HRP20060124A2 - Process for the preparation of n-amino substituted heterocyclic compounds - Google Patents

Process for the preparation of n-amino substituted heterocyclic compounds

Info

Publication number
HRP20060124A2
HRP20060124A2 HR20060124A HRP20060124A HRP20060124A2 HR P20060124 A2 HRP20060124 A2 HR P20060124A2 HR 20060124 A HR20060124 A HR 20060124A HR P20060124 A HRP20060124 A HR P20060124A HR P20060124 A2 HRP20060124 A2 HR P20060124A2
Authority
HR
Croatia
Prior art keywords
preparation
heterocyclic compounds
compound
substituted heterocyclic
amino substituted
Prior art date
Application number
HR20060124A
Other languages
English (en)
Inventor
Weiberth Franz
E. Lee George
G. Hanna Reda
Dubberke Silke
Utz Roland
Mueller-Lehar Jurgen
Original Assignee
Aventis Pharmaceuticals Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharmaceuticals Inc. filed Critical Aventis Pharmaceuticals Inc.
Publication of HRP20060124A2 publication Critical patent/HRP20060124A2/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C04CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04BLIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B35/00Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/622Forming processes; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/626Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B
    • C04B35/63Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B using additives specially adapted for forming the products, e.g.. binder binders
    • C04B35/632Organic additives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404Indoles, e.g. pindolol
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/08Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56Ring systems containing three or more rings
    • C07D209/80[b, c]- or [b, d]-condensed
    • C07D209/82Carbazoles; Hydrogenated carbazoles
    • C07D209/86Carbazoles; Hydrogenated carbazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Manufacturing & Machinery (AREA)
  • Ceramic Engineering (AREA)
  • Inorganic Chemistry (AREA)
  • Materials Engineering (AREA)
  • Structural Engineering (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)

Abstract

U ovoj specifikaciji opisan je štiti se poboljšani postupak dobivanja heterocikličkih spojeva s N-aminodušikom. U izvedbi ovog izuma dobiva se spoj formule (VI), počevši od odgovarajućeg indolskog derivata, N-aminacijom a zatim i dobivanjem hidrazona reakcijom s keto-spojem u jednom koraku. Sljedećom redukcijom hidrazona i naknadnom kondenzacijom s piridinskim spojem dobije se spoj formule VI ilinjegovu pogodnu sol.
HR20060124A 2003-10-03 2006-03-29 Process for the preparation of n-amino substituted heterocyclic compounds HRP20060124A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50833503P 2003-10-03 2003-10-03
PCT/US2004/032086 WO2005035496A1 (en) 2003-10-03 2004-10-01 Process for the preparation of n-amino substituted heterocyclic compounds

Publications (1)

Publication Number Publication Date
HRP20060124A2 true HRP20060124A2 (en) 2006-10-31

Family

ID=34434904

Family Applications (2)

Application Number Title Priority Date Filing Date
HR20060124A HRP20060124A2 (en) 2003-10-03 2006-03-29 Process for the preparation of n-amino substituted heterocyclic compounds
HR20090441T HRP20090441T1 (hr) 2003-10-03 2009-08-13 Postupak za pripravu n-amino supstituiranih heterocikličkih spojeva

Family Applications After (1)

Application Number Title Priority Date Filing Date
HR20090441T HRP20090441T1 (hr) 2003-10-03 2009-08-13 Postupak za pripravu n-amino supstituiranih heterocikličkih spojeva

Country Status (29)

Country Link
US (1) US7112682B2 (hr)
EP (1) EP1678135B1 (hr)
JP (1) JP2007507518A (hr)
KR (1) KR20060120028A (hr)
CN (2) CN100579963C (hr)
AR (1) AR046041A1 (hr)
AT (1) ATE431339T1 (hr)
AU (1) AU2004279808B2 (hr)
BR (1) BRPI0415002A (hr)
CA (1) CA2540867A1 (hr)
DE (1) DE602004021126D1 (hr)
DK (1) DK1678135T3 (hr)
ES (1) ES2327417T3 (hr)
HK (1) HK1095592A1 (hr)
HR (2) HRP20060124A2 (hr)
IL (1) IL174238A0 (hr)
MA (1) MA28117A1 (hr)
ME (1) MEP19508A (hr)
MX (1) MXPA06003446A (hr)
NO (1) NO20061929L (hr)
NZ (1) NZ545838A (hr)
PL (1) PL1678135T3 (hr)
PT (1) PT1678135E (hr)
RS (1) RS20060225A (hr)
RU (1) RU2364588C2 (hr)
SI (1) SI1678135T1 (hr)
TW (1) TW200519086A (hr)
WO (1) WO2005035496A1 (hr)
ZA (1) ZA200602694B (hr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040132708A1 (en) * 2002-05-01 2004-07-08 Wyeth Process for preparing 6-alkylidene penem derivatives
AR039475A1 (es) * 2002-05-01 2005-02-23 Wyeth Corp 6-alquiliden-penems triciclicos como inhibidores de beta-lactamasa
AR039774A1 (es) * 2002-05-01 2005-03-02 Wyeth Corp 6-alquiliden-penems biciclicos como inhibidores de beta-lactamasas
AR039476A1 (es) * 2002-05-01 2005-02-23 Wyeth Corp Proceso para preparar derivados de 6-alquiliden penem
US7538227B2 (en) * 2004-01-13 2009-05-26 Sanofi-Aventis Deutschland Gmbh Process for stabilizing 4-halopyridines
WO2006115456A1 (en) * 2005-04-26 2006-11-02 Cambrex Karlskoga Ab Synthesis of 1-aminopiperidine
GT200600332A (es) * 2005-07-27 2007-03-14 Inhibidores de 6-alquiliden-penem beta-lactamasa triciclicos y combinación de antibióticos de b-lactama: un antibiotico de amplio espectro
PE20070403A1 (es) * 2005-07-27 2007-05-15 Wyeth Corp COMPOSICION FARMACEUTICA QUE COMPRENDE CEFEPIME Y DERIVADOS DE 6-ALQUILIDEN-PENEM BICICLICOS COMO INHIBIDORES DE ß-LACTAMASA
GT200600380A (es) * 2005-08-24 2007-03-29 Proceso para la preparacion de inhibidores de beta-lactamasa
FR2897614B1 (fr) * 2006-02-20 2008-05-23 Urogene Forme cristalline du chlorhydrate de la besipirdine, procedes de preparation et utilisations
EP2493305B1 (en) 2009-10-30 2015-03-25 Genzyme Corporation 2-aminoindole compounds and methods for the treatment of malaria
CN105753838A (zh) * 2016-02-11 2016-07-13 安阳师范学院 喹啉衍生物高区域选择性胺化新方法
CN110799523A (zh) * 2017-05-12 2020-02-14 中外制药株式会社 用于制备环状有机化合物的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0629273B2 (ja) * 1986-06-13 1994-04-20 宇部興産株式会社 N−アミノヘキサメチレンイミンの製造法
JPH01157922A (ja) * 1987-12-15 1989-06-21 Citizen Watch Co Ltd ニトリル化合物の製造方法
US5459274A (en) * 1994-05-13 1995-10-17 Hoechst-Roussel Pharmaceuticals Inc. Preparation of N-alkyl-N-pyridinyl-1H-indol-1-amines

Also Published As

Publication number Publication date
DK1678135T3 (da) 2009-09-07
HK1095592A1 (en) 2007-05-11
NZ545838A (en) 2009-01-31
PT1678135E (pt) 2009-08-21
JP2007507518A (ja) 2007-03-29
BRPI0415002A (pt) 2006-11-07
RS20060225A (en) 2008-09-29
CA2540867A1 (en) 2005-04-21
IL174238A0 (en) 2006-08-01
MXPA06003446A (es) 2006-06-14
ES2327417T3 (es) 2009-10-29
CN101391976A (zh) 2009-03-25
AU2004279808B2 (en) 2010-04-22
MEP19508A (en) 2010-06-10
WO2005035496A1 (en) 2005-04-21
US20050101654A1 (en) 2005-05-12
TW200519086A (en) 2005-06-16
RU2364588C2 (ru) 2009-08-20
ZA200602694B (en) 2007-09-26
HRP20090441T1 (hr) 2009-09-30
AU2004279808A1 (en) 2005-04-21
EP1678135A1 (en) 2006-07-12
CN1890213A (zh) 2007-01-03
US7112682B2 (en) 2006-09-26
CN100579963C (zh) 2010-01-13
EP1678135B1 (en) 2009-05-13
NO20061929L (no) 2006-04-28
RU2006114667A (ru) 2006-09-10
KR20060120028A (ko) 2006-11-24
SI1678135T1 (sl) 2009-10-31
MA28117A1 (fr) 2006-08-01
PL1678135T3 (pl) 2009-10-30
AR046041A1 (es) 2005-11-23
DE602004021126D1 (de) 2009-06-25
ATE431339T1 (de) 2009-05-15

Similar Documents

Publication Publication Date Title
HRP20060124A2 (en) Process for the preparation of n-amino substituted heterocyclic compounds
NO20060142L (no) Syklisk tertiaer aminforbindelse
DE60304059D1 (de) 3-(2-hydroxy-phenyl)-1h-pyrazol-4-carbonsäureamid derivate als hsp90 inhibitoren zur behandlung von krebs
NO20063748L (no) Kinolinderivater og anvendelse derav som mykobakterielle inhibitorer
EA200701470A1 (ru) Способы получения производных 4-(фенокси-5-метилпиримидин-4-илокси)пиперидин-1-карбоновой кислоты и родственных соединений
NO20055099L (no) Fremgangsmate for fremstilling av 5-(haloacetyl)-8-(substituert oksy)-(1H)-kinolin-2-oner
NO20060184L (no) Fremgangsmate for fremstilling av ikke-peptid substituerte spirobenzoazepinderivater
NO20081617L (no) Metoder for fremstilling av Glutaminsyrederivater
DK1877370T3 (da) Fremgangsmåde til fremstilling af hydrazon-derivater
NO20081859L (no) Fremgangsmate for fremstillingen av sartanderivater og mellomprodukter som er nyttige i slike fremgangsmater
NO20060603L (no) Fremgangsmate for fremstillingen av fenyltetrazolderivater
GB0215392D0 (en) Chemical compounds
NO20053712L (no) Fremgangsmate for fremstilling av substituerte imidazolderivater og mellomprodukter anvendt i fremgangsmaten
MXPA03011647A (es) Procedimiento de resolucion para el acido ( r ) - (-) - 2-hidroxi - 2- (2 - clorofenil) acetico.
ATE374751T1 (de) 3,4-dihydro-1h-chinolin-2-onderivate als norepinephrin-wiederaufnahme-hemmern
TW200631943A (en) Chemical compounds, process for their preparation and use thereof
WO2006021654A8 (fr) Derives de 4-arylmorpholin-3-one, leur preparation et leur application en therapeutique
MX2007012386A (es) 7-fluoro-1,3-dihidro-indol-2-ona oxazolidinonas como agentes antibacterianos.
EA200701910A1 (ru) Способ получения замещенных бензотиазиноиндолов
SE0403003D0 (sv) Chemical compound 1
DK1296965T3 (da) Fremgangsmåde til fremstilling af 4-brom-anilinderivater
DE50304168D1 (de) Substituierte pyrazolincarboxanilide als schädlingsbekämpfungmittel
HUP0202296A2 (hu) Eljárás szubsztituált benzizotiazolszármazékok előállítására
TH118205A (th) อนุพันธ์อินแดโซลิลเอสเทอร์ หรืออนุพันธ์อินแดโซลิลแอมีดชนิดใหม่
TH78688A (th) กรรมวิธีสำหรับการเตรียมไพราโซล

Legal Events

Date Code Title Description
A1OB Publication of a patent application
ARAI Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application
PNAN Change of the applicant name, address/residence

Owner name: AVENTIS PHARMACEUTICALS INC., US

ODRP Renewal fee for the maintenance of a patent

Payment date: 20090929

Year of fee payment: 6

OBST Application withdrawn