HRP20161063T1 - Toltrazuril s poboljšanim svojstvima otapanja - Google Patents
Toltrazuril s poboljšanim svojstvima otapanja Download PDFInfo
- Publication number
- HRP20161063T1 HRP20161063T1 HRP20161063TT HRP20161063T HRP20161063T1 HR P20161063 T1 HRP20161063 T1 HR P20161063T1 HR P20161063T T HRP20161063T T HR P20161063TT HR P20161063 T HRP20161063 T HR P20161063T HR P20161063 T1 HRP20161063 T1 HR P20161063T1
- Authority
- HR
- Croatia
- Prior art keywords
- toltrazuril
- acids
- suspension
- group
- agent
- Prior art date
Links
- 238000004090 dissolution Methods 0.000 title claims 3
- OCINXEZVIIVXFU-UHFFFAOYSA-N 1-methyl-3-[3-methyl-4-[4-(trifluoromethylthio)phenoxy]phenyl]-1,3,5-triazinane-2,4,6-trione Chemical compound CC1=CC(N2C(N(C)C(=O)NC2=O)=O)=CC=C1OC1=CC=C(SC(F)(F)F)C=C1 OCINXEZVIIVXFU-UHFFFAOYSA-N 0.000 claims 14
- 229960000898 toltrazuril Drugs 0.000 claims 14
- 238000000034 method Methods 0.000 claims 10
- 239000003795 chemical substances by application Substances 0.000 claims 8
- 239000002245 particle Substances 0.000 claims 6
- 230000002378 acidificating effect Effects 0.000 claims 4
- 239000002904 solvent Substances 0.000 claims 4
- 239000000725 suspension Substances 0.000 claims 4
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical group [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical group Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 2
- 150000004703 alkoxides Chemical class 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 claims 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical class O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 150000007513 acids Chemical class 0.000 claims 1
- 150000001298 alcohols Chemical class 0.000 claims 1
- 239000003513 alkali Substances 0.000 claims 1
- 229910001854 alkali hydroxide Inorganic materials 0.000 claims 1
- 229910001860 alkaline earth metal hydroxide Inorganic materials 0.000 claims 1
- 150000003973 alkyl amines Chemical class 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 229910021529 ammonia Inorganic materials 0.000 claims 1
- 150000003868 ammonium compounds Chemical class 0.000 claims 1
- 150000001735 carboxylic acids Chemical class 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 150000002170 ethers Chemical class 0.000 claims 1
- 150000004679 hydroxides Chemical class 0.000 claims 1
- 150000002576 ketones Chemical class 0.000 claims 1
- 239000007791 liquid phase Substances 0.000 claims 1
- 238000002803 maceration Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 150000002825 nitriles Chemical class 0.000 claims 1
- 235000011007 phosphoric acid Nutrition 0.000 claims 1
- 150000003016 phosphoric acids Chemical class 0.000 claims 1
- 238000000634 powder X-ray diffraction Methods 0.000 claims 1
- 238000001556 precipitation Methods 0.000 claims 1
- 238000000926 separation method Methods 0.000 claims 1
- 150000003460 sulfonic acids Chemical class 0.000 claims 1
- 150000003462 sulfoxides Chemical class 0.000 claims 1
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid group Chemical class S(O)(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dispersion Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Claims (15)
1. Čestice toltrazurila, naznačene time, da imaju specifično površinsko područje između 4 i 40 m2/g.
2. Čestice toltrazurila prema zahtjevu 1, naznačene time, da imaju specifično površinsko područje između 7 i 30 m2/g.
3. Čestice toltrazurila prema zahtjevu 2, naznačene time, da imaju specifično površinsko područje između 10 i 25 m2/g.
4. Čestice toltrazurila prema zahtjevu 1, 2 ili 3, naznačene time, da su u kristalnom stanju.
5. Čestice toltrazurila prema zahtjevu 4, naznačene time, da imaju vršne vrijednosti uzorka difrakcije praha X-zraka na oko 5,5; 14,1; 16,5; 22,1 ± 0,2 stupnja 2θ.
6. Postupak proizvodnje čestica toltrazurila prema zahtjevu 1, 2 ili 3, naznačen time, da obuhvaća sljedeće korake:
a) suspenzija toltrazurila u otapalu;
b) otapanje toltrazurila s dodavanjem lužnatog sredstva u suspenziju;
c) taloženje toltrazurila s dodavanjem kiselog sredstva u otopinu ili s dodavanjem otopine toltrazurila u kiselo sredstvo;
d) odvajanje nataloženog toltrazurila iz tekuće faze; i
e) opcijski dalje maceracija toltrazurila.
7. Postupak prema zahtjevu 6, naznačen time, da se otapalo odabire iz skupine koju čine: voda, alkoholi, ketoni, nitrili, sulfoksidi, amidi, eteri, esteri i/ili bilo koja njihova mješavina.
8. Postupak prema zahtjevu 7, naznačen time, da otapalo je voda ili vodena smjesa otapala.
9. Postupak prema zahtjevu 6, naznačen time, da se pH-vrijednost suspenzije održava iznad 10 za vrijeme otapanja toltrazurila.
10. Postupak prema zahtjevu 9, naznačen time, da se pH-vrijednost suspenzije održava između 11 i 13 za vrijeme otapanja toltrazurila.
11. Postupak prema zahtjevu 6, naznačen time, da se lužnato sredstvo odabire iz skupine koju čine: bazični hidroksidi, alkoksidi i/ili bazični amonijevi spojevi.
12. Postupak prema zahtjevu 11, naznačen time, da se lužnato sredstvo odabire iz skupine koju čine: alkalijski i zemnoalkalijski metalni hidroksidi ili alkoksidi, amonijak i/ili alkilamini.
13. Postupak prema zahtjevu 12, naznačen time, da lužnato sredstvo je kalijev hidroksid ili natrijev hidroksid.
14. Postupak prema zahtjevu 6, naznačen time, da se kiselo sredstvo odabire iz skupine koju čine: halogenvodikove kiseline, karboksilne kiseline, dušične kiseline, sumporne kiseline, fosforne kiseline i/ili sulfonske kiseline.
15. Postupak prema zahtjevu 14, naznačen time, da kiselo sredstvo je klorovodična kiselina ili bromovodična kiselina.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SI200800078A SI22751A (sl) | 2008-04-03 | 2008-04-03 | Toltrazuril z izboljĺ animi lastnostmi za raztapljanje |
| PCT/EP2009/054012 WO2009121957A1 (en) | 2008-04-03 | 2009-04-03 | Toltrazuril with improved dissolution properties |
| EP09726974.0A EP2276347B1 (en) | 2008-04-03 | 2009-04-03 | Toltrazuril with improved dissolution properties |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20161063T1 true HRP20161063T1 (hr) | 2016-10-21 |
Family
ID=40810202
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20161063TT HRP20161063T1 (hr) | 2008-04-03 | 2016-08-22 | Toltrazuril s poboljšanim svojstvima otapanja |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP2276347B1 (hr) |
| DK (1) | DK2276347T3 (hr) |
| EA (1) | EA017015B1 (hr) |
| ES (1) | ES2588243T3 (hr) |
| HR (1) | HRP20161063T1 (hr) |
| HU (1) | HUE029447T2 (hr) |
| PL (1) | PL2276347T3 (hr) |
| PT (1) | PT2276347T (hr) |
| RS (1) | RS55048B1 (hr) |
| SI (2) | SI22751A (hr) |
| UA (1) | UA103476C2 (hr) |
| WO (1) | WO2009121957A1 (hr) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2740470A1 (en) | 2012-12-07 | 2014-06-11 | Ceva Sante Animale | Treatment of Coccidiosis with intramuscular triazine composition |
| EP2740492A1 (en) * | 2012-12-07 | 2014-06-11 | Ceva Sante Animale | Triazine formulations with a second active ingredient and surfactant(s) |
| EP2740469A1 (en) | 2012-12-07 | 2014-06-11 | Ceva Sante Animale | New treatments with triazines |
| CN102973497A (zh) * | 2012-12-13 | 2013-03-20 | 江苏恒丰强生物技术有限公司 | 一种托曲珠利溶液及其制备方法 |
| CN103142487A (zh) * | 2013-03-22 | 2013-06-12 | 黑龙江大学 | 一种高含量妥曲珠利可溶性粉剂及其制备方法和应用 |
| CN106906185B (zh) * | 2017-04-26 | 2019-11-12 | 江南大学 | 一株抗托曲珠利单克隆抗体杂交瘤细胞株k-5及其应用 |
| CN115166094A (zh) * | 2022-07-18 | 2022-10-11 | 镇江威特药业有限责任公司 | 一种托曲珠利含量的检测方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3468336D1 (en) | 1983-06-22 | 1988-02-11 | Univ Ohio State Res Found | Small particle formation |
| US4606939A (en) * | 1983-06-22 | 1986-08-19 | The Ohio State University Research Foundation | Small particle formation |
| DE3347579A1 (de) | 1983-12-30 | 1985-07-11 | Hoechst Ag, 6230 Frankfurt | Zubereitungen schwer wasserloeslicher anthelminthika und verfahren zu ihrer herstellung |
| DE19824483A1 (de) * | 1998-06-02 | 1999-12-09 | Bayer Ag | Halbfeste wäßrige Zubereitungen für orale Applikation von Toltrazuril-Sulfon |
| BR9914385A (pt) * | 1998-10-08 | 2001-07-17 | New Ace Res Company | Composição útil para o tratamento e prevenção de infecções protozoárias no homem e em animais, e, método de tratamento de uma infecção protozoária no homem e em animais |
| WO2001026660A1 (en) | 1999-10-08 | 2001-04-19 | New Ace Research Company | Novel compositions and methods for prevention and treatment of protozoal disease |
| DE10040174A1 (de) * | 2000-08-17 | 2002-02-28 | Bayer Ag | Verwendung von Triazintrion-Sulfonen zur Bekämpfung von Coccidiosen |
| US20070254008A1 (en) * | 2001-07-13 | 2007-11-01 | Flow Focusing, Inc. | Antibiotic formulation and method of treatment |
| CA2608930A1 (en) * | 2005-06-14 | 2006-12-28 | Baxter International Inc. | Pharmaceutical formulations for minimizing drug-drug interactions |
| WO2007145657A2 (en) * | 2005-11-01 | 2007-12-21 | Massachusetts Institute Of Technology | Initiated chemical vapor deposition of vinyl polymers for the encapsulation of particles |
| DE102007025908A1 (de) | 2007-06-01 | 2008-12-04 | Bayer Healthcare Ag | Formulierungen enthaltend Triazinone und Eisen |
-
2008
- 2008-04-03 SI SI200800078A patent/SI22751A/sl not_active IP Right Cessation
-
2009
- 2009-04-03 ES ES09726974.0T patent/ES2588243T3/es active Active
- 2009-04-03 UA UAA201012989A patent/UA103476C2/ru unknown
- 2009-04-03 DK DK09726974.0T patent/DK2276347T3/en active
- 2009-04-03 PL PL09726974T patent/PL2276347T3/pl unknown
- 2009-04-03 PT PT97269740T patent/PT2276347T/pt unknown
- 2009-04-03 WO PCT/EP2009/054012 patent/WO2009121957A1/en active Application Filing
- 2009-04-03 RS RS20160637A patent/RS55048B1/sr unknown
- 2009-04-03 HU HUE09726974A patent/HUE029447T2/en unknown
- 2009-04-03 EP EP09726974.0A patent/EP2276347B1/en not_active Revoked
- 2009-04-03 SI SI200931487A patent/SI2276347T1/sl unknown
- 2009-04-03 EA EA201001354A patent/EA017015B1/ru not_active IP Right Cessation
-
2016
- 2016-08-22 HR HRP20161063TT patent/HRP20161063T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2276347A1 (en) | 2011-01-26 |
| HUE029447T2 (en) | 2017-02-28 |
| WO2009121957A1 (en) | 2009-10-08 |
| SI2276347T1 (sl) | 2016-10-28 |
| EA201001354A1 (ru) | 2011-02-28 |
| PT2276347T (pt) | 2016-08-19 |
| PL2276347T3 (pl) | 2017-04-28 |
| EP2276347B1 (en) | 2016-05-25 |
| UA103476C2 (ru) | 2013-10-25 |
| DK2276347T3 (en) | 2016-08-29 |
| ES2588243T3 (es) | 2016-10-31 |
| SI22751A (sl) | 2009-10-31 |
| RS55048B1 (sr) | 2016-12-30 |
| EA017015B1 (ru) | 2012-09-28 |
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