HRP20200693T1 - Pojačivači topivosti u vodi na bazi glikogena - Google Patents
Pojačivači topivosti u vodi na bazi glikogena Download PDFInfo
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- HRP20200693T1 HRP20200693T1 HRP20200693TT HRP20200693T HRP20200693T1 HR P20200693 T1 HRP20200693 T1 HR P20200693T1 HR P20200693T T HRP20200693T T HR P20200693TT HR P20200693 T HRP20200693 T HR P20200693T HR P20200693 T1 HRP20200693 T1 HR P20200693T1
- Authority
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- Croatia
- Prior art keywords
- glycogen
- group
- based polymer
- complex
- carbon atoms
- Prior art date
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- 229920002527 Glycogen Polymers 0.000 title claims 18
- 229940096919 glycogen Drugs 0.000 title claims 18
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- 239000008137 solubility enhancer Substances 0.000 title 1
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- 150000002634 lipophilic molecules Chemical class 0.000 claims 11
- 125000004432 carbon atom Chemical group C* 0.000 claims 8
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- SZCBXWMUOPQSOX-PSXNNQPNSA-N violaxanthin Chemical compound C(\[C@@]12[C@](O1)(C)C[C@H](O)CC2(C)C)=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(\C)/C=C/C=C(\C)/C=C/[C@]1(C(C[C@@H](O)C2)(C)C)[C@]2(C)O1 SZCBXWMUOPQSOX-PSXNNQPNSA-N 0.000 claims 1
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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- A—HUMAN NECESSITIES
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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Claims (20)
1. Polimer na bazi glikogena, naznačen time, da obuhvaća najmanje jednu ponavljajuću jedinicu koja je predstavljena sljedećom formulom (I)
[image]
gdje je
svaka skupina R koja može biti ista ili različita, atom vodika, alkilna skupina koja ima od 1 do 9 ugljikovih atoma, alkenilna skupina koja ima od 2 do 12 ugljikovih atoma, arilalkilna skupina koja ima od 7 do 18 ugljikovih atoma ili
arilalkenilna skupina koja ima od 8 do 18 ugljikovih atoma, dok je alkilni ili alkenilni lanac navedenih skupina opcionalno supstituiran s hidroksilnom skupinom i /ili je prekinut s atomom kisika, a arilni ostatak navedenih skupina
je opcionalno supstituiran s atomom halogena, uz uvjet da najmanje jedan iz navedene R skupine bude različit od vodika, i
n je cijeli broj koji je veći od 1 ili je točno 1.
2. Polimer na bazi glikogena prema patentnom zahtjevu 1, naznačen time, da navedena alkilna skupina ima od 2 do 8 ugljikovih atoma.
3. Polimer na bazi glikogena prema patentnom zahtjevu 1, naznačen time, da navedena alkenilna skupina ima od 2 do 8 ugljikovih atoma.
4. Polimer na bazi glikogena prema patentnom zahtjevu 1, naznačen time, da navedena arilalkilna skupina ima od 8 do 14 ugljikovih atoma.
5. Polimer na bazi glikogena prema patentnom zahtjevu 1, naznačen time, da navedena arilalkenilna skupina ima od 8 do 14 ugljikovih atoma.
6. Polimer na bazi glikogena prema patentnom zahtjevu 1, naznačen time, da glikogen koji se upotrebljava za proizvodnju navedenog polimera na bazi glikogena, ima molekularnu masu od oko 2,7 X 105 do oko 3,5 X 106 daltona.
7. Polimer na bazi glikogena prema patentnom zahtjevu 1, naznačen time, da glikogen koji se upotrebljava za proizvodnju navedenog polimera na bazi glikogena, ima molekularnu masu od oko (2,5±0,1) x 106 daltona.
8. Kompleks, naznačen time, da se stvara između polimera na bazi glikogena, koji su definirani prema bilo kojem od prethodnih patentnih zahtjeva, i jednog lipofilnog spoja.
9. Kompleks prema patentnom zahtjevu 8, naznačen time, da je navedeni lipofilni spoj odabran iz skupine koja obuhvaća lijek slabe topivosti u vodi, karotenoid ili lipofilni spoj koji je strukturno srodan karotenoidu.
10. Kompleks prema patentnom zahtjevu 9, naznačen time, da je navedeni lijek koji je slabo topiv u vodi, odabran iz skupine koja se nsastoji od (i) lijekova BCS-razreda II i (ii) lijekova BCS-razreda IV.
11. Kompleks prema patentnom zahtjevu 10, naznačen time, da je navedeni lijek BCS-razreda II odabran iz skupine koja se sastoji od sljedećih: amiodaron, atorvastatin, azitromicin, karbamazepin, karvedilol, celekoksib, klorpromazin, cisaprid, ciprofloksacin, ciklosporin, danazol, dapson, diklofenak, diflunisal, digoksin, eritromicin, flurbiprofen, glipizid, gliburid, griseofulvin, ibuprofen, indinavir, indometacin, itrakonazol, ketokonazol, lansoprazolel, lovastatin, mebendazol, naproksen, nelfinavir, ofloksacin, oksaprozin, fenazopiridin, fenitoin, piroksikam, raloksifen, repaglinid, ritonavir, sakvinavir, sirolimus, spironolakton, takrolimus, talinolol, tamoksifen i terfenadin.
12. Kompleks prema patentnom zahtjevu 10, naznačen time, da je navedeni lijek BCS-razreda IV odabran iz skupine koja se sastoji od sljedećih: amfotericin B, klortalidon, klorotiazid, kolistin, ciprofloksacin, docetaksel, furosemid, hidroklorotiazid, mebendazol, metotreksat, neomicin i paklitaksel.
13. Kompleks prema patentnom zahtjevu 8, naznačen time, da je navedeni lipofilni spoj odabran iz skupine koja obuhvaća sljedeće: (i) karoteni, (ii) ksantofili, (iii) apokarotenoidi, (iv) retinoidi vitamina A, (v) retinoidne supstance i (vi) ostali lipofilni vitaminski i nutritivni faktori.
14. Kompleks prema patentnom zahtjevu 13, naznačen time, da su navedeni (i) karoteni odabrani iz skupine koja obuhvaća sljedeće: α-karoten, ß-karoten, γ-karoten, δ-karoten, ε-karoten, likopen, fitoen, fitofluen i torulen.
15. Kompleks prema patentnom zahtjevu 13, naznačen time, da su navedeni (ii) ksantofili odabrani iz skupine koja obuhvaća sljedeće: anteraksantin, astaksantin, kantaksantin, citranaksantin, kriptoksantin, diadinoksantin, diatoksantin, dinoksantin, flavoksantin, fukoksantin, lutein, neoksantin, rodoksantin, rubiksantin, violaksantin i zeaksantin.
16. Farmaceutski pripravak, naznačen time, da obuhvaća (i) kompleks između polimera na bazi glikogena koji su definirani u bilo kojem od prethodnih patentnih zahtjeva 1 do 7, i jednog lipofilnog spoja odabranog iz skupine koja sadrži lijekove slabe topivosti u vodi, te (ii) najmanje jedno farmaceutski prihvatljivo pomoćno sredstvo.
17. Nutraceutski pripravak, naznačen time, da obuhvaća (i) kompleks između polimera na bazi glikogena koji su definirani u bilo kojem od prethodnih patentnih zahtjeva 1 do 7, i jednog lipofilnog spoja odabranog iz skupine koja sadrži karotenoide ili lipofilne spojeve koji su strukturno srodni karotenoidima, te (ii) najmanje jedno nutraceutski prihvatljivo pomoćno sredstvo.
18. Kozmetički pripravak, naznačen time, da obuhvaća (i) kompleks između polimera na bazi glikogena koji su definirani u bilo kojem od prethodnih patentnih zahtjeva 1 do 7, i jednog lipofilnog spoja odabranog iz skupine koja sadrži karotenoide ili lipofilne spojeve koji su strukturno srodni karotenoidima, te (ii) najmanje jedno kozmetički prihvatljivo pomoćno sredstvo.
19. Uporaba polimera na bazi glikogena koji su definirani u bilo kojem od prethodnih patentnih zahtjeva 1 do 7, naznačena time, da je za pojačavanje topivosti lipofilnih spojeva u vodi.
20. Kompleks između polimera na bazi glikogena koji su definirani u bilo kojem od prethodnih patentnih zahtjeva 1 do 7, i jednog lipofilnog spoja, naznačen time, da se upotrebljava kao medikament.
Applications Claiming Priority (3)
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EP13162453 | 2013-04-05 | ||
PCT/EP2014/056451 WO2014161815A1 (en) | 2013-04-05 | 2014-03-31 | Glycogen-based water solubility enhancers |
EP14713507.3A EP2981557B1 (en) | 2013-04-05 | 2014-03-31 | Glycogen-based water solubility enhancers |
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Publication Number | Publication Date |
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HRP20200693T1 true HRP20200693T1 (hr) | 2020-07-24 |
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Family Applications (1)
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HRP20200693TT HRP20200693T1 (hr) | 2013-04-05 | 2020-04-29 | Pojačivači topivosti u vodi na bazi glikogena |
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US (1) | US10662259B2 (hr) |
EP (1) | EP2981557B1 (hr) |
JP (1) | JP6312801B2 (hr) |
KR (1) | KR102113707B1 (hr) |
CN (1) | CN105143274B (hr) |
AR (1) | AR095937A1 (hr) |
AU (1) | AU2014247145B2 (hr) |
BR (1) | BR112015024825A2 (hr) |
CA (1) | CA2905273A1 (hr) |
CY (1) | CY1122935T1 (hr) |
DK (1) | DK2981557T3 (hr) |
EA (1) | EA032500B1 (hr) |
ES (1) | ES2786900T3 (hr) |
GE (1) | GEP201706742B (hr) |
HK (1) | HK1215955A1 (hr) |
HR (1) | HRP20200693T1 (hr) |
HU (1) | HUE049561T2 (hr) |
IL (1) | IL241690B (hr) |
LT (1) | LT2981557T (hr) |
MX (1) | MX369778B (hr) |
PL (1) | PL2981557T3 (hr) |
PT (1) | PT2981557T (hr) |
RS (1) | RS60506B1 (hr) |
SG (2) | SG10201708099YA (hr) |
SI (1) | SI2981557T1 (hr) |
UA (1) | UA119441C2 (hr) |
WO (1) | WO2014161815A1 (hr) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2014172786A1 (en) | 2013-04-26 | 2014-10-30 | Mirexus Biotechnologies Inc | Phytoglycogen nanoparticles and methods of manufacture thereof |
US20160303242A1 (en) | 2013-12-09 | 2016-10-20 | Durect Corporation | Pharmaceutically Active Agent Complexes, Polymer Complexes, and Compositions and Methods Involving the Same |
JP6750740B2 (ja) * | 2018-03-30 | 2020-09-02 | ソニー株式会社 | 磁気記録媒体 |
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GB1514720A (en) * | 1974-10-07 | 1978-06-21 | Secr Defence | Preparation of hydroxyethyl starch |
US4228277A (en) * | 1979-02-12 | 1980-10-14 | Hercules Incorporated | Modified nonionic cellulose ethers |
IT1255488B (it) | 1992-08-04 | 1995-11-06 | Angelini Francesco Ist Ricerca | Polisaccaridi del glicogeno |
US5607839A (en) * | 1993-07-22 | 1997-03-04 | Nippon Oil Company, Ltd. | Bacteria belonging to new genus process for production of carotenoids using same |
US6248361B1 (en) * | 1999-02-26 | 2001-06-19 | Integ, Ltd. | Water-soluble folic acid compositions |
ATE360651T1 (de) * | 2001-08-22 | 2007-05-15 | Supramol Parenteral Colloids | Hyperverzweigtes amylopektin zum einsatz in verfahren zur chirurgischen oder therapeutischen behandlung von säugern oder in diagnostizierverfahren, insbesondere zur verwendung als plasmavolumenexpander |
DE10237442B4 (de) * | 2002-08-16 | 2004-08-19 | Fresenius Kabi Deutschland Gmbh | Hochverzweigte, niedrig substituierte Stärkeprodukte |
US7446101B1 (en) | 2003-12-12 | 2008-11-04 | Bioactives, Llc | Bioavailable carotenoid-cyclodextrin formulations for soft-gels and other encapsulation systems |
WO2006040335A1 (en) * | 2004-10-15 | 2006-04-20 | Danisco A/S | A derivatized highly branched polysaccharide and a mix for production of polyurethane thereof |
US7781572B2 (en) | 2005-10-05 | 2010-08-24 | Nse Products, Inc. | Nanosized carotenoid cyclodextrin complexes |
WO2008080037A2 (en) * | 2006-12-21 | 2008-07-03 | Isp Investments Inc. | Carotenoids of enhanced bioavailability |
US8323615B2 (en) * | 2008-08-20 | 2012-12-04 | Baxter International Inc. | Methods of processing multi-phasic dispersions |
US9315715B2 (en) * | 2009-10-20 | 2016-04-19 | Nalco Company | Method of reducing the viscosity of hydrocarbons |
US8901092B2 (en) * | 2010-12-29 | 2014-12-02 | Surmodics, Inc. | Functionalized polysaccharides for active agent delivery |
DK2825565T3 (da) | 2012-03-15 | 2019-06-24 | Acraf | Glycogenbaserede kationiske polymere |
FR2989001B1 (fr) * | 2012-04-06 | 2017-07-21 | Centre Nat Rech Scient | Microparticules et nanoparticules constituees de polysaccharides hydrophobises et d'une alpha-cyclodextrine |
-
2014
- 2014-03-28 AR ARP140101413A patent/AR095937A1/es active IP Right Grant
- 2014-03-31 EA EA201591860A patent/EA032500B1/ru not_active IP Right Cessation
- 2014-03-31 GE GEAP201413971A patent/GEP201706742B/en unknown
- 2014-03-31 LT LTEP14713507.3T patent/LT2981557T/lt unknown
- 2014-03-31 EP EP14713507.3A patent/EP2981557B1/en active Active
- 2014-03-31 RS RS20200457A patent/RS60506B1/sr unknown
- 2014-03-31 UA UAA201509813A patent/UA119441C2/uk unknown
- 2014-03-31 KR KR1020157030658A patent/KR102113707B1/ko active IP Right Grant
- 2014-03-31 SI SI201431559T patent/SI2981557T1/sl unknown
- 2014-03-31 SG SG10201708099YA patent/SG10201708099YA/en unknown
- 2014-03-31 CN CN201480018127.4A patent/CN105143274B/zh not_active Expired - Fee Related
- 2014-03-31 WO PCT/EP2014/056451 patent/WO2014161815A1/en active Application Filing
- 2014-03-31 US US14/780,423 patent/US10662259B2/en active Active
- 2014-03-31 AU AU2014247145A patent/AU2014247145B2/en not_active Ceased
- 2014-03-31 CA CA2905273A patent/CA2905273A1/en not_active Abandoned
- 2014-03-31 MX MX2015013739A patent/MX369778B/es active IP Right Grant
- 2014-03-31 ES ES14713507T patent/ES2786900T3/es active Active
- 2014-03-31 DK DK14713507.3T patent/DK2981557T3/da active
- 2014-03-31 PT PT147135073T patent/PT2981557T/pt unknown
- 2014-03-31 PL PL14713507T patent/PL2981557T3/pl unknown
- 2014-03-31 SG SG11201507932RA patent/SG11201507932RA/en unknown
- 2014-03-31 HU HUE14713507A patent/HUE049561T2/hu unknown
- 2014-03-31 JP JP2016505785A patent/JP6312801B2/ja active Active
- 2014-03-31 BR BR112015024825A patent/BR112015024825A2/pt not_active Application Discontinuation
-
2015
- 2015-09-17 IL IL241690A patent/IL241690B/en active IP Right Grant
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2016
- 2016-04-06 HK HK16103869.4A patent/HK1215955A1/zh unknown
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2020
- 2020-04-29 HR HRP20200693TT patent/HRP20200693T1/hr unknown
- 2020-04-30 CY CY20201100399T patent/CY1122935T1/el unknown
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