HRP20090100T3 - 15beta-SUBSTITUTED STEROIDS HAVING SELECTIVE ESTROGENIC ACTIVITY - Google Patents
15beta-SUBSTITUTED STEROIDS HAVING SELECTIVE ESTROGENIC ACTIVITYInfo
- Publication number
- HRP20090100T3 HRP20090100T3 HR20090100T HRP20090100T HRP20090100T3 HR P20090100 T3 HRP20090100 T3 HR P20090100T3 HR 20090100 T HR20090100 T HR 20090100T HR P20090100 T HRP20090100 T HR P20090100T HR P20090100 T3 HRP20090100 T3 HR P20090100T3
- Authority
- HR
- Croatia
- Prior art keywords
- 15beta
- alkyl
- estrogenic activity
- substituted steroids
- selective estrogenic
- Prior art date
Links
- 230000001076 estrogenic effect Effects 0.000 title 1
- 150000003431 steroids Chemical class 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- -1 steroid compound Chemical class 0.000 abstract 2
- 125000006526 (C1-C2) alkyl group Chemical group 0.000 abstract 1
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
- 125000006592 (C2-C3) alkenyl group Chemical group 0.000 abstract 1
- 125000006593 (C2-C3) alkynyl group Chemical group 0.000 abstract 1
- HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Natural products C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 abstract 1
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 abstract 1
- 125000005740 oxycarbonyl group Chemical group [*:1]OC([*:2])=O 0.000 abstract 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
15ß-supstituiran steroidni spoj Formule I: u kojoj, R1 je H, (C1-C5)alkil, (C1-C12)acil, di-((C1-C5)alkil)aminokarbonil, ((C1-C5)alkil)oksikarbonil ili sulfamoil, R2 je H, (C1-C3)alkil, (C2-C3)alkenil ili (C2-C3)alkinil, od kojih svaki može proizvoljno biti zamijenjen halogenom, R3 je (C1-C2)alkil, etenil ili etinil, od kojih svaki može proizvoljno biti supstituiran halogenom, iR4 je H ili (C1-C12)acil. Patent sadrži još 12 patentnih zahtjeva.A 15ß-substituted steroid compound of Formula I: wherein, R 1 is H, (C 1 -C 5 )alkyl, (C 1 -C 12 )acyl, di-((C 1 -C 5 )alkyl)aminocarbonyl, ((C 1 -C 5 )alkyl)oxycarbonyl or sulfamoyl, R 2 is H, (C 1 -C 3 )alkyl, (C 2 -C 3 )alkenyl or (C 2 -C 3 )alkynyl, each of which may be optionally substituted with halogen, R 3 is (C 1 -C 2 )alkyl, ethenyl or ethynyl, each of which may be optionally substituted with halogen, and R 4 is H or (C 1 -C 12 )acyl. The patent contains 12 more patent claims.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60850104P | 2004-09-08 | 2004-09-08 | |
| EP04104334 | 2004-09-08 | ||
| PCT/EP2005/054368 WO2006027347A1 (en) | 2004-09-08 | 2005-09-05 | 15β-SUBSTITUTED STEROIDS HAVING SELECTIVE ESTROGENIC ACTIVITY |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20090100T3 true HRP20090100T3 (en) | 2009-03-31 |
Family
ID=35520526
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20090100T HRP20090100T3 (en) | 2004-09-08 | 2009-02-17 | 15beta-SUBSTITUTED STEROIDS HAVING SELECTIVE ESTROGENIC ACTIVITY |
Country Status (9)
| Country | Link |
|---|---|
| KR (1) | KR20070061557A (en) |
| CY (1) | CY1109412T1 (en) |
| DE (1) | DE602005011168D1 (en) |
| EC (1) | ECSP077305A (en) |
| HK (1) | HK1105296A1 (en) |
| HR (1) | HRP20090100T3 (en) |
| IL (1) | IL181334A0 (en) |
| MX (1) | MX2007002815A (en) |
| NO (1) | NO20071397L (en) |
-
2005
- 2005-09-05 MX MX2007002815A patent/MX2007002815A/en active IP Right Grant
- 2005-09-05 DE DE602005011168T patent/DE602005011168D1/en active Active
- 2005-09-05 KR KR1020077007550A patent/KR20070061557A/en not_active Application Discontinuation
-
2007
- 2007-02-14 IL IL181334A patent/IL181334A0/en not_active IP Right Cessation
- 2007-03-08 EC EC2007007305A patent/ECSP077305A/en unknown
- 2007-03-15 NO NO20071397A patent/NO20071397L/en not_active Application Discontinuation
- 2007-12-17 HK HK07113686A patent/HK1105296A1/en not_active IP Right Cessation
-
2009
- 2009-01-23 CY CY20091100087T patent/CY1109412T1/en unknown
- 2009-02-17 HR HR20090100T patent/HRP20090100T3/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MX2007002815A (en) | 2007-04-30 |
| NO20071397L (en) | 2007-04-02 |
| ECSP077305A (en) | 2007-04-26 |
| IL181334A0 (en) | 2007-07-04 |
| CY1109412T1 (en) | 2014-08-13 |
| KR20070061557A (en) | 2007-06-13 |
| DE602005011168D1 (en) | 2009-01-02 |
| HK1105296A1 (en) | 2008-02-06 |
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