ECSP077305A - STEROIDS REPLACED IN POSITION 15b THAT HAVE SELECTIVE STROGEN ACTIVITY - Google Patents
STEROIDS REPLACED IN POSITION 15b THAT HAVE SELECTIVE STROGEN ACTIVITYInfo
- Publication number
- ECSP077305A ECSP077305A EC2007007305A ECSP077305A ECSP077305A EC SP077305 A ECSP077305 A EC SP077305A EC 2007007305 A EC2007007305 A EC 2007007305A EC SP077305 A ECSP077305 A EC SP077305A EC SP077305 A ECSP077305 A EC SP077305A
- Authority
- EC
- Ecuador
- Prior art keywords
- alkyl
- selective
- strogen
- steroids
- activity
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La invención provee compuestos esteroides sustituidos en la posición 15b que tienen actividad selectiva del receptor de estrógeno de acuerdo con la Fórmula (I), en donde R1 es H, alquilo C1-5, acilo C1-12, di-(alquilo C1-5)aminocarbonilo, (alquilo C1-5)oxicarbonilo o sulfamoilo, R2 es H, alquilo C1-3, alquenilo C2-3 o alquinilo C2-3, cada uno de los cuales puede ser opcionalmente sustituido con un halógeno, R3 es alquilo C1-2, etenilo o etinilo, cada uno de los cuales puede ser opcionalmente sustituido con un halógeno, y R4 es H o acilo C1-12.The invention provides substituted steroid compounds at position 15b which have selective estrogen receptor activity according to Formula (I), wherein R1 is H, C1-5 alkyl, C1-12 acyl, di- (C1-5 alkyl ) aminocarbonyl, (C1-5 alkyl) oxycarbonyl or sulfamoyl, R2 is H, C1-3 alkyl, C2-3 alkenyl or C2-3 alkynyl, each of which may be optionally substituted with a halogen, R3 is C1- alkyl 2, ethenyl or ethynyl, each of which may be optionally substituted with a halogen, and R4 is H or C1-12 acyl.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60850104P | 2004-09-08 | 2004-09-08 | |
| EP04104334 | 2004-09-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP077305A true ECSP077305A (en) | 2007-04-26 |
Family
ID=35520526
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EC2007007305A ECSP077305A (en) | 2004-09-08 | 2007-03-08 | STEROIDS REPLACED IN POSITION 15b THAT HAVE SELECTIVE STROGEN ACTIVITY |
Country Status (9)
| Country | Link |
|---|---|
| KR (1) | KR20070061557A (en) |
| CY (1) | CY1109412T1 (en) |
| DE (1) | DE602005011168D1 (en) |
| EC (1) | ECSP077305A (en) |
| HK (1) | HK1105296A1 (en) |
| HR (1) | HRP20090100T3 (en) |
| IL (1) | IL181334A0 (en) |
| MX (1) | MX2007002815A (en) |
| NO (1) | NO20071397L (en) |
-
2005
- 2005-09-05 KR KR1020077007550A patent/KR20070061557A/en not_active Application Discontinuation
- 2005-09-05 DE DE602005011168T patent/DE602005011168D1/en active Active
- 2005-09-05 MX MX2007002815A patent/MX2007002815A/en active IP Right Grant
-
2007
- 2007-02-14 IL IL181334A patent/IL181334A0/en not_active IP Right Cessation
- 2007-03-08 EC EC2007007305A patent/ECSP077305A/en unknown
- 2007-03-15 NO NO20071397A patent/NO20071397L/en not_active Application Discontinuation
- 2007-12-17 HK HK07113686A patent/HK1105296A1/en not_active IP Right Cessation
-
2009
- 2009-01-23 CY CY20091100087T patent/CY1109412T1/en unknown
- 2009-02-17 HR HR20090100T patent/HRP20090100T3/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MX2007002815A (en) | 2007-04-30 |
| HRP20090100T3 (en) | 2009-03-31 |
| KR20070061557A (en) | 2007-06-13 |
| IL181334A0 (en) | 2007-07-04 |
| HK1105296A1 (en) | 2008-02-06 |
| DE602005011168D1 (en) | 2009-01-02 |
| CY1109412T1 (en) | 2014-08-13 |
| NO20071397L (en) | 2007-04-02 |
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