HRP20030192A2 - Fusion protein from antibody cytokine-cytokine inhibitor (selectokine) for use as target specific prodrug - Google Patents
Fusion protein from antibody cytokine-cytokine inhibitor (selectokine) for use as target specific prodrug Download PDFInfo
- Publication number
- HRP20030192A2 HRP20030192A2 HR20030192A HRP20030192A HRP20030192A2 HR P20030192 A2 HRP20030192 A2 HR P20030192A2 HR 20030192 A HR20030192 A HR 20030192A HR P20030192 A HRP20030192 A HR P20030192A HR P20030192 A2 HRP20030192 A2 HR P20030192A2
- Authority
- HR
- Croatia
- Prior art keywords
- region
- polypeptide according
- tnf
- seq
- amino acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/525—Tumour necrosis factor [TNF]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10045592A DE10045592A1 (de) | 2000-09-15 | 2000-09-15 | Ein Antikörper-TNF-TNF Inhibitor Fusionsprotein (TNF-Selektokin) als zielspezifisches Prozytokin zur Tumortherapie |
| PCT/EP2001/010730 WO2002022833A1 (de) | 2000-09-15 | 2001-09-17 | Fusionsprotein aus antikörper-zytokin-zytokin inhibitor (selektokin) als zielspezifisches prodrug |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20030192A2 true HRP20030192A2 (en) | 2005-10-31 |
Family
ID=7656260
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20030192A HRP20030192A2 (en) | 2000-09-15 | 2001-09-17 | Fusion protein from antibody cytokine-cytokine inhibitor (selectokine) for use as target specific prodrug |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US20040053829A1 (pl) |
| EP (1) | EP1317556A1 (pl) |
| JP (1) | JP2004508828A (pl) |
| KR (1) | KR20030048041A (pl) |
| CN (1) | CN1214115C (pl) |
| AU (1) | AU2001293819A1 (pl) |
| BG (1) | BG107613A (pl) |
| BR (1) | BR0113928A (pl) |
| CA (1) | CA2422759A1 (pl) |
| DE (1) | DE10045592A1 (pl) |
| EE (1) | EE200300100A (pl) |
| HR (1) | HRP20030192A2 (pl) |
| HU (1) | HUP0301693A3 (pl) |
| IL (1) | IL154185A0 (pl) |
| MX (1) | MXPA03002229A (pl) |
| NO (1) | NO20031185L (pl) |
| PL (1) | PL360540A1 (pl) |
| RU (1) | RU2003106429A (pl) |
| SK (1) | SK2812003A3 (pl) |
| WO (1) | WO2002022833A1 (pl) |
| YU (1) | YU18903A (pl) |
| ZA (1) | ZA200302008B (pl) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7468354B2 (en) | 2000-12-01 | 2008-12-23 | Genspera, Inc. | Tissue specific prodrugs |
| PE20021080A1 (es) * | 2001-04-12 | 2003-02-12 | Boehringer Ingelheim Int | Un anticuerpo especifico fapo bibh1 en el tratamiento del cancer |
| DE10144252A1 (de) | 2001-08-31 | 2003-03-27 | Fraunhofer Ges Forschung | Nanopartikel mit daran immobilisiertem biologisch aktivem TNF |
| US7057026B2 (en) | 2001-12-04 | 2006-06-06 | Solexa Limited | Labelled nucleotides |
| DE10247755B4 (de) * | 2002-10-14 | 2006-01-19 | Pfizenmaier, Klaus, Prof. Dr. | Selektive, lokale Aktivierung von Mitgliedern der TNF-Rezeptorfamilie durch systemisch inaktive nicht-Antikörper-TNF-Liganden-Fusionsproteine |
| CA2515100A1 (en) * | 2003-02-06 | 2004-08-19 | Micromet Ag | Trimeric polypeptide construct to induce an enduring t cell response |
| US7374898B2 (en) * | 2004-10-12 | 2008-05-20 | The Research Foundation Of State University Of New York | Peptide inhibitors against seprase |
| WO2006117910A1 (ja) | 2005-04-28 | 2006-11-09 | Mochida Pharmaceutical Co., Ltd. | 抗血小板膜糖蛋白質ⅵモノクローナル抗体 |
| EP1736482A1 (en) * | 2005-06-20 | 2006-12-27 | INSERM (Institut National de la Santé et de la Recherche Medicale) | Recombinant trimeric 4-1BBL |
| DE102005036542A1 (de) * | 2005-08-03 | 2007-02-08 | Universität Stuttgart | CTL-Prodrug |
| EP1972350A1 (en) * | 2007-03-20 | 2008-09-24 | Rijksuniversiteit Groningen | Dual targeting system |
| EP2009022A1 (en) * | 2007-06-26 | 2008-12-31 | Apogenix GmbH | Trimeric death ligands with enhanced activity (tenascin) |
| EP2190861A4 (en) * | 2007-08-22 | 2011-03-30 | Univ California | ACTIVE BINDING POLYPEPTIDES AND METHOD FOR THEIR IDENTIFICATION AND USE |
| US8895702B2 (en) | 2008-12-08 | 2014-11-25 | City Of Hope | Development of masked therapeutic antibodies to limit off-target effects; application to anti-EGFR antibodies |
| EP3543256A1 (en) | 2009-01-12 | 2019-09-25 | Cytomx Therapeutics Inc. | Modified antibody compositions, methods of making and using thereof |
| US8399219B2 (en) | 2009-02-23 | 2013-03-19 | Cytomx Therapeutics, Inc. | Protease activatable interferon alpha proprotein |
| CA3115461A1 (en) * | 2018-03-09 | 2019-09-12 | AskGene Pharma, Inc. | Novel cytokine prodrugs |
| US20210130430A1 (en) | 2018-05-14 | 2021-05-06 | Werewolf Therapeutics, Inc. | Activatable cytokine polypeptides and methods of use thereof |
| WO2019222296A1 (en) | 2018-05-14 | 2019-11-21 | Werewolf Therapeutics, Inc. | Activatable interleukin 12 polypeptides and methods of use thereof |
| MX2020012251A (es) | 2018-05-14 | 2021-04-28 | Werewolf Therapeutics Inc | Polipeptidos de interleucina-2 activables y metodos de uso de los mismos. |
| WO2020023702A1 (en) * | 2018-07-25 | 2020-01-30 | AskGene Pharma, Inc. | Novel il-21 prodrugs and methods of use thereof |
| CN113286812B (zh) | 2018-09-27 | 2025-05-30 | 西里欧发展公司 | 掩蔽型细胞因子多肽 |
| BR112021022666A2 (pt) | 2019-05-14 | 2022-03-29 | Werewolf Therapeutics Inc | Frações de separação e seus métodos e uso |
| CN114341189A (zh) * | 2019-06-12 | 2022-04-12 | 奥美药业有限公司 | 全新il-15前药及其应用 |
| EP4017594A1 (en) * | 2019-08-21 | 2022-06-29 | Askgene Pharma, Inc. | Novel il-21 prodrugs and methods of use thereof |
| WO2021062406A1 (en) * | 2019-09-28 | 2021-04-01 | AskGene Pharma, Inc. | Cytokine prodrugs and dual-prodrugs |
| BR112022009110A2 (pt) | 2019-11-14 | 2022-07-26 | Werewolf Therapeutics Inc | Polipeptídeos de citocina ativáveis e métodos de uso destes |
| AU2021205981A1 (en) | 2020-01-11 | 2022-07-14 | AskGene Pharma, Inc. | Novel masked cytokines and methods of use thereof |
| EP4251187A4 (en) | 2020-11-25 | 2025-09-10 | Xilio Dev Inc | TUMOR-SPECIFIC CLASSIBLE LINKERS |
| WO2025151752A1 (en) | 2024-01-10 | 2025-07-17 | Xilio Development, Inc. | Masked il-2 cytokines and methods of use thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1981001145A1 (en) * | 1979-10-18 | 1981-04-30 | Univ Illinois | Hydrolytic enzyme-activatible pro-drugs |
| US5502037A (en) * | 1993-07-09 | 1996-03-26 | Neuromed Technologies, Inc. | Pro-cytotoxic drug conjugates for anticancer therapy |
| US5763733A (en) * | 1994-10-13 | 1998-06-09 | Enzon, Inc. | Antigen-binding fusion proteins |
| US5614191A (en) * | 1995-03-15 | 1997-03-25 | The United States Of America As Represented By The Department Of Health And Human Services | IL-13 receptor specific chimeric proteins and uses thereof |
| DE19900709A1 (de) * | 1999-01-11 | 2000-07-13 | Falkenberg Frank W | Eine neue Applikationsform für biologisch wirksame Substanzen zur Anwendung bei Menschen und Tieren |
-
2000
- 2000-09-15 DE DE10045592A patent/DE10045592A1/de not_active Withdrawn
-
2001
- 2001-09-17 BR BR0113928-2A patent/BR0113928A/pt not_active IP Right Cessation
- 2001-09-17 RU RU2003106429/13A patent/RU2003106429A/ru not_active Application Discontinuation
- 2001-09-17 WO PCT/EP2001/010730 patent/WO2002022833A1/de not_active Ceased
- 2001-09-17 MX MXPA03002229A patent/MXPA03002229A/es unknown
- 2001-09-17 SK SK281-2003A patent/SK2812003A3/sk unknown
- 2001-09-17 IL IL15418501A patent/IL154185A0/xx unknown
- 2001-09-17 US US10/380,438 patent/US20040053829A1/en not_active Abandoned
- 2001-09-17 JP JP2002527275A patent/JP2004508828A/ja active Pending
- 2001-09-17 EP EP01974261A patent/EP1317556A1/de not_active Withdrawn
- 2001-09-17 PL PL36054001A patent/PL360540A1/pl not_active Application Discontinuation
- 2001-09-17 HU HU0301693A patent/HUP0301693A3/hu unknown
- 2001-09-17 CA CA002422759A patent/CA2422759A1/en not_active Abandoned
- 2001-09-17 AU AU2001293819A patent/AU2001293819A1/en not_active Abandoned
- 2001-09-17 CN CNB018157645A patent/CN1214115C/zh not_active Expired - Fee Related
- 2001-09-17 YU YU18903A patent/YU18903A/sh unknown
- 2001-09-17 KR KR10-2003-7003738A patent/KR20030048041A/ko not_active Withdrawn
- 2001-09-17 EE EEP200300100A patent/EE200300100A/xx unknown
- 2001-09-17 HR HR20030192A patent/HRP20030192A2/hr not_active Application Discontinuation
-
2003
- 2003-03-06 BG BG107613A patent/BG107613A/bg unknown
- 2003-03-12 ZA ZA200302008A patent/ZA200302008B/en unknown
- 2003-03-14 NO NO20031185A patent/NO20031185L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2422759A1 (en) | 2003-03-17 |
| US20040053829A1 (en) | 2004-03-18 |
| PL360540A1 (pl) | 2004-09-06 |
| IL154185A0 (en) | 2003-07-31 |
| NO20031185D0 (no) | 2003-03-14 |
| JP2004508828A (ja) | 2004-03-25 |
| RU2003106429A (ru) | 2004-08-27 |
| EP1317556A1 (de) | 2003-06-11 |
| WO2002022833A1 (de) | 2002-03-21 |
| HUP0301693A2 (hu) | 2003-08-28 |
| HUP0301693A3 (en) | 2005-11-28 |
| CN1458977A (zh) | 2003-11-26 |
| MXPA03002229A (es) | 2005-06-20 |
| NO20031185L (no) | 2003-05-05 |
| BR0113928A (pt) | 2003-07-22 |
| BG107613A (bg) | 2003-12-31 |
| DE10045592A1 (de) | 2002-03-28 |
| AU2001293819A1 (en) | 2002-03-26 |
| ZA200302008B (en) | 2004-06-25 |
| EE200300100A (et) | 2005-02-15 |
| CN1214115C (zh) | 2005-08-10 |
| SK2812003A3 (en) | 2003-11-04 |
| YU18903A (sh) | 2006-05-25 |
| KR20030048041A (ko) | 2003-06-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ODRP | Renewal fee for the maintenance of a patent |
Payment date: 20050817 Year of fee payment: 5 |
|
| A1OB | Publication of a patent application | ||
| OBST | Application withdrawn |