HRP20180155T1 - Novo protutijelo protiv ljudskog ngf - Google Patents

Novo protutijelo protiv ljudskog ngf Download PDF

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Publication number
HRP20180155T1
HRP20180155T1 HRP20180155TT HRP20180155T HRP20180155T1 HR P20180155 T1 HRP20180155 T1 HR P20180155T1 HR P20180155T T HRP20180155T T HR P20180155TT HR P20180155 T HRP20180155 T HR P20180155T HR P20180155 T1 HRP20180155 T1 HR P20180155T1
Authority
HR
Croatia
Prior art keywords
fragment
fab
antibody against
against human
human ngf
Prior art date
Application number
HRP20180155TT
Other languages
English (en)
Croatian (hr)
Inventor
Masazumi Kamohara
Hirotsugu Tanaka
Yukari KOYA
Jun Takasaki
Atsuo YONEZAWA
Eiji Yoshimi
Original Assignee
Astellas Pharma Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Inc. filed Critical Astellas Pharma Inc.
Publication of HRP20180155T1 publication Critical patent/HRP20180155T1/hr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
HRP20180155TT 2011-08-11 2012-08-10 Novo protutijelo protiv ljudskog ngf HRP20180155T1 (hr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2011176209 2011-08-11
JP2011269215 2011-12-08
EP12821758.5A EP2743348B1 (en) 2011-08-11 2012-08-10 Novel anti-human ngf antibody
PCT/JP2012/070433 WO2013022083A1 (ja) 2011-08-11 2012-08-10 新規抗ヒトngf抗体

Publications (1)

Publication Number Publication Date
HRP20180155T1 true HRP20180155T1 (hr) 2018-03-23

Family

ID=47668585

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20180155TT HRP20180155T1 (hr) 2011-08-11 2012-08-10 Novo protutijelo protiv ljudskog ngf

Country Status (30)

Country Link
US (2) US8986952B2 (cg-RX-API-DMAC10.html)
EP (1) EP2743348B1 (cg-RX-API-DMAC10.html)
JP (1) JP5376095B2 (cg-RX-API-DMAC10.html)
KR (1) KR101999867B1 (cg-RX-API-DMAC10.html)
CN (1) CN103748222B (cg-RX-API-DMAC10.html)
AR (1) AR087506A1 (cg-RX-API-DMAC10.html)
AU (1) AU2012293161B2 (cg-RX-API-DMAC10.html)
BR (1) BR112014002576B1 (cg-RX-API-DMAC10.html)
CA (1) CA2841181C (cg-RX-API-DMAC10.html)
CY (1) CY1119914T1 (cg-RX-API-DMAC10.html)
DK (1) DK2743348T3 (cg-RX-API-DMAC10.html)
EA (1) EA024292B1 (cg-RX-API-DMAC10.html)
ES (1) ES2663968T3 (cg-RX-API-DMAC10.html)
HR (1) HRP20180155T1 (cg-RX-API-DMAC10.html)
HU (1) HUE036079T2 (cg-RX-API-DMAC10.html)
IL (1) IL230797A (cg-RX-API-DMAC10.html)
IN (1) IN2014CN00614A (cg-RX-API-DMAC10.html)
LT (1) LT2743348T (cg-RX-API-DMAC10.html)
ME (1) ME02944B (cg-RX-API-DMAC10.html)
MX (1) MX351273B (cg-RX-API-DMAC10.html)
NO (1) NO2743348T3 (cg-RX-API-DMAC10.html)
PH (1) PH12014500001A1 (cg-RX-API-DMAC10.html)
PL (1) PL2743348T3 (cg-RX-API-DMAC10.html)
PT (1) PT2743348T (cg-RX-API-DMAC10.html)
RS (1) RS56876B1 (cg-RX-API-DMAC10.html)
SI (1) SI2743348T1 (cg-RX-API-DMAC10.html)
SM (1) SMT201800166T1 (cg-RX-API-DMAC10.html)
TW (1) TWI554519B (cg-RX-API-DMAC10.html)
WO (1) WO2013022083A1 (cg-RX-API-DMAC10.html)
ZA (1) ZA201400741B (cg-RX-API-DMAC10.html)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9783601B2 (en) 2010-12-01 2017-10-10 Alderbio Holdings Llc Methods of preventing inflammation and treating pain using anti-NGF compositions
US9884909B2 (en) 2010-12-01 2018-02-06 Alderbio Holdings Llc Anti-NGF compositions and use thereof
US9078878B2 (en) 2010-12-01 2015-07-14 Alderbio Holdings Llc Anti-NGF antibodies that selectively inhibit the association of NGF with TrkA, without affecting the association of NGF with p75
US9539324B2 (en) 2010-12-01 2017-01-10 Alderbio Holdings, Llc Methods of preventing inflammation and treating pain using anti-NGF compositions
US11214610B2 (en) 2010-12-01 2022-01-04 H. Lundbeck A/S High-purity production of multi-subunit proteins such as antibodies in transformed microbes such as Pichia pastoris
US9067988B2 (en) 2010-12-01 2015-06-30 Alderbio Holdings Llc Methods of preventing or treating pain using anti-NGF antibodies
US9127055B2 (en) 2013-02-08 2015-09-08 Astellas Pharma Inc. Method of treating pain with anti-human NGF antibody
JP6135161B2 (ja) * 2013-02-08 2017-05-31 アステラス製薬株式会社 新規抗ヒトngf抗体
WO2016190263A1 (ja) * 2015-05-22 2016-12-01 アステラス製薬株式会社 新規抗ヒトNGF抗体Fabフラグメント
EP3434283A4 (en) * 2016-03-25 2019-11-13 Astellas Pharma Inc. MEDICAL COMPOSITION WITH A FAB 'FRAGMENT OF A HUMAN ANTI-NGF ANTIBODY AGAINST PEG
CN109929035B (zh) * 2017-12-15 2022-06-28 安源医药科技(上海)有限公司 抗人ngf抗体及其制备方法和用途
JPWO2019221097A1 (ja) 2018-05-15 2021-05-27 アステラス製薬株式会社 抗ヒトngf抗体又はその抗原結合フラグメントを有効成分とする心房細動の抑制用医薬組成物
WO2025149667A1 (en) 2024-01-12 2025-07-17 Pheon Therapeutics Ltd Antibody drug conjugates and uses thereof

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Publication number Priority date Publication date Assignee Title
IL162181A (en) 1988-12-28 2006-04-10 Pdl Biopharma Inc A method of producing humanized immunoglubulin, and polynucleotides encoding the same
DE69433422T2 (de) 1993-03-11 2004-09-16 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Monoklonaler anti-hiv antikörper
GB9625640D0 (en) 1996-12-10 1997-01-29 Celltech Therapeutics Ltd Biological products
US6596541B2 (en) 2000-10-31 2003-07-22 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
KR20100132559A (ko) 2001-05-30 2010-12-17 제넨테크, 인크. 다양한 질환의 치료에 유용한 항-엔지에프 항체
DK1575517T3 (da) 2002-12-24 2012-05-14 Rinat Neuroscience Corp Anti-ngf-antistoffer og fremgangsmåder til anvendelse af samme
US7569364B2 (en) 2002-12-24 2009-08-04 Pfizer Inc. Anti-NGF antibodies and methods using same
UA97086C2 (uk) 2003-07-15 2012-01-10 Емджен, Інк. Виділене людське антитіло, яке специфічно зв'язується з фактором росту нервової тканини (ngf)
ITRM20030601A1 (it) 2003-12-24 2005-06-25 Lay Line Genomics Spa Metodo per l'umanizzazione di anticorpi e anticorpi umanizzati con esso ottenuti.
JP5096167B2 (ja) 2005-01-24 2012-12-12 メドイミューン リミテッド Ngfに対する特異的結合メンバー
US8309088B2 (en) 2007-08-10 2012-11-13 Regeneron Pharmaceuticals, Inc. Method of treating osteoarthritis with an antibody to NGF
PL2187964T3 (pl) * 2007-08-10 2015-03-31 Regeneron Pharma Ludzkie przeciwciała o wysokim powinowactwie przeciw ludzkiemu czynnikowi wzrostu nerwu
SI2206707T1 (sl) 2007-10-24 2014-11-28 Astellas Pharma Inc. Azolkarboksamidna spojina ali njena sol
ES2514319T3 (es) 2009-05-04 2014-10-28 Abbvie Research B.V. Anticuerpos contra el factor de crecimiento nervioso (NGF) con estabilidad in vivo mejorada

Also Published As

Publication number Publication date
IL230797A0 (en) 2014-03-31
DK2743348T3 (en) 2018-02-26
EA024292B1 (ru) 2016-09-30
US20140155582A1 (en) 2014-06-05
EP2743348A4 (en) 2015-04-29
BR112014002576A2 (pt) 2021-01-12
ES2663968T3 (es) 2018-04-17
IN2014CN00614A (cg-RX-API-DMAC10.html) 2015-04-03
ZA201400741B (en) 2014-11-26
CA2841181C (en) 2022-01-25
CY1119914T1 (el) 2018-06-27
KR20140047116A (ko) 2014-04-21
BR112014002576B1 (pt) 2022-08-23
KR101999867B1 (ko) 2019-07-12
CA2841181A1 (en) 2013-02-14
PT2743348T (pt) 2018-02-23
SMT201800166T1 (it) 2018-05-02
SI2743348T1 (en) 2018-04-30
RS56876B1 (sr) 2018-04-30
EP2743348B1 (en) 2018-01-10
AU2012293161B2 (en) 2017-04-27
TWI554519B (zh) 2016-10-21
PH12014500001A1 (en) 2014-02-10
MX351273B (es) 2017-10-06
ME02944B (me) 2018-04-20
JPWO2013022083A1 (ja) 2015-03-05
PL2743348T3 (pl) 2018-04-30
LT2743348T (lt) 2018-05-10
WO2013022083A1 (ja) 2013-02-14
HUE036079T2 (hu) 2018-06-28
JP5376095B2 (ja) 2013-12-25
TW201319086A (zh) 2013-05-16
CN103748222B (zh) 2015-07-22
EP2743348A1 (en) 2014-06-18
AU2012293161A1 (en) 2014-02-06
CN103748222A (zh) 2014-04-23
AR087506A1 (es) 2014-03-26
EA201490433A1 (ru) 2014-05-30
IL230797A (en) 2017-06-29
MX2014001627A (es) 2014-05-28
NO2743348T3 (cg-RX-API-DMAC10.html) 2018-06-09
US20150218265A1 (en) 2015-08-06
US8986952B2 (en) 2015-03-24

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