HRP20090151T3 - Derivati indozolona kao inhibitori 11b-hsd1 - Google Patents

Derivati indozolona kao inhibitori 11b-hsd1

Info

Publication number
HRP20090151T3
HRP20090151T3 HR20090151T HRP20090151T HRP20090151T3 HR P20090151 T3 HRP20090151 T3 HR P20090151T3 HR 20090151 T HR20090151 T HR 20090151T HR P20090151 T HRP20090151 T HR P20090151T HR P20090151 T3 HRP20090151 T3 HR P20090151T3
Authority
HR
Croatia
Prior art keywords
alkyl
fluoro
alkoxy
hydrogen
aryl
Prior art date
Application number
HR20090151T
Other languages
English (en)
Inventor
Amrein Kurt
Cai Jianping
Alan Jr. Goodnow Robert
Hunziker Daniel
Kuhn Bernd
Mayweg Alexander
Neidhart Werner
Original Assignee
F. Hoffmann - La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F. Hoffmann - La Roche Ag filed Critical F. Hoffmann - La Roche Ag
Publication of HRP20090151T3 publication Critical patent/HRP20090151T3/hr

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56Benzopyrazoles; Hydrogenated benzopyrazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4151,2-Diazoles
    • A61K31/4161,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245Oxadiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Spojevi formule (I) ,naznačeni time, da jeR1 vodik, C1-C7-alkil, aril, ili aril-C1-C7-alkil; R2 je aril, aril-C1-C7-alkil, heteroaril, heteroaril-C1-C7-alkil, cikloalkil, cikloalkil-C1-C7-alkil, fluor-C1-C7-alkil, ili C1-C7-alkil, gdje je C1-C7-alkil opcijski supstituiran s 1 do 3 supstituenta izabranih iz skupine koja se sastoji od OH, CN, halogen, C1-C7-alkoksi i C(O)NR8R9;R3 je vodik, halogen, C1-C7-alkil, fluor-C1-C7-alkil, C1-C7-alkoksi ili fluor-C1-C7-alkoksi; R4 je vodik, halogen, C1-C7-alkil, fluor-C1-C7-alkil, C1-C7-alkoksi ili fluor-C1-C7-alkoksi; R5 je vodik, halogen, C1-C7-alkil, fluor-C1-C7-alkil, C1-C7-alkoksi ili fluor-C1-C7-alkoksi; R6 je vodik ili C1-C7-alkil; R7 je aril, heteroaril, fluor-C1-C7-alkil ili C1-C7-alkil gdje je C1-C7-alkil opcijski supstituiran s 1 do 3 supstituenta izabranih iz skupine koja se sastoji od OH, CN, halogen, C1-C7-alkoksi i cikloalkila; R8 i R9 su neovisno jedan od drugog izabrani iz skupine koja se sastoji od vodika i C1-C7-alkila; i njihove farmaceutski prihvatljive soli. Patent sadrži još 30 patentnih zahtjeva.
HR20090151T 2004-09-29 2009-03-16 Derivati indozolona kao inhibitori 11b-hsd1 HRP20090151T3 (hr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04104753 2004-09-29
PCT/EP2005/010175 WO2006034804A1 (en) 2004-09-29 2005-09-21 Indozolone derivatives as 11b-hsd1 inhibitors

Publications (1)

Publication Number Publication Date
HRP20090151T3 true HRP20090151T3 (hr) 2009-04-30

Family

ID=35447579

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20090151T HRP20090151T3 (hr) 2004-09-29 2009-03-16 Derivati indozolona kao inhibitori 11b-hsd1

Country Status (28)

Country Link
US (1) US7528158B2 (hr)
EP (1) EP1797042B1 (hr)
JP (1) JP4682207B2 (hr)
KR (1) KR100856164B1 (hr)
CN (1) CN101027286B (hr)
AR (1) AR050952A1 (hr)
AT (1) ATE420076T1 (hr)
AU (1) AU2005289107B2 (hr)
BR (1) BRPI0515931A (hr)
CA (1) CA2581865C (hr)
DE (1) DE602005012292D1 (hr)
DK (1) DK1797042T3 (hr)
ES (1) ES2317305T3 (hr)
HK (1) HK1107348A1 (hr)
HR (1) HRP20090151T3 (hr)
IL (1) IL182212A (hr)
MX (1) MX2007003546A (hr)
MY (1) MY140841A (hr)
NO (1) NO20071617L (hr)
NZ (1) NZ553849A (hr)
PL (1) PL1797042T3 (hr)
PT (1) PT1797042E (hr)
RU (1) RU2392272C2 (hr)
SG (1) SG148178A1 (hr)
SI (1) SI1797042T1 (hr)
TW (1) TWI309646B (hr)
WO (1) WO2006034804A1 (hr)
ZA (1) ZA200702394B (hr)

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US7579360B2 (en) 2005-06-09 2009-08-25 Bristol-Myers Squibb Company Triazolopyridine 11-beta hydroxysteroid dehydrogenase type I inhibitors
US7572807B2 (en) 2005-06-09 2009-08-11 Bristol-Myers Squibb Company Heteroaryl 11-beta-hydroxysteroid dehydrogenase type I inhibitors
US8318941B2 (en) 2006-07-06 2012-11-27 Bristol-Myers Squibb Company Pyridone/hydroxypyridine 11-beta hydroxysteroid dehydrogenase type I inhibitors
CA2666193A1 (en) 2006-08-08 2008-02-14 Sanofi-Aventis Arylaminoaryl-alkyl-substituted imidazolidine-2,4-diones, process for preparing them, medicaments comprising these compounds, and their use
CL2008001839A1 (es) 2007-06-21 2009-01-16 Incyte Holdings Corp Compuestos derivados de 2,7-diazaespirociclos, inhibidores de 11-beta hidroxil esteroide deshidrogenasa tipo 1; composicion farmaceutica que comprende a dichos compuestos; utiles para tratar la obesidad, diabetes, intolerancia a la glucosa, diabetes tipo ii, entre otras enfermedades.
EP2025674A1 (de) 2007-08-15 2009-02-18 sanofi-aventis Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
US20090076783A1 (en) * 2007-09-13 2009-03-19 Tyco Healthcare Retail Services Ag Digitally optimized fastener assembly and method of making the same
US8119658B2 (en) 2007-10-01 2012-02-21 Bristol-Myers Squibb Company Triazolopyridine 11-beta hydroxysteroid dehydrogenase type I inhibitors
JP2011513409A (ja) * 2008-03-06 2011-04-28 メルク・シャープ・エンド・ドーム・コーポレイション 選択的グルココルチコイドレセプターモジュレーターとしてのヘキサヒドロシクロペンチル[f]インダゾールスルホンアミドおよびこれらの誘導体
AR072707A1 (es) 2008-07-09 2010-09-15 Sanofi Aventis Compuestos heterociclicos, procesos para su preparacion, medicamentos que comprenden estos compuestos y el uso de los mismos
WO2010068601A1 (en) 2008-12-08 2010-06-17 Sanofi-Aventis A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof
DK2470552T3 (en) 2009-08-26 2014-02-17 Sanofi Sa NOVEL, CRYSTALLINE, heteroaromatic FLUORGLYCOSIDHYDRATER, MEDICINES COVERING THESE COMPOUNDS AND THEIR USE
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
EP2582709B1 (de) 2010-06-18 2018-01-24 Sanofi Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
WO2012120050A1 (de) 2011-03-08 2012-09-13 Sanofi Neue substituierte phenyl-oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
US8828994B2 (en) 2011-03-08 2014-09-09 Sanofi Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
WO2012120058A1 (de) 2011-03-08 2012-09-13 Sanofi Mit benzyl- oder heteromethylengruppen substituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
US8895547B2 (en) 2011-03-08 2014-11-25 Sanofi Substituted phenyl-oxathiazine derivatives, method for producing them, drugs containing said compounds and the use thereof
WO2012120055A1 (de) 2011-03-08 2012-09-13 Sanofi Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
WO2012120053A1 (de) 2011-03-08 2012-09-13 Sanofi Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
US8871758B2 (en) 2011-03-08 2014-10-28 Sanofi Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof
EP2766349B1 (de) 2011-03-08 2016-06-01 Sanofi Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
WO2012120051A1 (de) 2011-03-08 2012-09-13 Sanofi Mit adamantan- oder noradamantan substituierte benzyl-oxathiazinderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
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EP2760862B1 (en) 2011-09-27 2015-10-21 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
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Also Published As

Publication number Publication date
IL182212A (en) 2011-03-31
TW200626558A (en) 2006-08-01
PL1797042T3 (pl) 2009-06-30
MX2007003546A (es) 2007-05-18
TWI309646B (en) 2009-05-11
IL182212A0 (en) 2007-07-24
RU2392272C2 (ru) 2010-06-20
BRPI0515931A (pt) 2008-08-12
AU2005289107A1 (en) 2006-04-06
NZ553849A (en) 2010-04-30
ES2317305T3 (es) 2009-04-16
EP1797042B1 (en) 2009-01-07
AU2005289107B2 (en) 2010-12-16
ATE420076T1 (de) 2009-01-15
KR100856164B1 (ko) 2008-09-03
MY140841A (en) 2010-01-29
EP1797042A1 (en) 2007-06-20
SI1797042T1 (sl) 2009-04-30
CN101027286B (zh) 2011-05-25
JP2008514659A (ja) 2008-05-08
WO2006034804A1 (en) 2006-04-06
CA2581865A1 (en) 2006-04-06
CN101027286A (zh) 2007-08-29
US20060069269A1 (en) 2006-03-30
NO20071617L (no) 2007-04-20
CA2581865C (en) 2010-04-20
HK1107348A1 (en) 2008-04-03
PT1797042E (pt) 2009-02-12
RU2007116033A (ru) 2008-11-10
SG148178A1 (en) 2008-12-31
US7528158B2 (en) 2009-05-05
ZA200702394B (en) 2008-11-26
KR20070047839A (ko) 2007-05-07
AR050952A1 (es) 2006-12-06
DE602005012292D1 (de) 2009-02-26
JP4682207B2 (ja) 2011-05-11
DK1797042T3 (da) 2009-03-02

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