HRP20000140A2 - 8a-azalides as veterinary antimicrobial agents - Google Patents
8a-azalides as veterinary antimicrobial agents Download PDFInfo
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- HRP20000140A2 HRP20000140A2 HR20000140A HRP20000140A HRP20000140A2 HR P20000140 A2 HRP20000140 A2 HR P20000140A2 HR 20000140 A HR20000140 A HR 20000140A HR P20000140 A HRP20000140 A HR P20000140A HR P20000140 A2 HRP20000140 A2 HR P20000140A2
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- Prior art keywords
- amino
- alkyl
- hydrogen
- substituted
- infection
- Prior art date
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- 239000004599 antimicrobial Substances 0.000 title description 4
- -1 hydroxy, amino Chemical group 0.000 claims description 56
- 229910052739 hydrogen Inorganic materials 0.000 claims description 38
- 239000001257 hydrogen Substances 0.000 claims description 38
- 238000000034 method Methods 0.000 claims description 32
- 125000003118 aryl group Chemical group 0.000 claims description 23
- 206010057190 Respiratory tract infections Diseases 0.000 claims description 21
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 21
- 125000005843 halogen group Chemical group 0.000 claims description 20
- 241000283690 Bos taurus Species 0.000 claims description 18
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 18
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 16
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 16
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 16
- 241000282887 Suidae Species 0.000 claims description 14
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 14
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims description 14
- 125000004391 aryl sulfonyl group Chemical group 0.000 claims description 14
- 206010022678 Intestinal infections Diseases 0.000 claims description 13
- 125000001072 heteroaryl group Chemical group 0.000 claims description 13
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims description 12
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 12
- 230000001580 bacterial effect Effects 0.000 claims description 12
- 208000015181 infectious disease Diseases 0.000 claims description 12
- 125000004043 oxo group Chemical group O=* 0.000 claims description 11
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 10
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- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 9
- 244000005700 microbiome Species 0.000 claims description 9
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims description 8
- 241000606831 Histophilus somni Species 0.000 claims description 8
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims description 8
- 125000005099 aryl alkyl carbonyl group Chemical group 0.000 claims description 8
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 8
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- 125000005196 alkyl carbonyloxy group Chemical group 0.000 claims description 6
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- 229910052794 bromium Inorganic materials 0.000 claims description 6
- 229910052801 chlorine Inorganic materials 0.000 claims description 6
- 229910052731 fluorine Inorganic materials 0.000 claims description 6
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims description 6
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- 125000004777 2-fluoroethyl group Chemical group [H]C([H])(F)C([H])([H])* 0.000 claims description 4
- 125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 claims description 4
- 125000001494 2-propynyl group Chemical group [H]C#CC([H])([H])* 0.000 claims description 4
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- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 4
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 claims description 4
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- 229950009183 ibufenac Drugs 0.000 description 1
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- DKYWVDODHFEZIM-UHFFFAOYSA-N ketoprofen Chemical compound OC(=O)C(C)C1=CC=CC(C(=O)C=2C=CC=CC=2)=C1 DKYWVDODHFEZIM-UHFFFAOYSA-N 0.000 description 1
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- 150000005599 propionic acid derivatives Chemical class 0.000 description 1
- ROSDSFDQCJNGOL-UHFFFAOYSA-N protonated dimethyl amine Natural products CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 description 1
- YSAUAVHXTIETRK-AATRIKPKSA-N pyrantel Chemical compound CN1CCCN=C1\C=C\C1=CC=CS1 YSAUAVHXTIETRK-AATRIKPKSA-N 0.000 description 1
- 229960005134 pyrantel Drugs 0.000 description 1
- 150000007660 quinolones Chemical class 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
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- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
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- 150000008163 sugars Chemical class 0.000 description 1
- 229960000894 sulindac Drugs 0.000 description 1
- MLKXDPUZXIRXEP-MFOYZWKCSA-N sulindac Chemical compound CC1=C(CC(O)=O)C2=CC(F)=CC=C2\C1=C/C1=CC=C(S(C)=O)C=C1 MLKXDPUZXIRXEP-MFOYZWKCSA-N 0.000 description 1
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- 229940040944 tetracyclines Drugs 0.000 description 1
- JTSDBFGMPLKDCD-XVFHVFLVSA-N tilmicosin Chemical compound O([C@@H]1[C@@H](C)[C@H](O)CC(=O)O[C@@H]([C@H](/C=C(\C)/C=C/C(=O)[C@H](C)C[C@@H]1CCN1C[C@H](C)C[C@H](C)C1)CO[C@H]1[C@@H]([C@H](OC)[C@H](O)[C@@H](C)O1)OC)CC)[C@@H]1O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]1O JTSDBFGMPLKDCD-XVFHVFLVSA-N 0.000 description 1
- 229960000223 tilmicosin Drugs 0.000 description 1
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- YEZNLOUZAIOMLT-UHFFFAOYSA-N tolfenamic acid Chemical compound CC1=C(Cl)C=CC=C1NC1=CC=CC=C1C(O)=O YEZNLOUZAIOMLT-UHFFFAOYSA-N 0.000 description 1
- 229960001017 tolmetin Drugs 0.000 description 1
- UPSPUYADGBWSHF-UHFFFAOYSA-N tolmetin Chemical compound C1=CC(C)=CC=C1C(=O)C1=CC=C(CC(O)=O)N1C UPSPUYADGBWSHF-UHFFFAOYSA-N 0.000 description 1
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- 239000008158 vegetable oil Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5832997P | 1997-09-10 | 1997-09-10 | |
| GBGB9806029.6A GB9806029D0 (en) | 1998-03-20 | 1998-03-20 | 8a-Azalides as veterinary antimicrobial agents |
| PCT/US1998/018573 WO1999012542A1 (fr) | 1997-09-10 | 1998-09-04 | 8a-AZALIDES UTILISES COMME AGENTS ANTIMICROBIENS VETERINAIRES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20000140A2 true HRP20000140A2 (en) | 2000-12-31 |
Family
ID=46203437
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20000140A HRP20000140A2 (en) | 1997-09-10 | 2000-03-10 | 8a-azalides as veterinary antimicrobial agents |
Country Status (9)
| Country | Link |
|---|---|
| KR (1) | KR100426510B1 (fr) |
| AR (1) | AR016920A1 (fr) |
| BE (1) | BE2012C011I2 (fr) |
| BG (1) | BG64765B1 (fr) |
| CY (2) | CY1112647T1 (fr) |
| FR (1) | FR12C0022I2 (fr) |
| HR (1) | HRP20000140A2 (fr) |
| LU (1) | LU91963I2 (fr) |
| NO (1) | NO312746B1 (fr) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2064634C (fr) * | 1991-04-04 | 1998-08-04 | James V. Heck | Derives de 9-desoxo-8a-aza-8a-homoerythromycine a modifies en positions 4"- et 8a |
-
1998
- 1998-09-04 KR KR10-2000-7002497A patent/KR100426510B1/ko not_active IP Right Cessation
- 1998-09-09 AR ARP980104488A patent/AR016920A1/es not_active Application Discontinuation
-
2000
- 2000-03-09 NO NO20001231A patent/NO312746B1/no not_active IP Right Cessation
- 2000-03-10 HR HR20000140A patent/HRP20000140A2/hr not_active Application Discontinuation
- 2000-03-13 BG BG104235A patent/BG64765B1/bg unknown
-
2012
- 2012-02-29 CY CY20121100211T patent/CY1112647T1/el unknown
- 2012-03-21 BE BE2012C011C patent/BE2012C011I2/de unknown
- 2012-03-26 LU LU91963C patent/LU91963I2/fr unknown
- 2012-03-27 FR FR12C0022C patent/FR12C0022I2/fr active Active
- 2012-04-09 CY CY2012008C patent/CY2012008I2/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO312746B1 (no) | 2002-07-01 |
| BG64765B1 (bg) | 2006-03-31 |
| NO20001231D0 (no) | 2000-03-09 |
| KR100426510B1 (ko) | 2004-04-13 |
| BG104235A (en) | 2000-11-30 |
| NO20001231L (no) | 2000-05-08 |
| CY1112647T1 (el) | 2016-02-10 |
| LU91963I2 (fr) | 2012-05-29 |
| FR12C0022I1 (fr) | 2012-04-27 |
| FR12C0022I2 (fr) | 2013-11-01 |
| AR016920A1 (es) | 2001-08-01 |
| CY2012008I1 (el) | 2016-04-13 |
| KR20010023822A (ko) | 2001-03-26 |
| BE2012C011I2 (en) | 2018-02-05 |
| CY2012008I2 (el) | 2016-04-13 |
| LU91963I9 (fr) | 2019-01-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A1OB | Publication of a patent application | ||
| ARAI | Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application | ||
| ODRP | Renewal fee for the maintenance of a patent |
Payment date: 20080904 Year of fee payment: 11 |
|
| PNAN | Change of the applicant name, address/residence |
Owner name: MERCK SHARP & DOHME CORP., US |
|
| ODBI | Application refused |