HRP20100071T1 - Derivati diamino biotina i njihovi konjugati sa makrocikličnim helatirajućim sredstvima - Google Patents
Derivati diamino biotina i njihovi konjugati sa makrocikličnim helatirajućim sredstvima Download PDFInfo
- Publication number
- HRP20100071T1 HRP20100071T1 HR20100071T HRP20100071T HRP20100071T1 HR P20100071 T1 HRP20100071 T1 HR P20100071T1 HR 20100071 T HR20100071 T HR 20100071T HR P20100071 T HRP20100071 T HR P20100071T HR P20100071 T1 HRP20100071 T1 HR P20100071T1
- Authority
- HR
- Croatia
- Prior art keywords
- group
- nhr
- integer
- linear
- independently
- Prior art date
Links
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 title 2
- 229960002685 biotin Drugs 0.000 title 1
- 235000020958 biotin Nutrition 0.000 title 1
- 239000011616 biotin Substances 0.000 title 1
- 239000002738 chelating agent Substances 0.000 title 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims abstract 9
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims abstract 8
- 150000001875 compounds Chemical class 0.000 claims abstract 8
- 125000000623 heterocyclic group Chemical group 0.000 claims abstract 7
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 7
- 239000001257 hydrogen Substances 0.000 claims abstract 7
- 125000003118 aryl group Chemical group 0.000 claims abstract 6
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract 6
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract 6
- 125000004433 nitrogen atom Chemical group N* 0.000 claims abstract 6
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims abstract 4
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims abstract 4
- 125000005842 heteroatom Chemical group 0.000 claims abstract 4
- 229910052760 oxygen Inorganic materials 0.000 claims abstract 4
- 125000002373 5 membered heterocyclic group Chemical group 0.000 claims abstract 3
- 125000004070 6 membered heterocyclic group Chemical group 0.000 claims abstract 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims abstract 2
- 239000002202 Polyethylene glycol Substances 0.000 claims abstract 2
- 229910052799 carbon Inorganic materials 0.000 claims abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims abstract 2
- UKJLNMAFNRKWGR-UHFFFAOYSA-N cyclohexatrienamine Chemical group NC1=CC=C=C[CH]1 UKJLNMAFNRKWGR-UHFFFAOYSA-N 0.000 claims abstract 2
- 150000002678 macrocyclic compounds Chemical class 0.000 claims abstract 2
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims abstract 2
- 125000004430 oxygen atom Chemical group O* 0.000 claims abstract 2
- 229920001223 polyethylene glycol Polymers 0.000 claims abstract 2
- 229910052717 sulfur Inorganic materials 0.000 claims abstract 2
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 230000002285 radioactive effect Effects 0.000 claims 3
- 239000000969 carrier Substances 0.000 claims 2
- 239000000945 filler Substances 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940121896 radiopharmaceutical Drugs 0.000 claims 1
- 239000012217 radiopharmaceutical Substances 0.000 claims 1
- 230000002799 radiopharmaceutical effect Effects 0.000 claims 1
- 238000001959 radiotherapy Methods 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0495—Pretargeting
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Polyethers (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05021034 | 2005-09-27 | ||
| PCT/EP2006/066440 WO2007039437A1 (en) | 2005-09-27 | 2006-09-18 | Biotin diaminoderivatives and their conjugates with macrocyclic chelating agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20100071T1 true HRP20100071T1 (hr) | 2010-03-31 |
Family
ID=35825361
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20100071T HRP20100071T1 (hr) | 2005-09-27 | 2010-02-08 | Derivati diamino biotina i njihovi konjugati sa makrocikličnim helatirajućim sredstvima |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US7816388B2 (ja) |
| EP (1) | EP1928508B1 (ja) |
| JP (1) | JP5207969B2 (ja) |
| KR (1) | KR101301549B1 (ja) |
| CN (1) | CN101272809B (ja) |
| AR (1) | AR056201A1 (ja) |
| AT (1) | ATE447977T1 (ja) |
| AU (1) | AU2006298827B2 (ja) |
| BR (1) | BRPI0616441B8 (ja) |
| CA (1) | CA2621960C (ja) |
| CY (1) | CY1109836T1 (ja) |
| DE (1) | DE602006010413D1 (ja) |
| DK (1) | DK1928508T3 (ja) |
| EA (1) | EA200800948A1 (ja) |
| ES (1) | ES2335609T3 (ja) |
| HK (1) | HK1125036A1 (ja) |
| HR (1) | HRP20100071T1 (ja) |
| ME (1) | ME01845B (ja) |
| PL (1) | PL1928508T3 (ja) |
| PT (1) | PT1928508E (ja) |
| RS (1) | RS51254B (ja) |
| SI (1) | SI1928508T1 (ja) |
| TW (1) | TWI381852B (ja) |
| WO (1) | WO2007039437A1 (ja) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100543342B1 (ko) * | 2002-06-28 | 2006-01-20 | 한국 한의학 연구원 | 뇌신경세포의 손상을 치료하기 위한 한약재 조성물 |
| JP5263805B2 (ja) * | 2007-06-13 | 2013-08-14 | 国立大学法人群馬大学 | 両親媒性の高分子配位子によって安定化された高分子錯体および検査用組成物および医薬組成物 |
| GB0922369D0 (en) | 2009-12-22 | 2010-02-03 | Hammersmith Imanet Ltd | Labelled biotin conjugates |
| EP2630132A1 (en) * | 2010-10-22 | 2013-08-28 | Université de Strasbourg | Pochoxime conjugates useful for the treatment of hsp90 related pathologies |
| WO2023240135A2 (en) | 2022-06-07 | 2023-12-14 | Actinium Pharmaceuticals, Inc. | Bifunctional chelators and conjugates |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5283342A (en) | 1992-06-09 | 1994-02-01 | Neorx Corporation | Biotinylated small molecules |
| EP1138334A3 (en) | 1992-06-09 | 2002-04-03 | Neorx Corporation | Pretargeting methods and compounds |
| US5911969A (en) | 1992-06-09 | 1999-06-15 | Neorx Corporation | Pretargeting protocols for enhanced localization of active agents to target sites |
| US6120768A (en) * | 1993-05-17 | 2000-09-19 | Immunomedics, Inc. | Dota-biotin derivatives |
| US5955605A (en) | 1995-02-21 | 1999-09-21 | Neorx Corporation | Biotinidase resistant biotin-DOTA conjugates |
| ITRM20010079A1 (it) * | 2001-02-16 | 2002-08-16 | Sigma Tau Ind Farmaceuti | Amminoderivati della biotina e loro coniugati con chelanti macrociclici. |
-
2006
- 2006-09-15 TW TW095134322A patent/TWI381852B/zh not_active IP Right Cessation
- 2006-09-18 DK DK06793583.3T patent/DK1928508T3/da active
- 2006-09-18 DE DE602006010413T patent/DE602006010413D1/de active Active
- 2006-09-18 EP EP06793583A patent/EP1928508B1/en active Active
- 2006-09-18 BR BRPI0616441A patent/BRPI0616441B8/pt not_active IP Right Cessation
- 2006-09-18 KR KR1020087006421A patent/KR101301549B1/ko active IP Right Grant
- 2006-09-18 ME MEP-2010-31A patent/ME01845B/me unknown
- 2006-09-18 EA EA200800948A patent/EA200800948A1/ru not_active IP Right Cessation
- 2006-09-18 JP JP2008532721A patent/JP5207969B2/ja not_active Expired - Fee Related
- 2006-09-18 ES ES06793583T patent/ES2335609T3/es active Active
- 2006-09-18 CA CA2621960A patent/CA2621960C/en not_active Expired - Fee Related
- 2006-09-18 WO PCT/EP2006/066440 patent/WO2007039437A1/en active Application Filing
- 2006-09-18 US US12/065,833 patent/US7816388B2/en not_active Expired - Fee Related
- 2006-09-18 PT PT06793583T patent/PT1928508E/pt unknown
- 2006-09-18 AT AT06793583T patent/ATE447977T1/de active
- 2006-09-18 SI SI200630557T patent/SI1928508T1/sl unknown
- 2006-09-18 RS RSP-2010/0031A patent/RS51254B/sr unknown
- 2006-09-18 AU AU2006298827A patent/AU2006298827B2/en not_active Ceased
- 2006-09-18 PL PL06793583T patent/PL1928508T3/pl unknown
- 2006-09-18 CN CN2006800356289A patent/CN101272809B/zh not_active Expired - Fee Related
- 2006-09-26 AR ARP060104193A patent/AR056201A1/es unknown
-
2009
- 2009-03-23 HK HK09102783.8A patent/HK1125036A1/xx not_active IP Right Cessation
-
2010
- 2010-02-02 CY CY20101100098T patent/CY1109836T1/el unknown
- 2010-02-08 HR HR20100071T patent/HRP20100071T1/hr unknown
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