HK1252631A1 - 替諾福韋艾拉酚胺的共晶體，鹽和固體形式 - Google Patents
替諾福韋艾拉酚胺的共晶體，鹽和固體形式Info
- Publication number
- HK1252631A1 HK1252631A1 HK18111934.6A HK18111934A HK1252631A1 HK 1252631 A1 HK1252631 A1 HK 1252631A1 HK 18111934 A HK18111934 A HK 18111934A HK 1252631 A1 HK1252631 A1 HK 1252631A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- crystals
- salts
- solid forms
- tenofovir alafenamide
- alafenamide
- Prior art date
Links
- 239000013078 crystal Substances 0.000 title 1
- 150000003839 salts Chemical group 0.000 title 1
- 239000007787 solid Chemical group 0.000 title 1
- LDEKQSIMHVQZJK-CAQYMETFSA-N tenofovir alafenamide Chemical compound O([P@@](=O)(CO[C@H](C)CN1C2=NC=NC(N)=C2N=C1)N[C@@H](C)C(=O)OC(C)C)C1=CC=CC=C1 LDEKQSIMHVQZJK-CAQYMETFSA-N 0.000 title 1
- 229960004946 tenofovir alafenamide Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
- C07C57/13—Dicarboxylic acids
- C07C57/15—Fumaric acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562180963P | 2015-06-17 | 2015-06-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1252631A1 true HK1252631A1 (zh) | 2019-05-31 |
Family
ID=56204022
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK18111934.6A HK1252631A1 (zh) | 2015-06-17 | 2018-09-17 | 替諾福韋艾拉酚胺的共晶體，鹽和固體形式 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US9777028B2 (zh) |
| EP (2) | EP3310797A1 (zh) |
| JP (1) | JP2018524308A (zh) |
| AU (2) | AU2016277859B2 (zh) |
| CA (1) | CA2987085A1 (zh) |
| HK (1) | HK1252631A1 (zh) |
| MA (1) | MA46677A (zh) |
| WO (1) | WO2016205141A1 (zh) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107427529A (zh) | 2014-12-26 | 2017-12-01 | 埃莫里大学 | N4‑羟基胞苷和衍生物及与其相关的抗病毒用途 |
| WO2018115046A1 (en) * | 2016-12-23 | 2018-06-28 | Sandoz Ag | Crystalline solid forms of tenofovir alafenamide |
| CN108341841B (zh) * | 2017-01-22 | 2020-07-17 | 成都倍特药业股份有限公司 | 一种替诺福韦艾拉酚胺与门冬氨酸的盐 |
| TWI820984B (zh) * | 2017-01-31 | 2023-11-01 | 美商基利科學股份有限公司 | 替諾福韋埃拉酚胺(tenofovir alafenamide)之晶型 |
| RU2647576C1 (ru) * | 2017-02-28 | 2018-03-16 | Васильевич Иващенко Александр | Циклобутил (S)-2-[[[(R)-2-(6-аминопурин-9-ил)-1-метил-этокси]метил-фенокси-фосфорил]амино]-пропаноаты, способ их получения и применения |
| KR102626210B1 (ko) | 2017-12-07 | 2024-01-18 | 에모리 유니버시티 | N4-하이드록시사이티딘 및 유도체 및 이와 관련된 항-바이러스 용도 |
| CN108997428B (zh) * | 2018-06-13 | 2021-04-13 | 中山大学 | 一种替诺福韦艾拉酚胺与香草酸的共晶及其制备方法 |
| US20220257619A1 (en) | 2019-07-18 | 2022-08-18 | Gilead Sciences, Inc. | Long-acting formulations of tenofovir alafenamide |
| CN110746461A (zh) * | 2019-11-20 | 2020-02-04 | 江苏科本药业有限公司 | 一种替诺福韦衍生物盐及其制备方法和一种药物组合物 |
| WO2021165995A1 (en) | 2020-02-20 | 2021-08-26 | Cipla Limited | Novel salts and/or co-crystals of tenofovir alafenamide |
| US20230144640A1 (en) | 2020-03-25 | 2023-05-11 | Bosch Corporation | Event data processing device and vehicle assessment system |
| US11667656B2 (en) | 2021-01-27 | 2023-06-06 | Apotex Inc. | Crystalline forms of Tenofovir alafenamide |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5922695A (en) | 1996-07-26 | 1999-07-13 | Gilead Sciences, Inc. | Antiviral phosphonomethyoxy nucleotide analogs having increased oral bioavarilability |
| EP0903341A1 (en) * | 1997-07-22 | 1999-03-24 | Akzo Nobel N.V. | "Novel ortho-mercaptoaniline compounds" |
| KR100749160B1 (ko) | 2000-07-21 | 2007-08-14 | 길리애드 사이언시즈, 인코포레이티드 | 포스포네이트 뉴클레오티드 유사체의 전구 약물의 제조방법 |
| MY140618A (en) * | 2003-02-28 | 2009-12-31 | Kowa Co | Method for preparing acid addition salts of polyacidic basic compounds |
| WO2005014532A1 (en) * | 2003-08-08 | 2005-02-17 | Transtech Pharma, Inc. | Aryl and heteroaryl compounds, compositions and methods of use |
| HUE031253T2 (en) | 2011-08-16 | 2017-07-28 | Gilead Sciences Inc | Tenofovir alafenamid hemifumarate |
| US9676803B2 (en) * | 2013-06-07 | 2017-06-13 | Cipla Limited | Efficient process for separation of diastereomers of 9-[(R)-2-[[(R,S)-[[(S)-1-(isopropoxycarbonyl)ethyl]amino]-phenoxyphosphinyl]methoxy]propyl]adenine |
| WO2015040640A2 (en) * | 2013-09-20 | 2015-03-26 | Laurus Labs Private Limited | An improved process for the preparation of tenofovir alafenamide or pharmaceutically acceptable salts thereof |
| ES2842123T3 (es) * | 2014-01-14 | 2021-07-12 | Mylan Laboratories Ltd | Purificación de tenofovir alafenamida y sus intermedios |
| CN105085571A (zh) * | 2014-05-20 | 2015-11-25 | 四川海思科制药有限公司 | 替诺福韦艾拉酚胺复合物及其制备方法和用途 |
| CN104558036A (zh) * | 2014-12-11 | 2015-04-29 | 杭州和泽医药科技有限公司 | 一种替诺福韦艾拉酚胺半反丁烯二酸盐晶型及其制备方法 |
| CZ2015384A3 (cs) | 2015-06-05 | 2016-12-14 | Zentiva, K.S. | Pevné formy Tenofovir alafenamidu |
-
2016
- 2016-06-13 CA CA2987085A patent/CA2987085A1/en not_active Abandoned
- 2016-06-13 EP EP16732143.9A patent/EP3310797A1/en not_active Withdrawn
- 2016-06-13 EP EP22168367.5A patent/EP4092037A1/en active Pending
- 2016-06-13 AU AU2016277859A patent/AU2016277859B2/en not_active Ceased
- 2016-06-13 US US15/181,213 patent/US9777028B2/en active Active
- 2016-06-13 WO PCT/US2016/037268 patent/WO2016205141A1/en active Application Filing
- 2016-06-13 MA MA046677A patent/MA46677A/fr unknown
- 2016-06-13 JP JP2017564860A patent/JP2018524308A/ja active Pending
-
2017
- 2017-09-05 US US15/695,878 patent/US10155781B2/en active Active
-
2018
- 2018-09-17 HK HK18111934.6A patent/HK1252631A1/zh unknown
-
2019
- 2019-07-15 AU AU2019205989A patent/AU2019205989A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20160368938A1 (en) | 2016-12-22 |
| US10155781B2 (en) | 2018-12-18 |
| JP2018524308A (ja) | 2018-08-30 |
| MA46677A (fr) | 2019-09-11 |
| AU2016277859A1 (en) | 2017-12-14 |
| US20180127446A1 (en) | 2018-05-10 |
| WO2016205141A1 (en) | 2016-12-22 |
| US9777028B2 (en) | 2017-10-03 |
| CA2987085A1 (en) | 2016-12-22 |
| EP4092037A1 (en) | 2022-11-23 |
| AU2016277859B2 (en) | 2019-08-01 |
| EP3310797A1 (en) | 2018-04-25 |
| AU2019205989A1 (en) | 2019-08-01 |
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