PT1928508E - Derivados diamino de biotina e seus conjugados com agentes quelantes macrocíclicos - Google Patents

Derivados diamino de biotina e seus conjugados com agentes quelantes macrocíclicos Download PDF

Info

Publication number
PT1928508E
PT1928508E PT06793583T PT06793583T PT1928508E PT 1928508 E PT1928508 E PT 1928508E PT 06793583 T PT06793583 T PT 06793583T PT 06793583 T PT06793583 T PT 06793583T PT 1928508 E PT1928508 E PT 1928508E
Authority
PT
Portugal
Prior art keywords
diaminoderivatives
conjugates
biotin
chelating agents
macrocyclic chelating
Prior art date
Application number
PT06793583T
Other languages
English (en)
Inventor
Mauro Ginanneschi
Paolo Carminati
Giovanni Paganelli
Marco Chinol
Original Assignee
Sigma Tau Ind Farmaceuti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti
Publication of PT1928508E publication Critical patent/PT1928508E/pt

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0495—Pretargeting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Polyethers (AREA)
PT06793583T 2005-09-27 2006-09-18 Derivados diamino de biotina e seus conjugados com agentes quelantes macrocíclicos PT1928508E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP05021034 2005-09-27

Publications (1)

Publication Number Publication Date
PT1928508E true PT1928508E (pt) 2010-01-28

Family

ID=35825361

Family Applications (1)

Application Number Title Priority Date Filing Date
PT06793583T PT1928508E (pt) 2005-09-27 2006-09-18 Derivados diamino de biotina e seus conjugados com agentes quelantes macrocíclicos

Country Status (24)

Country Link
US (1) US7816388B2 (pt)
EP (1) EP1928508B1 (pt)
JP (1) JP5207969B2 (pt)
KR (1) KR101301549B1 (pt)
CN (1) CN101272809B (pt)
AR (1) AR056201A1 (pt)
AT (1) ATE447977T1 (pt)
AU (1) AU2006298827B2 (pt)
BR (1) BRPI0616441B8 (pt)
CA (1) CA2621960C (pt)
CY (1) CY1109836T1 (pt)
DE (1) DE602006010413D1 (pt)
DK (1) DK1928508T3 (pt)
EA (1) EA013130B1 (pt)
ES (1) ES2335609T3 (pt)
HK (1) HK1125036A1 (pt)
HR (1) HRP20100071T1 (pt)
ME (1) ME01845B (pt)
PL (1) PL1928508T3 (pt)
PT (1) PT1928508E (pt)
RS (1) RS51254B (pt)
SI (1) SI1928508T1 (pt)
TW (1) TWI381852B (pt)
WO (1) WO2007039437A1 (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100543342B1 (ko) * 2002-06-28 2006-01-20 한국 한의학 연구원 뇌신경세포의 손상을 치료하기 위한 한약재 조성물
JP5263805B2 (ja) * 2007-06-13 2013-08-14 国立大学法人群馬大学 両親媒性の高分子配位子によって安定化された高分子錯体および検査用組成物および医薬組成物
GB0922369D0 (en) * 2009-12-22 2010-02-03 Hammersmith Imanet Ltd Labelled biotin conjugates
WO2012052843A1 (en) * 2010-10-22 2012-04-26 Universite De Strasbourg Pochoxime conjugates useful for the treatment of hsp90 related pathologies
WO2023240135A2 (en) 2022-06-07 2023-12-14 Actinium Pharmaceuticals, Inc. Bifunctional chelators and conjugates

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5283342A (en) * 1992-06-09 1994-02-01 Neorx Corporation Biotinylated small molecules
US5911969A (en) * 1992-06-09 1999-06-15 Neorx Corporation Pretargeting protocols for enhanced localization of active agents to target sites
US5608060A (en) * 1992-06-09 1997-03-04 Neorx Corporation Biotinidase-resistant biotin-DOTA conjugates
US6120768A (en) * 1993-05-17 2000-09-19 Immunomedics, Inc. Dota-biotin derivatives
US5955605A (en) * 1995-02-21 1999-09-21 Neorx Corporation Biotinidase resistant biotin-DOTA conjugates
ITRM20010079A1 (it) * 2001-02-16 2002-08-16 Sigma Tau Ind Farmaceuti Amminoderivati della biotina e loro coniugati con chelanti macrociclici.

Also Published As

Publication number Publication date
HRP20100071T1 (hr) 2010-03-31
KR20080059159A (ko) 2008-06-26
CA2621960A1 (en) 2007-04-12
TWI381852B (zh) 2013-01-11
JP5207969B2 (ja) 2013-06-12
TW200744647A (en) 2007-12-16
JP2009510009A (ja) 2009-03-12
EA200800948A1 (ru) 2010-02-26
BRPI0616441B8 (pt) 2021-05-25
DK1928508T3 (da) 2010-03-29
BRPI0616441A2 (pt) 2011-06-21
ME01845B (me) 2010-12-31
AU2006298827B2 (en) 2011-02-03
PL1928508T3 (pl) 2010-04-30
EP1928508B1 (en) 2009-11-11
CA2621960C (en) 2015-09-15
ATE447977T1 (de) 2009-11-15
US7816388B2 (en) 2010-10-19
AU2006298827A1 (en) 2007-04-12
CY1109836T1 (el) 2014-09-10
SI1928508T1 (sl) 2010-03-31
EP1928508A1 (en) 2008-06-11
AR056201A1 (es) 2007-09-26
CN101272809A (zh) 2008-09-24
HK1125036A1 (en) 2009-07-31
EA013130B1 (ru) 2010-02-26
DE602006010413D1 (de) 2009-12-24
CN101272809B (zh) 2011-01-26
KR101301549B1 (ko) 2013-09-04
BRPI0616441B1 (pt) 2019-07-02
ES2335609T3 (es) 2010-03-30
US20080249152A1 (en) 2008-10-09
RS51254B (sr) 2010-12-31
WO2007039437A1 (en) 2007-04-12

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