HRP20180566T1 - Kortikospinalni gornji motorički neuroni, postupci i pripravci za diferenciranje neuralnih matičnih stanica moduliranjem signaliziranja kanabinoidnim receptorom cb1 i njihova upotreba - Google Patents

Kortikospinalni gornji motorički neuroni, postupci i pripravci za diferenciranje neuralnih matičnih stanica moduliranjem signaliziranja kanabinoidnim receptorom cb1 i njihova upotreba

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Publication number
HRP20180566T1
HRP20180566T1 HRP20180566TT HRP20180566T HRP20180566T1 HR P20180566 T1 HRP20180566 T1 HR P20180566T1 HR P20180566T T HRP20180566T T HR P20180566TT HR P20180566 T HRP20180566 T HR P20180566T HR P20180566 T1 HRP20180566 T1 HR P20180566T1
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HR
Croatia
Prior art keywords
stamps
modulating
preparations
signaling
procedures
Prior art date
Application number
HRP20180566TT
Other languages
English (en)
Croatian (hr)
Inventor
Ismael Galve-Roperh
Manuel Guzmán Pastor
Javier Díaz-Alonso
Tania Aguado Sanchez
Juan Paraíso Luna
Original Assignee
Centro De Investigacíon Biomédica En Red De Enfermedades Neurodegenerativas Ciberned
Universidad Complutense De Madrid
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Centro De Investigacíon Biomédica En Red De Enfermedades Neurodegenerativas Ciberned, Universidad Complutense De Madrid filed Critical Centro De Investigacíon Biomédica En Red De Enfermedades Neurodegenerativas Ciberned
Publication of HRP20180566T1 publication Critical patent/HRP20180566T1/hr

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0619—Neurons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/658—Medicinal preparations containing organic active ingredients o-phenolic cannabinoids, e.g. cannabidiol, cannabigerolic acid, cannabichromene or tetrahydrocannabinol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/80—Neurotransmitters; Neurohormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Neurosurgery (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
HRP20180566TT 2012-11-20 2018-04-09 Kortikospinalni gornji motorički neuroni, postupci i pripravci za diferenciranje neuralnih matičnih stanica moduliranjem signaliziranja kanabinoidnim receptorom cb1 i njihova upotreba HRP20180566T1 (hr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP12382455.9A EP2733205B1 (en) 2012-11-20 2012-11-20 Corticospinal upper motor neurons, methods and compositions for differentiating neural stem cells by modulating CB1 cannabinoid receptor signaling and uses thereof

Publications (1)

Publication Number Publication Date
HRP20180566T1 true HRP20180566T1 (hr) 2018-05-18

Family

ID=47221998

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20180566TT HRP20180566T1 (hr) 2012-11-20 2018-04-09 Kortikospinalni gornji motorički neuroni, postupci i pripravci za diferenciranje neuralnih matičnih stanica moduliranjem signaliziranja kanabinoidnim receptorom cb1 i njihova upotreba

Country Status (6)

Country Link
EP (2) EP2733205B1 (enExample)
DK (1) DK2733205T3 (enExample)
ES (1) ES2670590T3 (enExample)
HR (1) HRP20180566T1 (enExample)
NO (1) NO2733205T3 (enExample)
PT (1) PT2733205T (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017081033A1 (en) * 2015-11-09 2017-05-18 Universite De Nice Sophia Antipolis Cell differentiation or reprogramming using fezf2 and lmo4
EP3762034B1 (en) 2018-03-05 2025-08-27 Wylder Nation Foundation A fatty acid amide hydrolase (faahi) inhibitor for use in inhibiting the cellular accumulation of a sphingolipid in a subject that has lysosomal storage disease or disorder
CN110652515A (zh) * 2018-06-29 2020-01-07 中国科学院深圳先进技术研究院 AMPK抑制剂Compound C在治疗肿瘤药物中的应用
CN109633472B (zh) * 2019-01-23 2020-11-24 刘平 一种锂电池单体的荷电状态估计算法
CN110004179B (zh) * 2019-04-16 2023-06-06 浙江诺迦生物科技有限公司 一种大麻素类活性物质的通用检测方法及其检测试剂盒
WO2022230851A1 (ja) * 2021-04-30 2022-11-03 国立大学法人東海国立大学機構 筋萎縮性側索硬化症の予防及び／又は治療剤

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5707796A (en) 1990-06-11 1998-01-13 Nexstar Pharmaceuticals, Inc. Method for selecting nucleic acids on the basis of structure
US5580737A (en) 1990-06-11 1996-12-03 Nexstar Pharmaceuticals, Inc. High-affinity nucleic acid ligands that discriminate between theophylline and caffeine
US5567588A (en) 1990-06-11 1996-10-22 University Research Corporation Systematic evolution of ligands by exponential enrichment: Solution SELEX
US5763177A (en) 1990-06-11 1998-06-09 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: photoselection of nucleic acid ligands and solution selex
US5660985A (en) 1990-06-11 1997-08-26 Nexstar Pharmaceuticals, Inc. High affinity nucleic acid ligands containing modified nucleotides
US6699843B2 (en) 1995-06-07 2004-03-02 Gilead Sciences, Inc. Method for treatment of tumors using nucleic acid ligands to PDGF
US6011577A (en) 1997-06-30 2000-01-04 Polaroid Corporation Modular optical print head assembly
US20030198627A1 (en) 2001-09-01 2003-10-23 Gert-Jan Arts siRNA knockout assay method and constructs
JP5764730B2 (ja) 2008-09-10 2015-08-19 ラトガース，ザ ステート ユニバーシティ オブ ニュー ジャージー １個だけで標識された多種類のプローブを用いるｍＲＮＡ単一分子の画像化
WO2010079241A1 (es) * 2009-01-12 2010-07-15 Fundacion Hospital Nacional De Paraplejicos Para La Investigacion Y La Integracion Uso de antagonistas y/o agonistas inversos de los receptores cb1 para la preparación de medicamentos que incrementen la excitabilidad de las motoneuronas

Also Published As

Publication number Publication date
EP2733205A1 (en) 2014-05-21
EP2733205B1 (en) 2018-01-10
ES2670590T3 (es) 2018-05-31
EP3279316A1 (en) 2018-02-07
DK2733205T3 (en) 2018-04-23
EP3279316B1 (en) 2023-09-20
PT2733205T (pt) 2018-05-09
NO2733205T3 (enExample) 2018-06-09

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