 2002-07-05 2003-02-26 뉴림 파머슈티칼스 (1991) 리미티드 항고혈압제에 대한 내성 및 관련 질환의 치료를 위한 방법및 제형
AU2004207578B2 (en) * 2003-01-28 2007-06-28 Collegium Pharmaceutical, Inc. Multiparticulate compositions of milnacipran for oral administration
IL155666A (en) 2003-04-29 2013-12-31 Neurim Pharma 1991 Insomnia treatment
EP1696959A2 (en) 2003-12-24 2006-09-06 Sepracor, Inc. Melatonin combination therapy for improving sleep quality
FR2889811B1 (fr) * 2005-08-19 2009-10-09 Sanofi Aventis Sa Association d'un agent hypnotique a duree d'action longue et d'un agent hypnotique a duree d'action courte, composition pharmaceutique la contenant et son application en therapeutique.
DE102006006532B4 (de) 2006-02-10 2007-11-08 Biogenerics Pharma Gmbh Pharmazeutische Zubereitung
WO2008148015A1 (en) 2007-05-24 2008-12-04 The Trustees Of Columbia University In The City Of New York Sustained release formulation of melatonin
US20100159001A1 (en) * 2008-12-19 2010-06-24 Cardinal John R Extended-Release Pharmaceutical Formulations
US9532952B2 (en) 2011-01-28 2017-01-03 Physician's Seal, LLC Controlled-release compositions of melatonin combined with sedative and/or analgesic ingredients
US8691275B2 (en) 2011-01-28 2014-04-08 Zx Pharma, Llc Controlled-release melatonin compositions and related methods
RU2488388C1 (ru) * 2012-05-24 2013-07-27 Ооо "Валента Интеллект" Фармацевтическая композиция для профилактики и лечения психических, поведенческих, когнитивных расстройств
EP2949322B1 (en) 2014-05-28 2018-04-25 Valpharma S.p.A. Formulation for oral administration comprising melatonin in stable form and method of production thereof

Also Published As

Publication number Publication date
US10869857B2 (en) 2020-12-22
PL3337462T3 (pl) 2021-01-25
MX2019004736A (es) 2019-06-17
AU2016426598A1 (en) 2018-05-17
US20200306227A1 (en) 2020-10-01
PT3337462T (pt) 2020-10-30
PT3777842T (pt) 2025-02-11
PL3777842T3 (pl) 2025-05-12
CY1123449T1 (el) 2022-03-24
EP3777842A1 (en) 2021-02-17
NZ782840A (en) 2025-02-28
KR102167190B1 (ko) 2020-10-19
US20190060277A1 (en) 2019-02-28
JP6830156B2 (ja) 2021-02-17
AU2023202003A1 (en) 2023-05-04
IL262537B (en) 2021-03-25
HRP20201722T1 (hr) 2021-03-05
EP3777842B1 (en) 2024-12-11
HUE051362T2 (hu) 2021-03-01
IL262537A (en) 2018-12-31
EP4474012A3 (en) 2025-03-12
SMT202000575T1 (it) 2021-01-05
LT3337462T (lt) 2021-01-11
AU2021200268A1 (en) 2021-03-18
ES2828034T3 (es) 2021-05-25
CA3040027A1 (en) 2018-05-03
TWI787164B (zh) 2022-12-21
LT3777842T (lt) 2025-04-10
FI3777842T3 (fi) 2025-02-11
AU2019101470B4 (en) 2020-06-25
CN109922795A (zh) 2019-06-21
US10722494B2 (en) 2020-07-28
DK3337462T3 (da) 2020-10-12
AU2019200479B2 (en) 2020-10-22
AU2016426598B2 (en) 2018-11-01
AU2025234204A1 (en) 2025-10-09
RS61024B1 (sr) 2020-12-31
EP3337462A1 (en) 2018-06-27
KR20190014512A (ko) 2019-02-12
SI3777842T1 (sl) 2025-03-31
AU2019101470A4 (en) 2020-01-16
SI3337462T1 (sl) 2021-01-29
AU2019200479A1 (en) 2019-02-14
MX386987B (es) 2025-03-19
SG11201903829PA (en) 2019-05-30
DK3777842T3 (da) 2025-02-03
HUE070190T2 (hu) 2025-05-28
TW201817418A (zh) 2018-05-16
SMT202500046T1 (it) 2025-03-12
JP2019533672A (ja) 2019-11-21
NZ747702A (en) 2022-08-26
CN109922795B (zh) 2021-10-08
RS66471B1 (sr) 2025-03-31
EP3337462B1 (en) 2020-09-30
EP4474012A2 (en) 2024-12-11
WO2018078429A1 (en) 2018-05-03
AU2016426598C1 (en) 2024-02-08
ES3009413T3 (en) 2025-03-26
CA3040027C (en) 2023-08-15

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