PT2733205T - Neurónios motores superiores corticoespinhais, métodos e composições para diferenciar células estaminais neuronais por modulação da sinalização do recetor canabinoide cb1 e seus usos - Google Patents

Neurónios motores superiores corticoespinhais, métodos e composições para diferenciar células estaminais neuronais por modulação da sinalização do recetor canabinoide cb1 e seus usos

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Publication number
PT2733205T
PT2733205T PT123824559T PT12382455T PT2733205T PT 2733205 T PT2733205 T PT 2733205T PT 123824559 T PT123824559 T PT 123824559T PT 12382455 T PT12382455 T PT 12382455T PT 2733205 T PT2733205 T PT 2733205T
Authority
PT
Portugal
Prior art keywords
modulating
compositions
methods
stem cells
neural stem
Prior art date
Application number
PT123824559T
Other languages
English (en)
Inventor
Galve-Roperh Ismael
Guzmán Pastor Manuel
Díaz-Alonso Javier
Aguado Sanchez Tania
Paraí­So Luna Juan
Original Assignee
Univ Madrid Complutense
Centro De Investig Biomedica En Red De Enfermedades Neurodegenerativas Ciberned
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Madrid Complutense, Centro De Investig Biomedica En Red De Enfermedades Neurodegenerativas Ciberned filed Critical Univ Madrid Complutense
Publication of PT2733205T publication Critical patent/PT2733205T/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0619—Neurons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/80—Neurotransmitters; Neurohormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Neurosurgery (AREA)
  • Biochemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
PT123824559T 2012-11-20 2012-11-20 Neurónios motores superiores corticoespinhais, métodos e composições para diferenciar células estaminais neuronais por modulação da sinalização do recetor canabinoide cb1 e seus usos PT2733205T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP12382455.9A EP2733205B1 (en) 2012-11-20 2012-11-20 Corticospinal upper motor neurons, methods and compositions for differentiating neural stem cells by modulating CB1 cannabinoid receptor signaling and uses thereof

Publications (1)

Publication Number Publication Date
PT2733205T true PT2733205T (pt) 2018-05-09

Family

ID=47221998

Family Applications (1)

Application Number Title Priority Date Filing Date
PT123824559T PT2733205T (pt) 2012-11-20 2012-11-20 Neurónios motores superiores corticoespinhais, métodos e composições para diferenciar células estaminais neuronais por modulação da sinalização do recetor canabinoide cb1 e seus usos

Country Status (6)

Country Link
EP (2) EP3279316B1 (pt)
DK (1) DK2733205T3 (pt)
ES (1) ES2670590T3 (pt)
HR (1) HRP20180566T1 (pt)
NO (1) NO2733205T3 (pt)
PT (1) PT2733205T (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017081033A1 (en) * 2015-11-09 2017-05-18 Universite De Nice Sophia Antipolis Cell differentiation or reprogramming using fezf2 and lmo4
CN110652515A (zh) * 2018-06-29 2020-01-07 中国科学院深圳先进技术研究院 AMPK抑制剂Compound C在治疗肿瘤药物中的应用
CN109633472B (zh) * 2019-01-23 2020-11-24 刘平 一种锂电池单体的荷电状态估计算法
CN110004179B (zh) * 2019-04-16 2023-06-06 浙江诺迦生物科技有限公司 一种大麻素类活性物质的通用检测方法及其检测试剂盒
US20240207262A1 (en) * 2021-04-30 2024-06-27 National University Corporation Tokai National Higher Education And Research System Prophylactic and/or therapeutic agent for amyotrophic lateral sclerosis

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5763177A (en) 1990-06-11 1998-06-09 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: photoselection of nucleic acid ligands and solution selex
US5580737A (en) 1990-06-11 1996-12-03 Nexstar Pharmaceuticals, Inc. High-affinity nucleic acid ligands that discriminate between theophylline and caffeine
US5660985A (en) 1990-06-11 1997-08-26 Nexstar Pharmaceuticals, Inc. High affinity nucleic acid ligands containing modified nucleotides
US5567588A (en) 1990-06-11 1996-10-22 University Research Corporation Systematic evolution of ligands by exponential enrichment: Solution SELEX
US5707796A (en) 1990-06-11 1998-01-13 Nexstar Pharmaceuticals, Inc. Method for selecting nucleic acids on the basis of structure
US6699843B2 (en) 1995-06-07 2004-03-02 Gilead Sciences, Inc. Method for treatment of tumors using nucleic acid ligands to PDGF
US6011577A (en) 1997-06-30 2000-01-04 Polaroid Corporation Modular optical print head assembly
US20030198627A1 (en) 2001-09-01 2003-10-23 Gert-Jan Arts siRNA knockout assay method and constructs
ES2799507T3 (es) 2008-09-10 2020-12-18 Univ Rutgers Obtención de imágenes de moléculas de ARNm individuales, usando múltiples sondas marcadas con un solo marcador
WO2010079241A1 (es) * 2009-01-12 2010-07-15 Fundacion Hospital Nacional De Paraplejicos Para La Investigacion Y La Integracion Uso de antagonistas y/o agonistas inversos de los receptores cb1 para la preparación de medicamentos que incrementen la excitabilidad de las motoneuronas

Also Published As

Publication number Publication date
HRP20180566T1 (hr) 2018-05-18
NO2733205T3 (pt) 2018-06-09
EP2733205B1 (en) 2018-01-10
EP3279316B1 (en) 2023-09-20
DK2733205T3 (en) 2018-04-23
EP3279316A1 (en) 2018-02-07
ES2670590T3 (es) 2018-05-31
EP2733205A1 (en) 2014-05-21

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