HRP20200342T1 - Derivati dihidroimidazopirazinona korisni u liječenju raka - Google Patents

Derivati dihidroimidazopirazinona korisni u liječenju raka Download PDF

Info

Publication number
HRP20200342T1
HRP20200342T1 HRP20200342TT HRP20200342T HRP20200342T1 HR P20200342 T1 HRP20200342 T1 HR P20200342T1 HR P20200342T T HRP20200342T T HR P20200342TT HR P20200342 T HRP20200342 T HR P20200342T HR P20200342 T1 HRP20200342 T1 HR P20200342T1
Authority
HR
Croatia
Prior art keywords
methyl
compound
pharmaceutically acceptable
adduct
difluoromethyl
Prior art date
Application number
HRP20200342TT
Other languages
English (en)
Croatian (hr)
Inventor
Richard Andrew Ward
Clifford David Jones
Steven Swallow
Mark Andrew Graham
Andrew Hornby Dobson
James Francis Mccabe
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of HRP20200342T1 publication Critical patent/HRP20200342T1/hr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HRP20200342TT 2015-11-09 2016-11-08 Derivati dihidroimidazopirazinona korisni u liječenju raka HRP20200342T1 (hr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562252726P 2015-11-09 2015-11-09
US201662401351P 2016-09-29 2016-09-29
PCT/EP2016/076932 WO2017080979A1 (en) 2015-11-09 2016-11-08 Dihydroimidazopyrazinone derivatives useful in the treatment of cancer
EP16791420.9A EP3374359B1 (en) 2015-11-09 2016-11-08 Dihydroimidazopyrazinone derivatives useful in the treatment of cancer

Publications (1)

Publication Number Publication Date
HRP20200342T1 true HRP20200342T1 (hr) 2020-06-12

Family

ID=57241113

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20200342TT HRP20200342T1 (hr) 2015-11-09 2016-11-08 Derivati dihidroimidazopirazinona korisni u liječenju raka

Country Status (35)

Country Link
US (2) US9902731B2 (OSRAM)
EP (1) EP3374359B1 (OSRAM)
JP (1) JP6877423B2 (OSRAM)
KR (1) KR20180074788A (OSRAM)
CN (1) CN108349983B (OSRAM)
AU (1) AU2016351813B2 (OSRAM)
BR (1) BR112018008397B1 (OSRAM)
CA (1) CA3003549A1 (OSRAM)
CL (1) CL2018001226A1 (OSRAM)
CO (1) CO2018004857A2 (OSRAM)
CR (1) CR20180316A (OSRAM)
CY (1) CY1123627T1 (OSRAM)
DK (1) DK3374359T3 (OSRAM)
EA (1) EA038028B1 (OSRAM)
ES (1) ES2780650T3 (OSRAM)
HR (1) HRP20200342T1 (OSRAM)
IL (1) IL258953A (OSRAM)
LT (1) LT3374359T (OSRAM)
ME (1) ME03770B (OSRAM)
MX (1) MX376639B (OSRAM)
MY (1) MY197626A (OSRAM)
NI (1) NI201800058A (OSRAM)
PE (1) PE20181288A1 (OSRAM)
PH (1) PH12018500987A1 (OSRAM)
PL (1) PL3374359T3 (OSRAM)
PT (1) PT3374359T (OSRAM)
RS (1) RS60155B1 (OSRAM)
SG (1) SG11201803066VA (OSRAM)
SI (1) SI3374359T1 (OSRAM)
SM (1) SMT202000152T1 (OSRAM)
SV (1) SV2018005687A (OSRAM)
TN (1) TN2018000119A1 (OSRAM)
TW (1) TWI730012B (OSRAM)
WO (1) WO2017080979A1 (OSRAM)
ZA (1) ZA201803742B (OSRAM)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL3365334T3 (pl) 2015-10-21 2024-11-25 Otsuka Pharmaceutical Co., Ltd. Związki benzolaktamu jako inhibitory kinazy białkowej
PE20181288A1 (es) * 2015-11-09 2018-08-07 Astrazeneca Ab Derivados de dihidroimidazopirazinona usados en el tratamiento del cancer
GB201706327D0 (en) 2017-04-20 2017-06-07 Otsuka Pharma Co Ltd A pharmaceutical compound
JP7352981B2 (ja) * 2018-10-10 2023-09-29 深▲チェン▼市塔吉瑞生物医薬有限公司 ジヒドロイミダゾピラジノン化合物、該化合物を含む組成物およびその使用
TW202102511A (zh) 2019-03-28 2021-01-16 大陸商江蘇恆瑞醫藥股份有限公司 噻吩并雜環類衍生物、其製備方法及其在醫藥上的應用
CN113825757B (zh) 2019-05-24 2023-10-20 江苏恒瑞医药股份有限公司 取代的稠合双环类衍生物、其制备方法及其在医药上的应用
CA3140475A1 (en) 2019-06-06 2020-12-10 Wei-Guo Su Tricyclic compounds and their use
CA3157504A1 (en) * 2019-12-05 2021-06-10 Astrazeneca Ab Process and intermediates for the production of formula (i)
AU2020398022B2 (en) * 2019-12-06 2023-04-27 D3 Bio (Wuxi) Co., Ltd. Thiazololactam compound as ERK inhibitor and use thereof
EP4223758A4 (en) 2020-09-29 2024-04-03 Jiangsu Hengrui Pharmaceuticals Co., Ltd. CRYSTALLINE FORM OF A PYRROLO-HETEROCYCLIC DERIVATIVE AND PREPARATION METHOD THEREFOR
AR126166A1 (es) * 2021-06-18 2023-09-27 Antengene Discovery Ltd Combinación de un inhibidor de erk y un inhibidor de kras y usos de estos
WO2022268065A1 (en) * 2021-06-22 2022-12-29 Fochon Biosciences, Ltd. Compounds as erk inhibitors
CN117677398A (zh) 2021-07-27 2024-03-08 东丽株式会社 用于癌的治疗和/或预防的药品
WO2023081857A1 (en) 2021-11-04 2023-05-11 Skyhawk Therapeutics, Inc. Condensed pyridazine amine derivatives treating sca3
WO2023212237A1 (en) 2022-04-27 2023-11-02 Skyhawk Therapeutics, Inc. Compositions useful for modulating splicing
US20250304593A1 (en) 2022-05-12 2025-10-02 Skyhawk Therapeutics, Inc. Compositions useful for modulating splicing
WO2024006971A2 (en) * 2022-07-01 2024-01-04 The Scripps Research Institute Antimalarial compounds

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US7485640B2 (en) * 2002-11-06 2009-02-03 Merck Sharp & Dohme Limited Imidazopyrazinones as GABA-A receptor anxiolytics
GB0520958D0 (en) * 2005-10-14 2005-11-23 Cyclacel Ltd Compound
JP5178738B2 (ja) * 2006-12-20 2013-04-10 メルク・シャープ・アンド・ドーム・コーポレーション 新規なｊｎｋ阻害剤
US9840507B2 (en) * 2010-12-22 2017-12-12 Janssen Pharmaceutica, Nv 5,6-dihydro-imidazo[1,2-a]pyrazin-8-ylamine derivatives useful as inhibitors of beta-secretase (BACE)
HK1211023A1 (zh) * 2011-10-10 2016-05-13 H. Lundbeck A/S 具有咪唑并吡嗪骨架pde9i
JP2013166727A (ja) * 2012-02-16 2013-08-29 Dainippon Sumitomo Pharma Co Ltd ジヒドロイミダゾピラジノン誘導体
SI2820009T1 (en) 2012-03-01 2018-05-31 Array Biopharma, Inc. Serine / Threonine kinase inhibitors
US9532987B2 (en) 2013-09-05 2017-01-03 Genentech, Inc. Use of a combination of a MEK inhibitor and an ERK inhibitor for treatment of hyperproliferative diseases
JP6449293B2 (ja) * 2013-12-06 2019-01-09 ジェネンテック， インコーポレイテッド セリン／トレオニンキナーゼ阻害剤
KR102379517B1 (ko) 2013-12-30 2022-03-25 제넨테크, 인크. 세린/트레오닌 키나아제 억제제
KR102396710B1 (ko) 2013-12-30 2022-05-10 어레이 바이오파마 인크. 세린/트레오닌 키나제 저해제
AR099989A1 (es) 2014-04-09 2016-08-31 Genentech Inc Proceso de preparación de (s)-1-(1-(4-cloro-3-fluorofenil)-2-hidroxietil)-4-(2-((1-metil-1h-pirazol-5-il)amino)pirimidin-4-il)-2(1h)-ona y sus sales
US10412619B2 (en) * 2014-11-14 2019-09-10 Qualcomm Incorporated Buffer status report for eDCS
WO2016162325A1 (en) * 2015-04-07 2016-10-13 Astrazeneca Ab Substituted 3,4-dihydropyrrolo[1,2-a]pyrazin-1 (2h)-one derivatives as kinase inhibitors
EP3303335B1 (en) 2015-06-03 2021-07-28 JS Innopharm (Shanghai) Ltd. Heterocyclic compounds for treating psoriasis
CN107849046B (zh) 2015-06-03 2020-06-12 常州捷凯医药科技有限公司 作为erk抑制剂的杂环化合物
PE20181288A1 (es) * 2015-11-09 2018-08-07 Astrazeneca Ab Derivados de dihidroimidazopirazinona usados en el tratamiento del cancer

Also Published As

Publication number Publication date
EA038028B1 (ru) 2021-06-24
MY197626A (en) 2023-06-29
AU2016351813A1 (en) 2018-06-21
PT3374359T (pt) 2020-03-27
CR20180316A (es) 2018-10-05
US9902731B2 (en) 2018-02-27
EA201891063A1 (ru) 2018-12-28
BR112018008397B1 (pt) 2023-12-12
CO2018004857A2 (es) 2018-07-19
SMT202000152T1 (it) 2020-05-08
CN108349983B (zh) 2021-02-26
LT3374359T (lt) 2020-03-25
JP2019503337A (ja) 2019-02-07
ZA201803742B (en) 2020-08-26
PE20181288A1 (es) 2018-08-07
AU2016351813B2 (en) 2019-05-30
US20170204100A1 (en) 2017-07-20
SV2018005687A (es) 2018-07-20
MX376639B (es) 2025-03-07
KR20180074788A (ko) 2018-07-03
CY1123627T1 (el) 2022-03-24
NI201800058A (es) 2018-10-18
TW201728586A (zh) 2017-08-16
RS60155B1 (sr) 2020-05-29
EP3374359B1 (en) 2020-01-08
MX2018005725A (es) 2018-08-14
DK3374359T3 (da) 2020-03-30
IL258953A (en) 2018-06-28
US10202391B2 (en) 2019-02-12
EP3374359A1 (en) 2018-09-19
CL2018001226A1 (es) 2018-10-05
PL3374359T3 (pl) 2020-06-29
CN108349983A (zh) 2018-07-31
PH12018500987A1 (en) 2019-01-28
SI3374359T1 (sl) 2020-04-30
BR112018008397A2 (pt) 2018-10-23
ES2780650T3 (es) 2020-08-26
TN2018000119A1 (en) 2019-10-04
ME03770B (me) 2021-04-20
SG11201803066VA (en) 2018-05-30
WO2017080979A1 (en) 2017-05-18
HK1256283A1 (en) 2019-09-20
JP6877423B2 (ja) 2021-05-26
CA3003549A1 (en) 2017-05-18
US20180237443A1 (en) 2018-08-23
TWI730012B (zh) 2021-06-11

Similar Documents

Publication Publication Date Title
HRP20200342T1 (hr) Derivati dihidroimidazopirazinona korisni u liječenju raka
CO2019006598A2 (es) Benzoisotiazol, isotiazolo[3,4-b]piridina, quinazolina, ftalazina, pirido[2,3-d]piridazina y derivados de pirido[2,3- d]pirimidina como inhibidores de kras g12c para tratar el cáncer de pulmón, pancreático o colorrectal
JP2019503337A5 (OSRAM)
CY1125460T1 (el) Ενωσεις ιμιδαζο [4,5-d]πυρρολο [2,3-β]πυριδινης ως αναστολεις κινασων janus
HRP20191268T1 (hr) Derivati tieno[2,3-c]pirol-4-ona kao inhibitori erk
NZ629432A (en) Heterocyclyl compounds as mek inhibitors
NZ627277A (en) Imidazopyrrolidinone compounds
HK1202541A1 (en) 2-amino, 6-phenyl substituted pyrido [2, 3 - d] pyrimidine derivatives useful as raf kinase inhibitors
PH12016501164A1 (en) Heteroaryl substituted nicotinamide compounds
JP2016520116A5 (OSRAM)
JP2016529292A5 (OSRAM)
PH12014502886A1 (en) NOVEL 4-(SUBSTITUTED-AMINO)-7H-PYRROLO[2,3-d]PYRIMIDINES AS LRRK2 INHIBITORS
PE20170128A1 (es) Compuestos para tratar atrofia muscular espinal
JP2016537384A5 (OSRAM)
EA201991109A1 (ru) ПРОИЗВОДНЫЕ [1,2,4]ТРИАЗОЛО[1,5-a]ПИРИМИДИНА В КАЧЕСТВЕ ИНГИБИТОРОВ PDE2
JP2017527548A5 (OSRAM)
HRP20181008T1 (hr) Terapeutski aktivni pirazolo-pirimidin derivati
JP2018537408A5 (OSRAM)
PE20090944A1 (es) PIRIMIDINAS BICICLICAS FUSIONADAS COMO INHIBIDORES DE LA VIA Pi3K/AKT
NZ730189A (en) Pharmaceutical formulations, processes, solid forms and methods of use relating to 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one
NZ630580A (en) 6-(4-(1-amino-3-hydroxycyclobutyl)phenyl)-5-phenyl(furo,thieno or pyrrolo) [2, 3-d] pyrimidin-4-one derivatives for the treatment of cancer
EA201991094A1 (ru) СОЕДИНЕНИЯ [1,2,4]ТРИАЗОЛО[1,5-a]ПИРИМИДИНА В КАЧЕСТВЕ ИНГИБИТОРОВ PDE2
PH12017500159A1 (en) [1,2,4]triazolo[4,3-b]pyridazines for use in the treatment of proliferative diseases
HRP20151419T1 (hr) Derivati 2-okso-1-imidazolidinil imidazotiadiazola
EA201990973A1 (ru) СОЕДИНЕНИЯ [1,2,4]ТРИАЗОЛО[1,5-a]ПИРИМИДИНА В КАЧЕСТВЕ ИНГИБИТОРОВ PDE2