HRP20020021B1 - Method for preparing 2-(2-arylmorpholin-2-yl)ethanol derivatives and intermediates - Google Patents

Method for preparing 2-(2-arylmorpholin-2-yl)ethanol derivatives and intermediates

Info

Publication number
HRP20020021B1
HRP20020021B1 HR20020021A HRP20020021A HRP20020021B1 HR P20020021 B1 HRP20020021 B1 HR P20020021B1 HR 20020021 A HR20020021 A HR 20020021A HR P20020021 A HRP20020021 A HR P20020021A HR P20020021 B1 HRP20020021 B1 HR P20020021B1
Authority
HR
Croatia
Prior art keywords
intermediates
arylmorpholin
preparing
ethanol derivatives
derivatives
Prior art date
Application number
HR20020021A
Other languages
English (en)
Inventor
Alain Aulombard
Francoise Bernon
Sabrina Bonnefoy
Alain Burgos
Claude Cabos
Eric Lucas
Original Assignee
Sanofi Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo filed Critical Sanofi Synthelabo
Publication of HRP20020021A2 publication Critical patent/HRP20020021A2/hr
Publication of HRP20020021B1 publication Critical patent/HRP20020021B1/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D265/00Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/281,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/301,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/22Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C215/28Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C07C215/30Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings containing hydroxy groups and carbon atoms of six-membered aromatic rings bound to the same carbon atom of the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/02Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C225/14Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated
    • C07C225/16Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/40Halogenated unsaturated alcohols
    • C07C33/46Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts
    • C07C33/48Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts with unsaturation outside the aromatic rings
    • C07C33/483Monocyclic
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46Friedel-Crafts reactions
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C07C45/562Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with nitrogen as the only hetero atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D303/00Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02Compounds containing oxirane rings
    • C07D303/08Compounds containing oxirane rings with hydrocarbon radicals, substituted by halogen atoms, nitro radicals or nitroso radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Epoxy Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
HR20020021A 1999-07-09 2002-01-09 Method for preparing 2-(2-arylmorpholin-2-yl)ethanol derivatives and intermediates HRP20020021B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9909061A FR2796069B3 (fr) 1999-07-09 1999-07-09 Nouveaux procedes de preparation de derives de 2-(2- arylmorpholin-2-yl)ethanol substitues, enantiomeriquement purs, et composes intermediaires utiles dans ces procedes
PCT/FR2000/001966 WO2001004105A1 (fr) 1999-07-09 2000-07-07 Preparation de derives de 2-(2-arylmorpholin-2-yl)ethanol et intermediaires

Publications (2)

Publication Number Publication Date
HRP20020021A2 HRP20020021A2 (en) 2003-08-31
HRP20020021B1 true HRP20020021B1 (en) 2004-10-31

Family

ID=9548041

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20020021A HRP20020021B1 (en) 1999-07-09 2002-01-09 Method for preparing 2-(2-arylmorpholin-2-yl)ethanol derivatives and intermediates

Country Status (19)

Country Link
US (3) US7038044B1 (cs)
EP (1) EP1200417B1 (cs)
JP (1) JP3891840B2 (cs)
CN (2) CN1266115C (cs)
AT (1) ATE252566T1 (cs)
AU (1) AU6295600A (cs)
BR (1) BR0012324A (cs)
CA (1) CA2378002C (cs)
CZ (1) CZ300744B6 (cs)
DE (1) DE60006125T2 (cs)
ES (1) ES2208381T3 (cs)
FR (1) FR2796069B3 (cs)
HR (1) HRP20020021B1 (cs)
HU (1) HUP0202383A3 (cs)
MX (1) MXPA02000307A (cs)
PL (1) PL203213B1 (cs)
SI (1) SI1200417T1 (cs)
SK (1) SK286671B6 (cs)
WO (1) WO2001004105A1 (cs)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2796069B3 (fr) * 1999-07-09 2001-08-24 Sanofi Synthelabo Nouveaux procedes de preparation de derives de 2-(2- arylmorpholin-2-yl)ethanol substitues, enantiomeriquement purs, et composes intermediaires utiles dans ces procedes
JP2008273841A (ja) * 2005-07-14 2008-11-13 Zeria Pharmaceut Co Ltd エチレンジアミン誘導体及びその製造法
CA3215310A1 (en) * 2010-04-12 2011-10-20 Supernus Pharmaceuticals Inc. Methods for producing viloxazine salts and novel polymorphs thereof
CN115448816B (zh) * 2022-09-16 2024-04-12 中国石油大学(华东) 一种β-氟代烯基醇的合成方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH396942A (de) * 1959-03-21 1965-08-15 Thomae Gmbh Dr K Verfahren zur Herstellung basisch substituierter Carbinole
BE790604A (fr) * 1971-10-28 1973-04-26 Sandoz Sa Nouveaux aminoalcanols, leur preparation et leur application comme medicaments
GB9108629D0 (en) * 1991-04-23 1991-06-12 Wellcome Found Heterocyclic pharmaceutical compounds,preparation and use
FR2729954B1 (fr) 1995-01-30 1997-08-01 Sanofi Sa Composes heterocycliques substitues, procede pour leur preparation et compositions pharmaceutiques les contenant
US5780466A (en) 1995-01-30 1998-07-14 Sanofi Substituted heterocyclic compounds method of preparing them and pharmaceutical compositions in which they are present
US5616777A (en) * 1995-04-19 1997-04-01 Schering Corporation Chiral hydrazine derivatives
US5760466A (en) * 1995-04-20 1998-06-02 Kyocera Corporation Semiconductor device having improved heat resistance
HU224225B1 (hu) * 1995-12-01 2005-06-28 Sankyo Co. Ltd. Tachikinin receptor antagonista hatású heterociklusos vegyületek, ezek előállítási eljárása és alkalmazásuk gyógyszerkészítmények előállítására
WO1999028307A1 (fr) 1997-12-04 1999-06-10 Sankyo Company, Limited Derives heterocycliques alicycliques acyles
CN1249038C (zh) 1998-12-29 2006-04-05 法玛西雅厄普约翰美国公司 芳基醚的制备方法
FR2796069B3 (fr) * 1999-07-09 2001-08-24 Sanofi Synthelabo Nouveaux procedes de preparation de derives de 2-(2- arylmorpholin-2-yl)ethanol substitues, enantiomeriquement purs, et composes intermediaires utiles dans ces procedes

Also Published As

Publication number Publication date
EP1200417A1 (fr) 2002-05-02
US20060149058A1 (en) 2006-07-06
HUP0202383A3 (en) 2004-12-28
SK286671B6 (sk) 2009-03-05
US7378521B2 (en) 2008-05-27
BR0012324A (pt) 2002-03-19
CN1367781A (zh) 2002-09-04
ES2208381T3 (es) 2004-06-16
CN1183121C (zh) 2005-01-05
PL203213B1 (pl) 2009-09-30
CZ200259A3 (cs) 2002-04-17
CA2378002A1 (en) 2001-01-18
DE60006125D1 (de) 2003-11-27
ATE252566T1 (de) 2003-11-15
FR2796069A1 (fr) 2001-01-12
CZ300744B6 (cs) 2009-07-29
MXPA02000307A (es) 2002-07-30
JP2003504362A (ja) 2003-02-04
EP1200417B1 (fr) 2003-10-22
CA2378002C (en) 2007-03-27
HRP20020021A2 (en) 2003-08-31
US20070167623A1 (en) 2007-07-19
CN1534015A (zh) 2004-10-06
US7223860B2 (en) 2007-05-29
AU6295600A (en) 2001-01-30
CN1266115C (zh) 2006-07-26
WO2001004105A1 (fr) 2001-01-18
US7038044B1 (en) 2006-05-02
JP3891840B2 (ja) 2007-03-14
SI1200417T1 (en) 2004-04-30
PL356064A1 (en) 2004-06-14
DE60006125T2 (de) 2004-07-08
FR2796069B3 (fr) 2001-08-24
SK182002A3 (en) 2002-06-04
HUP0202383A2 (hu) 2002-11-28

Similar Documents

Publication Publication Date Title
HU9601857D0 (en) New benzyl-piperidine- or -tetrahydro-pyridine derivatives and processes for producing them
BG101833A (en) Guanine derivative
BG105009A (en) Method for producing 4-carboxyamino-2-substituted 1,2,3,4-tetrahydroquinoline
CY1106743T1 (el) Μεθοδος παρασκευης θειαμεθοξαμης
PL371127A1 (en) 6-aminomorphinane derivatives, method for the production and use thereof
EA200200101A1 (ru) Получение замещенных пиперидин-4-онов
MY120237A (en) Method for the synthesis of quinoline derivatives
AU6578400A (en) Novel method for preparing benzoperhydroisoindole compounds
BG105766A (en) New process for preparing pesticidal intermediates
EP1231215A4 (en) PROCESS FOR PRODUCING ASPARTYLDIPEPTIDE ESTER DERIVATIVES, NOVEL MATCHING INTERMEDIATES AND PROCESS FOR PRODUCING SUCH INTERMEDIATES
HRP20020021B1 (en) Method for preparing 2-(2-arylmorpholin-2-yl)ethanol derivatives and intermediates
BG106002A (en) Process for preparing pesticidal intermediates
MY120024A (en) Process for preparation of eprosartan using regioselective protection of 2,4-disubstituted-imidazole intermediates.
AU2003252467A1 (en) Process for preparation of 1,3-benzodioxole-2-spiro- cycloalkane derivatives
ATE196292T1 (de) Zwischenprodukte um 2-imidazolin-5onederivate herzustellen.
PT1230252E (pt) Derivados de beta-d-5-tioxilose processo de preparacao e utilizacao em terapeutica
AU6584601A (en) Method for producing indols
AU4757000A (en) Method of producing methoxyimino acetic amide
YU71400A (sh) Poboljšani postupak za pripremanje farmaceutski dragocenih derivata norbenzomorfana
AU1392600A (en) Alkyl esters of 3-(3,4-dihalogenophenyl)-2,6-dioxopiperidine-3-propionic acid useful as intermediates
TR200001161A2 (tr) 8-Siklopentil-6-etil-3-[ikame edilmiş]-5, 8-Dihidro-4H-1, 2, 3A, 7, 8-Pentaaza-As-Indasenlerin hazırlandığı işlem ve burada yararlı ara bağlar.
IN184757B (cs)
AU2407400A (en) Process for the formation of intermediates useful for the preparation of pharmaceuticals
MXPA04004537A (es) Derivados de gabusectina, metodo para produccion de los mismos y uso de los mismos.
HU9903736D0 (en) Process an intermediates for preparing hicotinamide derivatives

Legal Events

Date Code Title Description
ARAI Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application
A1OB Publication of a patent application
B1PR Patent granted
PNAN Change of the applicant name, address/residence

Owner name: SANOFI-AVENTIS, FR

ODRP Renewal fee for the maintenance of a patent

Payment date: 20100705

Year of fee payment: 11

PBON Lapse due to non-payment of renewal fee

Effective date: 20110708