HK1258312A1 - 高效誘導人多能幹細胞向心肌細胞分化的小分子化合物組合物 - Google Patents

高效誘導人多能幹細胞向心肌細胞分化的小分子化合物組合物

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Publication number
HK1258312A1
HK1258312A1 HK19100679.7A HK19100679A HK1258312A1 HK 1258312 A1 HK1258312 A1 HK 1258312A1 HK 19100679 A HK19100679 A HK 19100679A HK 1258312 A1 HK1258312 A1 HK 1258312A1
Authority
HK
Hong Kong
Prior art keywords
small molecule
pluripotent stem
cells
human pluripotent
compound composition
Prior art date
Application number
HK19100679.7A
Other languages
English (en)
Inventor
荊清
邱曉旭
劉洋
張一凡
Original Assignee
中國科學院上海生命科學研究院
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Application filed by 中國科學院上海生命科學研究院 filed Critical 中國科學院上海生命科學研究院
Publication of HK1258312A1 publication Critical patent/HK1258312A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0657—Cardiomyocytes; Heart cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/34—Muscles; Smooth muscle cells; Heart; Cardiac stem cells; Myoblasts; Myocytes; Cardiomyocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/04—Immunosuppressors, e.g. cyclosporin, tacrolimus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C12N2501/415—Wnt; Frizzeled
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cardiology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
HK19100679.7A 2016-01-20 2019-01-15 高效誘導人多能幹細胞向心肌細胞分化的小分子化合物組合物 HK1258312A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201610038160.4A CN106987555B (zh) 2016-01-20 2016-01-20 高效诱导人多能干细胞向心肌细胞分化的小分子化合物组合物
PCT/CN2017/070989 WO2017124963A1 (zh) 2016-01-20 2017-01-12 高效诱导人多能干细胞向心肌细胞分化的小分子化合物组合物

Publications (1)

Publication Number Publication Date
HK1258312A1 true HK1258312A1 (zh) 2019-11-08

Family

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Family Applications (1)

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HK19100679.7A HK1258312A1 (zh) 2016-01-20 2019-01-15 高效誘導人多能幹細胞向心肌細胞分化的小分子化合物組合物

Country Status (6)

Country Link
EP (1) EP3406248A4 (zh)
JP (1) JP6713159B6 (zh)
CN (1) CN106987555B (zh)
CA (1) CA3012064C (zh)
HK (1) HK1258312A1 (zh)
WO (1) WO2017124963A1 (zh)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2019321641A1 (en) * 2018-08-17 2021-04-15 Frequency Therapeutics, Inc. Compositions and methods for generating hair cells by upregulating Jag-1
US11850266B2 (en) * 2019-06-06 2023-12-26 President And Fellows Of Harvard College Cardiomyocytes and compositions and methods for producing the same
KR102200612B1 (ko) * 2020-04-29 2021-02-01 네이처바이오팜(주) 항생제 저항성 유전자를 포함하는 테라토마 제거용 dna 구조체
CN111876377A (zh) * 2020-07-07 2020-11-03 湖南师范大学 一种基于自噬的干细胞心肌细胞诱导分化方法及其应用
CN112359012B (zh) * 2020-10-22 2022-11-25 中国科学院水生生物研究所 诱导多能干细胞分化制备心脏瓣膜内皮细胞的方法及其应用
CN113249310B (zh) * 2021-05-17 2022-10-11 湖北大学 一种拓展性多能干细胞诱导分化为心肌细胞的方法及应用
WO2024041645A1 (zh) * 2022-08-25 2024-02-29 北京大学 用于制备心肌细胞的化合物及其用途
CN117511976A (zh) * 2023-11-08 2024-02-06 西北农林科技大学 一种Tnnt2 H2B-mCherry报告细胞系的构建方法及应用
CN117467599B (zh) * 2023-12-27 2024-03-29 广东省农业科学院动物科学研究所 一种重编程鸡性腺体细胞为鸡多能干细胞的化学诱导剂及重编程方法

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006027545A2 (en) * 2004-09-10 2006-03-16 Agency For Science, Technology And Research Method
KR101996343B1 (ko) * 2012-01-27 2019-07-05 고쿠리츠 다이가쿠 호진 교토 다이가쿠 전능성 줄기세포의 심근분화 유도방법
AU2013295940B2 (en) * 2012-07-23 2019-01-31 Institute Of Biophysics, Chinese Academy Of Sciences Method for inducing pluripotent stem cells to differentiate into ventricular myocytes in vitro
SG11201500918YA (en) * 2012-08-07 2015-04-29 Singapore Health Serv Pte Ltd Method, combination and/or composition for inducing cardiomyocyte differentation
JP6494515B2 (ja) * 2012-10-19 2019-04-03 エージェンシー フォー サイエンス， テクノロジー アンド リサーチ 幹細胞を１又は２以上の細胞系列に分化させる方法

Also Published As

Publication number Publication date
CN106987555B (zh) 2021-10-19
EP3406248A4 (en) 2019-09-04
WO2017124963A1 (zh) 2017-07-27
CN106987555A (zh) 2017-07-28
EP3406248A1 (en) 2018-11-28
JP2019506157A (ja) 2019-03-07
CA3012064C (en) 2021-10-19
JP6713159B2 (ja) 2020-06-24
JP6713159B6 (ja) 2020-07-22
CA3012064A1 (en) 2017-07-27

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