HRP20050034A2 - N,n-disubstituted diazocycloalkanes useful for the disfunction - Google Patents

N,n-disubstituted diazocycloalkanes useful for the disfunction Download PDF

Info

Publication number
HRP20050034A2
HRP20050034A2 HR20050034A HRP20050034A HRP20050034A2 HR P20050034 A2 HRP20050034 A2 HR P20050034A2 HR 20050034 A HR20050034 A HR 20050034A HR P20050034 A HRP20050034 A HR P20050034A HR P20050034 A2 HRP20050034 A2 HR P20050034A2
Authority
HR
Croatia
Prior art keywords
cyclohexyl
piperazine
compound
fluorophenyl
compounds
Prior art date
Application number
HR20050034A
Other languages
English (en)
Croatian (hr)
Inventor
Leonardi Amedeo
Motta Gianni
Riva Carlo
Testa Rodolfo
Original Assignee
Recordati Ireland Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Recordati Ireland Limited filed Critical Recordati Ireland Limited
Publication of HRP20050034A2 publication Critical patent/HRP20050034A2/hr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/092—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings with aromatic radicals attached to the chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Nutrition Science (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HR20050034A 2002-06-14 2005-01-12 N,n-disubstituted diazocycloalkanes useful for the disfunction HRP20050034A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT2002MI001328A ITMI20021328A1 (it) 2002-06-14 2002-06-14 Nuove piperazine 1,4 - disostituite
PCT/EP2003/006280 WO2003106444A1 (en) 2002-06-14 2003-06-16 N,n-disubstituted diazocycloalkanes useful for the treatment of cns disorders due to serotonergic dysfunction

Publications (1)

Publication Number Publication Date
HRP20050034A2 true HRP20050034A2 (en) 2005-08-31

Family

ID=29727277

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20050034A HRP20050034A2 (en) 2002-06-14 2005-01-12 N,n-disubstituted diazocycloalkanes useful for the disfunction

Country Status (19)

Country Link
US (1) US20060148821A1 (ja)
EP (1) EP1515961A1 (ja)
JP (1) JP2005538063A (ja)
CN (1) CN1662516A (ja)
AU (1) AU2003276979A1 (ja)
BR (1) BR0311805A (ja)
CA (1) CA2489450A1 (ja)
EA (1) EA007503B1 (ja)
HR (1) HRP20050034A2 (ja)
IL (1) IL165568A0 (ja)
IT (1) ITMI20021328A1 (ja)
MX (1) MXPA04012602A (ja)
NO (1) NO20050146L (ja)
NZ (1) NZ537469A (ja)
PL (1) PL372531A1 (ja)
RS (1) RS108904A (ja)
TW (1) TW200400947A (ja)
WO (1) WO2003106444A1 (ja)
ZA (1) ZA200500318B (ja)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7365076B2 (en) * 2003-10-14 2008-04-29 Wyeth Substituted aryl cycloalkanol derivatives and methods of their use
US20050165025A1 (en) * 2004-01-22 2005-07-28 Recordati Ireland Ltd. Combination therapy with 5HT 1A and 5HT 1B-receptor antagonists
WO2011020861A1 (en) 2009-08-20 2011-02-24 Novartis Ag Heterocyclic oxime compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999006382A1 (en) * 1997-08-01 1999-02-11 Recordati S.A., Chemical And Pharmaceutical Company 1,4-disubstituted piperazines
IT1293804B1 (it) * 1997-08-01 1999-03-10 Recordati Chem Pharm Diarilalchilpiperazine attive sulle basse vie urinarie
UA66370C2 (en) * 1997-12-16 2004-05-17 Lilly Co Eli Arylpiperazines having activity to setotonin 1 receptors

Also Published As

Publication number Publication date
CA2489450A1 (en) 2003-12-24
US20060148821A1 (en) 2006-07-06
NO20050146L (no) 2005-03-14
EP1515961A1 (en) 2005-03-23
AU2003276979A1 (en) 2003-12-31
EA007503B1 (ru) 2006-10-27
IL165568A0 (en) 2006-01-15
TW200400947A (en) 2004-01-16
ZA200500318B (en) 2006-07-26
NO20050146D0 (no) 2005-01-11
BR0311805A (pt) 2005-03-15
JP2005538063A (ja) 2005-12-15
EA200500023A1 (ru) 2005-06-30
RS108904A (en) 2007-02-05
PL372531A1 (en) 2005-07-25
WO2003106444A8 (en) 2004-08-12
CN1662516A (zh) 2005-08-31
NZ537469A (en) 2006-07-28
MXPA04012602A (es) 2005-09-30
ITMI20021328A1 (it) 2003-12-15
WO2003106444A1 (en) 2003-12-24

Similar Documents

Publication Publication Date Title
US7071197B2 (en) N,N-disubstituted diazocycloalkanes
KR101172170B1 (ko) 카파 선택적 오피오이드 수용체 길항제
ES2262612T3 (es) Moduladpres del receptor de glucocorticoides.
JP2011516599A (ja) ニコチン性アセチルコリン受容体サブタイプα７のモジュレーターとしてのインドール類
CN103180299A (zh) 四氢化萘和二氢化茚衍生物、含其的药物组合物及其在治疗中的用途
CN103189337A (zh) 氨基二氢化茚衍生物、包含所述氨基二氢化茚衍生物的药物组合物及其在治疗中的用途
CN103237788A (zh) 苯烷基胺衍生物、包含所述苯烷基胺衍生物的药物组合物及其在治疗中的用途
ITMI971864A1 (it) Derivati 1- (n-fenilaminoalchil) piperazinici sostituiti alla posizione 2 dell'anello fenilico
JP2009518337A (ja) 皮質カテコールアミン作動性神経伝達のモジュレーターとしての二置換フェニルピペリジン
AU2016302755A1 (en) 5-HT2C receptor agonists and compositions and methods of use
HRP20050034A2 (en) N,n-disubstituted diazocycloalkanes useful for the disfunction
DK2546255T3 (en) benzazepine
TW450954B (en) Phenylsulfonamide-phenylethylamines useful as dopamine receptors
JP2007533713A (ja) Ｎ−［４−４（４−モルホリニル）フェニル］−［（４−ピペリジニル）メチル］カルボキシアミド誘導体、およびグリシントランスポーター阻害薬としてのその使用
Gao et al. Design, synthesis and biological evaluation of N1-(isoquinolin-5-yl)-N2-phenylpyrrolidine-1, 2-dicarboxamide derivatives as potent TRPV1 antagonists
EP1683790A1 (en) 3,4-dihydro-2-naphthamide derivatives as selective dopamine D3 ligands
JP2010537951A (ja) 新規化合物
US20040058962A1 (en) Phenylalkylamines and pyridylalkylamines
WO2003106421A2 (en) Phenylalkylamines and pyridylalkylamines
US20040072839A1 (en) 1-Phenylalkylpiperazines
KR20050055628A (ko) 1-페닐알킬-피페라진
JP2009535301A (ja) グリシントランスポーターを阻害する化合物およびその使用
KR20050044867A (ko) 세로토닌계 장애에 기인한 ｃｎｓ 장애 치료에 유용한ｎ,ｎ-이치환 디아조시클로알칸
JP2010126527A (ja) 新規インドール誘導体
JP2007533714A (ja) Ｎ−［６−（４−モルホリニル）−３−ピリジニル］−２−（テトラヒドロ−２ｈ−ピラン−４−イル）−ｎ−［（１−｛［フェニル］メチル｝−４−ピペリジニル）メチル］アセトアミド誘導体および統合失調症などの精神病を治療するためのｇｌｙｔ１輸送阻害剤としての関連化合物

Legal Events

Date Code Title Description
A1OB Publication of a patent application
AIPI Request for the grant of a patent on the basis of a substantive examination of a patent application
ODRP Renewal fee for the maintenance of a patent

Payment date: 20060601

Year of fee payment: 4

OBST Application withdrawn