HRP20192139T1 - Liofilizirani pripravci melfalan flufenamida - Google Patents
Liofilizirani pripravci melfalan flufenamida Download PDFInfo
- Publication number
- HRP20192139T1 HRP20192139T1 HRP20192139TT HRP20192139T HRP20192139T1 HR P20192139 T1 HRP20192139 T1 HR P20192139T1 HR P20192139T T HRP20192139T T HR P20192139TT HR P20192139 T HRP20192139 T HR P20192139T HR P20192139 T1 HRP20192139 T1 HR P20192139T1
- Authority
- HR
- Croatia
- Prior art keywords
- pharmaceutical preparation
- lyophilized pharmaceutical
- melphalan flufenamide
- cancer
- sucrose
- Prior art date
Links
- YQZNKYXGZSVEHI-VXKWHMMOSA-N ethyl (2s)-2-[[(2s)-2-amino-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoyl]amino]-3-(4-fluorophenyl)propanoate Chemical compound C([C@@H](C(=O)OCC)NC(=O)[C@@H](N)CC=1C=CC(=CC=1)N(CCCl)CCCl)C1=CC=C(F)C=C1 YQZNKYXGZSVEHI-VXKWHMMOSA-N 0.000 title claims 10
- 229950009924 melphalan flufenamide Drugs 0.000 title claims 6
- 238000002360 preparation method Methods 0.000 title claims 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims 14
- 206010028980 Neoplasm Diseases 0.000 claims 4
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 4
- 229930006000 Sucrose Natural products 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 239000005720 sucrose Substances 0.000 claims 4
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010027406 Mesothelioma Diseases 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000002489 hematologic effect Effects 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000003960 organic solvent Substances 0.000 claims 1
- 230000002611 ovarian Effects 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 238000002054 transplantation Methods 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261719184P | 2012-10-26 | 2012-10-26 | |
| SE1251211 | 2012-10-26 | ||
| PCT/SE2013/051246 WO2014065751A1 (en) | 2012-10-26 | 2013-10-24 | Lyophilized preparations of melphalan flufenamide |
| EP13849763.1A EP2928463B1 (en) | 2012-10-26 | 2013-10-24 | Lyophilized preparations of melphalan flufenamide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20192139T1 true HRP20192139T1 (hr) | 2020-02-21 |
Family
ID=69399521
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20192139TT HRP20192139T1 (hr) | 2012-10-26 | 2019-11-28 | Liofilizirani pripravci melfalan flufenamida |
Country Status (8)
| Country | Link |
|---|---|
| KR (1) | KR102226082B1 (lt) |
| DK (1) | DK2928463T3 (lt) |
| ES (1) | ES2768268T3 (lt) |
| HR (1) | HRP20192139T1 (lt) |
| HU (1) | HUE047813T2 (lt) |
| LT (1) | LT2928463T (lt) |
| PT (1) | PT2928463T (lt) |
| ZA (1) | ZA201503635B (lt) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0002202D0 (sv) * | 2000-06-13 | 2000-06-13 | Karolinska Innovations Ab | New peptides |
| CN101584669B (zh) * | 2009-06-19 | 2010-12-29 | 江苏奥赛康药业有限公司 | 美法仑冻干粉针剂 |
| WO2011078782A1 (en) * | 2009-12-22 | 2011-06-30 | Oncopeptides Ab | A composition comprising of melphalan derivatives and gemcitabine or etoposide useful in the treatment of cancer |
| WO2012146625A1 (en) * | 2011-04-28 | 2012-11-01 | Oncopeptides Ab | Lyophilized preparation of cytotoxic dipeptides |
-
2013
- 2013-10-24 PT PT138497631T patent/PT2928463T/pt unknown
- 2013-10-24 ES ES13849763T patent/ES2768268T3/es active Active
- 2013-10-24 DK DK13849763.1T patent/DK2928463T3/da active
- 2013-10-24 LT LTEP13849763.1T patent/LT2928463T/lt unknown
- 2013-10-24 HU HUE13849763A patent/HUE047813T2/hu unknown
- 2013-10-24 KR KR1020207015430A patent/KR102226082B1/ko active IP Right Grant
-
2015
- 2015-05-22 ZA ZA2015/03635A patent/ZA201503635B/en unknown
-
2019
- 2019-11-28 HR HRP20192139TT patent/HRP20192139T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT2928463T (pt) | 2020-02-25 |
| ZA201503635B (en) | 2021-08-25 |
| DK2928463T3 (da) | 2020-02-24 |
| ES2768268T3 (es) | 2020-06-22 |
| HUE047813T2 (hu) | 2020-05-28 |
| KR102226082B1 (ko) | 2021-03-10 |
| KR20200081440A (ko) | 2020-07-07 |
| LT2928463T (lt) | 2020-02-10 |
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| HRP20192139T1 (hr) | Liofilizirani pripravci melfalan flufenamida |