HRP20040325A2 - Supstituted 4-phenyl-4-[1h-imidazol-2-yl]-piperidine derivatives for reducing ishaemic damagetive substances for the treatment of wounds - Google Patents
Supstituted 4-phenyl-4-[1h-imidazol-2-yl]-piperidine derivatives for reducing ishaemic damagetive substances for the treatment of woundsInfo
- Publication number
- HRP20040325A2 HRP20040325A2 HR20040325A HRP20040325A HRP20040325A2 HR P20040325 A2 HRP20040325 A2 HR P20040325A2 HR 20040325 A HR20040325 A HR 20040325A HR P20040325 A HRP20040325 A HR P20040325A HR P20040325 A2 HRP20040325 A2 HR P20040325A2
- Authority
- HR
- Croatia
- Prior art keywords
- alkyl
- phenyl
- group
- forms
- imidazol
- Prior art date
Links
- GBANLFWFVPIRMO-UHFFFAOYSA-N 4-(1h-imidazol-2-yl)-4-phenylpiperidine Chemical class C1CNCCC1(C=1C=CC=CC=1)C1=NC=CN1 GBANLFWFVPIRMO-UHFFFAOYSA-N 0.000 title description 5
- 239000000126 substance Substances 0.000 title description 4
- 206010052428 Wound Diseases 0.000 title 1
- 208000027418 Wounds and injury Diseases 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims description 134
- 150000003839 salts Chemical class 0.000 claims description 50
- 239000002253 acid Substances 0.000 claims description 48
- -1 phenyloxy, phenylcarbonyloxy Chemical group 0.000 claims description 40
- 230000000302 ischemic effect Effects 0.000 claims description 39
- 241000124008 Mammalia Species 0.000 claims description 36
- 210000002216 heart Anatomy 0.000 claims description 32
- 239000000651 prodrug Substances 0.000 claims description 31
- 229940002612 prodrug Drugs 0.000 claims description 31
- 125000000217 alkyl group Chemical group 0.000 claims description 28
- 238000002360 preparation method Methods 0.000 claims description 25
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 24
- 125000004432 carbon atom Chemical group C* 0.000 claims description 22
- 210000000056 organ Anatomy 0.000 claims description 21
- 239000003814 drug Substances 0.000 claims description 20
- 230000006378 damage Effects 0.000 claims description 19
- 125000005843 halogen group Chemical group 0.000 claims description 17
- 239000001257 hydrogen Substances 0.000 claims description 17
- 229910052739 hydrogen Inorganic materials 0.000 claims description 17
- 125000003545 alkoxy group Chemical group 0.000 claims description 16
- 239000003795 chemical substances by application Substances 0.000 claims description 16
- 210000004556 brain Anatomy 0.000 claims description 15
- 125000001424 substituent group Chemical group 0.000 claims description 12
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 11
- 230000003293 cardioprotective effect Effects 0.000 claims description 11
- 125000004122 cyclic group Chemical group 0.000 claims description 11
- 229940079593 drug Drugs 0.000 claims description 11
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 11
- 125000006684 polyhaloalkyl group Polymers 0.000 claims description 11
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims description 10
- 229910052799 carbon Inorganic materials 0.000 claims description 10
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims description 10
- 229910052760 oxygen Inorganic materials 0.000 claims description 10
- 229930195734 saturated hydrocarbon Natural products 0.000 claims description 10
- 239000004480 active ingredient Substances 0.000 claims description 9
- 210000004072 lung Anatomy 0.000 claims description 9
- 239000003937 drug carrier Substances 0.000 claims description 8
- 230000001939 inductive effect Effects 0.000 claims description 8
- 210000003734 kidney Anatomy 0.000 claims description 8
- 238000004519 manufacturing process Methods 0.000 claims description 8
- 239000003146 anticoagulant agent Substances 0.000 claims description 7
- 239000004615 ingredient Substances 0.000 claims description 7
- 210000004185 liver Anatomy 0.000 claims description 7
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 7
- 125000000446 sulfanediyl group Chemical group *S* 0.000 claims description 7
- 125000005196 alkyl carbonyloxy group Chemical group 0.000 claims description 6
- 125000004414 alkyl thio group Chemical group 0.000 claims description 6
- 230000002491 angiogenic effect Effects 0.000 claims description 6
- 229960004676 antithrombotic agent Drugs 0.000 claims description 6
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 6
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 6
- 125000004473 dialkylaminocarbonyl group Chemical group 0.000 claims description 6
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims description 6
- 239000003102 growth factor Substances 0.000 claims description 6
- 230000008816 organ damage Effects 0.000 claims description 6
- 125000004076 pyridyl group Chemical group 0.000 claims description 6
- 229940124597 therapeutic agent Drugs 0.000 claims description 6
- 125000000335 thiazolyl group Chemical group 0.000 claims description 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 5
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 5
- 125000001624 naphthyl group Chemical group 0.000 claims description 5
- 125000003386 piperidinyl group Chemical group 0.000 claims description 5
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims description 4
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims description 4
- 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 claims description 4
- 125000004541 benzoxazolyl group Chemical group O1C(=NC2=C1C=CC=C2)* 0.000 claims description 4
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 4
- 125000004663 dialkyl amino group Chemical group 0.000 claims description 4
- 125000002883 imidazolyl group Chemical group 0.000 claims description 4
- 125000003884 phenylalkyl group Chemical group 0.000 claims description 4
- 125000004193 piperazinyl group Chemical group 0.000 claims description 4
- 125000000714 pyrimidinyl group Chemical group 0.000 claims description 4
- 125000000168 pyrrolyl group Chemical group 0.000 claims description 4
- 125000001246 bromo group Chemical group Br* 0.000 claims description 3
- 239000008148 cardioplegic solution Substances 0.000 claims description 3
- 125000001309 chloro group Chemical group Cl* 0.000 claims description 3
- IDNSINQXOXDMHW-UHFFFAOYSA-N ethyl 4-(1-benzylimidazol-2-yl)-4-phenylpiperidine-1-carboxylate Chemical compound C1CN(C(=O)OCC)CCC1(C=1C=CC=CC=1)C1=NC=CN1CC1=CC=CC=C1 IDNSINQXOXDMHW-UHFFFAOYSA-N 0.000 claims description 3
- 125000001153 fluoro group Chemical group F* 0.000 claims description 3
- 238000001727 in vivo Methods 0.000 claims description 3
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims description 3
- TXWOTCVSUZXJMH-UHFFFAOYSA-N 2-methoxy-1-[4-phenyl-4-[1-(1-phenylethyl)imidazol-2-yl]piperidin-1-yl]ethanone Chemical compound C1CN(C(=O)COC)CCC1(C=1C=CC=CC=1)C1=NC=CN1C(C)C1=CC=CC=C1 TXWOTCVSUZXJMH-UHFFFAOYSA-N 0.000 claims description 2
- FBLAYKAWVSYTGT-UHFFFAOYSA-N 4-(1-benzylimidazol-2-yl)-n,4-diphenylpiperidine-1-sulfonamide Chemical compound C1CC(C=2C=CC=CC=2)(C=2N(C=CN=2)CC=2C=CC=CC=2)CCN1S(=O)(=O)NC1=CC=CC=C1 FBLAYKAWVSYTGT-UHFFFAOYSA-N 0.000 claims description 2
- DTIMTKCIDGMMKY-UHFFFAOYSA-N 4-[[2-(1-benzoyl-4-phenylpiperidin-4-yl)imidazol-1-yl]methyl]-2-methylbenzoic acid Chemical compound C1=C(C(O)=O)C(C)=CC(CN2C(=NC=C2)C2(CCN(CC2)C(=O)C=2C=CC=CC=2)C=2C=CC=CC=2)=C1 DTIMTKCIDGMMKY-UHFFFAOYSA-N 0.000 claims description 2
- 239000004215 Carbon black (E152) Substances 0.000 claims description 2
- XHGVOFUYLQFSIW-UHFFFAOYSA-N [4-(1-benzylimidazol-2-yl)-4-phenylpiperidin-1-yl]-phenylmethanone Chemical compound C=1C=CC=CC=1C(=O)N(CC1)CCC1(C=1C=CC=CC=1)C1=NC=CN1CC1=CC=CC=C1 XHGVOFUYLQFSIW-UHFFFAOYSA-N 0.000 claims description 2
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- 125000000753 cycloalkyl group Chemical group 0.000 claims description 2
- 125000005883 dithianyl group Chemical group 0.000 claims description 2
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- LJZHXWZDNFILOV-UHFFFAOYSA-N ethyl 4-[1-[(4-methoxycarbonylphenyl)methyl]imidazol-2-yl]-4-phenylpiperidine-1-carboxylate Chemical compound C1CN(C(=O)OCC)CCC1(C=1C=CC=CC=1)C1=NC=CN1CC1=CC=C(C(=O)OC)C=C1 LJZHXWZDNFILOV-UHFFFAOYSA-N 0.000 claims description 2
- NIXTVCWNTYCMHM-UHFFFAOYSA-N ethyl 4-[1-[1-(4-ethoxycarbonylphenyl)ethyl]imidazol-2-yl]-4-phenylpiperidine-1-carboxylate Chemical compound C1CN(C(=O)OCC)CCC1(C=1C=CC=CC=1)C1=NC=CN1C(C)C1=CC=C(C(=O)OCC)C=C1 NIXTVCWNTYCMHM-UHFFFAOYSA-N 0.000 claims description 2
- AZPCCLQAOVOOKT-UHFFFAOYSA-N ethyl 4-phenyl-4-[1-(1-phenylethyl)imidazol-2-yl]piperidine-1-carboxylate Chemical compound C1CN(C(=O)OCC)CCC1(C=1C=CC=CC=1)C1=NC=CN1C(C)C1=CC=CC=C1 AZPCCLQAOVOOKT-UHFFFAOYSA-N 0.000 claims description 2
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- 125000005842 heteroatom Chemical group 0.000 claims description 2
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- 125000002768 hydroxyalkyl group Chemical group 0.000 claims description 2
- 125000002632 imidazolidinyl group Chemical group 0.000 claims description 2
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- JXUWRZZEVUREMV-UHFFFAOYSA-N phenyl-[4-phenyl-4-[1-(1-phenylethyl)imidazol-2-yl]piperidin-1-yl]methanone Chemical compound C1=CN=C(C2(CCN(CC2)C(=O)C=2C=CC=CC=2)C=2C=CC=CC=2)N1C(C)C1=CC=CC=C1 JXUWRZZEVUREMV-UHFFFAOYSA-N 0.000 claims description 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 2
- LFIFXAGOMGUFLO-UHFFFAOYSA-N propan-2-yl 4-(1-benzylimidazol-2-yl)-4-phenylpiperidine-1-carboxylate Chemical compound C1CN(C(=O)OC(C)C)CCC1(C=1C=CC=CC=1)C1=NC=CN1CC1=CC=CC=C1 LFIFXAGOMGUFLO-UHFFFAOYSA-N 0.000 claims description 2
- MYVZSNZLGIJIOS-UHFFFAOYSA-N propyl 4-(1-benzylimidazol-2-yl)-4-phenylpiperidine-1-carboxylate Chemical compound C1CN(C(=O)OCCC)CCC1(C=1C=CC=CC=1)C1=NC=CN1CC1=CC=CC=C1 MYVZSNZLGIJIOS-UHFFFAOYSA-N 0.000 claims description 2
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- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims 3
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01203927 | 2001-10-15 | ||
| PCT/EP2002/011371 WO2003039440A2 (fr) | 2001-10-15 | 2002-10-10 | Derives de 4-phenyl-4-(1h-imidazol-2-yl)-piperidine substituee utiles pour reduire les lesions ischemiques |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20040325A2 true HRP20040325A2 (en) | 2005-04-30 |
Family
ID=8181081
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20040325A HRP20040325A2 (en) | 2001-10-15 | 2004-04-06 | Supstituted 4-phenyl-4-[1h-imidazol-2-yl]-piperidine derivatives for reducing ishaemic damagetive substances for the treatment of wounds |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US7390822B2 (fr) |
| EP (1) | EP1438049B1 (fr) |
| JP (1) | JP4418676B2 (fr) |
| KR (1) | KR100967599B1 (fr) |
| CN (1) | CN1283252C (fr) |
| AR (1) | AR036800A1 (fr) |
| AT (1) | ATE345799T1 (fr) |
| AU (1) | AU2002363369B2 (fr) |
| BR (1) | BR0213325A (fr) |
| CA (1) | CA2462374C (fr) |
| CY (1) | CY1106335T1 (fr) |
| DE (1) | DE60216310T2 (fr) |
| EA (1) | EA007657B1 (fr) |
| ES (1) | ES2276980T3 (fr) |
| HK (1) | HK1072562A1 (fr) |
| HR (1) | HRP20040325A2 (fr) |
| HU (1) | HUP0402332A3 (fr) |
| IL (1) | IL161347A0 (fr) |
| MX (1) | MXPA04003480A (fr) |
| MY (1) | MY139586A (fr) |
| NO (1) | NO20041681L (fr) |
| NZ (1) | NZ531733A (fr) |
| PL (1) | PL370371A1 (fr) |
| PT (1) | PT1438049E (fr) |
| UA (1) | UA75980C2 (fr) |
| WO (1) | WO2003039440A2 (fr) |
| ZA (1) | ZA200402816B (fr) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200403058A (en) * | 2002-04-19 | 2004-03-01 | Bristol Myers Squibb Co | Heterocyclo inhibitors of potassium channel function |
| CL2004000754A1 (es) * | 2003-04-11 | 2005-02-25 | Janssen Pharmaceutica Nv | Uso de compuestos derivados de 4-fenil-4-(1h-imidazol-2-il)piperidina, como agonistas delta-opioides no peptidicos, para preparar un medicamento util en prevenir o tratar trastornos del sistema nervioso central. |
| WO2005005478A2 (fr) * | 2003-07-02 | 2005-01-20 | Bayer Healthcare Ag | Diagnostics et traitements de maladies associees au recepteur opioide delta 1 (oprd1) couple a une proteine g |
| WO2005015242A1 (fr) * | 2003-08-06 | 2005-02-17 | Bayer Healthcare Ag | Agents diagnostiques et agents therapeutiques destines a des maladies associees au recepteur opioide kappa 1 (opkr1) couple aux proteines g |
| TW200633990A (en) | 2004-11-18 | 2006-10-01 | Takeda Pharmaceuticals Co | Amide compound |
| DE502008003324D1 (de) * | 2007-11-30 | 2011-06-01 | Bayer Schering Pharma Ag | Heteroaryl-substituierte piperidine |
| DE102009014484A1 (de) | 2009-03-23 | 2010-09-30 | Bayer Schering Pharma Aktiengesellschaft | Substituierte Piperidine |
| DE102009022896A1 (de) | 2009-05-27 | 2010-12-02 | Bayer Schering Pharma Aktiengesellschaft | Substituierte Piperidine |
| DE102009022894A1 (de) | 2009-05-27 | 2010-12-02 | Bayer Schering Pharma Aktiengesellschaft | Substituierte Piperidine |
| DE102009056387B9 (de) * | 2009-10-30 | 2020-05-07 | Osram Opto Semiconductors Gmbh | Kantenemittierender Halbleiterlaser mit einem Phasenstrukturbereich zur Selektion lateraler Lasermoden |
| JP7450534B2 (ja) | 2017-10-19 | 2024-03-15 | 帝人ファーマ株式会社 | ベンズイミダゾール誘導体及びその用途 |
| CN113209294B (zh) * | 2020-02-05 | 2023-06-13 | 复旦大学 | Dor激动剂在制备对抗肾脏纤维化药物中的应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996027380A1 (fr) | 1995-03-06 | 1996-09-12 | Interneuron Pharmaceuticals, Inc. | Reduction de l'ampleur des infarctus par la citicoline |
| DK2107109T3 (da) | 1996-08-23 | 2012-09-24 | Vegenics Pty Ltd | Rekombinant vaskulær endotelcelle-vækstfaktor D (VEGF-D) |
| JP2001524828A (ja) | 1997-04-25 | 2001-12-04 | コラテラル・セラピューティクス | 切断型ｖｅｇｆ関連蛋白質 |
| US6103722A (en) | 1997-07-23 | 2000-08-15 | The Medical College Of Wisconsin Research Foundation Inc. | Ischemic preconditioning |
| GB2332373A (en) | 1997-12-19 | 1999-06-23 | Merck & Co Inc | Treatment of coronary and/or peripheral ischemia using an antithrombotic agent and an angiogenesis promoter |
| AU764820C (en) | 1998-12-19 | 2004-11-18 | Janssen Pharmaceutica N.V. | Antihistaminic spiro compounds |
| EP1038872A1 (fr) * | 1999-02-22 | 2000-09-27 | Pfizer Products Inc. | Dérivés de 4-phényl-4-hétéroarylpiperdine comme ligands des récepteurs opioides |
| US6297256B1 (en) | 1999-06-15 | 2001-10-02 | Neurogen Corporation | Aryl and heteroaryl substituted pyridino derivatives GABA brain receptor ligands |
| CA2462953C (fr) * | 2001-10-15 | 2011-01-04 | Janssen Pharmaceutica N.V. | Derives substitues de la 4-phenyl-4-[1h-imidazol-2-yl]-piperidine et leur utilisation en tant qu'agonistes selectifs non peptidiques des recepteurs delta-opioides |
| FR2831166B1 (fr) | 2001-10-18 | 2004-02-27 | Sanofi Synthelabo | Aralkyl-tetrahydro-pyridines, leur preparation et compositions pharmaceutiques les contenant |
-
2002
- 2002-10-10 WO PCT/EP2002/011371 patent/WO2003039440A2/fr active IP Right Grant
- 2002-10-10 ES ES02799040T patent/ES2276980T3/es not_active Expired - Lifetime
- 2002-10-10 KR KR1020047002380A patent/KR100967599B1/ko not_active IP Right Cessation
- 2002-10-10 CA CA2462374A patent/CA2462374C/fr not_active Expired - Lifetime
- 2002-10-10 MX MXPA04003480A patent/MXPA04003480A/es active IP Right Grant
- 2002-10-10 AT AT02799040T patent/ATE345799T1/de active
- 2002-10-10 UA UA20040503666A patent/UA75980C2/uk unknown
- 2002-10-10 PL PL02370371A patent/PL370371A1/xx not_active Application Discontinuation
- 2002-10-10 PT PT02799040T patent/PT1438049E/pt unknown
- 2002-10-10 DE DE60216310T patent/DE60216310T2/de not_active Expired - Lifetime
- 2002-10-10 HU HU0402332A patent/HUP0402332A3/hu unknown
- 2002-10-10 NZ NZ531733A patent/NZ531733A/en not_active IP Right Cessation
- 2002-10-10 BR BR0213325-3A patent/BR0213325A/pt not_active Application Discontinuation
- 2002-10-10 US US10/492,778 patent/US7390822B2/en not_active Expired - Fee Related
- 2002-10-10 EA EA200400547A patent/EA007657B1/ru not_active IP Right Cessation
- 2002-10-10 CN CNB028202961A patent/CN1283252C/zh not_active Expired - Fee Related
- 2002-10-10 EP EP02799040A patent/EP1438049B1/fr not_active Expired - Lifetime
- 2002-10-10 JP JP2003541732A patent/JP4418676B2/ja not_active Expired - Fee Related
- 2002-10-10 AU AU2002363369A patent/AU2002363369B2/en not_active Ceased
- 2002-10-10 IL IL16134702A patent/IL161347A0/xx not_active IP Right Cessation
- 2002-10-11 AR ARP020103836A patent/AR036800A1/es unknown
- 2002-10-11 MY MYPI20023801A patent/MY139586A/en unknown
-
2004
- 2004-04-06 HR HR20040325A patent/HRP20040325A2/hr not_active Application Discontinuation
- 2004-04-13 ZA ZA2004/02816A patent/ZA200402816B/en unknown
- 2004-04-23 NO NO20041681A patent/NO20041681L/no not_active Application Discontinuation
-
2005
- 2005-06-28 HK HK05105375A patent/HK1072562A1/xx not_active IP Right Cessation
-
2007
- 2007-02-22 CY CY20071100249T patent/CY1106335T1/el unknown
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