HRP20080536T5 - Polysubstituted 1,1-pyridinyloxycyclopropanamine derivatives, process for their preparation and pharmaceutical compositions containing them - Google Patents
Polysubstituted 1,1-pyridinyloxycyclopropanamine derivatives, process for their preparation and pharmaceutical compositions containing themInfo
- Publication number
- HRP20080536T5 HRP20080536T5 HR20080536T HRP20080536T HRP20080536T5 HR P20080536 T5 HRP20080536 T5 HR P20080536T5 HR 20080536 T HR20080536 T HR 20080536T HR P20080536 T HRP20080536 T HR P20080536T HR P20080536 T5 HRP20080536 T5 HR P20080536T5
- Authority
- HR
- Croatia
- Prior art keywords
- straight
- branched
- branched alkyl
- groups
- group
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical compound C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 125000004952 trihaloalkoxy group Chemical group 0.000 abstract 2
- 125000004385 trihaloalkyl group Chemical group 0.000 abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 235000010290 biphenyl Nutrition 0.000 abstract 1
- 239000004305 biphenyl Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000005046 dihydronaphthyl group Chemical group 0.000 abstract 1
- 125000003392 indanyl group Chemical group C1(CCC2=CC=CC=C12)* 0.000 abstract 1
- 125000003454 indenyl group Chemical group C1(C=CC2=CC=CC=C12)* 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001712 tetrahydronaphthyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/65—One oxygen atom attached in position 3 or 5
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0508033A FR2889187B1 (fr) | 2005-07-28 | 2005-07-28 | Nouveaux composes 1,1-pyridinyloxycyclopropanamines polysusbstitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HRP20080536T3 HRP20080536T3 (en) | 2009-02-28 |
| HRP20080536T5 true HRP20080536T5 (en) | 2009-03-31 |
Family
ID=35841768
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20080536T HRP20080536T5 (en) | 2005-07-28 | 2008-11-19 | Polysubstituted 1,1-pyridinyloxycyclopropanamine derivatives, process for their preparation and pharmaceutical compositions containing them |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US7348344B2 (no) |
| EP (1) | EP1748043B1 (no) |
| JP (1) | JP2007077135A (no) |
| KR (1) | KR100824830B1 (no) |
| CN (1) | CN100519531C (no) |
| AR (1) | AR054875A1 (no) |
| AT (1) | ATE405550T1 (no) |
| AU (1) | AU2006203241A1 (no) |
| BR (1) | BRPI0603064A (no) |
| CA (1) | CA2552827A1 (no) |
| DE (1) | DE602006002328D1 (no) |
| DK (1) | DK1748043T3 (no) |
| EA (1) | EA011126B1 (no) |
| ES (1) | ES2313589T3 (no) |
| FR (1) | FR2889187B1 (no) |
| GE (1) | GEP20084548B (no) |
| HR (1) | HRP20080536T5 (no) |
| MA (1) | MA28426B1 (no) |
| MX (1) | MXPA06008415A (no) |
| NO (1) | NO20063461L (no) |
| NZ (1) | NZ548747A (no) |
| PL (1) | PL1748043T3 (no) |
| PT (1) | PT1748043E (no) |
| SG (1) | SG129411A1 (no) |
| SI (1) | SI1748043T1 (no) |
| WO (1) | WO2007012762A1 (no) |
| ZA (1) | ZA200606277B (no) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2896800B1 (fr) * | 2006-01-30 | 2008-04-11 | Servier Lab | Nouveaux composes pyridinylaminoalkylene-et pyridinyloxyalkylene-cyclopropanamines polysubstitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| EA020506B1 (ru) * | 2009-11-18 | 2014-11-28 | Сувен Лайф Сайенсиз Лимитед | БИЦИКЛИЧЕСКИЕ СОЕДИНЕНИЯ В КАЧЕСТВЕ ЛИГАНДОВ αβНИКОТИНОВОГО АЦЕТИЛХОЛИНОВОГО РЕЦЕПТОРА |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2095350C1 (ru) * | 1993-10-13 | 1997-11-10 | Центр по химии лекарственных средств (ЦХЛС-ВНИХФИ) | 3-(n,n-диметилкарбамоилокси)-2-этил-6-метилпиридина сукцинат, обладающий антигипоксической активностью |
| TW544448B (en) * | 1997-07-11 | 2003-08-01 | Novartis Ag | Pyridine derivatives |
| FR2810664B1 (fr) * | 2000-06-27 | 2004-12-24 | Adir | Nouveaux composes cyclopropaniques 1,1 et 1,2-dissubstitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
-
2005
- 2005-07-28 FR FR0508033A patent/FR2889187B1/fr not_active Expired - Fee Related
-
2006
- 2006-07-10 MA MA29177A patent/MA28426B1/fr unknown
- 2006-07-20 CA CA002552827A patent/CA2552827A1/fr not_active Abandoned
- 2006-07-21 SG SG200604914A patent/SG129411A1/en unknown
- 2006-07-26 NZ NZ548747A patent/NZ548747A/en unknown
- 2006-07-26 US US11/493,070 patent/US7348344B2/en not_active Expired - Fee Related
- 2006-07-26 MX MXPA06008415A patent/MXPA06008415A/es active IP Right Grant
- 2006-07-27 AR ARP060103249A patent/AR054875A1/es unknown
- 2006-07-27 KR KR1020060070569A patent/KR100824830B1/ko not_active IP Right Cessation
- 2006-07-27 DK DK06291219T patent/DK1748043T3/da active
- 2006-07-27 NO NO20063461A patent/NO20063461L/no not_active Application Discontinuation
- 2006-07-27 EA EA200601248A patent/EA011126B1/ru not_active IP Right Cessation
- 2006-07-27 PL PL06291219T patent/PL1748043T3/pl unknown
- 2006-07-27 SI SI200630083T patent/SI1748043T1/sl unknown
- 2006-07-27 WO PCT/FR2006/001832 patent/WO2007012762A1/fr active Application Filing
- 2006-07-27 ES ES06291219T patent/ES2313589T3/es active Active
- 2006-07-27 AT AT06291219T patent/ATE405550T1/de not_active IP Right Cessation
- 2006-07-27 DE DE602006002328T patent/DE602006002328D1/de not_active Expired - Fee Related
- 2006-07-27 GE GEAP20069543A patent/GEP20084548B/en unknown
- 2006-07-27 PT PT06291219T patent/PT1748043E/pt unknown
- 2006-07-27 EP EP06291219A patent/EP1748043B1/fr active Active
- 2006-07-28 AU AU2006203241A patent/AU2006203241A1/en not_active Abandoned
- 2006-07-28 JP JP2006206041A patent/JP2007077135A/ja active Pending
- 2006-07-28 CN CNB2006101089323A patent/CN100519531C/zh not_active Expired - Fee Related
- 2006-07-28 BR BRPI0603064-5A patent/BRPI0603064A/pt not_active IP Right Cessation
- 2006-07-28 ZA ZA200606277A patent/ZA200606277B/xx unknown
-
2008
- 2008-11-19 HR HR20080536T patent/HRP20080536T5/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NZ548747A (en) | 2007-06-29 |
| AR054875A1 (es) | 2007-07-25 |
| CA2552827A1 (fr) | 2007-01-28 |
| EA200601248A1 (ru) | 2007-04-27 |
| MA28426B1 (fr) | 2007-02-01 |
| BRPI0603064A (pt) | 2007-08-14 |
| CN1903843A (zh) | 2007-01-31 |
| DE602006002328D1 (de) | 2008-10-02 |
| EP1748043B1 (fr) | 2008-08-20 |
| MXPA06008415A (es) | 2007-01-29 |
| JP2007077135A (ja) | 2007-03-29 |
| CN100519531C (zh) | 2009-07-29 |
| US7348344B2 (en) | 2008-03-25 |
| SG129411A1 (en) | 2007-02-26 |
| WO2007012762A1 (fr) | 2007-02-01 |
| EP1748043A1 (fr) | 2007-01-31 |
| SI1748043T1 (sl) | 2008-12-31 |
| PL1748043T3 (pl) | 2008-12-31 |
| NO20063461L (no) | 2007-01-29 |
| US20070027191A1 (en) | 2007-02-01 |
| ATE405550T1 (de) | 2008-09-15 |
| HRP20080536T3 (en) | 2009-02-28 |
| KR100824830B1 (ko) | 2008-04-23 |
| AU2006203241A1 (en) | 2007-02-15 |
| DK1748043T3 (da) | 2008-12-08 |
| FR2889187A1 (fr) | 2007-02-02 |
| ES2313589T3 (es) | 2009-03-01 |
| GEP20084548B (en) | 2008-11-25 |
| FR2889187B1 (fr) | 2007-09-07 |
| ZA200606277B (en) | 2007-04-25 |
| PT1748043E (pt) | 2008-10-07 |
| KR20070015011A (ko) | 2007-02-01 |
| EA011126B1 (ru) | 2008-12-30 |
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