HRP20161140T1 - Postupak za proizvodnju primicina, komponenanta primicina, njegovih prekursora i metabolita putem fermentacije uporabom bakterijskih vrsta saccharomonospora azurea - Google Patents
Postupak za proizvodnju primicina, komponenanta primicina, njegovih prekursora i metabolita putem fermentacije uporabom bakterijskih vrsta saccharomonospora azurea Download PDFInfo
- Publication number
- HRP20161140T1 HRP20161140T1 HRP20161140TT HRP20161140T HRP20161140T1 HR P20161140 T1 HRP20161140 T1 HR P20161140T1 HR P20161140T T HRP20161140T T HR P20161140TT HR P20161140 T HRP20161140 T HR P20161140T HR P20161140 T1 HRP20161140 T1 HR P20161140T1
- Authority
- HR
- Croatia
- Prior art keywords
- primicin
- primycin
- components
- acid
- formula
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 8
- 241000125139 Saccharomonospora azurea Species 0.000 title claims 3
- NYWSLZMTZNODJM-MCGDBQAWSA-N 2-[5-[(4e,20e)-35-butyl-19-[(2s,3s,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-10,12,14,16,18,22,26,30,34-nonahydroxy-3,5,21,33-tetramethyl-36-oxo-1-oxacyclohexatriaconta-4,20-dien-2-yl]-4-hydroxyhexyl]guanidine Chemical compound OC1CC(O)CC(O)CC(O)CC(O)CCCC\C(C)=C\C(C)C(C(C)C(O)CCCN=C(N)N)OC(=O)C(CCCC)C(O)C(C)CCC(O)CCCC(O)CCCC(O)\C(C)=C\C1O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O1 NYWSLZMTZNODJM-MCGDBQAWSA-N 0.000 title 2
- 229950010664 primycin Drugs 0.000 title 2
- NYWSLZMTZNODJM-SDUQVVOESA-N primycin Natural products CCCC[C@H]1[C@H](O)[C@H](C)CC[C@@H](O)CCC[C@@H](O)CCC[C@@H](O)C(=C[C@H](O[C@H]2O[C@H](CO)[C@@H](O)[C@@H]2O)[C@@H](O)C[C@H](O)C[C@@H](O)C[C@H](O)C[C@H](O)CCCCC(=C[C@@H](C)[C@@H](OC1=O)[C@H](C)[C@H](O)CCCNC(=N)N)C)C NYWSLZMTZNODJM-SDUQVVOESA-N 0.000 title 2
- 230000001580 bacterial effect Effects 0.000 title 1
- 239000002207 metabolite Substances 0.000 title 1
- 239000002243 precursor Substances 0.000 title 1
- 239000002253 acid Substances 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 235000014113 dietary fatty acids Nutrition 0.000 claims 2
- 229930195729 fatty acid Natural products 0.000 claims 2
- 239000000194 fatty acid Substances 0.000 claims 2
- 150000004665 fatty acids Chemical class 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000002609 medium Substances 0.000 claims 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 235000021355 Stearic acid Nutrition 0.000 claims 1
- 239000003925 fat Substances 0.000 claims 1
- 150000002191 fatty alcohols Chemical class 0.000 claims 1
- 238000000855 fermentation Methods 0.000 claims 1
- 230000004151 fermentation Effects 0.000 claims 1
- 239000001963 growth medium Substances 0.000 claims 1
- 229910052500 inorganic mineral Inorganic materials 0.000 claims 1
- 244000005700 microbiome Species 0.000 claims 1
- 239000011707 mineral Chemical class 0.000 claims 1
- 150000007522 mineralic acids Chemical group 0.000 claims 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 125000001280 n-hexyl group Chemical group C(CCCCC)* 0.000 claims 1
- 125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims 1
- 239000003921 oil Substances 0.000 claims 1
- 150000007524 organic acids Chemical class 0.000 claims 1
- 125000001477 organic nitrogen group Chemical class 0.000 claims 1
- 238000011084 recovery Methods 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000008117 stearic acid Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
- C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (5)
1. Postupak za proizvodnju primicina ili komponenata primicina, gdje su navedene komponente primicina tvari formule (I)
[image]
gdje
R1 je n-butil, n-pentil ili n-heksil,
R2 je H, OH ili grupa formule (A)
[image]
X- je bilo kiselinski ostatak anorganske kiseline ili kiselinski ostatak organske kiseline, navedeni postupak obuhvaća korake fermentiranja mikroorganizma odabranog iz grupe koja se sastoji od Saccharomonospora azurea, različitih sojeva i njihovih mutanata u mediju za kultiviranje, a nakon toga postizanje odgovarajuće koncentracije, obnavljanje primicina ili komponente primicina poznatim postupkom ili kombinacijom poznatih postupaka.
2. Postupak u skladu s patentnim zahtjevom 1, pri čemu se kao medij za kultiviranje koristi medij koji sadrži izvor organskog ugljika, izvor organskog dušika, mineralne soli i poželjno prirodne ili sintetske masti, ulja, masne alkohole i/ili masne kiseline.
3. Postupak u skladu s patentnim zahtjevima 1 ili 2, pri čemu je navedena masna kiselina stearinska kiselina.
4. Postupak u skladu s patentnim zahtjevima 1 ili 3, pri čemu se fermentacija provodi kod temperature od 18 do 35°C, kod pH vrijednosti 6 do 9 tijekom najmanje 48 sati.
5. Uporaba Saccharomonospora azurea, različitih sojeva i njihovih mutanata za proizvodnju primicina ili komponenata primicina, u skladu s formulom (1) kako je navedeno u patentnom zahtjevu 1.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU0900678A HU229804B1 (en) | 2009-10-29 | 2009-10-29 | Method of production of primycin, primycin components, and/or precursors and metabolites of primycin via fementation by the use of bacterial species saccharomonospora azurea |
| PCT/HU2010/000116 WO2011051741A1 (en) | 2009-10-29 | 2010-10-29 | Process for producing primycin, primycin component(s), precursors and metabolites thereof via fementation by the use of bacterial species saccharomonospora azurea |
| EP10795761.5A EP2501821B1 (en) | 2009-10-29 | 2010-10-29 | Process for producing primycin, primycin component(s), precursors and metabolites thereof via fementation by the use of bacterial species saccharomonospora azurea |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20161140T1 true HRP20161140T1 (hr) | 2016-11-04 |
Family
ID=89989339
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20161140TT HRP20161140T1 (hr) | 2009-10-29 | 2016-09-06 | Postupak za proizvodnju primicina, komponenanta primicina, njegovih prekursora i metabolita putem fermentacije uporabom bakterijskih vrsta saccharomonospora azurea |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP2501821B1 (hr) |
| DK (1) | DK2501821T3 (hr) |
| HR (1) | HRP20161140T1 (hr) |
| HU (1) | HU229804B1 (hr) |
| PL (1) | PL2501821T3 (hr) |
| SI (1) | SI2501821T1 (hr) |
| WO (1) | WO2011051741A1 (hr) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU230455B1 (hu) * | 2011-10-25 | 2016-07-28 | Pannonpharma Gyógyszergyártó Zrt. | Primycin vagy primycin komponensek vagy ezek kombinációi mint speciális kórokozócsoportok által okozott fertőzések kezelésére vagy megelőzésére alkalmas gyógyszerhatóanyagok |
| CN109943610B (zh) * | 2019-05-06 | 2021-05-25 | 淮北师范大学 | 一种基于外源饱和脂肪酸添加的纳他霉素发酵工艺 |
| CN113786418A (zh) * | 2021-09-18 | 2021-12-14 | 哈尔滨工业大学 | 一种深海菌代谢产物抑菌液的制备方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT268522B (de) * | 1965-10-20 | 1969-02-10 | Chinoin Gyogyszer Es Vegyeszet | Verfahren zur Herstellung von Primycin |
| CH655747A5 (de) | 1982-09-20 | 1986-05-15 | Schulthess & Co Ag Maschf | Vorrichtung zum lockern von an der trommelwand nach dem entwaessern festklebender waesche und verfahren zu ihrem betrieb. |
| CA1274508A (en) | 1984-05-31 | 1990-09-25 | Imre Szilagyi | Primycin components and process for the separation of the antibiotic complex |
| HU205366B (en) | 1988-11-18 | 1992-04-28 | Chinoin Gyogyszer Es Vegyeszet | Process for producing water-soluble primycin complexes and pharmaceutical compositions comprising such active ingredient |
| PT971707E (pt) | 1997-04-04 | 2003-01-31 | Human Oltoanyagtermeloe Es Gyo | Composicoes para o tratamento de queimaduras e de ulceras externas e um processo para a sua preparacao |
| AU3418400A (en) | 1999-03-30 | 2000-10-23 | Novozymes A/S | Preparation of dough and baked products |
| JP3128577B1 (ja) | 1999-11-04 | 2001-01-29 | 工業技術院長 | ポリ乳酸樹脂の分解方法 |
| US8158152B2 (en) | 2005-11-18 | 2012-04-17 | Scidose Llc | Lyophilization process and products obtained thereby |
-
2009
- 2009-10-29 HU HU0900678A patent/HU229804B1/hu unknown
-
2010
- 2010-10-29 EP EP10795761.5A patent/EP2501821B1/en active Active
- 2010-10-29 PL PL10795761T patent/PL2501821T3/pl unknown
- 2010-10-29 WO PCT/HU2010/000116 patent/WO2011051741A1/en active Application Filing
- 2010-10-29 SI SI201031274A patent/SI2501821T1/sl unknown
- 2010-10-29 DK DK10795761.5T patent/DK2501821T3/en active
-
2016
- 2016-09-06 HR HRP20161140TT patent/HRP20161140T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0900678A2 (en) | 2012-03-28 |
| SI2501821T1 (sl) | 2017-02-28 |
| EP2501821A1 (en) | 2012-09-26 |
| HU229804B1 (en) | 2014-07-28 |
| WO2011051741A1 (en) | 2011-05-05 |
| DK2501821T3 (en) | 2016-09-19 |
| PL2501821T3 (pl) | 2017-02-28 |
| EP2501821B1 (en) | 2016-06-15 |
| HU0900678D0 (en) | 2010-01-28 |
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