HRP20160454T1 - Kombinacija spoja morfinana i antidepresiva za liječenje pseudobulbarnog afekta - Google Patents
Kombinacija spoja morfinana i antidepresiva za liječenje pseudobulbarnog afekta Download PDFInfo
- Publication number
- HRP20160454T1 HRP20160454T1 HRP20160454TT HRP20160454T HRP20160454T1 HR P20160454 T1 HRP20160454 T1 HR P20160454T1 HR P20160454T T HRP20160454T T HR P20160454TT HR P20160454 T HRP20160454 T HR P20160454T HR P20160454 T1 HRP20160454 T1 HR P20160454T1
- Authority
- HR
- Croatia
- Prior art keywords
- combination
- use according
- serotonin reuptake
- selective serotonin
- reuptake inhibitor
- Prior art date
Links
- 206010054196 Affect lability Diseases 0.000 title claims 2
- 230000001430 anti-depressive effect Effects 0.000 title 1
- 239000000935 antidepressant agent Substances 0.000 title 1
- 229940005513 antidepressants Drugs 0.000 title 1
- INAXVFBXDYWQFN-XHSDSOJGSA-N morphinan Chemical class C1C2=CC=CC=C2[C@]23CCCC[C@H]3[C@@H]1NCC2 INAXVFBXDYWQFN-XHSDSOJGSA-N 0.000 title 1
- 229940124834 selective serotonin reuptake inhibitor Drugs 0.000 claims 8
- 239000012896 selective serotonin reuptake inhibitor Substances 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 7
- AHOUBRCZNHFOSL-YOEHRIQHSA-N (+)-Casbol Chemical compound C1=CC(F)=CC=C1[C@H]1[C@H](COC=2C=C3OCOC3=CC=2)CNCC1 AHOUBRCZNHFOSL-YOEHRIQHSA-N 0.000 claims 6
- AHOUBRCZNHFOSL-UHFFFAOYSA-N Paroxetine hydrochloride Natural products C1=CC(F)=CC=C1C1C(COC=2C=C3OCOC3=CC=2)CNCC1 AHOUBRCZNHFOSL-UHFFFAOYSA-N 0.000 claims 6
- 229960002296 paroxetine Drugs 0.000 claims 6
- WSEQXVZVJXJVFP-HXUWFJFHSA-N (R)-citalopram Chemical compound C1([C@@]2(C3=CC=C(C=C3CO2)C#N)CCCN(C)C)=CC=C(F)C=C1 WSEQXVZVJXJVFP-HXUWFJFHSA-N 0.000 claims 4
- 229960001653 citalopram Drugs 0.000 claims 4
- 229960004038 fluvoxamine Drugs 0.000 claims 4
- CJOFXWAVKWHTFT-XSFVSMFZSA-N fluvoxamine Chemical compound COCCCC\C(=N/OCCN)C1=CC=C(C(F)(F)F)C=C1 CJOFXWAVKWHTFT-XSFVSMFZSA-N 0.000 claims 4
- 229960002073 sertraline Drugs 0.000 claims 4
- VGKDLMBJGBXTGI-SJCJKPOMSA-N sertraline Chemical compound C1([C@@H]2CC[C@@H](C3=CC=CC=C32)NC)=CC=C(Cl)C(Cl)=C1 VGKDLMBJGBXTGI-SJCJKPOMSA-N 0.000 claims 4
- WIQRCHMSJFFONW-UHFFFAOYSA-N norfluoxetine Chemical compound C=1C=CC=CC=1C(CCN)OC1=CC=C(C(F)(F)F)C=C1 WIQRCHMSJFFONW-UHFFFAOYSA-N 0.000 claims 3
- RTHCYVBBDHJXIQ-MRXNPFEDSA-N (R)-fluoxetine Chemical compound O([C@H](CCNC)C=1C=CC=CC=1)C1=CC=C(C(F)(F)F)C=C1 RTHCYVBBDHJXIQ-MRXNPFEDSA-N 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- USRHYDPUVLEVMC-FQEVSTJZSA-N dapoxetine Chemical compound C1([C@H](CCOC=2C3=CC=CC=C3C=CC=2)N(C)C)=CC=CC=C1 USRHYDPUVLEVMC-FQEVSTJZSA-N 0.000 claims 2
- 229960005217 dapoxetine Drugs 0.000 claims 2
- 229960004341 escitalopram Drugs 0.000 claims 2
- WSEQXVZVJXJVFP-FQEVSTJZSA-N escitalopram Chemical compound C1([C@]2(C3=CC=C(C=C3CO2)C#N)CCCN(C)C)=CC=C(F)C=C1 WSEQXVZVJXJVFP-FQEVSTJZSA-N 0.000 claims 2
- 229960002464 fluoxetine Drugs 0.000 claims 2
- 108010001237 Cytochrome P-450 CYP2D6 Proteins 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/15—Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4525—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (10)
1. Kombinacija:
(a) terapijski efikasne količine selektivnog inhibitora ponovnog preuzimanja serotonina; i
(b) terapijski efikasne količine spoja sa formulom II:
[image]
ili farmaceutski prihvatljive soli tog spoja, gdje:
R3 je odabrano od -OCH2D, -OCHD2, i -OCD3;
R4 je odabrano od -CH3, -CH2D, -CHD2, i -CD3;
pod uvjetom kada R3 je -OCD3, onda R4 nije -CH3;
za primjenu u liječenju pseudobulbarnog afekta.
2. Kombinacija za primjenu prema patentnom zahtjevu 1, gdje R4 je -CH3, -CHD2, ili -CD3.
3. Kombinacija za primjenu prema patentnom zahtjevu 1, gdje R3 je -OCD3.
4. Kombinacija za primjenu prema patentnom zahtjevu 1, gdje selektivni inhibitor ponovnog preuzimanja serotonina je inhibitor citohrom p450 2D6 enzima.
5. Kombinacija za primjenu prema bilo kojem od patentnih zahtjeva 1 do 4, gdje je selektivni inhibitor ponovnog preuzimanja serotonina odabran od grupe koja obuhvaća fluoksetin, norfluoksetin, citalopram, dapoksetin, escitalopram, fluvoksamin, paroksetin, i sertralin, ili njihove farmaceutski prihvatljive soli.
6. Kombinacija za primjenu prema patentnom zahtjevu 5, gdje je selektivni inhibitor ponovnog preuzimanja serotonina odabran od grupe koja obuhvaća citalopram, norfluoksetin, dapoksetin, escitalopram, fluvoksamin, paroksetin, i sertralin, ili njihove farmaceutski prihvatljive soli.
7. Kombinacija za primjenu prema patentnom zahtjevu 6, gdje selektivni inhibitor ponovnog preuzimanja serotonina je paroksetin, ili njegova farmaceutski prihvatljiva sol.
8. Kombinacija za primjenu prema patentnom zahtjevu 1, gdje je selektivni inhibitor ponovnog preuzimanja serotonina odabran od grupe koja obuhvaća citalopram, fluvoksamin, norfluoksetin, fluoksetin, paroksetin i sertralin, i spoj čija je formula II je odabrana od grupe koja se sastoji od:
[image]
ili njihovih farmaceutski prihvatljivih soli.
9. Kombinacija za primjenu prema patentnom zahtjevu 8, gdje je selektivni inhibitor ponovnog preuzimanja serotonina odabran od grupe koja obuhvaća citalopram, fluvoksamin, paroksetin i sertralin, ili njihovu farmaceutski prihvatljivu sol.
10. Kombinacija za primjenu prema patentnom zahtjevu 8 ili patentnom zahtjevu 9, gdje selektivni inhibitor ponovnog preuzimanja serotonina je paroksetin, ili njegova farmaceutski prihvatljiva sol.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10983208P | 2008-10-30 | 2008-10-30 | |
| EP11180603.0A EP2397158B1 (en) | 2008-10-30 | 2009-10-30 | Combination of morphinan compounds and antidepressant for the treatment of pseudobulbar affect |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20160454T1 true HRP20160454T1 (hr) | 2016-07-01 |
Family
ID=41346111
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20160454TT HRP20160454T1 (hr) | 2008-10-30 | 2016-04-28 | Kombinacija spoja morfinana i antidepresiva za liječenje pseudobulbarnog afekta |
Country Status (11)
| Country | Link |
|---|---|
| US (5) | US20120083487A1 (hr) |
| EP (4) | EP2365808B1 (hr) |
| CY (1) | CY1117760T1 (hr) |
| DK (1) | DK2397158T3 (hr) |
| HK (2) | HK1165294A1 (hr) |
| HR (1) | HRP20160454T1 (hr) |
| HU (1) | HUE028956T2 (hr) |
| PL (1) | PL2397158T3 (hr) |
| PT (1) | PT2397158T (hr) |
| SI (1) | SI2397158T1 (hr) |
| WO (1) | WO2010062692A1 (hr) |
Families Citing this family (109)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2792662T3 (da) | 2007-05-01 | 2016-07-25 | Concert Pharmaceuticals Inc | Morphinanforbindelser |
| PL2522667T3 (pl) | 2007-05-01 | 2015-01-30 | Concert Pharmaceuticals Inc | Związki morfinanu |
| CN103044327B (zh) * | 2013-01-07 | 2014-12-17 | 苏州立新制药有限公司 | 一种右美沙芬的制备方法 |
| US11541021B2 (en) | 2013-11-05 | 2023-01-03 | Antecip Bioventures Ii Llc | Bupropion as a modulator of drug activity |
| US11207281B2 (en) | 2013-11-05 | 2021-12-28 | Antecip Bioventures Ii Llc | Bupropion as a modulator of drug activity |
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| US10786469B2 (en) | 2013-11-05 | 2020-09-29 | Antecip Bioventures Ii Llc | Compositions and methods for increasing the metabolic lifetime of dextromethorphan and related pharmacodynamic effects |
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2009
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- 2009-10-30 DK DK11180603.0T patent/DK2397158T3/en active
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- 2009-10-30 EP EP09744582.9A patent/EP2365808B1/en not_active Not-in-force
- 2009-10-30 SI SI200931423A patent/SI2397158T1/sl unknown
- 2009-10-30 EP EP19194893.4A patent/EP3603674A1/en active Pending
- 2009-10-30 EP EP11180603.0A patent/EP2397158B1/en active Active
- 2009-10-30 EP EP16166277.0A patent/EP3090760A1/en not_active Withdrawn
- 2009-10-30 HU HUE11180603A patent/HUE028956T2/en unknown
- 2009-10-30 US US13/126,397 patent/US20120083487A1/en not_active Abandoned
- 2009-10-30 WO PCT/US2009/062783 patent/WO2010062692A1/en active Application Filing
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2012
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2016
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| EP3603674A1 (en) | 2020-02-05 |
| EP3090760A1 (en) | 2016-11-09 |
| HK1165294A1 (zh) | 2012-10-05 |
| US20180344727A1 (en) | 2018-12-06 |
| EP2397158A2 (en) | 2011-12-21 |
| US20230285387A1 (en) | 2023-09-14 |
| WO2010062692A1 (en) | 2010-06-03 |
| EP2397158A3 (en) | 2012-02-22 |
| PL2397158T3 (pl) | 2016-09-30 |
| CY1117760T1 (el) | 2017-05-17 |
| EP2397158B1 (en) | 2016-04-13 |
| US20220023292A1 (en) | 2022-01-27 |
| HUE028956T2 (en) | 2017-01-30 |
| HK1225642A1 (zh) | 2017-09-15 |
| PT2397158T (pt) | 2016-07-07 |
| DK2397158T3 (en) | 2016-07-25 |
| US20160143902A1 (en) | 2016-05-26 |
| EP2365808B1 (en) | 2018-01-10 |
| EP2365808A1 (en) | 2011-09-21 |
| SI2397158T1 (sl) | 2016-07-29 |
| US20120083487A1 (en) | 2012-04-05 |
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