HRP20171917T1 - Terapeutski pripravci koji sadrže macitentan - Google Patents

Terapeutski pripravci koji sadrže macitentan Download PDF

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Publication number
HRP20171917T1
HRP20171917T1 HRP20171917TT HRP20171917T HRP20171917T1 HR P20171917 T1 HRP20171917 T1 HR P20171917T1 HR P20171917T T HRP20171917T T HR P20171917TT HR P20171917 T HRP20171917 T HR P20171917T HR P20171917 T1 HRP20171917 T1 HR P20171917T1
Authority
HR
Croatia
Prior art keywords
pharmaceutically acceptable
compound
acceptable salt
butoxy
isopropyl
Prior art date
Application number
HRP20171917TT
Other languages
English (en)
Croatian (hr)
Inventor
Martine Clozel
Original Assignee
Actelion Pharmaceuticals Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41346591&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP20171917(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Actelion Pharmaceuticals Ltd. filed Critical Actelion Pharmaceuticals Ltd.
Publication of HRP20171917T1 publication Critical patent/HRP20171917T1/hr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5578—Eicosanoids, e.g. leukotrienes or prostaglandins having a pentalene ring system, e.g. carbacyclin, iloprost
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
HRP20171917TT 2008-08-13 2009-08-12 Terapeutski pripravci koji sadrže macitentan HRP20171917T1 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IB2008053252 2008-08-13
EP09786912.7A EP2315587B1 (en) 2008-08-13 2009-08-12 Therapeutic compositions containing macitentan
PCT/IB2009/053553 WO2010018549A2 (en) 2008-08-13 2009-08-12 Therapeutic compositions containing macitentan

Publications (1)

Publication Number Publication Date
HRP20171917T1 true HRP20171917T1 (hr) 2018-02-09

Family

ID=41346591

Family Applications (2)

Application Number Title Priority Date Filing Date
HRP20171917TT HRP20171917T1 (hr) 2008-08-13 2009-08-12 Terapeutski pripravci koji sadrže macitentan
HRP20192204TT HRP20192204T1 (hr) 2008-08-13 2019-12-06 Terapeutski sastavi koji sadrže macitentan

Family Applications After (1)

Application Number Title Priority Date Filing Date
HRP20192204TT HRP20192204T1 (hr) 2008-08-13 2019-12-06 Terapeutski sastavi koji sadrže macitentan

Country Status (30)

Country Link
US (3) US8809334B2 (enEXAMPLES)
EP (2) EP2315587B1 (enEXAMPLES)
JP (3) JP5764061B2 (enEXAMPLES)
KR (1) KR101678699B1 (enEXAMPLES)
CN (1) CN102099026B (enEXAMPLES)
AR (1) AR073031A1 (enEXAMPLES)
AU (1) AU2009280843B2 (enEXAMPLES)
BR (1) BRPI0917661B8 (enEXAMPLES)
CA (1) CA2731370C (enEXAMPLES)
CY (2) CY1119826T1 (enEXAMPLES)
DK (2) DK3300729T3 (enEXAMPLES)
ES (2) ES2652590T3 (enEXAMPLES)
HK (1) HK1253355B (enEXAMPLES)
HR (2) HRP20171917T1 (enEXAMPLES)
HU (2) HUE036071T2 (enEXAMPLES)
IL (1) IL211143A0 (enEXAMPLES)
LT (2) LT3300729T (enEXAMPLES)
MA (1) MA32614B1 (enEXAMPLES)
MX (1) MX350011B (enEXAMPLES)
MY (1) MY178894A (enEXAMPLES)
NO (1) NO2315587T3 (enEXAMPLES)
NZ (1) NZ591601A (enEXAMPLES)
PL (2) PL2315587T3 (enEXAMPLES)
PT (2) PT2315587T (enEXAMPLES)
RU (1) RU2519161C2 (enEXAMPLES)
SI (2) SI2315587T1 (enEXAMPLES)
SM (2) SMT201900740T1 (enEXAMPLES)
TW (1) TWI446911B (enEXAMPLES)
WO (1) WO2010018549A2 (enEXAMPLES)
ZA (1) ZA201101900B (enEXAMPLES)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL1928409T3 (pl) 2005-09-12 2013-02-28 Actelion Pharmaceuticals Ltd Trwała kompozycja farmaceutyczna zawierająca pirymidynosulfamid
MX2010001837A (es) 2007-08-17 2010-03-10 Actelion Pharmaceuticals Ltd Derivados de 4-pirimidinasulfamida.
DK2246336T3 (da) * 2008-02-28 2020-07-20 Nippon Shinyaku Co Ltd Fibroseinhibitor
KR101678699B1 (ko) 2008-08-13 2016-11-23 액테리온 파마슈티칼 리미티드 마시텐탄을 포함하는 치료 조성물
US9505737B2 (en) 2013-01-11 2016-11-29 Corsair Pharma, Inc. Treprostinil derivative compounds and methods of using same
EP2943479B1 (en) 2013-01-11 2020-04-15 Corsair Pharma, Inc. Prodrugs of treprostinil
US9643911B2 (en) 2015-06-17 2017-05-09 Corsair Pharma, Inc. Treprostinil derivatives and compositions and uses thereof
US9394227B1 (en) 2015-06-17 2016-07-19 Corsair Pharma, Inc. Treprostinil derivatives and compositions and uses thereof
US9794795B1 (en) 2016-04-29 2017-10-17 Corning Optical Communications Wireless Ltd Implementing a live distributed antenna system (DAS) configuration from a virtual DAS design using an original equipment manufacturer (OEM) specific software system in a DAS
CA3046025A1 (en) 2016-12-14 2018-06-21 Respira Therapeutics, Inc. Methods and compositions for treatment of pulmonary hypertension and other lung disorders
KR20210046018A (ko) * 2018-09-14 2021-04-27 파모사 바이오팜 인코포레이티드 약산성 약물의 방출 제어를 위한 약제학적 조성물 및 이의 용도
WO2020128017A1 (en) 2018-12-21 2020-06-25 Actelion Pharmaceuticals Ltd Pharmaceutical composition for the treatment of pulmonary arterial hypertension
TW202042818A (zh) 2019-01-25 2020-12-01 瑞士商艾克泰聯製藥有限公司 用於治療慢性血栓性肺高血壓之醫藥組成物
JOP20220127A1 (ar) 2019-11-29 2023-01-30 Actelion Pharmaceuticals Ltd طرق علاج ارتفاع ضغط الدم الشرياني الرئوي
AU2020408323A1 (en) 2019-12-16 2022-08-11 Tenax Therapeutics, Inc. Levosimendan for treating pulmonary hypertension with heart failure with preserved ejection fraction (PH-HF-pEF)
CA3240614A1 (en) 2021-12-31 2023-07-06 Stuart Rich Oral formulations of levosimendan for treating pulmonary hypertension with heart failure with preserved ejection fraction

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1097239A (en) * 1976-05-11 1981-03-10 Salvador Moncada Enzymatic preparation of prostacyclin and its salts
DE2845770A1 (de) * 1978-10-19 1980-04-30 Schering Ag Neue prostacyclin-derivate und verfahren zu ihrer herstellung
JPS58124778A (ja) * 1982-01-20 1983-07-25 Toray Ind Inc ５，６，７−トリノル−４，８−インタ−ｍ−フエニレンＰＧＩ↓２誘導体
US4683330A (en) 1984-03-08 1987-07-28 The Upjohn Company Interphenylene carbacyclin derivatives
IL155805A0 (en) * 2000-12-18 2003-12-23 Actelion Pharmaceuticals Ltd Novel sulfamides and their use as endothelin receptor antagonists
BR0115995A (pt) * 2000-12-19 2004-01-13 Merck Patent Gmbh Formulação farmacêutica compreendendo pirazolo[4,3-d]pirimidinas e antitrombóticos, antagonistas de cálcio, prostaglandinas ou derivados de prostaglandina
DE10100426B4 (de) 2001-01-08 2006-04-06 Steag Hamatech Ag Verfahren und Vorrichtung zum Zusammenfügen von Substraten
TWI316055B (enEXAMPLES) * 2001-04-26 2009-10-21 Nippon Shinyaku Co Ltd
WO2004017993A1 (en) * 2002-08-12 2004-03-04 Actelion Pharmaceuticals Ltd Combination of prostacyclin or prostacyclin analogues and endothelin receptor antagonists for the treatment of pulmonary arterial hypertension
US7452896B2 (en) * 2002-12-02 2008-11-18 Actelion Pharmaceuticals Ltd. Pyrimidine-sulfamides and their use as endothelian receptor antagonist
US20050101608A1 (en) * 2003-09-24 2005-05-12 Santel Donald J. Iloprost in combination therapies for the treatment of pulmonary arterial hypertension
TW200628467A (en) * 2004-11-11 2006-08-16 Actelion Pharmaceuticals Ltd Novel sulfamides
PL1928409T3 (pl) * 2005-09-12 2013-02-28 Actelion Pharmaceuticals Ltd Trwała kompozycja farmaceutyczna zawierająca pirymidynosulfamid
AR062501A1 (es) 2006-08-29 2008-11-12 Actelion Pharmaceuticals Ltd Composiciones terapeuticas
EP2254570B1 (en) * 2008-02-20 2013-12-18 Actelion Pharmaceuticals Ltd. Combination comprising paclitaxel for treating ovarian cancer
KR101678699B1 (ko) 2008-08-13 2016-11-23 액테리온 파마슈티칼 리미티드 마시텐탄을 포함하는 치료 조성물

Also Published As

Publication number Publication date
KR20110045006A (ko) 2011-05-03
NZ591601A (en) 2012-12-21
HUE036071T2 (hu) 2018-06-28
TW201010985A (en) 2010-03-16
US20110136818A1 (en) 2011-06-09
EP3300729A1 (en) 2018-04-04
BRPI0917661B8 (pt) 2021-05-25
US20140329824A1 (en) 2014-11-06
AR073031A1 (es) 2010-10-06
PL2315587T3 (pl) 2018-03-30
DK3300729T3 (da) 2020-01-20
CA2731370C (en) 2017-03-14
JP5956025B2 (ja) 2016-07-20
ZA201101900B (en) 2012-08-29
NO2315587T3 (enEXAMPLES) 2018-03-24
JP2015180683A (ja) 2015-10-15
SI3300729T1 (sl) 2020-02-28
HRP20192204T1 (hr) 2020-03-06
JP2011530581A (ja) 2011-12-22
JP5764061B2 (ja) 2015-08-12
WO2010018549A3 (en) 2010-07-29
PT2315587T (pt) 2018-01-31
IL211143A0 (en) 2011-04-28
WO2010018549A2 (en) 2010-02-18
US20160022678A1 (en) 2016-01-28
CN102099026A (zh) 2011-06-15
CA2731370A1 (en) 2010-02-18
MX350011B (es) 2017-08-22
RU2011109084A (ru) 2012-09-20
JP2015187148A (ja) 2015-10-29
CY1119826T1 (el) 2018-06-27
RU2519161C2 (ru) 2014-06-10
SMT201900740T1 (it) 2020-01-14
PL3300729T3 (pl) 2020-04-30
ES2652590T3 (es) 2018-02-05
ES2763176T3 (es) 2020-05-27
EP2315587A2 (en) 2011-05-04
MX2011001625A (es) 2011-03-29
US8809334B2 (en) 2014-08-19
US9597331B2 (en) 2017-03-21
CN102099026B (zh) 2012-08-29
LT3300729T (lt) 2020-01-10
MY178894A (en) 2020-10-21
SMT201700592T1 (it) 2018-03-08
SI2315587T1 (en) 2018-04-30
LT2315587T (lt) 2018-01-10
HK1253355B (en) 2020-06-19
AU2009280843B2 (en) 2015-03-05
BRPI0917661B1 (pt) 2019-12-17
AU2009280843A1 (en) 2010-02-18
EP3300729B1 (en) 2019-10-09
CY1122641T1 (el) 2021-03-12
DK2315587T3 (en) 2018-01-02
BRPI0917661A2 (pt) 2015-12-01
TWI446911B (zh) 2014-08-01
HUE047767T2 (hu) 2020-05-28
US9173881B2 (en) 2015-11-03
KR101678699B1 (ko) 2016-11-23
MA32614B1 (fr) 2011-09-01
HK1253355A1 (en) 2019-06-14
PT3300729T (pt) 2020-01-20
EP2315587B1 (en) 2017-10-25
JP5956026B2 (ja) 2016-07-20

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