HK37392A - New morpholino derivatives of daunorubicin and doxorubicin - Google Patents

New morpholino derivatives of daunorubicin and doxorubicin

Info

Publication number
HK37392A
HK37392A HK373/92A HK37392A HK37392A HK 37392 A HK37392 A HK 37392A HK 373/92 A HK373/92 A HK 373/92A HK 37392 A HK37392 A HK 37392A HK 37392 A HK37392 A HK 37392A
Authority
HK
Hong Kong
Prior art keywords
daunorubicin
doxorubicin
new
morpholino derivatives
morpholino
Prior art date
Application number
HK373/92A
Other languages
English (en)
Inventor
Alberto Bargiotti
Pierangelo Zini
Sergio Penco
Fernando Giuliani
Original Assignee
Erba Carlo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Carlo Spa filed Critical Erba Carlo Spa
Publication of HK37392A publication Critical patent/HK37392A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
HK373/92A 1985-03-22 1992-05-28 New morpholino derivatives of daunorubicin and doxorubicin HK37392A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB08507577A GB2172594B (en) 1985-03-22 1985-03-22 New morpholino derivatives of daunorubicin and doxorubicin

Publications (1)

Publication Number Publication Date
HK37392A true HK37392A (en) 1992-06-04

Family

ID=10576503

Family Applications (1)

Application Number Title Priority Date Filing Date
HK373/92A HK37392A (en) 1985-03-22 1992-05-28 New morpholino derivatives of daunorubicin and doxorubicin

Country Status (10)

Country Link
US (1) US4672057A (xx)
JP (1) JPS61221194A (xx)
BE (1) BE904431A (xx)
BG (1) BG60535B2 (xx)
BR (1) BR1100255A (xx)
CZ (1) CZ419591A3 (xx)
DE (1) DE3609052C2 (xx)
GB (1) GB2172594B (xx)
HK (1) HK37392A (xx)
MX (1) MX9203114A (xx)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3823224A1 (de) * 1988-07-08 1990-01-11 Behringwerke Ag Morpholino-derivate der rhodomycine, verfahren zu ihrer herstellung und ihre verwendung
GB8905668D0 (en) * 1989-03-13 1989-04-26 Erba Carlo Spa New 3'-(4-morpholinyl)-and 3'-(2-methoxy-4-morpholinyl)-anthracycline derivatives
US5304687A (en) * 1989-12-19 1994-04-19 Farmitalia Carlo Erba S.R.L. Morpholinyl derivatives of doxorubicin and process for their preparation
DE69028610T2 (de) * 1989-12-19 1997-02-06 Pharmacia S.P.A., Mailand/Milano Chirale 1,5-diiodo-2-methoxy oder benzyloxy Zwischenprodukte
GB9019933D0 (en) * 1990-09-12 1990-10-24 Erba Carlo Spa 13-dihydro-3'-(2-alkoxy-4-morphlinyl)anthracyclines
GB9019934D0 (en) * 1990-09-12 1990-10-24 Erba Carlo Spa 2-hydroxy-and 2-acyloxy-4-morpholinyl anthracyclines
GB9026491D0 (en) * 1990-12-05 1991-01-23 Erba Carlo Spa Anthracycline-conjugates
US5776458A (en) * 1990-12-05 1998-07-07 Pharmacia & Upjohn S.P.A. Anthracycline-conjugates
GB9028105D0 (en) * 1990-12-27 1991-02-13 Erba Carlo Spa Process for the preparation of substituted benzofuran derivatives
GB9216962D0 (en) * 1992-08-11 1992-09-23 Erba Carlo Spa Therapeutically active naphthalenesulfonic-pyrrolecarboxamido derivatives
GB9909925D0 (en) 1999-04-29 1999-06-30 Pharmacia & Upjohn Spa Combined preparations comprising anthracycline derivatives
ATE344801T1 (de) 1999-12-29 2006-11-15 Immunogen Inc Doxorubicin- und daunorubicin-enthaltende, zytotoxische mittel und deren therapeutische anwendung
US20040038904A1 (en) * 2002-05-21 2004-02-26 Angela Ogden Method of treating multiple sclerosis
BRPI0408494A (pt) * 2003-03-18 2006-04-04 Pharmacia Italia Spa terapia combinada contra tumores compreendendo nemorubicina com terapia de radiação
WO2004087097A2 (en) * 2003-03-31 2004-10-14 Yissum Research Development Company Of The Hebrew University Of Jerusalem Stable liposomes or micelles comprising a sphinolipid and a peg-lipopolymer
US20080058274A1 (en) * 2004-11-15 2008-03-06 Yechezkel Barenholz Combination Therapy
JP4513765B2 (ja) * 2005-04-15 2010-07-28 日本ビクター株式会社 電気音響変換器
EA200970116A1 (ru) * 2006-07-12 2009-08-28 НЕРВИАНО МЕДИКАЛ САЙЕНСИЗ С.р.л. Кристаллический гидрохлорид неморубицина
US20100104566A1 (en) * 2007-01-29 2010-04-29 Nerviano Medical Sciences S.R.L. Antitumor combination comprising a morpholinyl anthracycline and an antibody
EP2152236B1 (en) 2007-05-11 2015-09-02 Nerviano Medical Sciences S.r.l. Pharmaceutical composition of an anthracycline
EP2182984A2 (en) * 2007-08-02 2010-05-12 Nerviano Medical Sciences S.r.l. A morpholinyl anthracycline derivative combined with protein kinase inhibitors
WO2009099741A1 (en) 2008-02-01 2009-08-13 Genentech, Inc. Nemorubicin metabolite and analog reagents, antibody-drug conjugates and methods
JP2011513274A (ja) * 2008-02-26 2011-04-28 ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ モルホリニルアントラサイクリン誘導体および脱メチル化剤を含む、抗腫瘍性組合せ
ES2532635T3 (es) 2008-07-15 2015-03-30 Genentech, Inc. Conjugados de antraciclina, proceso para su preparación y su uso como compuestos antitumorales
EP2588490B1 (en) 2010-07-02 2017-02-22 Angiochem Inc. Short and d-amino acid-containing polypeptides for therapeutic conjugates and uses thereof
EP4029881A1 (en) 2010-11-08 2022-07-20 F. Hoffmann-La Roche AG Subcutaneously administered anti-il-6 receptor antibody
CN103270043B (zh) 2010-12-02 2015-12-16 内尔维阿诺医学科学有限公司 用于制备吗啉基蒽环衍生物的方法
CA2867381C (en) 2012-03-16 2016-09-20 The Johns Hopkins University Controlled release formulations for the delivery of hif-1 inhibitors
KR101640912B1 (ko) * 2014-07-03 2016-07-20 현대자동차주식회사 고온 저마찰성 코팅층 및 이의 제조방법
WO2016040825A1 (en) 2014-09-12 2016-03-17 Genentech, Inc. Anthracycline disulfide intermediates, antibody-drug conjugates and methods
EP4180061A1 (en) 2021-11-10 2023-05-17 Nerviano Medical Sciences S.r.l. Anthracycline derivative linker reagents, antibody-drug conjugates and methods

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE639897A (xx) *
US4464529A (en) * 1982-07-20 1984-08-07 Sri International Analogues of morpholinyl daunorubicin and morpholinyl doxorubicin

Also Published As

Publication number Publication date
JPS61221194A (ja) 1986-10-01
BG60535B2 (bg) 1995-07-28
GB2172594B (en) 1988-06-08
BR1100255A (pt) 2002-04-02
DE3609052C2 (de) 1994-10-27
MX9203114A (es) 1992-07-01
GB2172594A (en) 1986-09-24
US4672057A (en) 1987-06-09
GB8507577D0 (en) 1985-05-01
BE904431A (fr) 1986-07-16
DE3609052A1 (de) 1986-09-25
JPH0482160B2 (xx) 1992-12-25
CZ419591A3 (en) 1993-03-17

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Legal Events

Date Code Title Description
PF Patent in force
PE Patent expired

Effective date: 20050321