HRP20080644T3 - Method for the separation of intermediates which may be used for the preparation of escitalopram - Google Patents
Method for the separation of intermediates which may be used for the preparation of escitalopramInfo
- Publication number
- HRP20080644T3 HRP20080644T3 HR20080644T HRP20080644T HRP20080644T3 HR P20080644 T3 HRP20080644 T3 HR P20080644T3 HR 20080644 T HR20080644 T HR 20080644T HR P20080644 T HRP20080644 T HR P20080644T HR P20080644 T3 HRP20080644 T3 HR P20080644T3
- Authority
- HR
- Croatia
- Prior art keywords
- alkyl
- group
- aryl
- formula
- hydrogen
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- WSEQXVZVJXJVFP-FQEVSTJZSA-N escitalopram Chemical compound C1([C@]2(C3=CC=C(C=C3CO2)C#N)CCCN(C)C)=CC=C(F)C=C1 WSEQXVZVJXJVFP-FQEVSTJZSA-N 0.000 title 1
- 229960004341 escitalopram Drugs 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
- 238000000926 separation method Methods 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 5
- 229910052736 halogen Inorganic materials 0.000 abstract 5
- 150000002367 halogens Chemical class 0.000 abstract 5
- 125000003118 aryl group Chemical group 0.000 abstract 4
- 229910052760 oxygen Inorganic materials 0.000 abstract 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 4
- 229910052717 sulfur Inorganic materials 0.000 abstract 4
- -1 -MgHal Chemical group 0.000 abstract 3
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 150000002009 diols Chemical class 0.000 abstract 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 3
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 2
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 abstract 2
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- 125000006222 dimethylaminomethyl group Chemical group [H]C([H])([H])N(C([H])([H])[H])C([H])([H])* 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 125000006239 protecting group Chemical group 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000003003 spiro group Chemical group 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 abstract 1
- 125000006728 (C1-C6) alkynyl group Chemical group 0.000 abstract 1
- 101100516554 Caenorhabditis elegans nhr-5 gene Proteins 0.000 abstract 1
- 125000003158 alcohol group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000005110 aryl thio group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 150000003949 imides Chemical class 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
- 229910052727 yttrium Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/32—Separation; Purification; Stabilisation; Use of additives
- C07C253/34—Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54497004P | 2004-02-12 | 2004-02-12 | |
| DKPA200400217 | 2004-02-12 | ||
| PCT/DK2005/000075 WO2005077891A1 (en) | 2004-02-12 | 2005-02-02 | Method for the separation of intermediates which may be used for the preparation of escitalopram |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20080644T3 true HRP20080644T3 (en) | 2009-01-31 |
Family
ID=34862963
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20080644T HRP20080644T3 (en) | 2004-02-12 | 2008-12-10 | Method for the separation of intermediates which may be used for the preparation of escitalopram |
Country Status (5)
| Country | Link |
|---|---|
| CY (1) | CY1108641T1 (xx) |
| DE (1) | DE602005010395D1 (xx) |
| EG (1) | EG24309A (xx) |
| HR (1) | HRP20080644T3 (xx) |
| NO (1) | NO20064086L (xx) |
-
2005
- 2005-02-02 DE DE602005010395T patent/DE602005010395D1/de active Active
-
2006
- 2006-08-06 EG EGNA2006000744 patent/EG24309A/xx active
- 2006-09-12 NO NO20064086A patent/NO20064086L/no not_active Application Discontinuation
-
2008
- 2008-12-10 HR HR20080644T patent/HRP20080644T3/xx unknown
- 2008-12-10 CY CY20081101428T patent/CY1108641T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO20064086L (no) | 2006-09-12 |
| CY1108641T1 (el) | 2014-04-09 |
| EG24309A (en) | 2009-01-14 |
| DE602005010395D1 (de) | 2008-11-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RS54199B1 (en) | PROCEDURE FOR OBTAINING INTERMEDIERS OF USEFUL USES AS OPIOID RECEPTOR MODULATORS | |
| RS52100B (en) | PROCEDURES AND UNITS FOR PREPARING ANALOG CC-1065 | |
| EA201490554A1 (ru) | Пирролобензодиазепины | |
| SE9904850D0 (sv) | Novel process and intermediates | |
| EA201591000A1 (ru) | Пирролобензодиазепины | |
| JP2017511305A5 (xx) | ||
| HRP20211922T1 (hr) | Postupci i intermedijeri za pripravu jak inhibitora | |
| EP2903614B1 (en) | Novel compounds, their synthesis and their uses | |
| NZ511739A (en) | New esters derived from substituted phenyl-cyclohexyl compounds | |
| HK1039727A1 (en) | Synthetic analogs of ecteinascidin-743 | |
| AR051373A1 (es) | Procedimiento para la preparacion de analogos aciclicos de nucleotidos de fosfonatos | |
| SE0103045D0 (sv) | förfarande för framställning av citalopram | |
| DK453389D0 (da) | Hidtil ukendte forbindelser | |
| DE69015322D1 (de) | Substituierte Zyklobutendion-Verbindungen. | |
| HRP20080644T3 (en) | Method for the separation of intermediates which may be used for the preparation of escitalopram | |
| DE3171116D1 (en) | Arylamine derivatives, process for their preparation and their use as microbicides | |
| ATE428693T1 (de) | Prostaglandinsynthese | |
| RS50689B (sr) | Postupak za odvajanje intermedijera koji se mogu koristiti za pripremu escitaloprama | |
| Elneairy et al. | Synthesis of thiazole, triazole, pyrazolo [3, 4-b]-pyridinyl-3-phenylthiourea, aminopyrazolo [3, 4-b] pyridine derivatives and their biological evaluation | |
| JP2019507765A5 (xx) | ||
| Patel et al. | Synthesis and biological evaluation of coumarinyl sydnone derivatives | |
| PT786459E (pt) | Processo para a preparacao de um enantiomero de alcool heterobiciclico | |
| DK0858447T3 (da) | Fremgangsmåder til fremstilling af aminophenylsulfonylurinstoffer samt mellemprodukter til fremgangsmåderne | |
| JP2005504079A (ja) | γ−ブチロラクトンとイミダゾールとの反応によるイミダゾ−［１，２−ａ］−５，６，７，８−テトラヒドロピリジン−８−オンの製造法、新規のイミダゾ−［１，２−ａ］−５，６，７，８−テトラヒドロピリジン−８−オン、並びにイミダゾ−［１，２−ａ］ピリジンを製造するためのその使用 | |
| Mignani et al. | Stereoselective Cycloaddition of Monosubstituted Ketene to a Methyl Glyoxylate-and Threonine-Derived Imine: Synthesis of Optically Pure β-Lactamic α-Amino Ester with High Functionality |