HRP20100699T1 - Topikalni antibioticki sastav za prevenciju lajmske bolesti - Google Patents
Topikalni antibioticki sastav za prevenciju lajmske bolesti Download PDFInfo
- Publication number
- HRP20100699T1 HRP20100699T1 HR20100699T HRP20100699T HRP20100699T1 HR P20100699 T1 HRP20100699 T1 HR P20100699T1 HR 20100699 T HR20100699 T HR 20100699T HR P20100699 T HRP20100699 T HR P20100699T HR P20100699 T1 HRP20100699 T1 HR P20100699T1
- Authority
- HR
- Croatia
- Prior art keywords
- pharmaceutical composition
- weight
- use according
- topical pharmaceutical
- composition
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract 6
- 208000016604 Lyme disease Diseases 0.000 title claims abstract 4
- 230000002265 prevention Effects 0.000 title claims abstract 4
- 230000003115 biocidal effect Effects 0.000 title claims 5
- 230000000699 topical effect Effects 0.000 title 1
- 239000012049 topical pharmaceutical composition Substances 0.000 claims abstract 9
- 241000589969 Borreliella burgdorferi Species 0.000 claims abstract 4
- 239000002904 solvent Substances 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 229960004099 azithromycin Drugs 0.000 claims 3
- MQTOSJVFKKJCRP-BICOPXKESA-N azithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)N(C)C[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 MQTOSJVFKKJCRP-BICOPXKESA-N 0.000 claims 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 3
- 206010003399 Arthropod bite Diseases 0.000 claims 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- 208000004374 Tick Bites Diseases 0.000 claims 2
- 239000003242 anti bacterial agent Substances 0.000 claims 2
- 230000008030 elimination Effects 0.000 claims 2
- 238000003379 elimination reaction Methods 0.000 claims 2
- 239000002562 thickening agent Substances 0.000 claims 2
- RXZBMPWDPOLZGW-XMRMVWPWSA-N (E)-roxithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=N/OCOCCOC)/[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 RXZBMPWDPOLZGW-XMRMVWPWSA-N 0.000 claims 1
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims 1
- 239000004099 Chlortetracycline Substances 0.000 claims 1
- FMTDIUIBLCQGJB-UHFFFAOYSA-N Demethylchlortetracyclin Natural products C1C2C(O)C3=C(Cl)C=CC(O)=C3C(=O)C2=C(O)C2(O)C1C(N(C)C)C(O)=C(C(N)=O)C2=O FMTDIUIBLCQGJB-UHFFFAOYSA-N 0.000 claims 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 1
- 239000004100 Oxytetracycline Substances 0.000 claims 1
- 229920006322 acrylamide copolymer Polymers 0.000 claims 1
- 229940088710 antibiotic agent Drugs 0.000 claims 1
- 229920005601 base polymer Polymers 0.000 claims 1
- CYDMQBQPVICBEU-UHFFFAOYSA-N chlorotetracycline Natural products C1=CC(Cl)=C2C(O)(C)C3CC4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O CYDMQBQPVICBEU-UHFFFAOYSA-N 0.000 claims 1
- 229960004475 chlortetracycline Drugs 0.000 claims 1
- 235000019365 chlortetracycline Nutrition 0.000 claims 1
- CYDMQBQPVICBEU-XRNKAMNCSA-N chlortetracycline Chemical compound C1=CC(Cl)=C2[C@](O)(C)[C@H]3C[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O CYDMQBQPVICBEU-XRNKAMNCSA-N 0.000 claims 1
- 229960002626 clarithromycin Drugs 0.000 claims 1
- AGOYDEPGAOXOCK-KCBOHYOISA-N clarithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@](C)([C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)OC)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 AGOYDEPGAOXOCK-KCBOHYOISA-N 0.000 claims 1
- 229960002398 demeclocycline Drugs 0.000 claims 1
- FMTDIUIBLCQGJB-SEYHBJAFSA-N demeclocycline Chemical compound C1([C@@H](O)[C@H]2C3)=C(Cl)C=CC(O)=C1C(=O)C2=C(O)[C@@]1(O)[C@@H]3[C@H](N(C)C)C(O)=C(C(N)=O)C1=O FMTDIUIBLCQGJB-SEYHBJAFSA-N 0.000 claims 1
- 229960004100 dirithromycin Drugs 0.000 claims 1
- WLOHNSSYAXHWNR-NXPDYKKBSA-N dirithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H]2O[C@H](COCCOC)N[C@H]([C@@H]2C)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 WLOHNSSYAXHWNR-NXPDYKKBSA-N 0.000 claims 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 1
- 229940057917 medium chain triglycerides Drugs 0.000 claims 1
- 229940042016 methacycline Drugs 0.000 claims 1
- MHIGBKBJSQVXNH-IWVLMIASSA-N methacycline Chemical compound C=C([C@H]1[C@@H]2O)C3=CC=CC(O)=C3C(=O)C1=C(O)[C@@]1(O)[C@@H]2[C@H](N(C)C)C(O)=C(C(N)=O)C1=O MHIGBKBJSQVXNH-IWVLMIASSA-N 0.000 claims 1
- 229960004023 minocycline Drugs 0.000 claims 1
- DYKFCLLONBREIL-KVUCHLLUSA-N minocycline Chemical compound C([C@H]1C2)C3=C(N(C)C)C=CC(O)=C3C(=O)C1=C(O)[C@@]1(O)[C@@H]2[C@H](N(C)C)C(O)=C(C(N)=O)C1=O DYKFCLLONBREIL-KVUCHLLUSA-N 0.000 claims 1
- 229960000625 oxytetracycline Drugs 0.000 claims 1
- 235000019366 oxytetracycline Nutrition 0.000 claims 1
- IWVCMVBTMGNXQD-PXOLEDIWSA-N oxytetracycline Chemical compound C1=CC=C2[C@](O)(C)[C@H]3[C@H](O)[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-PXOLEDIWSA-N 0.000 claims 1
- 229920000058 polyacrylate Polymers 0.000 claims 1
- 229960005224 roxithromycin Drugs 0.000 claims 1
- 229960003250 telithromycin Drugs 0.000 claims 1
- LJVAJPDWBABPEJ-PNUFFHFMSA-N telithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)[C@@H](C)C(=O)O[C@@H]([C@]2(OC(=O)N(CCCCN3C=C(N=C3)C=3C=NC=CC=3)[C@@H]2[C@@H](C)C(=O)[C@H](C)C[C@@]1(C)OC)C)CC)[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O LJVAJPDWBABPEJ-PNUFFHFMSA-N 0.000 claims 1
- IWVCMVBTMGNXQD-UHFFFAOYSA-N terramycin dehydrate Natural products C1=CC=C2C(O)(C)C3C(O)C4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-UHFFFAOYSA-N 0.000 claims 1
- 229960005041 troleandomycin Drugs 0.000 claims 1
- LQCLVBQBTUVCEQ-QTFUVMRISA-N troleandomycin Chemical compound O1[C@@H](C)[C@H](OC(C)=O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](C)C(=O)O[C@H](C)[C@H](C)[C@H](OC(C)=O)[C@@H](C)C(=O)[C@@]2(OC2)C[C@H](C)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)OC(C)=O)[C@H]1C LQCLVBQBTUVCEQ-QTFUVMRISA-N 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 239000003053 toxin Substances 0.000 abstract 1
- 231100000765 toxin Toxicity 0.000 abstract 1
- 108700012359 toxins Proteins 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07113143 | 2007-07-25 | ||
| PCT/EP2008/059696 WO2009013331A1 (en) | 2007-07-25 | 2008-07-24 | Topical antibiotic composition for the prevention of lyme disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20100699T1 true HRP20100699T1 (hr) | 2011-01-31 |
Family
ID=39149162
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20100699T HRP20100699T1 (hr) | 2007-07-25 | 2010-12-17 | Topikalni antibioticki sastav za prevenciju lajmske bolesti |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US8710019B2 (es) |
| EP (1) | EP2079441B1 (es) |
| JP (1) | JP2010534221A (es) |
| AT (1) | ATE481964T1 (es) |
| AU (1) | AU2008280131B9 (es) |
| CA (1) | CA2694403C (es) |
| CY (1) | CY1110971T1 (es) |
| DE (1) | DE602008002692D1 (es) |
| DK (1) | DK2079441T3 (es) |
| ES (1) | ES2349906T3 (es) |
| HR (1) | HRP20100699T1 (es) |
| PL (1) | PL2079441T3 (es) |
| PT (1) | PT2079441E (es) |
| SI (1) | SI2079441T1 (es) |
| WO (1) | WO2009013331A1 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT106679B (pt) | 2012-11-27 | 2015-03-25 | Hovione Farmaciencia Sa | Formulações tópicas de tetraciclinas, sua preparação e usos |
| WO2015171225A1 (en) * | 2014-05-09 | 2015-11-12 | The Johns Hopkins University | Identification of novel anti-persister activity for borrelia burgdorferi |
| EP3307275B1 (en) * | 2015-06-10 | 2021-05-26 | Piedmont Animal Health Inc. | Injectable antibiotic formulations and use thereof |
| EP3252470B1 (en) | 2016-06-03 | 2020-07-29 | Te?ted Oy | A method and a solid support for detecting tick-borne microbes in a biological sample |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2748399C2 (de) * | 1976-11-01 | 1983-09-15 | The Procter & Gamble Co., 45202 Cincinnati, Ohio | Antimikrobielles Mittel zur örtlichen Anwendung |
| CA1165240A (en) * | 1980-07-09 | 1984-04-10 | The Procter & Gamble Company | Penetrating topical pharmaceutical compositions |
| IL132096A0 (en) * | 1997-03-31 | 2001-03-19 | Johnson & Johnson Consumer | Solvent system for enhanced penetration of pharmaceutical compounds |
| US7179475B1 (en) * | 1998-12-04 | 2007-02-20 | Johnson & Johnson Consumer Companies, Inc. | Anhydrous topical skin preparations |
| US6239113B1 (en) * | 1999-03-31 | 2001-05-29 | Insite Vision, Incorporated | Topical treatment or prevention of ocular infections |
| US6914051B1 (en) * | 2000-06-28 | 2005-07-05 | David M Allen | Penetrating antibiotic gel for soft tissue diseases |
| US6589568B2 (en) * | 2001-02-16 | 2003-07-08 | Nurad, Inc. | Therapeutic body lotion containing alkali metal hypohalite |
| WO2003039418A1 (en) * | 2001-11-06 | 2003-05-15 | Maxim Pharmaceuticals, Inc. | Compositions for the treatment of infectious diseases |
| US8907153B2 (en) * | 2004-06-07 | 2014-12-09 | Nuvo Research Inc. | Adhesive peel-forming formulations for dermal delivery of drugs and methods of using the same |
-
2008
- 2008-07-24 AT AT08786388T patent/ATE481964T1/de active
- 2008-07-24 CA CA2694403A patent/CA2694403C/en active Active
- 2008-07-24 DK DK08786388.2T patent/DK2079441T3/da active
- 2008-07-24 SI SI200830088T patent/SI2079441T1/sl unknown
- 2008-07-24 PT PT08786388T patent/PT2079441E/pt unknown
- 2008-07-24 PL PL08786388T patent/PL2079441T3/pl unknown
- 2008-07-24 US US12/452,805 patent/US8710019B2/en active Active
- 2008-07-24 AU AU2008280131A patent/AU2008280131B9/en active Active
- 2008-07-24 JP JP2010517402A patent/JP2010534221A/ja active Pending
- 2008-07-24 EP EP08786388A patent/EP2079441B1/en active Active
- 2008-07-24 ES ES08786388T patent/ES2349906T3/es active Active
- 2008-07-24 DE DE602008002692T patent/DE602008002692D1/de active Active
- 2008-07-24 WO PCT/EP2008/059696 patent/WO2009013331A1/en active Application Filing
-
2010
- 2010-11-25 CY CY20101101077T patent/CY1110971T1/el unknown
- 2010-12-17 HR HR20100699T patent/HRP20100699T1/hr unknown
-
2014
- 2014-03-13 US US14/208,491 patent/US9610244B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20100130437A1 (en) | 2010-05-27 |
| AU2008280131A1 (en) | 2009-01-29 |
| SI2079441T1 (sl) | 2010-12-31 |
| ATE481964T1 (de) | 2010-10-15 |
| CA2694403A1 (en) | 2009-01-29 |
| US20140194375A1 (en) | 2014-07-10 |
| JP2010534221A (ja) | 2010-11-04 |
| ES2349906T3 (es) | 2011-01-12 |
| EP2079441B1 (en) | 2010-09-22 |
| PL2079441T3 (pl) | 2011-02-28 |
| US8710019B2 (en) | 2014-04-29 |
| DE602008002692D1 (de) | 2010-11-04 |
| CA2694403C (en) | 2013-09-24 |
| WO2009013331A1 (en) | 2009-01-29 |
| CY1110971T1 (el) | 2015-06-11 |
| PT2079441E (pt) | 2010-11-19 |
| AU2008280131A8 (en) | 2010-03-04 |
| AU2008280131B2 (en) | 2014-06-26 |
| US9610244B2 (en) | 2017-04-04 |
| EP2079441A1 (en) | 2009-07-22 |
| AU2008280131B9 (en) | 2014-11-13 |
| DK2079441T3 (da) | 2010-12-13 |
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