HRP20110914T1 - Kombinacija flupirtina i tramadola - Google Patents
Kombinacija flupirtina i tramadola Download PDFInfo
- Publication number
- HRP20110914T1 HRP20110914T1 HR20110914T HRP20110914T HRP20110914T1 HR P20110914 T1 HRP20110914 T1 HR P20110914T1 HR 20110914 T HR20110914 T HR 20110914T HR P20110914 T HRP20110914 T HR P20110914T HR P20110914 T1 HRP20110914 T1 HR P20110914T1
- Authority
- HR
- Croatia
- Prior art keywords
- pain
- flupirtine
- tramadol
- lower extremities
- spastic
- Prior art date
Links
- TVYLLZQTGLZFBW-ZBFHGGJFSA-N (R,R)-tramadol Chemical compound COC1=CC=CC([C@]2(O)[C@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-ZBFHGGJFSA-N 0.000 title claims abstract 4
- JUUFBMODXQKSTD-UHFFFAOYSA-N N-[2-amino-6-[(4-fluorophenyl)methylamino]-3-pyridinyl]carbamic acid ethyl ester Chemical compound N1=C(N)C(NC(=O)OCC)=CC=C1NCC1=CC=C(F)C=C1 JUUFBMODXQKSTD-UHFFFAOYSA-N 0.000 title claims abstract 4
- 229960003667 flupirtine Drugs 0.000 title claims abstract 4
- 229960004380 tramadol Drugs 0.000 title claims abstract 4
- TVYLLZQTGLZFBW-GOEBONIOSA-N tramadol Natural products COC1=CC=CC([C@@]2(O)[C@@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-GOEBONIOSA-N 0.000 title claims abstract 4
- 208000002193 Pain Diseases 0.000 claims abstract 3
- 150000003839 salts Chemical class 0.000 claims abstract 2
- 210000003141 lower extremity Anatomy 0.000 claims 3
- 206010033892 Paraplegia Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000001148 spastic effect Effects 0.000 claims 2
- 208000011580 syndromic disease Diseases 0.000 claims 2
- 206010004663 Biliary colic Diseases 0.000 claims 1
- 208000010392 Bone Fractures Diseases 0.000 claims 1
- 206010016059 Facial pain Diseases 0.000 claims 1
- 208000019695 Migraine disease Diseases 0.000 claims 1
- 208000002740 Muscle Rigidity Diseases 0.000 claims 1
- 208000008238 Muscle Spasticity Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000001132 Osteoporosis Diseases 0.000 claims 1
- 206010033885 Paraparesis Diseases 0.000 claims 1
- 208000007542 Paresis Diseases 0.000 claims 1
- 206010065016 Post-traumatic pain Diseases 0.000 claims 1
- 206010036376 Postherpetic Neuralgia Diseases 0.000 claims 1
- 206010038419 Renal colic Diseases 0.000 claims 1
- 208000025747 Rheumatic disease Diseases 0.000 claims 1
- 208000008548 Tension-Type Headache Diseases 0.000 claims 1
- 230000017531 blood circulation Effects 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 206010008129 cerebral palsy Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 230000001667 episodic effect Effects 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 206010027599 migraine Diseases 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 208000004296 neuralgia Diseases 0.000 claims 1
- 201000001119 neuropathy Diseases 0.000 claims 1
- 230000007823 neuropathy Effects 0.000 claims 1
- 208000033808 peripheral neuropathy Diseases 0.000 claims 1
- 230000000552 rheumatic effect Effects 0.000 claims 1
- 208000018198 spasticity Diseases 0.000 claims 1
- 208000020431 spinal cord injury Diseases 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 208000004371 toothache Diseases 0.000 claims 1
- 208000009174 transverse myelitis Diseases 0.000 claims 1
- 206010044652 trigeminal neuralgia Diseases 0.000 claims 1
- 229940035676 analgesics Drugs 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Artificial Filaments (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Uporaba flupirtina u kombinaciji s tramadolom ili njihovim odnosnim fiziološki prihvatljivim solima, naznačena time, da se oni koriste za proizvodnju lijeka za liječenje boli prouzročene indikacijama odabranim između sljedećeg: karcinom, reumatska bola, sindrom bolnih križa, ischio-lumbalgia te one indikacije koje su posljedica ozljeda kičmene moždine, osteoporoze, rigidnosti/spasticiteta ili neuralgije/neuropatije (npr. miofacijalna bol, trigeminalna neuralgija, postherpetična neuralgija), epizodična glavobolja tenzijskog tipa, migrena, postkirurška, posttraumatska bol (npr. puknuće kosti), zubobolja, sindrom spastične parapereze donjih ekstremiteta, tetrapareza (npr. paraspazam donjih ekstremiteta, transverzalni mijelitis, multipla skleroza, nasljedna spastična paraplegija inferior (Struempel paraplegija), poremećaji krvotoka u kralježnici, cerebralna paraliza sa spastičnom parezom donjih ekstremiteta) te žučnih ili bubrežnih kolika. Patent sadrži još 2 patentna zahtjeva.
Claims (3)
1. Uporaba flupirtina u kombinaciji s tramadolom ili njihovim odnosnim fiziološki prihvatljivim solima, naznačena time, da se oni koriste za proizvodnju lijeka za liječenje boli prouzročene indikacijama odabranim između sljedećeg: karcinom, reumatska bola, sindrom bolnih križa, ischio-lumbalgia te one indikacije koje su posljedica ozljeda kičmene moždine, osteoporoze, rigidnosti/spasticiteta ili neuralgije/neuropatije (npr. miofacijalna bol, trigeminalna neuralgija, postherpetična neuralgija), epizodična glavobolja tenzijskog tipa, migrena, postkirurška, posttraumatska bol (npr. puknuće kosti), zubobolja, sindrom spastične parapereze donjih ekstremiteta, tetrapareza (npr. paraspazam donjih ekstremiteta, transverzalni mijelitis, multipla skleroza, nasljedna spastična paraplegija inferior (Struempel paraplegija), poremećaji krvotoka u kralježnici, cerebralna paraliza sa spastičnom parezom donjih ekstremiteta) te žučnih ili bubrežnih kolika.
2. Uporaba u skladu s patentnim zahtjevom 1, naznačena time, da je dotični lijek namijenjen za peroralnu, rektalnu, intravensku, transdermalnu ili subkutanu, odnosno intrakutanu primjenu.
3. Uporaba u skladu s patentnim zahtjevom 2, naznačena time, da je dnevna doza tramadola u rasponu od 50 do 400 mg/dan, a dnevna doza flupirtina je u rasponu od 100 do 800 mg/dan.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52976103P | 2003-12-17 | 2003-12-17 | |
| PCT/EP2004/014025 WO2005058420A1 (en) | 2003-12-17 | 2004-12-09 | Combination of flupirtine and tramadol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20110914T1 true HRP20110914T1 (hr) | 2011-12-31 |
Family
ID=34700037
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20110914T HRP20110914T1 (hr) | 2003-12-17 | 2011-12-06 | Kombinacija flupirtina i tramadola |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7553858B2 (hr) |
| EP (1) | EP1697005B1 (hr) |
| JP (1) | JP4933265B2 (hr) |
| CN (1) | CN1889996A (hr) |
| AT (1) | ATE525112T1 (hr) |
| AU (1) | AU2004298333B2 (hr) |
| CA (1) | CA2546302C (hr) |
| DK (1) | DK1697005T3 (hr) |
| ES (1) | ES2373957T3 (hr) |
| HR (1) | HRP20110914T1 (hr) |
| MX (1) | MXPA06006999A (hr) |
| NO (1) | NO335734B1 (hr) |
| NZ (1) | NZ547256A (hr) |
| PL (1) | PL1697005T3 (hr) |
| PT (1) | PT1697005E (hr) |
| RU (1) | RU2463042C2 (hr) |
| SI (1) | SI1697005T1 (hr) |
| WO (1) | WO2005058420A1 (hr) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060052370A1 (en) * | 2004-08-24 | 2006-03-09 | Meyerson Laurence R | Methods and compositions for treating nociceptive pain |
| US7619007B2 (en) | 2004-11-23 | 2009-11-17 | Adamas Pharmaceuticals, Inc. | Method and composition for administering an NMDA receptor antagonist to a subject |
| CA2604052C (en) | 2005-04-06 | 2014-07-08 | Adamas Pharmaceuticals, Inc. | Methods and compositions for the treatment of cns-related conditions |
| JP2010525069A (ja) * | 2007-04-27 | 2010-07-22 | パラテック ファーマシューティカルズ インコーポレイテッド | アミノアルキルテトラサイクリン化合物の合成方法および精製方法 |
| WO2010085848A1 (en) * | 2009-01-30 | 2010-08-05 | Relevare Aust. Pty Ltd | Drug abuse deterrent, methods and compositions |
| DE102010063609A1 (de) | 2010-12-20 | 2012-06-21 | Awd.Pharma Gmbh & Co. Kg | Neue Multikomponentenkristalle aus ([2-Amino-6-(4-fluoro-benzylamino)-pyridin-3yl)-carbamidsäureethylester und einer Arylpropionsäure |
| DE102010063612A1 (de) | 2010-12-20 | 2012-06-21 | Awd.Pharma Gmbh & Co. Kg | Neue Multikomponentenkristalle aus ([2-Amino-6-(4-fluoro-benzylamino)-pyridin-3-yl]-carbamidsäureethylester und 2-[2-[(2,6-Dichlorphenyl)-amino]-phenyl]-essigsäure |
| JP2015508789A (ja) * | 2012-03-02 | 2015-03-23 | メダ ファーマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト | 医薬製剤 |
| US9693949B1 (en) | 2015-12-22 | 2017-07-04 | Revogenex Ireland Ltd | Intravenous administration of tramadol |
| US9980900B2 (en) | 2015-12-22 | 2018-05-29 | Revogenex Ireland Ltd | Intravenous administration of tramadol |
| RU2678976C1 (ru) * | 2018-03-21 | 2019-02-05 | федеральное государственное бюджетное образовательное учреждение высшего образования "Тверской государственный медицинский университет" Министерства здравоохранения Российской Федерации | Способ профилактики длительного болевого синдрома в отдаленном послеоперационном периоде у пациентов с дисплазией соединительной ткани |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0532627A (ja) * | 1991-07-29 | 1993-02-09 | Asta Medica Ag | 筋肉痙攣により帰因するか又は筋肉痙攣の結果である疾病及び症候群を治療するための医薬品及びその製法 |
| DE4236752A1 (de) * | 1992-10-30 | 1994-05-05 | Asta Medica Ag | Kombinationspräparat aus Flupirtin und Morphin zur Behandlung von Schmerzen und zur Vermeidung der Morphin-Abhängigkeit |
| DE19807535A1 (de) * | 1998-02-21 | 1999-08-26 | Asta Medica Ag | Pharmazeutische Kombinationen mit Tramadol |
| AU7271700A (en) * | 1999-08-03 | 2001-02-19 | Awd.Pharma Gmbh & Co. Kg | Use of flupirtine for alleviating pain caused by degenerative joint diseases in dogs and cats |
| RU2218189C1 (ru) * | 2002-05-28 | 2003-12-10 | Нижегородская государственная медицинская академия | Способ лечения мигрени в межприступном периоде заболевания |
-
2004
- 2004-12-03 US US11/002,762 patent/US7553858B2/en not_active Expired - Fee Related
- 2004-12-09 EP EP04803682A patent/EP1697005B1/en active Active
- 2004-12-09 CA CA2546302A patent/CA2546302C/en not_active Expired - Fee Related
- 2004-12-09 AT AT04803682T patent/ATE525112T1/de active
- 2004-12-09 MX MXPA06006999A patent/MXPA06006999A/es active IP Right Grant
- 2004-12-09 JP JP2006544286A patent/JP4933265B2/ja not_active Expired - Fee Related
- 2004-12-09 WO PCT/EP2004/014025 patent/WO2005058420A1/en active Application Filing
- 2004-12-09 SI SI200431786T patent/SI1697005T1/sl unknown
- 2004-12-09 RU RU2006125520/15A patent/RU2463042C2/ru not_active IP Right Cessation
- 2004-12-09 DK DK04803682.6T patent/DK1697005T3/da active
- 2004-12-09 PL PL04803682T patent/PL1697005T3/pl unknown
- 2004-12-09 NZ NZ547256A patent/NZ547256A/en unknown
- 2004-12-09 PT PT04803682T patent/PT1697005E/pt unknown
- 2004-12-09 CN CNA2004800366436A patent/CN1889996A/zh active Pending
- 2004-12-09 AU AU2004298333A patent/AU2004298333B2/en not_active Ceased
- 2004-12-09 ES ES04803682T patent/ES2373957T3/es active Active
-
2006
- 2006-07-17 NO NO20063308A patent/NO335734B1/no not_active IP Right Cessation
-
2011
- 2011-12-06 HR HR20110914T patent/HRP20110914T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP4933265B2 (ja) | 2012-05-16 |
| CA2546302A1 (en) | 2005-06-30 |
| US7553858B2 (en) | 2009-06-30 |
| MXPA06006999A (es) | 2006-12-14 |
| ATE525112T1 (de) | 2011-10-15 |
| NZ547256A (en) | 2009-04-30 |
| AU2004298333B2 (en) | 2009-12-17 |
| AU2004298333A1 (en) | 2005-06-30 |
| NO20063308L (no) | 2006-09-12 |
| JP2007514672A (ja) | 2007-06-07 |
| PL1697005T3 (pl) | 2012-02-29 |
| ES2373957T3 (es) | 2012-02-10 |
| CN1889996A (zh) | 2007-01-03 |
| SI1697005T1 (sl) | 2012-01-31 |
| PT1697005E (pt) | 2011-12-29 |
| DK1697005T3 (da) | 2011-12-12 |
| WO2005058420A1 (en) | 2005-06-30 |
| EP1697005B1 (en) | 2011-09-21 |
| CA2546302C (en) | 2012-05-22 |
| RU2463042C2 (ru) | 2012-10-10 |
| US20050137235A1 (en) | 2005-06-23 |
| RU2006125520A (ru) | 2008-01-27 |
| NO335734B1 (no) | 2015-02-02 |
| EP1697005A1 (en) | 2006-09-06 |
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