CY1109412T1 - Steroids Substituted In 15 Beta Which Have An Ex selective Estrogenic Activity - Google Patents
Steroids Substituted In 15 Beta Which Have An Ex selective Estrogenic ActivityInfo
- Publication number
- CY1109412T1 CY1109412T1 CY20091100087T CY091100087T CY1109412T1 CY 1109412 T1 CY1109412 T1 CY 1109412T1 CY 20091100087 T CY20091100087 T CY 20091100087T CY 091100087 T CY091100087 T CY 091100087T CY 1109412 T1 CY1109412 T1 CY 1109412T1
- Authority
- CY
- Cyprus
- Prior art keywords
- alkyl
- beta
- substituted
- estrogenic activity
- selective estrogenic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Η εφεύρεση παρέχει στεροειδείς ενώσεις που υποκαθίστανται στο 15β οι οποίες έχουν εκλεκτική δραστηριότητα υποδοχέων οιστρογόνων σύμφωνα με τον Τύπο (I) όπου R1 είναι Η, C1-5 alkyl, C1-12 acyl, di-(C1-5 alkyl)aminocarbonyl, (C1-5 alkyl) oxycarbonyl ή sulfamoyl, R2 είναι Η, C1-3 alkyl, C2-3 alkenyl ή C2-3 alkynyl, το καθένα από τα οποία μπορεί προαιρετικά να υποκαθίσταται από ένα αλογόνο, R3 είναι C1-2 alkyl, αιθενυλ ή αιθυνυλ, το καθένα από τα οποία μπορεί προαιρετικά να υποκαθίσταται από ένα αλογόνο, και R4 είναι Η ή C1-12 acyl.The invention provides steroid compounds substituted on 15b which have selective estrogen receptor activity according to Formula (I) wherein R1 is H, C1-5 alkyl, C1-12 acyl, di- (C1-5 alkyl) aminocarbonyl, (C1 -5 alkyl) oxycarbonyl or sulfamoyl, R2 is H, C1-3 alkyl, C2-3 alkenyl or C2-3 alkynyl, each of which may optionally be substituted by a halogen, R3 is C1-2 alkyl, ethenyl or ethynyl , each of which may optionally be substituted by a halogen, and R4 is H or C1-12 acyl.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60850104P | 2004-09-08 | 2004-09-08 | |
| EP04104334 | 2004-09-08 | ||
| EP05794597A EP1805201B1 (en) | 2004-09-08 | 2005-09-05 | 15beta-SUBSTITUTED STEROIDS HAVING SELECTIVE ESTROGENIC ACTIVITY |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1109412T1 true CY1109412T1 (en) | 2014-08-13 |
Family
ID=35520526
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20091100087T CY1109412T1 (en) | 2004-09-08 | 2009-01-23 | Steroids Substituted In 15 Beta Which Have An Ex selective Estrogenic Activity |
Country Status (9)
| Country | Link |
|---|---|
| KR (1) | KR20070061557A (en) |
| CY (1) | CY1109412T1 (en) |
| DE (1) | DE602005011168D1 (en) |
| EC (1) | ECSP077305A (en) |
| HK (1) | HK1105296A1 (en) |
| HR (1) | HRP20090100T3 (en) |
| IL (1) | IL181334A0 (en) |
| MX (1) | MX2007002815A (en) |
| NO (1) | NO20071397L (en) |
-
2005
- 2005-09-05 MX MX2007002815A patent/MX2007002815A/en active IP Right Grant
- 2005-09-05 DE DE602005011168T patent/DE602005011168D1/en active Active
- 2005-09-05 KR KR1020077007550A patent/KR20070061557A/en not_active Application Discontinuation
-
2007
- 2007-02-14 IL IL181334A patent/IL181334A0/en not_active IP Right Cessation
- 2007-03-08 EC EC2007007305A patent/ECSP077305A/en unknown
- 2007-03-15 NO NO20071397A patent/NO20071397L/en not_active Application Discontinuation
- 2007-12-17 HK HK07113686A patent/HK1105296A1/en not_active IP Right Cessation
-
2009
- 2009-01-23 CY CY20091100087T patent/CY1109412T1/en unknown
- 2009-02-17 HR HR20090100T patent/HRP20090100T3/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MX2007002815A (en) | 2007-04-30 |
| NO20071397L (en) | 2007-04-02 |
| HRP20090100T3 (en) | 2009-03-31 |
| ECSP077305A (en) | 2007-04-26 |
| IL181334A0 (en) | 2007-07-04 |
| KR20070061557A (en) | 2007-06-13 |
| DE602005011168D1 (en) | 2009-01-02 |
| HK1105296A1 (en) | 2008-02-06 |
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