HRP20170818T1 - Upotreba sigma liganada protiv boli kod raka kostiju - Google Patents
Upotreba sigma liganada protiv boli kod raka kostiju Download PDFInfo
- Publication number
- HRP20170818T1 HRP20170818T1 HRP20170818TT HRP20170818T HRP20170818T1 HR P20170818 T1 HRP20170818 T1 HR P20170818T1 HR P20170818T T HRP20170818T T HR P20170818TT HR P20170818 T HRP20170818 T HR P20170818T HR P20170818 T1 HRP20170818 T1 HR P20170818T1
- Authority
- HR
- Croatia
- Prior art keywords
- intended
- sigma ligand
- pain
- bone cancer
- cancer pain
- Prior art date
Links
- 239000003446 ligand Substances 0.000 title claims 7
- 208000002193 Pain Diseases 0.000 title claims 5
- 206010005949 Bone cancer Diseases 0.000 title claims 3
- 208000018084 Bone neoplasm Diseases 0.000 title claims 3
- 208000004454 Hyperalgesia Diseases 0.000 claims 2
- 208000035154 Hyperesthesia Diseases 0.000 claims 2
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 claims 2
- 208000004296 neuralgia Diseases 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- DGPGXHRHNRYVDH-UHFFFAOYSA-N 4-[2-(5-methyl-1-naphthalen-2-ylpyrazol-3-yl)oxyethyl]morpholine Chemical compound N=1N(C=2C=C3C=CC=CC3=CC=2)C(C)=CC=1OCCN1CCOCC1 DGPGXHRHNRYVDH-UHFFFAOYSA-N 0.000 claims 1
- SHRYQZBTQDMGLZ-UHFFFAOYSA-N 4-[2-(5-methyl-1-naphthalen-2-ylpyrazol-3-yl)oxyethyl]morpholine;hydrochloride Chemical compound Cl.N=1N(C=2C=C3C=CC=CC3=CC=2)C(C)=CC=1OCCN1CCOCC1 SHRYQZBTQDMGLZ-UHFFFAOYSA-N 0.000 claims 1
- 206010058019 Cancer Pain Diseases 0.000 claims 1
- 208000001387 Causalgia Diseases 0.000 claims 1
- 208000000094 Chronic Pain Diseases 0.000 claims 1
- 208000023890 Complex Regional Pain Syndromes Diseases 0.000 claims 1
- 206010029240 Neuritis Diseases 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 208000005298 acute pain Diseases 0.000 claims 1
- 206010053552 allodynia Diseases 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 claims 1
- 208000014439 complex regional pain syndrome type 2 Diseases 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 229960005181 morphine Drugs 0.000 claims 1
- 208000021722 neuropathic pain Diseases 0.000 claims 1
- 201000001119 neuropathy Diseases 0.000 claims 1
- 230000007823 neuropathy Effects 0.000 claims 1
- 229940127240 opiate Drugs 0.000 claims 1
- 208000033808 peripheral neuropathy Diseases 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
- C07D231/20—One oxygen atom attached in position 3 or 5
- C07D231/22—One oxygen atom attached in position 3 or 5 with aryl radicals attached to ring nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4152—1,2-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. antipyrine, phenylbutazone, sulfinpyrazone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Emergency Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Compression, Expansion, Code Conversion, And Decoders (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Steroid Compounds (AREA)
Claims (5)
1. Sigma ligand, namijenjen upotrebi u sprječavanju i/ili liječenje raka kostiju bol, naznačen time što je sigma ligand 4-{2-[5-metil-1-(naftalen-2-il)-1H-pirazol-3-iloksi]etil}morfolin, ili njegova farmaceutski prihvatljiva sol ili solvat.
2. Sigma ligand, namijenjen upotrebi u skladu s patentnim zahtjevom 1, naznačen time što se bol bira između akutne i/ili kronične boli koja se pojavljuje kao posljedica raka kostiju, po mogućnosti neuropatske boli, neuralgije, alodionije, kauzalgije, hiperalgezije, hiperestezija, hiperpatije, neuritisa ili neuropatije kirurškog zahvata.
3. Sigma ligand, namijenjen upotrebi u skladu s patentnih zahtjeva 1 ili 2, naznačen time što je sigma ligand 4-{2-[5-metil-1-(naftalen-2-il)-1H-pirazol-3-iloksi]etil}morfolin-hidroklorid.
4. Kombinacija najmanje jednog sigma liganda u skladu s bilo kojim od patentnih zahtjeva 1 do 3 s najmanje jednim opioidnim ili opijatnim spojem, namijenjena istodobnom, odvojenom ili uzastopnoj primjeni, naznačena time što je namijenjena upotrebi u sprječavanju i/ili liječenju boli povezane s rakom kostiju.
5. Kombinacija namijenjena upotrebi u skladu s patentnim zahtjevom 4, naznačena time što je opioid morfin.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10382330A EP2460519A1 (en) | 2010-12-03 | 2010-12-03 | Use of sigma ligands in bone cancer pain |
| PCT/EP2011/071584 WO2012072782A1 (en) | 2010-12-03 | 2011-12-02 | Use of sigma ligands in bone cancer pain |
| EP11794082.5A EP2646025B1 (en) | 2010-12-03 | 2011-12-02 | Use of sigma ligands in bone cancer pain |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20170818T1 true HRP20170818T1 (hr) | 2017-08-25 |
Family
ID=43629676
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20170818TT HRP20170818T1 (hr) | 2010-12-03 | 2017-05-30 | Upotreba sigma liganada protiv boli kod raka kostiju |
Country Status (33)
| Country | Link |
|---|---|
| US (1) | US20130324535A1 (hr) |
| EP (2) | EP2460519A1 (hr) |
| JP (1) | JP6027014B2 (hr) |
| KR (1) | KR101855358B1 (hr) |
| CN (1) | CN103313709B (hr) |
| AR (1) | AR084730A1 (hr) |
| BR (1) | BR112013013369A8 (hr) |
| CA (1) | CA2819442C (hr) |
| CO (1) | CO6781549A2 (hr) |
| CY (1) | CY1119030T1 (hr) |
| DK (1) | DK2646025T3 (hr) |
| ES (1) | ES2626672T3 (hr) |
| HR (1) | HRP20170818T1 (hr) |
| HU (1) | HUE033488T2 (hr) |
| IL (1) | IL226706A (hr) |
| LT (1) | LT2646025T (hr) |
| MA (1) | MA34878B1 (hr) |
| ME (1) | ME02852B (hr) |
| MX (1) | MX343773B (hr) |
| MY (1) | MY171994A (hr) |
| NZ (1) | NZ612119A (hr) |
| PL (1) | PL2646025T3 (hr) |
| PT (1) | PT2646025T (hr) |
| RS (1) | RS56081B1 (hr) |
| RU (1) | RU2585095C2 (hr) |
| SG (1) | SG190745A1 (hr) |
| SI (1) | SI2646025T1 (hr) |
| TN (1) | TN2013000227A1 (hr) |
| TR (1) | TR201708567T4 (hr) |
| TW (1) | TWI629060B (hr) |
| UA (1) | UA112638C2 (hr) |
| WO (1) | WO2012072782A1 (hr) |
| ZA (1) | ZA201304966B (hr) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2116539A1 (en) | 2008-04-25 | 2009-11-11 | Laboratorios Del. Dr. Esteve, S.A. | 1-aryl-3-aminoalkoxy-pyrazoles as sigma ligands enhancing analgesic effects of opioids and attenuating the dependency thereof |
| EP2353591A1 (en) | 2010-02-04 | 2011-08-10 | Laboratorios Del. Dr. Esteve, S.A. | Sigma ligands for potentiating the analgesic effect of opioids and opiates in post-operative pain and attenuating the dependency thereof |
| EP2353598A1 (en) | 2010-02-04 | 2011-08-10 | Laboratorios Del. Dr. Esteve, S.A. | Sigma ligands for use in the prevention and/or treatment of postoperative pain |
| EP2388005A1 (en) | 2010-05-21 | 2011-11-23 | Laboratorios Del. Dr. Esteve, S.A. | Sigma ligands for the prevention and/or treatment of emesis induced by chemotherapy or radiotherapy |
| EP2415471A1 (en) | 2010-08-03 | 2012-02-08 | Laboratorios Del. Dr. Esteve, S.A. | Use of sigma ligands in opioid-induced hyperalgesia |
| EP2426111A1 (en) * | 2010-08-09 | 2012-03-07 | Laboratorios Del. Dr. Esteve, S.A. | 4-[-2-[[5-methyl-1-(2-naphtalenyl)-1h-pyrazol-3-yl]oxy]ethyl]morpholine hydrochloride amorphous solid forms |
| EP2524694A1 (en) | 2011-05-19 | 2012-11-21 | Laboratorios Del. Dr. Esteve, S.A. | Use of sigma ligands in diabetes type-2 associated pain |
| EP2792352A1 (en) | 2013-04-16 | 2014-10-22 | Laboratorios Del. Dr. Esteve, S.A. | Alpha-2 adrenoreceptor and sigma receptor ligand combinations |
| EP2818166A1 (en) * | 2013-06-26 | 2014-12-31 | Laboratorios del Dr. Esteve S.A. | Use of sigma receptor ligands for the prevention and treatment of pain associated to interstitial cystitis/bladder pain syndrome (IC/BPS) |
| AR100021A1 (es) * | 2013-09-12 | 2016-09-07 | Esteve Labor Dr | Combinaciones de ligando de receptores sigma y aine |
| TW201607538A (zh) | 2013-12-17 | 2016-03-01 | 以斯提夫博士實驗室股份有限公司 | 血清素－去甲腎上腺素再攝取抑制劑（ＳＮＲＩＳ）和σ受體配體組合物 |
| MA39146A1 (fr) | 2013-12-17 | 2017-11-30 | Esteve Labor Dr | Combinaisons de gabapentanoïdes et de ligands des récepteurs sigma |
| EP2929883A1 (en) * | 2014-04-08 | 2015-10-14 | Institut Pasteur | Pyrazole derivatives as dihydroorotate dehydrogenase (DHODH) inhibitors |
| AR109024A1 (es) * | 2016-07-12 | 2018-10-17 | Esteve Labor Dr | Uso de ligandos del receptor sigma en el dolor post-herpético |
| US11975055B2 (en) * | 2018-05-21 | 2024-05-07 | Ipsen Biopharm Limited | Suppression of bone cancer-induced allodynia |
| EP3886854A4 (en) | 2018-11-30 | 2022-07-06 | Nuvation Bio Inc. | PYRROLE AND PYRAZOLE COMPOUNDS AND METHODS OF USE THERE |
| CN112341397B (zh) * | 2019-08-09 | 2023-05-23 | 成都苑东生物制药股份有限公司 | 吡嗪类衍生物或盐、异构体、其制备方法及用途 |
| KR20210151572A (ko) | 2020-06-05 | 2021-12-14 | 주식회사 허밍아비스 | 발열체 조성물 및 이를 이용한 마스크 제조방법 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1641764E (pt) * | 2003-06-26 | 2011-10-27 | Novartis Ag | Inibidores de p38 quinase a base de heterociclo de 5 elementos |
| JP5139061B2 (ja) * | 2004-08-27 | 2013-02-06 | ラボラトリオス デル ドクトール エステベ エセ．ア． | シグマ受容体阻害剤 |
| MX2007002341A (es) * | 2004-08-27 | 2007-09-25 | Esteve Labor Dr | Inhibidores del receptor sigma. |
| WO2007098953A1 (en) * | 2006-03-01 | 2007-09-07 | Laboratorios Del Dr. Esteve, S.A. | Pyrazole derivatives as sigma receptor inhibitors |
| EP2116539A1 (en) * | 2008-04-25 | 2009-11-11 | Laboratorios Del. Dr. Esteve, S.A. | 1-aryl-3-aminoalkoxy-pyrazoles as sigma ligands enhancing analgesic effects of opioids and attenuating the dependency thereof |
| EP2113501A1 (en) * | 2008-04-25 | 2009-11-04 | Laboratorios Del. Dr. Esteve, S.A. | 5-Methyl-1-(naphthalen-2-YL)-1H-Pyrazoles useful as sigma receptor inhibitors |
| EP2353591A1 (en) * | 2010-02-04 | 2011-08-10 | Laboratorios Del. Dr. Esteve, S.A. | Sigma ligands for potentiating the analgesic effect of opioids and opiates in post-operative pain and attenuating the dependency thereof |
-
2010
- 2010-12-03 EP EP10382330A patent/EP2460519A1/en not_active Withdrawn
-
2011
- 2011-02-12 UA UAA201308348A patent/UA112638C2/uk unknown
- 2011-11-25 TW TW100143323A patent/TWI629060B/zh not_active IP Right Cessation
- 2011-12-02 US US13/991,282 patent/US20130324535A1/en not_active Abandoned
- 2011-12-02 PL PL11794082T patent/PL2646025T3/pl unknown
- 2011-12-02 JP JP2013541369A patent/JP6027014B2/ja not_active Expired - Fee Related
- 2011-12-02 WO PCT/EP2011/071584 patent/WO2012072782A1/en active Application Filing
- 2011-12-02 EP EP11794082.5A patent/EP2646025B1/en active Active
- 2011-12-02 LT LTEP11794082.5T patent/LT2646025T/lt unknown
- 2011-12-02 SI SI201131191A patent/SI2646025T1/sl unknown
- 2011-12-02 MA MA36072A patent/MA34878B1/fr unknown
- 2011-12-02 AR ARP110104502A patent/AR084730A1/es unknown
- 2011-12-02 HU HUE11794082A patent/HUE033488T2/en unknown
- 2011-12-02 CN CN201180065232.XA patent/CN103313709B/zh not_active Expired - Fee Related
- 2011-12-02 KR KR1020137017344A patent/KR101855358B1/ko active IP Right Grant
- 2011-12-02 SG SG2013042569A patent/SG190745A1/en unknown
- 2011-12-02 MX MX2013006140A patent/MX343773B/es active IP Right Grant
- 2011-12-02 NZ NZ612119A patent/NZ612119A/en not_active IP Right Cessation
- 2011-12-02 ME MEP-2017-120A patent/ME02852B/me unknown
- 2011-12-02 MY MYPI2013001961A patent/MY171994A/en unknown
- 2011-12-02 DK DK11794082.5T patent/DK2646025T3/en active
- 2011-12-02 CA CA2819442A patent/CA2819442C/en not_active Expired - Fee Related
- 2011-12-02 BR BR112013013369A patent/BR112013013369A8/pt not_active Application Discontinuation
- 2011-12-02 PT PT117940825T patent/PT2646025T/pt unknown
- 2011-12-02 TR TR2017/08567T patent/TR201708567T4/tr unknown
- 2011-12-02 RU RU2013130222/15A patent/RU2585095C2/ru not_active IP Right Cessation
- 2011-12-02 RS RS20170575A patent/RS56081B1/sr unknown
- 2011-12-02 ES ES11794082.5T patent/ES2626672T3/es active Active
-
2013
- 2013-05-29 TN TNP2013000227A patent/TN2013000227A1/fr unknown
- 2013-06-03 IL IL226706A patent/IL226706A/en active IP Right Grant
- 2013-07-02 CO CO13155721A patent/CO6781549A2/es not_active Application Discontinuation
- 2013-07-03 ZA ZA2013/04966A patent/ZA201304966B/en unknown
-
2017
- 2017-05-30 HR HRP20170818TT patent/HRP20170818T1/hr unknown
- 2017-06-08 CY CY20171100604T patent/CY1119030T1/el unknown
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