HRP20231035T1 - Monoklonska antitijela protiv krevetnih stjenica i postupci njihove proizvodnje i uporabe - Google Patents

Monoklonska antitijela protiv krevetnih stjenica i postupci njihove proizvodnje i uporabe Download PDF

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HRP20231035T1
HRP20231035T1 HRP20231035TT HRP20231035T HRP20231035T1 HR P20231035 T1 HRP20231035 T1 HR P20231035T1 HR P20231035T T HRP20231035T T HR P20231035TT HR P20231035 T HRP20231035 T HR P20231035T HR P20231035 T1 HRP20231035 T1 HR P20231035T1
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conjugated
monoclonal antibody
antigen
bed bugs
binding fragment
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HRP20231035TT
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William John Hall
Min Wang
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Redcoat Solutions, Inc.
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Publication of HRP20231035T1 publication Critical patent/HRP20231035T1/hr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F1/00—Metallic powder; Treatment of metallic powder, e.g. to facilitate working or to improve properties
    • B22F1/05—Metallic powder characterised by the size or surface area of the particles
    • B22F1/054—Nanosized particles
    • B22F1/0545—Dispersions or suspensions of nanosized particles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
    • C—CHEMISTRY; METALLURGY
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
    • C12N5/16—Animal cells
    • C12N5/163—Animal cells one of the fusion partners being a B or a T lymphocyte
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54386—Analytical elements
    • G01N33/54387—Immunochromatographic test strips
    • G01N33/54388—Immunochromatographic test strips based on lateral flow
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/577—Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies; monoclonal antibodies per se are classified with their corresponding antigens
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/0004—Preparation of sols
    • B01J13/0043—Preparation of sols containing elemental metal
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F2301/00—Metallic composition of the powder or its coating
    • B22F2301/25—Noble metals, i.e. Ag Au, Ir, Os, Pd, Pt, Rh, Ru
    • B22F2301/255—Silver or gold
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F2304/00—Physical aspects of the powder
    • B22F2304/05—Submicron size particles
    • B22F2304/054—Particle size between 1 and 100 nm
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F2304/00—Physical aspects of the powder
    • B22F2304/05—Submicron size particles
    • B22F2304/056—Particle size above 100 nm up to 300 nm
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/43504—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from invertebrates
    • G01N2333/43552—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from invertebrates from insects
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Proteomics, Peptides & Aminoacids (AREA)
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Claims (16)

1. Monoklonska antitijela protiv krevetnih stjenica proizvedena pomoću: (a) hibrida deponiranog u Američkoj zbirci tipova kultura (American Type Culture Collection – ATCC) pod pristupnim brojem PTA-122644 (BB2), ili njegovog fragmenta vezanja antigena ili (b) hibrida deponiranog u Američkoj zbirci tipova kultura – ATCC pristupnim brojem PTA-122645 (BB7) ili njegovog fragmenta vezanja antigena.
2. Konjugirano monoklonsko antitijelo ili konjugirani fragment vezanja antigena koji obuhvaća monoklonsko antitijelo protiv krevetnih stjenica ili fragment vezanja antigena sukladno patentnom zahtjevu 1 i sredstvo otkrivanja.
3. Konjugirano monoklonsko antitijelo ili konjugirani fragment vezanja antigena sukladno patentnom zahtjevu 2, pri čemu je sredstvo za detekciju enzimska oznaka, radio-oznaka, fluorofor, kromofor, sredstvo koji se koristi prilikom medicinskih snimanja, metal, metalni ion, koloidno zlato ili nanočestice zlata.
4. Konjugirano antitijelo ili konjugirani fragment vezanja antigena sukladno patentnim zahtjevima 2 ili 3, koje obuhvaća monoklonsko antitijelo protiv krevetnih stjenica proizvedeno pomoću hibrida deponiranog u Američkoj zbirci tipova kultura ATCC pod pristupnim brojem PTA-122644 (BB2) ili njegovog fragmenta vezanja antigena.
5. Konjugirano antitijelo ili konjugirani fragment vezanja antigena sukladno patentnim zahtjevima 2 ili 3, obuhvaća monoklonsko antitijelo protiv krevetnih stjenica proizvedeno pomoću hibrida deponiranog u Američkoj zbirci tipova kultura ATCC pod pristupnim brojem PTA-122645 (BB7) ili njegovog fragmenta vezanja antigena.
6. Pripravak koja obuhvaća monoklonsko antitijelo protiv krevetnih stjenica ili fragment vezanja antigena sukladno patentnom zahtjevu 1 konjugirano antitijelo ili konjugirani fragment vezanja antigena sukladno bilo kojem patentnom zahtjevu od 2 do 5 ili kombinaciju navedenih.
7. Pripravak sukladno patentnom zahtjevu 6 nadalje obuhvaća: (a)(1) monoklonsko antitijelo protiv krevetnih stjenica sukladno patentnom zahtjevu 1 proizvedeno pomoću hibrida deponiranog u Američkoj zbirci tipova kultura ATCC pod pristupnim brojem PTA-122644 (BB2), i (2) monoklonsko antitijelo protiv krevetnih stjenica sukladno patentnom zahtjevu 1 proizvedeno pomoću hibrida deponiranog u Američkoj zbirci tipova kultura (ATCC) pod pristupnim brojem PTA-122645 (BB7) ili konjugirano antitijelo sukladno patentnom zahtjevu 5; ili (b)(1) monoklonsko antitijelo protiv krevetnih stjenica sukladno patentnom zahtjevu 1 proizvedeno pomoću hibrida deponiranog u Američkoj zbirci tipova kultura ATCC pod pristupnim brojem PTA-122645 (BB7), i (2) konjugirano antitijelo sukladno patentnom zahtjevu 4.
8. Pribor koji obuhvaća monoklonsko antitijelo protiv krevetnih stjenica ili fragment vezanja antitijela sukladno patentnom zahtjevu 1, konjugirano antitijelo ili konjugirani fragment vezanja antigena sukladno bilo kojem od patentnih zahtjeva 2 do 5, pripravak sukladno patentnim zahtjevima 6 ili 7 ili kombinaciju navedenih.
9. Hibrid koji je sposoban za proizvodnju monoklonskog antitijela protiv krevetnih stjenica, pri čemu je hibrid deponiran u Američkoj zbirci tipova kultura (ATCC) pod pristupnim brojem PTA-122644 (BB2) ili pristupnim brojem PTA-122645 (BB7).
10. Izolirana stanica koja proizvodi monoklonsko antitijelo protiv krevetnih stjenica ili fragment vezanja antitijela sukladno patentnom zahtjevu 1.
11. Postupak proizvodnje monoklonskog antitijela protiv krevetnih stjenica ili fragment vezanja antigena sukladno patentnom zahtjevu 1, koje obuhvaća (a) kultiviranje stanice sukladno patentnom zahtjevu 10 i (b) izoliranje monoklonskog antitijela protiv krevetnih stjenica ili fragment vezanja antigena iz kultivirane stanice.
12. Postupak otkrivanja krevetnih stjenica koji obuhvaća dovođenje u kontakt uzorka koji obuhvaća antigen krevetne stjenice s monoklonskim antitijelom protiv krevetnih stjenica ili fragment vezanja antigena sukladno patentnom zahtjevu 1, konjugirano antitijelo ili konjugirani fragment vezanja antigena sukladno bilo kojem od patentnih zahtjeva 2 do 5, pripravak sukladno patentnim zahtjevima 6 ili 7 ili kombinaciju navedenih i otkrivanje vezanja antigena krevetnih stjenica na monoklonsko antitijelo protiv krevetnih stjenica ili fragment vezanja antigena, konjugiranog antitijela ili konjugiranog fragmenta vezanja antigena, pripravka ili njihove kombinacije, pri čemu otkrivanje poželjno obuhvaća izvođenje analize bočnog protoka.
13. Postupak sukladno patentnom zahtjevu 12, pri čemu je taj uzorak doveden u kontakt s monoklonskim antitijelom protiv krevetnih stjenica sukladno patentnom zahtjevu 1 i konjugiranim antitijelom sukladno bilo kojem od patentnih zahtjeva 2 do 5.
14. Postupak sukladno patentnom zahtjevu 13, pri čemu: (a) monoklonsko antitijelo je protiv krevetnih stjenica je monoklonsko antitijelo protiv krevetnih stjenica sukladno patentnom zahtjevu 1 proizvedeno pomoću hibrida deponiranog u Američkoj zbirci tipova kultura (ATCC) pod pristupim brojem PTA-122644 (BB2) i konjugirano antitijelo je konjugirano antitijelo sukladno patentnom zahtjevu 5 ili (b) monoklonsko antitijelo je protiv krevetnih stjenica monoklonsko antitijelo protiv krevetnih stjenica sukladno patentnom zahtjevu 1 proizvedeno pomoću hibrida deponiranog u Američkoj zbirci tipova kultura (ATCC) pod pristupnim brojem PTA-122645 (BB7) i konjugirano antitijelo je konjugirano antitijelo sukladno patentnom zahtjevu 4.
15. Postupak sukladno bilo kojem od patentnih zahtjeva 12 do 14, pri čemu taj postupak nadalje obuhvaća prikupljanje uzorka koji obuhvaća antigen krevetnih stjenica s uređajem za prikupljanje i izlučivanje antigena iz tog uzorka.
16. Postupak sukladno patentnom zahtjevu 15, pri čemu je uređaj za prikupljanje bris.
HRP20231035TT 2015-10-21 2016-10-21 Monoklonska antitijela protiv krevetnih stjenica i postupci njihove proizvodnje i uporabe HRP20231035T1 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562244189P 2015-10-21 2015-10-21
EP16858386.2A EP3365367B1 (en) 2015-10-21 2016-10-21 Anti-bed bug monoclonal antibodies and methods of making and uses thereof
PCT/US2016/058300 WO2017070603A1 (en) 2015-10-21 2016-10-21 Anti-bed bug monoclonal antibodies and methods of making and uses thereof

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US (1) US10768172B2 (hr)
EP (2) EP3365367B1 (hr)
AU (2) AU2016342373B2 (hr)
CA (1) CA3041460A1 (hr)
ES (1) ES2953484T3 (hr)
HR (1) HRP20231035T1 (hr)
HU (1) HUE063822T2 (hr)
MA (1) MA45831B1 (hr)
MD (1) MD3365367T2 (hr)
MX (2) MX2018004986A (hr)
PL (1) PL3365367T3 (hr)
RS (1) RS64530B1 (hr)
WO (1) WO2017070603A1 (hr)

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AU2016342373A1 (en) 2018-06-07
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EP3365367C0 (en) 2023-06-07
MD3365367T2 (ro) 2024-02-29
AU2016342373B2 (en) 2023-09-21
ES2953484T3 (es) 2023-11-13
MA45831A (fr) 2019-06-12
US10768172B2 (en) 2020-09-08
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EP3365367A1 (en) 2018-08-29
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US20200363405A1 (en) 2020-11-19
WO2017070603A1 (en) 2017-04-27
AU2023282327A1 (en) 2024-01-18
RS64530B1 (sr) 2023-09-29
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HUE063822T2 (hu) 2024-02-28
MA45831B1 (fr) 2023-10-31

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