HRP20191806T1 - Transdermalni pripravci ibuprofena i postupci za njihovu uporabu - Google Patents
Transdermalni pripravci ibuprofena i postupci za njihovu uporabu Download PDFInfo
- Publication number
- HRP20191806T1 HRP20191806T1 HRP20191806TT HRP20191806T HRP20191806T1 HR P20191806 T1 HRP20191806 T1 HR P20191806T1 HR P20191806T T HRP20191806T T HR P20191806TT HR P20191806 T HRP20191806 T HR P20191806T HR P20191806 T1 HRP20191806 T1 HR P20191806T1
- Authority
- HR
- Croatia
- Prior art keywords
- preparation
- weight
- preparation according
- ibuprofen
- lower alkyl
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims 8
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 title claims 4
- 229960001680 ibuprofen Drugs 0.000 title claims 4
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims 6
- 125000005233 alkylalcohol group Chemical group 0.000 claims 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 4
- 239000003349 gelling agent Substances 0.000 claims 4
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 claims 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical group CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 3
- 239000003961 penetration enhancing agent Substances 0.000 claims 3
- 239000002904 solvent Substances 0.000 claims 3
- SVTBMSDMJJWYQN-UHFFFAOYSA-N 2-methylpentane-2,4-diol Chemical compound CC(O)CC(C)(C)O SVTBMSDMJJWYQN-UHFFFAOYSA-N 0.000 claims 2
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 claims 2
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 2
- 206010061218 Inflammation Diseases 0.000 claims 2
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 2
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 2
- 230000004054 inflammatory process Effects 0.000 claims 2
- LVGKNOAMLMIIKO-UHFFFAOYSA-N Elaidinsaeure-aethylester Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC LVGKNOAMLMIIKO-UHFFFAOYSA-N 0.000 claims 1
- 239000001856 Ethyl cellulose Substances 0.000 claims 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims 1
- 229920002125 Sokalan® Polymers 0.000 claims 1
- 235000019445 benzyl alcohol Nutrition 0.000 claims 1
- HEFNNWSXXWATRW-JTQLQIEISA-N dexibuprofen Chemical compound CC(C)CC1=CC=C([C@H](C)C(O)=O)C=C1 HEFNNWSXXWATRW-JTQLQIEISA-N 0.000 claims 1
- 229920001249 ethyl cellulose Polymers 0.000 claims 1
- 235000019325 ethyl cellulose Nutrition 0.000 claims 1
- LVGKNOAMLMIIKO-QXMHVHEDSA-N ethyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC LVGKNOAMLMIIKO-QXMHVHEDSA-N 0.000 claims 1
- 229940093471 ethyl oleate Drugs 0.000 claims 1
- 229940051250 hexylene glycol Drugs 0.000 claims 1
- -1 hydroxycellulose Polymers 0.000 claims 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims 1
- 229940074928 isopropyl myristate Drugs 0.000 claims 1
- XUGNVMKQXJXZCD-UHFFFAOYSA-N isopropyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(C)C XUGNVMKQXJXZCD-UHFFFAOYSA-N 0.000 claims 1
- 229940075495 isopropyl palmitate Drugs 0.000 claims 1
- 229920000609 methyl cellulose Polymers 0.000 claims 1
- 239000001923 methylcellulose Substances 0.000 claims 1
- 235000010981 methylcellulose Nutrition 0.000 claims 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Claims (13)
1. Pripravak za transdermalnu primjenu ibuprofena, gdje pripravak sadrži:
ibuprofen u količini od 5 težinskih % pripravka;
sredstvo za geliranje, pri čemu je sredstvo za geliranje izabrano iz skupine koja se sastoji od karboksivinilnih polimera, metil celuloze, etil celuloze, hidroksiceluloze, hidroksietil celuloze i hidroksipropil celuloze;
niži alkil alkohol;
vodu;
nehlapljivo otapalo, pri čemu je nehlapljivo otapalo izabrano između propilen glikola, heksilen glikola i benzil alkohola;
pri čemu pripravak ima prividni pH od 4.0 do 7.0; i
pri čemu pripravak dodatno sadrži pojačivač prodiranja kroz kožu izabran od izopropil miristata, izopropil palmitata i etil oleata.
2. Pripravak u skladu s patentnim zahtjevom 1, naznačen time što je ibuprofen S(+)-ibuprofen.
3. Pripravak u skladu s patentnim zahtjevom 1 ili 2, naznačen time što sredstvo za geliranje sadrži hidroksipropil celulozu.
4. Pripravak u skladu s bilo kojim od patentnih zahtjeva 1 do 3, naznačen time što je sredstvo za geliranje prisutno u količini između 1 težinskog % i 5 težinskih % pripravka.
5. Pripravak u skladu s bilo kojim od patentnih zahtjeva 1 do 4, naznačen time što je niži alkil alkohol izabran iz skupine koja se sastoji od etanola, propanola, izopropil alkohola i njihovih smjesa.
6. Pripravak u skladu s bilo kojim od patentnih zahtjeva 1 do 5, naznačen time što niži alkil alkohol sadrži izopropil alkohol.
7. Pripravak u skladu s bilo kojim od patentnih zahtjeva 1 do 6, naznačen time što niži alkil alkohol sadrži etanol.
8. Pripravak u skladu s bilo kojim od patentnih zahtjeva 1 do 7, naznačen time što je niži alkil alkohol u količini između 25 težinskih % i 40 težinskih % pripravka.
9. Pripravak u skladu s bilo kojim od patentnih zahtjeva 1 do 8, naznačen time što je nehlapljivo otapalo u količini između 20 težinskih % i 60 težinskih % pripravka.
10. Pripravak u skladu s bilo kojim od patentnih zahtjeva 1 do 9, naznačen time što je pojačivač prodiranja kroz kožu u količini između 0.1 težinskog % i 5 težinskih % pripravka.
11. Pripravak u skladu s bilo kojim od patentnih zahtjeva 1 do 10, naznačen time što je pojačivač prodiranja kroz kožu izopropil miristat.
12. Pripravak u skladu s bilo kojim od patentnih zahtjeva 1 do 11, naznačen time što je prividni pH pripravka 7.0.
13. Pripravak u skladu s bilo kojim od patentnih zahtjeva 1 do 12 za uporabu u smanjenju boli ili upale, naznačen time što se pripravak primjenjuje na površinu kože subjekta kojem je potrebno smanjenje boli ili upale.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161482058P | 2011-05-03 | 2011-05-03 | |
| EP12779275.2A EP2704703B1 (en) | 2011-05-03 | 2012-05-03 | Transdermal compositions of ibuprofen and methods of use thereof |
| PCT/US2012/036366 WO2012151427A1 (en) | 2011-05-03 | 2012-05-03 | Transdermal compositions of ibuprofen and methods of use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20191806T1 true HRP20191806T1 (hr) | 2020-01-10 |
Family
ID=47108054
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20191806TT HRP20191806T1 (hr) | 2011-05-03 | 2019-10-03 | Transdermalni pripravci ibuprofena i postupci za njihovu uporabu |
Country Status (25)
| Country | Link |
|---|---|
| US (7) | US9205041B2 (hr) |
| EP (2) | EP2704703B1 (hr) |
| JP (1) | JP5989095B2 (hr) |
| KR (1) | KR101926211B1 (hr) |
| CN (1) | CN103717213B (hr) |
| AU (3) | AU2012250664B2 (hr) |
| BR (1) | BR112013028435A2 (hr) |
| CA (1) | CA2835062C (hr) |
| CL (1) | CL2013003163A1 (hr) |
| CO (1) | CO6862148A2 (hr) |
| CY (1) | CY1122273T1 (hr) |
| DK (1) | DK2704703T3 (hr) |
| EA (1) | EA026697B1 (hr) |
| ES (1) | ES2749323T3 (hr) |
| HR (1) | HRP20191806T1 (hr) |
| HU (1) | HUE046750T2 (hr) |
| LT (1) | LT2704703T (hr) |
| ME (1) | ME03540B (hr) |
| MX (1) | MX365427B (hr) |
| PE (2) | PE20180399A1 (hr) |
| PL (1) | PL2704703T3 (hr) |
| PT (1) | PT2704703T (hr) |
| RS (1) | RS59484B1 (hr) |
| SI (1) | SI2704703T1 (hr) |
| WO (1) | WO2012151427A1 (hr) |
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| PT2704703T (pt) | 2011-05-03 | 2019-10-25 | Aponia Laboratories Inc | Composições transdermais de ibuprofeno e seus métodos de utilização. |
| UA119324C2 (uk) * | 2013-04-02 | 2019-06-10 | Теміс Медікер Лімітед | Композиції фармацевтично активних речовин, що містять моноетиловий ефір діетиленгліколю або інші алкільні похідні |
| JP6632810B2 (ja) * | 2015-03-31 | 2020-01-22 | 小林製薬株式会社 | 外用医薬組成物 |
| WO2017027778A1 (en) * | 2015-08-13 | 2017-02-16 | Temple University-Of The Commonwealth System Of Higher Education | Calcium alginate dosage formulations, and methods of making and using thereof |
| CN109414405A (zh) * | 2016-03-31 | 2019-03-01 | 智能科技专题公司 | 递送系统 |
| GB201609968D0 (en) * | 2016-06-07 | 2016-07-20 | Futura Medical Dev Ltd | Topical pharmaceutical formulation |
| EP3527205A4 (en) * | 2016-10-12 | 2020-04-15 | Teikoku Seiyaku Co., Ltd. | WATER-BASED ADHESIVE PATCH |
| US20190298688A1 (en) * | 2016-11-21 | 2019-10-03 | Vivier Canada Inc. | Putrescine slow-release topical formulations |
| GB201706969D0 (en) * | 2017-05-02 | 2017-06-14 | Medherant Ltd | Formulation |
| JP7025129B2 (ja) * | 2017-05-17 | 2022-02-24 | 小林製薬株式会社 | 筋痙攣治療剤 |
| US11129818B2 (en) | 2017-06-07 | 2021-09-28 | Arcutis Biotherapeutics, Inc. | Topical roflumilast formulation having improved delivery and plasma half life |
| US9895359B1 (en) | 2017-06-07 | 2018-02-20 | Arcutis, Inc. | Inhibition of crystal growth of roflumilast |
| US11534493B2 (en) * | 2017-09-22 | 2022-12-27 | Arcutis Biotherapeutics, Inc. | Pharmaceutical compositions of roflumilast in aqueous blends of water-miscible, pharmaceutically acceptable solvents |
| AU2018378072A1 (en) | 2017-12-04 | 2020-05-21 | Johnson & Johnson Consumer Inc. | Topical emulsion composition containing nonsteroidal anti-inflammatory drug |
| KR20190101140A (ko) * | 2018-02-22 | 2019-08-30 | 동아제약 주식회사 | 비스테로이드성 소염진통 활성성분을 함유하는 필름 형성 약제학적 조성물 |
| CA3155267A1 (en) | 2019-11-06 | 2021-05-14 | Thomas Hnat | Topical formulations of cyclooxygenase inhibitors and their use |
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| BRPI0925099A2 (pt) * | 2009-06-24 | 2018-10-16 | Strategic Science & Tech Llc | composição tópica contendo ibuprofeno |
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| GB0921686D0 (en) | 2009-12-11 | 2010-01-27 | Reckitt Benckiser Healthcare I | Topical formulation |
| CA2828086C (en) | 2010-03-10 | 2018-07-31 | Nuvo Research Inc. | Foamable formulation |
| PT2704703T (pt) | 2011-05-03 | 2019-10-25 | Aponia Laboratories Inc | Composições transdermais de ibuprofeno e seus métodos de utilização. |
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2012
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- 2012-05-03 MX MX2013012832A patent/MX365427B/es active IP Right Grant
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- 2012-05-03 DK DK12779275.2T patent/DK2704703T3/da active
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2013
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2015
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