HRP20230381T1 - Pripravci za čišćenje debelog crijeva i liječenje gastrointestinalnih poremećaja - Google Patents
Pripravci za čišćenje debelog crijeva i liječenje gastrointestinalnih poremećaja Download PDFInfo
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- HRP20230381T1 HRP20230381T1 HRP20230381TT HRP20230381T HRP20230381T1 HR P20230381 T1 HRP20230381 T1 HR P20230381T1 HR P20230381T T HRP20230381T T HR P20230381TT HR P20230381 T HRP20230381 T HR P20230381T HR P20230381 T1 HRP20230381 T1 HR P20230381T1
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- Croatia
- Prior art keywords
- cys
- seq
- glu leu
- tyr
- pro ala
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- 210000001072 colon Anatomy 0.000 title claims 6
- 239000000203 mixture Substances 0.000 title claims 5
- 208000018522 Gastrointestinal disease Diseases 0.000 title 1
- 108010010430 asparagine-proline-alanine Proteins 0.000 claims 62
- KABHAOSDMIYXTR-GUBZILKMSA-N Cys-Glu-Leu Chemical compound CC(C)C[C@@H](C(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CS)N KABHAOSDMIYXTR-GUBZILKMSA-N 0.000 claims 47
- PLTGTJAZQRGMPP-FXQIFTODSA-N Asn-Pro-Ala Chemical compound OC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CC(N)=O PLTGTJAZQRGMPP-FXQIFTODSA-N 0.000 claims 46
- ALNKNYKSZPSLBD-ZDLURKLDSA-N Cys-Thr-Gly Chemical compound [H]N[C@@H](CS)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(O)=O ALNKNYKSZPSLBD-ZDLURKLDSA-N 0.000 claims 33
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 32
- LZMQSTPFYJLVJB-GUBZILKMSA-N Glu-Leu-Cys Chemical compound CC(C)C[C@@H](C(=O)N[C@@H](CS)C(=O)O)NC(=O)[C@H](CCC(=O)O)N LZMQSTPFYJLVJB-GUBZILKMSA-N 0.000 claims 28
- 108010004073 cysteinylcysteine Proteins 0.000 claims 25
- BOMGEMDZTNZESV-QWRGUYRKSA-N Cys-Tyr-Gly Chemical compound SC[C@H](N)C(=O)N[C@H](C(=O)NCC(O)=O)CC1=CC=C(O)C=C1 BOMGEMDZTNZESV-QWRGUYRKSA-N 0.000 claims 20
- 108090000765 processed proteins & peptides Proteins 0.000 claims 18
- 108010061238 threonyl-glycine Proteins 0.000 claims 16
- UQJUGHFKNKGHFQ-VZFHVOOUSA-N Ala-Cys-Thr Chemical compound [H]N[C@@H](C)C(=O)N[C@@H](CS)C(=O)N[C@@H]([C@@H](C)O)C(O)=O UQJUGHFKNKGHFQ-VZFHVOOUSA-N 0.000 claims 14
- CBWCQCANJSGUOH-ZKWXMUAHSA-N Asn-Val-Ala Chemical compound [H]N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(O)=O CBWCQCANJSGUOH-ZKWXMUAHSA-N 0.000 claims 14
- SBMGKDLRJLYZCU-BIIVOSGPSA-N Cys-Asn-Pro Chemical compound C1C[C@@H](N(C1)C(=O)[C@H](CC(=O)N)NC(=O)[C@H](CS)N)C(=O)O SBMGKDLRJLYZCU-BIIVOSGPSA-N 0.000 claims 13
- NDUSUIGBMZCOIL-ZKWXMUAHSA-N Cys-Asn-Val Chemical compound CC(C)[C@@H](C(=O)O)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CS)N NDUSUIGBMZCOIL-ZKWXMUAHSA-N 0.000 claims 12
- YEELWQSXYBJVSV-UWJYBYFXSA-N Ala-Cys-Tyr Chemical compound [H]N[C@@H](C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=O YEELWQSXYBJVSV-UWJYBYFXSA-N 0.000 claims 11
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- 150000003839 salts Chemical class 0.000 claims 7
- SNYCNNPOFYBCEK-ZLUOBGJFSA-N Asn-Ser-Ser Chemical compound [H]N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(O)=O SNYCNNPOFYBCEK-ZLUOBGJFSA-N 0.000 claims 6
- DVKQPQKQDHHFTE-ZLUOBGJFSA-N Cys-Cys-Asn Chemical compound C([C@@H](C(=O)O)NC(=O)[C@H](CS)NC(=O)[C@H](CS)N)C(=O)N DVKQPQKQDHHFTE-ZLUOBGJFSA-N 0.000 claims 6
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- WYKJENSCCRJLRC-ZDLURKLDSA-N Thr-Gly-Cys Chemical compound C[C@H]([C@@H](C(=O)NCC(=O)N[C@@H](CS)C(=O)O)N)O WYKJENSCCRJLRC-ZDLURKLDSA-N 0.000 claims 6
- CGDZGRLRXPNCOC-SRVKXCTJSA-N Tyr-Cys-Cys Chemical compound SC[C@@H](C(O)=O)NC(=O)[C@H](CS)NC(=O)[C@@H](N)CC1=CC=C(O)C=C1 CGDZGRLRXPNCOC-SRVKXCTJSA-N 0.000 claims 6
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- 238000002360 preparation method Methods 0.000 claims 5
- -1 C12 alkyl carboxylic acid Chemical class 0.000 claims 4
- BUXAPSQPMALTOY-WHFBIAKZSA-N Cys-Glu Chemical compound SC[C@H](N)C(=O)N[C@H](C(O)=O)CCC(O)=O BUXAPSQPMALTOY-WHFBIAKZSA-N 0.000 claims 4
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- FORGMRSGVSYZQR-YFKPBYRVSA-N L-leucinamide Chemical compound CC(C)C[C@H](N)C(N)=O FORGMRSGVSYZQR-YFKPBYRVSA-N 0.000 claims 3
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- ALJGSKMBIUEJOB-FXQIFTODSA-N Pro-Ala-Cys Chemical compound C[C@@H](C(=O)N[C@@H](CS)C(=O)O)NC(=O)[C@@H]1CCCN1 ALJGSKMBIUEJOB-FXQIFTODSA-N 0.000 claims 3
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- WOCYUGQDXPTQPY-FXQIFTODSA-N Val-Ala-Cys Chemical compound C[C@@H](C(=O)N[C@@H](CS)C(=O)O)NC(=O)[C@H](C(C)C)N WOCYUGQDXPTQPY-FXQIFTODSA-N 0.000 claims 3
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- GZAUZBUKDXYPEH-CIUDSAMLSA-N Leu-Cys-Cys Chemical compound CC(C)C[C@@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CS)C(=O)O)N GZAUZBUKDXYPEH-CIUDSAMLSA-N 0.000 claims 2
- WMIOEVKKYIMVKI-DCAQKATOSA-N Leu-Pro-Ala Chemical compound [H]N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(O)=O WMIOEVKKYIMVKI-DCAQKATOSA-N 0.000 claims 2
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- BVAUMRCGVHUWOZ-ZETCQYMHSA-N (2s)-2-(cyclohexylazaniumyl)propanoate Chemical compound OC(=O)[C@H](C)NC1CCCCC1 BVAUMRCGVHUWOZ-ZETCQYMHSA-N 0.000 claims 1
- LJRDOKAZOAKLDU-UDXJMMFXSA-N (2s,3s,4r,5r,6r)-5-amino-2-(aminomethyl)-6-[(2r,3s,4r,5s)-5-[(1r,2r,3s,5r,6s)-3,5-diamino-2-[(2s,3r,4r,5s,6r)-3-amino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-hydroxycyclohexyl]oxy-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]oxyoxane-3,4-diol;sulfuric ac Chemical compound OS(O)(=O)=O.N[C@@H]1[C@@H](O)[C@H](O)[C@H](CN)O[C@@H]1O[C@H]1[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](N)C[C@@H](N)[C@@H]2O)O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)N)O[C@@H]1CO LJRDOKAZOAKLDU-UDXJMMFXSA-N 0.000 claims 1
- TVYLLZQTGLZFBW-ZBFHGGJFSA-N (R,R)-tramadol Chemical compound COC1=CC=CC([C@]2(O)[C@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-ZBFHGGJFSA-N 0.000 claims 1
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- HRJLVSQKBLZHSR-ZLUOBGJFSA-N Cys-Asn-Ala Chemical compound [H]N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(O)=O HRJLVSQKBLZHSR-ZLUOBGJFSA-N 0.000 claims 1
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- SAEVTQWAYDPXMU-KATARQTJSA-N Cys-Thr-Leu Chemical compound [H]N[C@@H](CS)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(O)=O SAEVTQWAYDPXMU-KATARQTJSA-N 0.000 claims 1
- YPWSLBHSMIKTPR-UHFFFAOYSA-N Cystathionine Natural products OC(=O)C(N)CCSSCC(N)C(O)=O YPWSLBHSMIKTPR-UHFFFAOYSA-N 0.000 claims 1
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- BIYXEUAFGLTAEM-WUJLRWPWSA-N Thr-Gly Chemical compound C[C@@H](O)[C@H](N)C(=O)NCC(O)=O BIYXEUAFGLTAEM-WUJLRWPWSA-N 0.000 claims 1
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- 229940126157 adrenergic receptor agonist Drugs 0.000 claims 1
- YIYBQIKDCADOSF-UHFFFAOYSA-N alpha-Butylen-alpha-carbonsaeure Natural products CCC=CC(O)=O YIYBQIKDCADOSF-UHFFFAOYSA-N 0.000 claims 1
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- 108010014502 beta-3 Adrenergic Receptors Proteins 0.000 claims 1
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- PMMYEEVYMWASQN-UHFFFAOYSA-N dl-hydroxyproline Natural products OC1C[NH2+]C(C([O-])=O)C1 PMMYEEVYMWASQN-UHFFFAOYSA-N 0.000 claims 1
- 201000006549 dyspepsia Diseases 0.000 claims 1
- 235000013922 glutamic acid Nutrition 0.000 claims 1
- 239000004220 glutamic acid Substances 0.000 claims 1
- 125000000291 glutamic acid group Chemical group N[C@@H](CCC(O)=O)C(=O)* 0.000 claims 1
- 229960002591 hydroxyproline Drugs 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 229940005483 opioid analgesics Drugs 0.000 claims 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
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Claims (14)
1. Peptid ili njegova farmaceutski prihvatljiva sol, naznačen time, da peptid sadrži aminokiselinski slijed:
(SEQ ID NO: 2) H-Ag Cys Glu Leu Cys Ag Asn Pro Ala Cys Thr Gly Cys Tyr-NH2;
(SEQ ID NO: 3) C12-BE BK Asn Ser Ser Tyr Cys Cys Glu Leu Cys Cys Asn Pro Ala Cys Thr Gly Cys Tyr-NH2;
(SEQ ID NO: 4) C16-BE BK Asn Ser Ser Tyr Cys Cys Glu Leu Cys Cys Asn Pro Ala Cys Thr Gly Cys Tyr-NH2;
(SEQ ID NO: 5) C12-BE BK Asn Ser Ser Tyr Cys Cys Glu Leu Cys Cys Asn Pro Ala Cys Thr Gly Cys Tyr-COOH;
(SEQ ID NO: 6) C14-BE BK Asn Ser Ser Tyr Cys Cys Glu Leu Cys Cys Asn Pro Ala Cys Thr Gly Cys Tyr-COOH;
(SEQ ID NO: 7) C16-BE BK Asn Ser Ser Tyr Cys Cys Glu Leu Cys Cys Asn Pro Ala Cys Thr Gly Cys Tyr-COOH;
(SEQ ID NO: 8) H-Cys Ag Glu Leu Cys Cys Asn Pro Ala Ag Thr Gly Cys Tyr-NH2;
(SEQ ID NO: 9) H-Asn Asp Asp Ag Glu Leu Cys Val Asn Val Ala Ag Thr Gly Cys Leu-NH2;
(SEQ ID NO: 10) H-Asn Asp Asp Cys Glu Leu Ag Val Asn Val Ala Cys Thr Gly Ag Leu-NH2;
(SEQ ID NO: 11) C18-BE BK Asn Ser Ser Tyr Cys Cys Glu Leu Cys Cys Asn Pro Ala Cys Thr Gly Cys Tyr-COOH;
(SEQ ID NO: 12) H-Ag Cys Glu Leu Cys Ag Asn Pro Ala Cys Thr Gly Cys-NH2;
(SEQ ID NO: 13) H-Ag Cys Glu Leu Cys Ag Asn Pro Ala Cys Ala Gly Cys-NH2;
(SEQ ID NO: 14) H-Ag Cys Glu Phe Cys Ag Asn Pro Ala Cys Thr Gly Cys Tyr-NH2;
(SEQ ID NO: 15) H-Ag Cys Glu (4-F)Phe Cys Ag Asn Pro Ala Cys Thr Gly Cys-NH2;
(SEQ ID NO: 16) H-Ag Cys Glu (4-F)Phe Cys Ag Asn Pro Ala Cys Thr Gly Cys Tyr-NH2;
(SEQ ID NO: 17) H-Ag Cys Glu (4-F)Phe Cys Ag Asn Pro Ala Cys Thr Gly Cys (4-F)Phe-NH2;
(SEQ ID NO: 18) H-Cys Cys Glu Leu Ag Cys Asn Pro Ala Cys Thr Gly Ag Tyr-NH2;
(SEQ ID NO: 19) H-Ag Cys Glu Phe Cys Ag Asn Pro Ala Cys Thr Gly Cys-NH2;
(SEQ ID NO: 20) H-Ag Cys Glu Phe Cys Ag Asn Pro Ala Cys Thr Gly Cys (4-F)Phe-NH2;
(SEQ ID NO: 21) H-Cys Cys Glu (4-F)Phe Cys Cys Asn Pro Ala Cys Thr Gly Cys Tyr-NH2;
(SEQ ID NO: 22) H-Cys Cys Glu (4-F)Phe Cys Cys Asn Pro Ala Cys Thr Gly Cys (4-F)Phe-NH2;
(SEQ ID NO: 23) H-Ag Cys Glu Leu Cys Ag Asn Pro Ala Cys Thr Gly Cys (4-F)Phe-NH2;
(SEQ ID NO: 24) H-(4-F)Phe Ag Cys Glu Leu Cys Ag Asn Pro Ala Cys Thr Gly Cys (4-F)Phe-NH2;
(SEQ ID NO: 25) H-Ag Cys Glu Leu Cys Ag Asn Pro Ala Cys Ala Gly Cys Tyr-NH2;
(SEQ ID NO: 26) H-Ag Cys Glu Leu Cys Ag Asn Pro Ala Cys Tyr Gly Cys Tyr-NH2;
(SEQ ID NO: 27) H-Ag Cys Glu Leu Cys Ag Asn Pro Ala Cys Phe Gly Cys Tyr-NH2;
(SEQ ID NO: 28) H-Ag Cys Glu Leu Cys Ag Asn Pro Ala Cys (4-F)Phe Gly Cys Tyr-NH2;
(SEQ ID NO: 29) H-Ag Cys Glu Leu Cys Ag Asn Pro Ala Cys Thr Gly Cys Leu-NH2;
(SEQ ID NO: 30) H-Ag Cys Glu Leu Cys Ag Asn Pro Ala Cys Thr Gly Cys Cha-NH2;
(SEQ ID NO: 31) H-Ag Cys Glu Cha Cys Ag Asn Pro Ala Cys Thr Gly Cys Tyr-NH2;
(SEQ ID NO: 32) H-Ag Cys Glu Leu Cys Ag Asn Pro Ala Cys Thr Gly Cys D-Tyr-NH2;
(SEQ ID NO: 33) H-Ag Pen Glu Leu Cys Ag Asn Pro Ala Pen Thr Gly Cys Tyr-NH2;
(SEQ ID NO: 34) H-Ag Cys Glu Leu Cys Ag Asn Pro Ala Cys Thr Gly Cys Leu Asn-NH2;
(SEQ ID NO: 35) H-Ag Cys Glu Leu Cys Ag Asn Pro Ala Cys Thr Gly Cys Tyr Asn-NH2;
(SEQ ID NO: 36) H-Asp Ag Cys Glu Leu Cys Ag Asn Pro Ala Cys Thr Gly Cys Tyr-NH2;
(SEQ ID NO: 37) H-Ile Asp Ag Cys Glu Leu Cys Ag Asn Pro Ala Cys Thr Gly Cys Tyr-NH2;
(SEQ ID NO: 38) H-Ag Cys Glu Leu Cys Ag Asn OH-Pro Ala Cys Thr Gly Cys Tyr-NH2;
(SEQ ID NO: 39) H-Ag Cys Glu Leu Cys Ag Asn OH-Pro Ala Cys Tyr Gly Cys-NH2;
(SEQ ID NO: 40) H-Ag Cys Glu Leu Pen Ag Asn Pro Ala Cys Thr Gly Pen Tyr-NH2;
(SEQ ID NO: 41) H-Ag Cys Glu Leu Pen Ag Asn Pro Ala Cys Thr Gly Pen Tyr-NH2;
(SEQ ID NO: 42) H-Ag Cys Glu Leu Cys Ag Asn Pro Ala Cys Tyr Gly Cys Nme-Tyr-NH2;
(SEQ ID NO: 43) H-Ag Cys Glu Leu Cys Ag Asn Pro Ala Cys Tyr Gly Cys-COOH;
(SEQ ID NO: 44) H-Ag Cys Glu Leu Cys Ag Asn Pro Ala Cys Cha Gly Cys Tyr-NH2;
(SEQ ID NO: 45) H-Ag Cys Glu Leu Cys Ag Asn Leu Ala Cys Thr Gly Cys Tyr-NH2;
(SEQ ID NO: 46) H-Ag Cys Glu Leu Cys Ag Asn Sar Ala Cys Thr Gly Cys Tyr-NH2;
(SEQ ID NO: 47) H-Ag Cys Glu Leu Cys Ag Asn Val Ala Cys Thr Gly Cys Tyr-NH2;
(SEQ ID NO: 48) H-Ag Cys Glu Leu Cys Ag Asn Pro Ala Cys Tyr Gly Cys Nme-Tyr-NH2;
(SEQ ID NO: 49) H-Ag Cys Glu Leu Cys Ag Leu Pro Ala Cys Tyr Gly Cys-COOH;
(SEQ ID NO: 50) H-Ag Cys Asp Leu Cys Ag Asn Pro Ala Cys Tyr Gly Cys-COOH;
(SEQ ID NO: 51) H-Ag Cys Ser Leu Cys Ag Asn Pro Ala Cys Tyr Gly Cys-COOH;
(SEQ ID NO: 52) H-Ag Cys Thr Leu Cys Ag Asn Pro Ala Cys Tyr Gly Cys-COOH;
(SEQ ID NO: 53) H-Hag Cys Glu Leu Cys Hag Asn Pro Ala Cys Thr Gly Cys Tyr-NH2;
(SEQ ID NO: 54) H-Ag Cys Gln Leu Cys Ag Asn Pro Ala Cys Tyr Gly Cys-COOH;
(SEQ ID NO: 55) H-Ag Cys Glu Leu Cys Ag Leu Pro Ala Cys Thr Gly Cys Tyr-NH2;
(SEQ ID NO: 56) Pent-Cys Glu Leu Cys Ag Asn Pro Ala Cys Tyr Gly Cys Tyr-NH2;
(SEQ ID NO: 57) H-Cys Cys Glu Leu Cys Ag Asn Pro Ala Cys Tyr Gly Ag-COOH;
(SEQ ID NO: 58) Pent-Cys Glu Leu Cys Ag Asn Pro Ala Cys Tyr Gly Cys-COOH;
(SEQ ID NO: 59) H-Hag Cys Glu Leu Cys Hag Asn Pro Ala Cys Tyr Gly Cys-COOH;
(SEQ ID NO: 60) H-Ag Cys Glu Leu Cys Ag Asn Val Ala Cys Tyr Gly Cys Tyr-NH2;
(SEQ ID NO: 61) H-Ag Cys Glu Leu Cys Ag Asn Val Ala Cys Tyr Gly Cys-COOH;
(SEQ ID NO: 62) H-Cys Cth Glu Leu Cys Cys Asn Pro Ala Cys Tyr Gly Cys Tyr-NH2;
(SEQ ID NO: 63) H-Cth Cys Glu Leu Cys Cys Asn Pro Ala Cys Tyr Gly Cys Tyr-NH2;
(SEQ ID NO: 64) H-Cth Cys Glu Leu Cys Cys Asn Pro Ala Cys Tyr Gly Cys-COOH;
(SEQ ID NO: 65) H-Cys Cth Glu Leu Cys Cys Asn Val Ala Cys Tyr Gly Cys Tyr-NH2;
(SEQ ID NO: 66) H-Cys Cth Glu Leu Cys Cys Asn Val Ala Cys Thr Gly Cys Tyr-NH2;
(SEQ ID NO: 67) Ac-Cys Cth Glu Leu Cys Cys Asn Val Ala Cys Thr Gly Cys Tyr-NH2;
(SEQ ID NO: 68) Ac-Cys Cth Glu Leu Cys Cys Asn Pro Ala Cys Tyr Gly Cys Tyr-NH2;
(SEQ ID NO: 69) Ac-Cys Cth Glu Leu Cys Cys Asn Val Ala Cys Tyr Gly Cys-COOH;
(SEQ ID NO: 70) H-Cys Cth Glu Leu Cys Cys Asn Val Ala Cys Tyr Gly Cys-COOH;
(SEQ ID NO: 71) Ac-Cys Cth Glu Leu Cys Cys Asn Pro Ala Cys Tyr Gly Cys-COOH;
(SEQ ID NO: 72) H-Cys Cys Glu Leu Cys Asn Val Ala Cth Tyr Gly Cys-COOH;
(SEQ ID NO: 73) H-Cys Cys Glu Leu Cys Cys Asn Val Ala Cth Tyr Gly Cys Tyr-NH2;
(SEQ ID NO: 74) H-Cys Cys Glu Leu Cys Cth Asn Val Ala Cth Thr Gly Cys Tyr-NH2;
(SEQ ID NO: 75) H-Cys Cys Glu Leu Cys Cth Asn Val Ala Cys Tyr Gly Cys-COOH;
(SEQ ID NO: 76) H-Cys Cys Glu Leu Cys Cth Asn Val Ala Cys Tyr Gly Cys Tyr-NH2;
(SEQ ID NO: 77) H-Cys Cys Glu Leu Cys Cth Asn Val Ala Cys Thr Gly Cys Tyr-NH2;
(SEQ ID NO: 78) 4-Mepip-Cys Cth Glu Leu Cys Cys Asn Val Ala Cys Tyr Gly Cys-COOH;
(SEQ ID NO: 79) H-Cys Cth Glu Leu Cys Cys Asn Val Ala Cys Thr Gly Cys-COOH;
(SEQ ID NO: 80) H-Cys Cth Glu Leu Cys Cys Asn Val Ala Cys Thr Gly Cys-NH2;
(SEQ ID NO: 81) H-Cys Cth Glu Leu Cys Cys Asn Val Ala Cys Phe Gly Cys-COOH;
(SEQ ID NO: 82) H-Ag Ag Glu Leu Ag Ag Asn Pro Ala Ag Thr Gly Ag Tyr-COOH;
(SEQ ID NO: 83) H-Cys Cth Glu Leu Cys Cys Asn Ala Ala Cys Thr Gly Cys Tyr-NH2;
(SEQ ID NO: 84) H-Asp Cys Glu Leu Cys Dpr Asn Val Ala Cys Thr Gly Cys Tyr-NH2;
(SEQ ID NO: 85) H-Cys Cth Glu Leu Cys Cys Asn Val Ala Cys Ser Gly Cys Tyr-NH2;
(SEQ ID NO: 86) H-Cth Glu Leu Cys Ag Asn Val Ala Cys Thr Gly Cys Tyr-NH2;
(SEQ ID NO: 87) H-Ag Cys Glu Leu Cys Ag Asn Val Ala Cys Thr Gly Cys Tyr-NH2;
(SEQ ID NO: 88) H-Ag Cys Glu Leu Cys Ag Asn Pro Ala Cys Thr Gly Cys Tyr-NH2;
(SEQ ID NO: 89) H-Cth Cys Glu Leu Cys Cys Asn Val Ala Cys Thr Gly Cys-COOH;
(SEQ ID NO: 90) H-Cth Cys Glu Leu Cys Cys Asn Val Ala Cys Thr Gly Cys Tyr-NH2;
(SEQ ID NO: 91) H-Cth Cys Glu Leu Cys Cys Asn Val Ala Cys Tyr Gly Cys Tyr-NH2; ili
(SEQ ID NO: 92) H-Cys Cys Glu Leu Cys Cys Asn Val Ala Cth Tyr Gly Cys-COOH;
pri čemu Ag je alilglicin; BE je glutaminska kiselina, gdje bočni lanac karboksilne kiseline formira peptidnu vezu;
BK je lizin, gdje bočni lanac amina formira peptidnu vezu; (4-F)Phe je 4-fluorofenilalanin; Cha je cikloheksilalanin; Pen je penicilamin; OH-Pro je hidroksiprolin; Nme-Tyr je N-metil tirozin; Sar je sarkozin; Hag je alilglicin s reduciranom dikarba vezom; Cth je cistationin; 4-Mepip je 1-metil-piperidin-4-karboksilna kiselina; Dpr je di-aminopropionska kiselina; i pri čemu Ac- označava acetilirani N-završetak; Pent- označava N-završetak pokriven s pentenskom kiselinom; C12- označava N-završetak pokriven sa C12 alkil karboksilnom kiselinom; C14- označava N-završetak pokriven sa C14 alkil karboksilnom kiselinom;
C16- označava N-završetak pokriven sa C16 alkil karboksilnom kiselinom;
C18- označava N-završetak pokriven sa C18 alkil karboksilnom kiselinom;
H- označava nemodificirani N-završetak; -NH2 označava amidirani C-završetak; i
-COOH označava nemodificirani C-završetak.
2. Peptid ili njegova farmaceutski prihvatljiva sol, prema patentnom zahtjevu 1, naznačen time, da peptid sadrži aminokiselinski slijed:
(SEQ ID NO: 2) H-Ag Cys Glu Leu Cys Ag Asn Pro Ala Cys Thr Gly Cys Tyr-NH2;
(SEQ ID NO: 26) H-Ag Cys Glu Leu Cys Ag Asn Pro Ala Cys Tyr Gly Cys Tyr-NH2;
(SEQ ID NO: 43) H-Ag Cys Glu Leu Cys Ag Asn Pro Ala Cys Tyr Gly Cys-COOH;
(SEQ ID NO: 47) H-Ag Cys Glu Leu Cys Ag Asn Val Ala Cys Thr Gly Cys Tyr-NH2;
(SEQ ID NO: 62) H-Ag Cys Glu Leu Cys Ag Asn Val Ala Cys Tyr Gly Cys Tyr-NH2;
(SEQ ID NO: 64) H-Cth Cys Glu Leu Cys Cys Asn Pro Ala Cys Tyr Gly Cys-COOH;
(SEQ ID NO: 68) Ac-Cys Cth Glu Leu Cys Cys Asn Pro Ala Cys Tyr Gly Cys Tyr-NH2;
(SEQ ID NO: 69) Ac-Cys Cth Glu Leu Cys Cys Asn Val Ala Cys Tyr Gly Cys-COOH;
(SEQ ID NO: 70) H-Cys Cth Glu Leu Cys Cys Asn Val Ala Cys Tyr Gly Cys-COOH; ili
(SEQ ID NO: 71) Ac-Cys Cth Glu Leu Cys Cys Asn Pro Ala Cys Tyr Gly Cys-COOH.
3. Peptid ili njegova farmaceutski prihvatljiva sol, prema patentnom zahtjevu 1 ili zahtjevu 2, naznačen time, da se peptid sastoji od jednog od navedenih aminokiselinskih sljedova.
4. Farmaceutski pripravak, naznačen time, da sadrži peptid ili njegovu farmaceutski prihvatljivu sol prema bilo kojem od patentnih zahtjeva 1 do 3, i najmanje jedno farmaceutski prihvatljivo pomoćno sredstvo, razrjeđivač ili nosač.
5. Farmaceutski pripravak prema patentnom zahtjevu 4, naznačen time, da je farmaceutski pripravak čvrsta formulacija za doziranje.
6. Farmaceutski pripravak prema patentnom zahtjevu 5, naznačen time, da je farmaceutski pripravak formuliran kao čvrsta oralna formulacija za doziranje.
7. Pripravak za čišćenje debelog crijeva, naznačen time, da je za uporabu u postupku čišćenja debelog crijeva kod pojedinca, u preparatu za kolonoskopsku proceduru, pri čemu pripravak sadrži farmaceutski prihvatljivo pomoćno sredstvo, razrjeđivač ili nosač, i peptid ili njegovu farmaceutski prihvatljivu sol, u skladu s bilo kojim od patentnih zahtjeva 1 do 3.
8. Pripravak za čišćenje debelog crijeva za uporabu prema patentnom zahtjevu 7, naznačen time, da postupak obuhvaća:
a. oralno ili rektalno davanje pojedincu učinkovite prve doze pripravka za čišćenje debelog crijeva; i
b. davanje pojedincu učinkovite druge doze pripravka za čišćenje debelog crijeva u svrhu temeljitog čišćenja debelog crijeva kod pojedinca.
9. Pripravak za čišćenje debelog crijeva za uporabu prema patentnom zahtjevu 8, naznačen time, da se učinkovita druga doza daje ujutro nakon davanja učinkovite prve doze.
10. Postupak za proizvodnju peptida prema bilo kojem od patentnih zahtjeva 1 do 3, naznačen time, da obuhvaća stvaranje staničnog uzgoja molekule nukleinske kiseline koja kodira peptid, kultiviranje stanice pod uvjetima u kojima se peptid eksprimira, te izoliranje eksprimiranog peptida.
11. Postupak za proizvodnju peptida prema bilo kojem od patentnih zahtjeva 1 do 3, naznačen time, da obuhvaća kemijsko sintetiziranje peptida i pročišćavanje sintetiziranog peptida.
12. Peptid ili njegova farmaceutski prihvatljiva sol prema bilo kojem od patentnih zahtjeva 1 do 3, naznačen time, da je za uporabu u postupku liječenja gastrointestinalnog ili organskog poremećaja kod pojedinca.
13. Peptid ili njegova farmaceutski prihvatljiva sol prema bilo kojem od patentnih zahtjeva 1 do 3, naznačen time, da je za uporabu u postupku liječenja poremećaja kod pojedinca, koji se bira od sljedećih: rak debelog crijeva, hereditarni nepolipozni kolorektalni rak (HNPCC), Lynchov sindrom, gastropareza (GP), polipi, bol, opća abdominalna bol, postoperativni ileus, konstipacija inducirana opoidima, funkcionalna dispepsija, divertikularna bolest uključujući, ali bez ograničenja na SUDD (simptomatska nekomplicirana divertikularna bolest) i SCAD (segmentalni kolitis povezan s divertikulozom), divertikuloza, sindrom iritabilnih crijeva pretežno s proljevom, bol povezana sa sindromom iritabilnih crijeva (IBS), ulcerativni kolitis, ulcerativni proktitis, Crohnova bolest, upalna bolest crijeva (IBD), kronična ili akutna radijacijska protopatija, rektalna bol, kronična proktalgija, proktalgija fugax, analna bol, kronična analna fisura, postoperativna analna bol, sindrom prekomjerne aktivnosti mokraćnog mjehura, stresna inkontinencija, intersticijalni cistitis, sindrom bolova u mokraćnom mjehuru, kolorektalni rak, bol povezana s rakom, opća bol u karlici, endometrioza, orhialgija, kronični prostatitis, prostatodinija, vulvodinija, uretralni sindrom, bol u penisu, perianalna bol i ostali gastrointestinalni i organski poremećaji.
14. Peptid za uporabu prema patentnom zahtjevu 13, naznačen time, da postupak nadalje obuhvaća davanje pojedincu farmaceutskog pripravka koji sadrži djelatni sastojak odabran od opoida, tramadola, agonista beta-3 adrenergijskog receptora, anti-holinergijskih sredstava, i tricikličkih antidepresiva.
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| US7494979B2 (en) * | 2003-06-13 | 2009-02-24 | Ironwood Pharmaceuticals, Inc. | Method for treating congestive heart failure and other disorders |
| WO2007022531A2 (en) * | 2005-08-19 | 2007-02-22 | Microbia, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| US20110172126A1 (en) * | 2008-09-03 | 2011-07-14 | Xenome Ltd | Libraries of peptide conjugates and methods for making them |
| DK2536742T3 (en) * | 2010-02-17 | 2017-09-04 | Ironwood Pharmaceuticals Inc | TREATMENTS FOR GASTROINTESTINAL DISORDERS |
| CA2902348C (en) * | 2013-02-25 | 2021-11-30 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
| WO2016015055A1 (en) * | 2014-07-25 | 2016-01-28 | Ironwood Pharmaceuticals, Inc. | Colon cleansing compositions |
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2016
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