HRP20230049T1 - Uređaj za frakcioniranje objekata i postupak frakcioniranja - Google Patents
Uređaj za frakcioniranje objekata i postupak frakcioniranja Download PDFInfo
- Publication number
- HRP20230049T1 HRP20230049T1 HRP20230049TT HRP20230049T HRP20230049T1 HR P20230049 T1 HRP20230049 T1 HR P20230049T1 HR P20230049T T HRP20230049T T HR P20230049TT HR P20230049 T HRP20230049 T HR P20230049T HR P20230049 T1 HRP20230049 T1 HR P20230049T1
- Authority
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- Croatia
- Prior art keywords
- fractionation
- liquid
- limiting
- channel
- flow rate
- Prior art date
Links
- 238000005194 fractionation Methods 0.000 title claims 20
- 238000000034 method Methods 0.000 title claims 8
- 239000007788 liquid Substances 0.000 claims 22
- 238000002347 injection Methods 0.000 claims 16
- 239000007924 injection Substances 0.000 claims 16
- 239000012530 fluid Substances 0.000 claims 14
- 238000011010 flushing procedure Methods 0.000 claims 8
- 238000005406 washing Methods 0.000 claims 5
- 239000012620 biological material Substances 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 239000006185 dispersion Substances 0.000 claims 1
- 238000002386 leaching Methods 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 210000000130 stem cell Anatomy 0.000 claims 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/0005—Field flow fractionation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
- B01L3/502776—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for focusing or laminating flows
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/40—Concentrating samples
- G01N1/405—Concentrating samples by adsorption or absorption
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0605—Metering of fluids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
- B01L2200/0652—Sorting or classification of particles or molecules
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0887—Laminated structure
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/08—Regulating or influencing the flow resistance
- B01L2400/082—Active control of flow resistance, e.g. flow controllers
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Dispersion Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Fluid Mechanics (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Separation Of Solids By Using Liquids Or Pneumatic Power (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Devices For Executing Special Programs (AREA)
- Vending Machines For Individual Products (AREA)
- Control Of Vending Devices And Auxiliary Devices For Vending Devices (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Claims (10)
1. Uređaj za dinamičko frakcioniranje faze raspršene u disperznoj tekućini, pri čemu navedeni uređaj sadrži:
kanal (221, 212, 222) za frakcioniranje,
prvi priključak (321) za injektiranje kroz koji se u kanal za frakcioniranje ubrizgava prva ograničavajuća tekućina i drugi priključak (321) za injektiranje kroz koji se u kanal (221, 212, 222) za frakcioniranje ubrizgava drugu ograničavajuću tekućinu,
treći priključak (311) za injektiranje kroz koji se u kanal (221, 212, 222) za frakcioniranje ubrizgava tekućina za ispiranje koja vrši transport disperzirane faze, gdje je treći priključak (311) za injektiranje postavljen između prvog i drugog priključka (321) za injektiranje, pri čemu prvi terminalni dio kanala (221, 212, 222) za frakcioniranje sadrži prvi do treći terminalni dio (241, 251) respektivno u skladu sa prvim i trećim priključcima (311, 321) za injektiranje, i pri čemu su terminalni dijelovi (241, 251) od prvog do trećeg dimenzionirani tako da prva i druga ograničavajuća tekućina imaju prvu i drugu unaprijed definiranu brzinu protoka i da tekućina za ispiranje može imati treću unaprijed definiranu brzinu protoka, pri čemu je treća unaprijed definirana brzina protoka veća od prve i druge brzine protoka tako da tekućina za ispiranje ograniči i zadrži između prve i druge ograničavajuće tekućine;
pri čemu navedeni uređaj dalje sadrži:
najmanje jedno sredstvo (441) za kontrolu prvog toka koje je u fluidnoj vezi sa prvim do trećim priključcima (211, 321) za injektiranje i koje je prilagođeno da kontrolira protok tekućine za ispiranje pri trećoj unaprijed definiranoj brzini protoka;
pri čemu je navedeno najmanje jedno sredstvo (441) za kontrolu prvog toka dalje prilagođeno da kontrolira protok prve ograničavajuće tekućine pri prvoj unaprijed definiranoj brzini protoka i da kontrolira protok druge ograničavajuće tekućine pri drugoj unaprijed definiranoj brzini protoka;
gdje je navedeni uređaj naznačen time:
što je širina osnove prvog i drugog terminalnog dijela (251) koji respektivno odgovaraju prvom i drugom priključku (321) za injektiranje u opsegu od 25% do 50% širine osnove trećeg terminalnog dijela (241) koji odgovara trećem priključku (311) za injektiranje, pri čemu izraz "osnova terminalnog dijela" označava dio terminalnog dijela koji je povezan sa kanalom za frakcioniranje;
i što su prva i druga unaprijed definirana brzina protoka prve i druge ograničavajuće tekućine u opsegu od 5% do 25% treće brzine protoka tekućine za ispiranje.
2. Uređaj prema zahtjevu 1, pri čemu su dijelovi od prvog do trećeg terminalnog dijela (241, 251) konfigurirani tako da su njihove odgovarajuće uzdužne osi paralelne jedna drugoj i uzdužnoj osi kanala (221, 212, 222) za frakcioniranje tako da tekućina za ispiranje može teći paralelno sa prvim i drugim ograničavajućim tekućinama.
3. Uređaj prema bilo kojem od zahtjeva 1 ili 2, pri čemu su dijelovi od prvog do trećeg terminalnog dijela (241, 251) u obliku luka.
4. Uređaj prema bilo kojem od zahtjeva 1 do 3, koji dalje sadrži priključak (331) za injektiranje uzorka namijenjen za ubrizgavanje faze disperzirane u disperznoj tekućini u kanal (221, 212, 222) za frakcioniranje, gdje je priključak (331) za injektiranje uzorka postavljen tako da omogućava ubrizgavanje disperzirane faze u tekućini za ispiranje u kanalu (221, 212, 222) za frakcioniranje.
5. Postupak za dinamičko frakcioniranje faze disperzirane u disperznoj tekućini, pri čemu navedeni postupak obuhvaća korake:
ubrizgavanja prve ograničavajuće tekućine kroz prvi priključak (321) za injektiranje i druge ograničavajuće tekućine kroz drugi priključak (321) za injektiranje u kanal (221, 212, 222) za frakcioniranje, gdje se prva i druga ograničavajuća tekućina dovode prvom i drugom unaprijed definiranom brzinom protoka,
ubrizgavanja tekućine za ispiranje radi dovođenja mobilne faze u kanal (221, 212, 222) za frakcioniranje kroz treći priključak (311) za injektiranje koji se nalazi između prvog i drugog priključka (321) za injektiranje, gdje se tekućina za ispiranje dovodi trećom unaprijed definiranom brzinom protoka,
pri čemu je treća unaprijed definirana brzina protoka veća od prve i druge unaprijed definirane brzine protoka, tako da tekućina za ispiranje ograničava između prve i druge ograničavajuće tekućine,
naznačen time:
što su prva i druga unaprijed definirana brzina protoka prve i druge ograničavajuće tekućine u opsegu od 5% do 2 5% treće brzine protoka tekućine za ispiranje.
6. Postupak prema zahtjevu 5, pri čemu se prva i druga ograničavajuća tekućina i tekućina za ispiranje ubrizgavaju u kanal (221, 212, 222) za frakcioniranje respektivno u skladu sa prvim do trećim terminalnim dijelovima (241, 251) prvog krajnjeg dijela kanala (221, 212, 222) za frakcioniranje.
7. Postupak prema zahtjevu 5 ili 6, pri čemu prva i druga unaprijed definirana brzina protoka prve i druge ograničavajuće tekućine iznose 10% od treće unaprijed definirane brzine protoka.
8. Postupak prema bilo kojem od zahtjeva 5 do 7, koji dalje sadrži korake:
pripreme uzorka disperzirane faze u disperznoj tekućini,
uvođenja pripremljenog uzorka kroz priključak (331) za injektiranje uzorka u tekućini za ispiranje koji teče kroz kanal (221, 212, 222) za frakcioniranje,
ispiranje pripremljenog uzorka iz kanala (221, 212, 222) za frakcioniranje, nakon koraka unošenja pripremljenog uzorka i prije koraka ispiranja pripremljenog uzorka, izborno prekidajući protok tekućine za ispiranje.
9. Postupak prema bilo kojem od zahtjeva 5 do 8, koji dalje sadrži korak podešavanja brzine protoka tekućine za ispiranje i/ili prve i druge ograničavajuće tekućine na osnovu uvjeta frakcioniranja i/ili tipa ubrizganog uzorka.
10. Postupak prema bilo kojem od zahtjeva 5 do 9, pri čemu disperzirana faza sadrži biološki materijal, poželjno stanice i/ili matične stanice.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITVI20140214 | 2014-08-20 | ||
EP15767304.7A EP3183568B1 (en) | 2014-08-20 | 2015-08-14 | Device for the fractionation of objects and fractionation method |
PCT/IB2015/056195 WO2016027204A1 (en) | 2014-08-20 | 2015-08-14 | Device for the fractionation of objects and fractionation method |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20230049T1 true HRP20230049T1 (hr) | 2023-03-03 |
Family
ID=51703352
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20230049TT HRP20230049T1 (hr) | 2014-08-20 | 2015-08-14 | Uređaj za frakcioniranje objekata i postupak frakcioniranja |
Country Status (17)
Country | Link |
---|---|
US (1) | US10788463B2 (hr) |
EP (2) | EP4155725A1 (hr) |
JP (1) | JP6487035B2 (hr) |
KR (1) | KR101984559B1 (hr) |
CN (1) | CN107076708B (hr) |
CA (1) | CA2958118C (hr) |
DK (1) | DK3183568T3 (hr) |
ES (1) | ES2936343T3 (hr) |
FI (1) | FI3183568T3 (hr) |
HR (1) | HRP20230049T1 (hr) |
HU (1) | HUE060950T2 (hr) |
LT (1) | LT3183568T (hr) |
PL (1) | PL3183568T3 (hr) |
PT (1) | PT3183568T (hr) |
RS (1) | RS63882B1 (hr) |
SI (1) | SI3183568T1 (hr) |
WO (1) | WO2016027204A1 (hr) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2019198178A1 (ja) * | 2018-04-11 | 2019-10-17 | 株式会社島津製作所 | フィールドフローフラクショネーション装置 |
US11971392B2 (en) * | 2019-06-25 | 2024-04-30 | Wyatt Technology, Llc | Sealing structure for a field flow fractionator |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU4113297A (en) * | 1996-09-04 | 1998-03-26 | Technical University Of Denmark | A micro flow system for particle separation and analysis |
US7118676B2 (en) * | 2003-09-04 | 2006-10-10 | Arryx, Inc. | Multiple laminar flow-based particle and cellular separation with laser steering |
JP2004097886A (ja) | 2002-09-05 | 2004-04-02 | Sumitomo Bakelite Co Ltd | マイクロ分離装置とそれを用いた分離方法 |
EP1622691B1 (en) * | 2003-03-14 | 2011-05-25 | The Trustees of Columbia University in the City of New York | Systems and methods of blood-based therapies having a microfluidic membraneless exchange device |
WO2005023391A2 (en) | 2003-07-31 | 2005-03-17 | Arryx, Inc. | Multiple laminar flow-based particle and cellular separation with laser steering |
CN100475317C (zh) * | 2003-09-04 | 2009-04-08 | 阿尔利克斯公司 | 利用激光操纵进行基于多层流的颗粒和细胞分离 |
FR2882939B1 (fr) * | 2005-03-11 | 2007-06-08 | Centre Nat Rech Scient | Dispositif de separation fluidique |
WO2007137245A2 (en) * | 2006-05-22 | 2007-11-29 | Columbia University | Systems and methods of microfluidic membraneless exchange using filtration of extraction fluid outlet streams |
BRPI0907473A2 (pt) * | 2008-02-04 | 2019-09-24 | Univ Columbia | métodos, sistemas e dispositivos de separação de fluidos |
-
2015
- 2015-08-14 ES ES15767304T patent/ES2936343T3/es active Active
- 2015-08-14 RS RS20230023A patent/RS63882B1/sr unknown
- 2015-08-14 PL PL15767304.7T patent/PL3183568T3/pl unknown
- 2015-08-14 EP EP22200216.4A patent/EP4155725A1/en active Pending
- 2015-08-14 PT PT157673047T patent/PT3183568T/pt unknown
- 2015-08-14 SI SI201531915T patent/SI3183568T1/sl unknown
- 2015-08-14 EP EP15767304.7A patent/EP3183568B1/en active Active
- 2015-08-14 HU HUE15767304A patent/HUE060950T2/hu unknown
- 2015-08-14 DK DK15767304.7T patent/DK3183568T3/da active
- 2015-08-14 LT LTEPPCT/IB2015/056195T patent/LT3183568T/lt unknown
- 2015-08-14 KR KR1020177006398A patent/KR101984559B1/ko active IP Right Grant
- 2015-08-14 JP JP2017510407A patent/JP6487035B2/ja active Active
- 2015-08-14 US US15/503,449 patent/US10788463B2/en active Active
- 2015-08-14 WO PCT/IB2015/056195 patent/WO2016027204A1/en active Application Filing
- 2015-08-14 HR HRP20230049TT patent/HRP20230049T1/hr unknown
- 2015-08-14 CN CN201580056727.4A patent/CN107076708B/zh active Active
- 2015-08-14 FI FIEP15767304.7T patent/FI3183568T3/fi active
- 2015-08-14 CA CA2958118A patent/CA2958118C/en active Active
Also Published As
Publication number | Publication date |
---|---|
US10788463B2 (en) | 2020-09-29 |
KR20170039742A (ko) | 2017-04-11 |
EP3183568A1 (en) | 2017-06-28 |
EP4155725A1 (en) | 2023-03-29 |
JP2017527281A (ja) | 2017-09-21 |
PT3183568T (pt) | 2023-01-16 |
KR101984559B1 (ko) | 2019-05-31 |
CA2958118C (en) | 2019-05-21 |
EP3183568B1 (en) | 2022-10-26 |
US20170241959A1 (en) | 2017-08-24 |
JP6487035B2 (ja) | 2019-03-20 |
LT3183568T (lt) | 2023-01-25 |
FI3183568T3 (fi) | 2023-01-31 |
PL3183568T3 (pl) | 2023-03-27 |
CN107076708B (zh) | 2020-02-28 |
CN107076708A (zh) | 2017-08-18 |
ES2936343T3 (es) | 2023-03-16 |
WO2016027204A1 (en) | 2016-02-25 |
CA2958118A1 (en) | 2016-02-25 |
HUE060950T2 (hu) | 2023-04-28 |
SI3183568T1 (sl) | 2023-02-28 |
DK3183568T3 (da) | 2023-01-30 |
RS63882B1 (sr) | 2023-02-28 |
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