HK1258115A1 - 用於治療呼吸道合胞病毒(rsv)感染的n-[(3-氨基-3-氧雜環丁基)甲基]-2-(2，3-二氫-1，1-二氧代-1，4-苯並噻氮䓬-4(5h)-基)-6-甲基-4-喹唑啉胺的晶形 - Google Patents
用於治療呼吸道合胞病毒(rsv)感染的n-[(3-氨基-3-氧雜環丁基)甲基]-2-(2，3-二氫-1，1-二氧代-1，4-苯並噻氮䓬-4(5h)-基)-6-甲基-4-喹唑啉胺的晶形Info
- Publication number
- HK1258115A1 HK1258115A1 HK19100140.8A HK19100140A HK1258115A1 HK 1258115 A1 HK1258115 A1 HK 1258115A1 HK 19100140 A HK19100140 A HK 19100140A HK 1258115 A1 HK1258115 A1 HK 1258115A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- methyl
- benzothiazepin
- quinazolinamine
- dioxido
- oxetanyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2015084225 | 2015-07-16 | ||
| PCT/EP2016/066482 WO2017009316A1 (en) | 2015-07-16 | 2016-07-12 | Crystalline forms of n-[(3-amino-3-oxetanyl)methyl]-2-(2,3-dihydro-1,1 -dioxido-1,4-benzothiazepin-4(5 h)-yl)-6-methyl-4-quinazolinamine for the treatment of respiratory syncytial virus (rsv) infections |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1258115A1 true HK1258115A1 (zh) | 2019-11-01 |
Family
ID=56409089
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK19100140.8A HK1258115A1 (zh) | 2015-07-16 | 2019-01-04 | 用於治療呼吸道合胞病毒(rsv)感染的n-[(3-氨基-3-氧雜環丁基)甲基]-2-(2，3-二氫-1，1-二氧代-1，4-苯並噻氮䓬-4(5h)-基)-6-甲基-4-喹唑啉胺的晶形 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US10071999B2 (zh) |
| EP (1) | EP3322704B1 (zh) |
| JP (1) | JP6779972B2 (zh) |
| CN (1) | CN108290882B (zh) |
| HK (1) | HK1258115A1 (zh) |
| TW (1) | TWI706949B (zh) |
| WO (1) | WO2017009316A1 (zh) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3322704B1 (en) * | 2015-07-16 | 2019-11-27 | H. Hoffnabb-La Roche Ag | Crystalline form of n-[(3-amino-3-oxetanyl)methyl]-2-(2,3-dihydro-1,1-dioxido-1,4-benzothiazepin-4(5h)-yl)-6-methyl-4-quinazolinamine for the treatment of respiratory syncytial virus (rsv) infections |
| MX2021011144A (es) | 2019-03-18 | 2022-01-18 | Enanta Pharm Inc | Derivados de las benzodiazepinas como inhibidores del vsr. |
| JP7357157B2 (ja) * | 2019-10-31 | 2023-10-05 | シャンハイ アーク バイオファーマスゥ－ティカル カンパニー リミテッド | 呼吸器合胞体ウイルス融合タンパク質阻害剤組成物及びそれを用いてｒｓｖ感染を治療及び予防する方法 |
| CN113149977A (zh) * | 2020-01-22 | 2021-07-23 | 苏州爱科百发生物医药技术有限公司 | 一类呼吸道合胞病毒抑制剂的合成与用途 |
| CN118239945A (zh) * | 2022-12-22 | 2024-06-25 | 甫康（上海）健康科技有限责任公司 | 一种苯并硫氮杂卓类化合物及其制备方法与用途 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1383409A (en) | 1972-09-09 | 1974-02-12 | Pfizer Ltd | Derivatives of 2-amino- and 4-amino-quinazoline and pharmaceutical compositions containing them |
| US6774134B2 (en) | 2000-12-20 | 2004-08-10 | Bristol-Myers Squibb Company | Heterocyclic substituted 2-methyl-benzimidazole antiviral agents |
| WO2005061513A1 (en) | 2003-12-24 | 2005-07-07 | Biota Scientific Management Pty Ltd | Polycyclic agents for the treatment of respiratory syncytial virus infections |
| US8871756B2 (en) * | 2011-08-11 | 2014-10-28 | Hoffmann-La Roche Inc. | Compounds for the treatment and prophylaxis of Respiratory Syncytial Virus disease |
| KR20140088555A (ko) | 2011-10-11 | 2014-07-10 | 에프. 호프만-라 로슈 아게 | 호흡기 세포융합 바이러스 질환의 치료 및 예방을 위한 화합물 |
| BR112015028475A2 (pt) | 2013-05-14 | 2017-07-25 | Hoffmann La Roche | novos aza-oxo-indois para o tratamento ou profilaxia de infecção virótica respiratória sincitial |
| AR099134A1 (es) * | 2014-01-24 | 2016-06-29 | Hoffmann La Roche | Procedimiento para la preparación de n-[(3-aminooxetán-3-il)metil]-2-(1,1-dioxo-3,5-dihidro-1,4-benzotiazepín-4-il)-6-metil-quinazolín-4-amina |
| EP3322704B1 (en) * | 2015-07-16 | 2019-11-27 | H. Hoffnabb-La Roche Ag | Crystalline form of n-[(3-amino-3-oxetanyl)methyl]-2-(2,3-dihydro-1,1-dioxido-1,4-benzothiazepin-4(5h)-yl)-6-methyl-4-quinazolinamine for the treatment of respiratory syncytial virus (rsv) infections |
-
2016
- 2016-07-12 EP EP16738155.7A patent/EP3322704B1/en active Active
- 2016-07-12 JP JP2018502002A patent/JP6779972B2/ja active Active
- 2016-07-12 CN CN201680038283.6A patent/CN108290882B/zh active Active
- 2016-07-12 WO PCT/EP2016/066482 patent/WO2017009316A1/en active Application Filing
- 2016-07-15 TW TW105122484A patent/TWI706949B/zh active
-
2018
- 2018-01-12 US US15/870,151 patent/US10071999B2/en active Active
- 2018-08-08 US US16/058,684 patent/US10556896B2/en active Active
-
2019
- 2019-01-04 HK HK19100140.8A patent/HK1258115A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| TWI706949B (zh) | 2020-10-11 |
| TW201708215A (zh) | 2017-03-01 |
| EP3322704A1 (en) | 2018-05-23 |
| EP3322704B1 (en) | 2019-11-27 |
| US10071999B2 (en) | 2018-09-11 |
| WO2017009316A1 (en) | 2017-01-19 |
| US20180155337A1 (en) | 2018-06-07 |
| CN108290882B (zh) | 2021-07-06 |
| JP2018520188A (ja) | 2018-07-26 |
| JP6779972B2 (ja) | 2020-11-04 |
| CN108290882A (zh) | 2018-07-17 |
| US20190092766A1 (en) | 2019-03-28 |
| US10556896B2 (en) | 2020-02-11 |
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