HK1259338A1 - 通過集體坐標偏置預測錯誤折叠的蛋白質表位的系統和方法 - Google Patents

通過集體坐標偏置預測錯誤折叠的蛋白質表位的系統和方法

Info

Publication number
HK1259338A1
HK1259338A1 HK19101704.4A HK19101704A HK1259338A1 HK 1259338 A1 HK1259338 A1 HK 1259338A1 HK 19101704 A HK19101704 A HK 19101704A HK 1259338 A1 HK1259338 A1 HK 1259338A1
Authority
HK
Hong Kong
Prior art keywords
systems
methods
misfolded protein
protein epitopes
collective coordinate
Prior art date
Application number
HK19101704.4A
Other languages
English (en)
Inventor
S‧S‧普洛特金
Original Assignee
英屬哥倫比亞大學
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 英屬哥倫比亞大學 filed Critical 英屬哥倫比亞大學
Publication of HK1259338A1 publication Critical patent/HK1259338A1/zh

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Classifications

    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B15/00—ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B15/00—ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
    • G16B15/20—Protein or domain folding
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B5/00—ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B50/00—ICT programming tools or database systems specially adapted for bioinformatics

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  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Theoretical Computer Science (AREA)
  • Evolutionary Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioethics (AREA)
  • Databases & Information Systems (AREA)
  • Molecular Biology (AREA)
  • Physiology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
HK19101704.4A 2015-11-09 2019-01-31 通過集體坐標偏置預測錯誤折叠的蛋白質表位的系統和方法 HK1259338A1 (zh)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201562253044P 2015-11-09 2015-11-09
US201662289893P 2016-02-01 2016-02-01
US201662309765P 2016-03-17 2016-03-17
US201662331925P 2016-05-04 2016-05-04
US201662352346P 2016-06-20 2016-06-20
US201662363566P 2016-07-18 2016-07-18
US201662365634P 2016-07-22 2016-07-22
US201662393615P 2016-09-12 2016-09-12
PCT/CA2016/051306 WO2017079836A1 (en) 2015-11-09 2016-11-09 Systems and methods for predicting misfolded protein epitopes by collective coordinate biasing

Publications (1)

Publication Number Publication Date
HK1259338A1 true HK1259338A1 (zh) 2019-11-29

Family

ID=58694580

Family Applications (1)

Application Number Title Priority Date Filing Date
HK19101704.4A HK1259338A1 (zh) 2015-11-09 2019-01-31 通過集體坐標偏置預測錯誤折叠的蛋白質表位的系統和方法

Country Status (9)

Country Link
US (1) US11756650B2 (zh)
EP (1) EP3374906B1 (zh)
JP (1) JP6952351B2 (zh)
KR (1) KR20180093910A (zh)
CN (1) CN108475298A (zh)
CA (1) CA3004593A1 (zh)
DK (1) DK3374906T3 (zh)
HK (1) HK1259338A1 (zh)
WO (1) WO2017079836A1 (zh)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10774120B2 (en) 2015-11-09 2020-09-15 The University Of British Columbia Anti-amyloid beta antibodies binding to a cyclic amyloid beta peptide
JP7452829B2 (ja) 2015-11-09 2024-03-19 ザ・ユニバーシティ・オブ・ブリティッシュ・コロンビア アミロイドベータのエピトープおよびそれに対する抗体
AU2016353552B2 (en) 2015-11-09 2022-01-06 The University Of British Columbia N-terminal epitopes in Amyloid beta and conformationally-selective antibodies thereto
US20180125920A1 (en) * 2016-11-09 2018-05-10 The University Of British Columbia Methods for preventing and treating A-beta oligomer-associated and/or -induced diseases and conditions
WO2018218352A1 (en) 2017-05-30 2018-12-06 The University Of British Columbia Epitopes in the rna recognition motif 1 (rrm1) of tdp-43 and misfolding-selective antibodies thereto
CN109086565B (zh) * 2018-07-12 2021-11-23 浙江工业大学 一种基于残基间接触约束的蛋白质结构预测方法
CN109273048B (zh) * 2018-09-12 2021-08-03 浙江工业大学 一种蛋白质表面残基的快速确定方法
CN114927160A (zh) * 2022-03-03 2022-08-19 北京晶泰科技有限公司 热点残基和靶点蛋白复合物结构的生成方法及装置
CN116386712B (zh) * 2023-02-20 2024-02-09 北京博康健基因科技有限公司 一种基于抗原蛋白动态空间结构的表位预测方法及装置

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Publication number Priority date Publication date Assignee Title
ATE359561T1 (de) 1997-06-02 2007-05-15 Univ Johns Hopkins Rechnerverfahren freie energieberechnung für ligandenentwurf verwendend und die voraussage von bindenden zielen
US6277970B1 (en) * 1999-05-11 2001-08-21 The Regents Of The University Of California PRP-like gene
DE10059720A1 (de) * 2000-11-30 2002-06-06 Roche Diagnostics Gmbh Verwendung intramolekular kovalent vernetzter Proteine als Bindepartner in Immunoassays
CN101082944A (zh) * 2007-06-01 2007-12-05 哈尔滨工程大学 基于综合算法的蛋白质折叠过程的计算机模拟方法
WO2009046257A1 (en) * 2007-10-05 2009-04-09 Ut-Battelle, Llc Identification and modification of dynamical regions in proteins for alteration of enzyme catalytic effect
WO2010036927A2 (en) 2008-09-26 2010-04-01 The Regents Of The University Of Michigan High-throughput ensemble-based docking and elucidation of 3-dimensional structural conformations of flexible biomolecular targets
JP5898495B2 (ja) 2008-10-06 2016-04-06 ザ ユニヴァーシティ オブ ブリティッシュ コロンビア ミスフォールドタンパク質エピトープを予測するための方法およびシステム
BR112012006727A2 (pt) * 2009-09-25 2019-09-24 Shanghai National Engineering Res Center Of Antibody Medicine Co Ltd método de aquisição de proteínas com alta afinidade por um desenho auxiliado por computador
RU2644335C2 (ru) 2010-03-03 2018-02-08 Зе Юниверсити Оф Бритиш Коламбия Эпитоп, специфичный к олигомеру амилоида бета, и антитела
DE102010026094B4 (de) * 2010-07-05 2012-01-12 Sigeng Han Ein neues Verfahren zum Charakterisieren und multidimensionalen Darstellen des Faltungsvorgangs der Proteine
JP5697638B2 (ja) * 2011-09-26 2015-04-08 富士フイルム株式会社 質点系の挙動を予測するシミュレーション装置およびシミュレーション方法並びにその方法を実行するためのプログラムおよび記録媒体
CA2881934C (en) * 2012-08-17 2021-06-29 Zymeworks Inc. Systems and methods for sampling and analysis of polymer conformational dynamics
EP3052514A4 (en) * 2013-10-04 2017-08-09 The Johns Hopkins University Insertion of ionizable groups in the interior of proteins as a strategy for engineering artificial ph-sensitive switch proteins
US20180346534A1 (en) 2015-11-09 2018-12-06 The University Of British Columbia C-terminal epitopes in amyloid beta and conformationally-selective antibodies thereto
US10774120B2 (en) 2015-11-09 2020-09-15 The University Of British Columbia Anti-amyloid beta antibodies binding to a cyclic amyloid beta peptide
JP7452829B2 (ja) 2015-11-09 2024-03-19 ザ・ユニバーシティ・オブ・ブリティッシュ・コロンビア アミロイドベータのエピトープおよびそれに対する抗体
AU2016353552B2 (en) 2015-11-09 2022-01-06 The University Of British Columbia N-terminal epitopes in Amyloid beta and conformationally-selective antibodies thereto
KR20180088661A (ko) 2015-11-09 2018-08-06 더 유니버시티 오브 브리티쉬 콜롬비아 아밀로이드 베타에서의 에피토프 및 이에 형태적으로-선택적인 항체

Also Published As

Publication number Publication date
EP3374906B1 (en) 2022-01-05
DK3374906T3 (da) 2022-03-07
CN108475298A (zh) 2018-08-31
EP3374906A1 (en) 2018-09-19
JP2018538254A (ja) 2018-12-27
US11756650B2 (en) 2023-09-12
JP6952351B2 (ja) 2021-10-20
CA3004593A1 (en) 2017-05-18
US20180330045A1 (en) 2018-11-15
EP3374906A4 (en) 2019-08-07
WO2017079836A1 (en) 2017-05-18
KR20180093910A (ko) 2018-08-22

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