HK1249507A1 - 用於治療炎性障礙的新化合物及其藥物組合物 - Google Patents
用於治療炎性障礙的新化合物及其藥物組合物Info
- Publication number
- HK1249507A1 HK1249507A1 HK18109028.7A HK18109028A HK1249507A1 HK 1249507 A1 HK1249507 A1 HK 1249507A1 HK 18109028 A HK18109028 A HK 18109028A HK 1249507 A1 HK1249507 A1 HK 1249507A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- treatment
- pharmaceutical compositions
- novel compounds
- inflammatory disorders
- disorders
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 1
- 208000027866 inflammatory disease Diseases 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Obesity (AREA)
- Oncology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Child & Adolescent Psychology (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361781174P | 2013-03-14 | 2013-03-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1249507A1 true HK1249507A1 (zh) | 2018-11-02 |
Family
ID=50236198
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK16107731.1A HK1219730A1 (zh) | 2013-03-14 | 2016-07-04 | 用於治療炎性障礙的化合物及其藥物組合物 |
HK18109028.7A HK1249507A1 (zh) | 2013-03-14 | 2018-07-11 | 用於治療炎性障礙的新化合物及其藥物組合物 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK16107731.1A HK1219730A1 (zh) | 2013-03-14 | 2016-07-04 | 用於治療炎性障礙的化合物及其藥物組合物 |
Country Status (30)
Country | Link |
---|---|
US (7) | US8993590B2 (zh) |
EP (3) | EP3760630A1 (zh) |
JP (2) | JP6339595B2 (zh) |
KR (2) | KR20210034098A (zh) |
CN (1) | CN105143221B (zh) |
AR (1) | AR095280A1 (zh) |
AU (3) | AU2014231009B2 (zh) |
BR (1) | BR112015020998B1 (zh) |
CA (1) | CA2902103C (zh) |
CY (2) | CY1119352T1 (zh) |
DK (2) | DK3269716T3 (zh) |
ES (2) | ES2638980T3 (zh) |
HK (2) | HK1219730A1 (zh) |
HR (2) | HRP20171219T1 (zh) |
HU (2) | HUE035966T2 (zh) |
IL (2) | IL240531B (zh) |
LT (2) | LT3269716T (zh) |
MX (1) | MX358342B (zh) |
MY (1) | MY170260A (zh) |
NZ (1) | NZ711202A (zh) |
PH (1) | PH12015502055A1 (zh) |
PL (2) | PL2970255T3 (zh) |
PT (2) | PT2970255T (zh) |
RU (1) | RU2675818C2 (zh) |
SG (1) | SG11201507224RA (zh) |
SI (2) | SI2970255T1 (zh) |
TW (2) | TWI749290B (zh) |
UY (1) | UY35437A (zh) |
WO (1) | WO2014139882A1 (zh) |
ZA (1) | ZA201505909B (zh) |
Families Citing this family (71)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PE20141678A1 (es) | 2011-09-14 | 2014-11-21 | Samumed Llc | Indazol-3-carboxamidas y su uso como inhibidores de la ruta de senalizacion de wnt/b-catenina |
PH12017500997A1 (en) | 2012-04-04 | 2018-02-19 | Samumed Llc | Indazole inhibitors of the wnt signal pathway and therapeutic uses thereof |
MY170260A (en) | 2013-03-14 | 2019-07-13 | Galapagos Nv | Novel compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders |
CN105339370B (zh) | 2013-06-19 | 2017-09-15 | 加拉帕戈斯股份有限公司 | 用于治疗炎症性疾病的化合物和及其药物组合物 |
US9943677B2 (en) | 2013-10-15 | 2018-04-17 | Radux Devices, LLC | Securing a medical device to a valve instrument |
PL3197277T3 (pl) | 2014-08-29 | 2022-04-04 | Chdi Foundation, Inc. | Sondy do obrazowania molekularnego białka huntingtyny |
WO2016040180A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 3-(1h-benzo[d]imidazol-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof |
WO2016040181A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 3-(1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof |
WO2016040184A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 3-(3h-imidazo[4,5-b]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof |
WO2016040193A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 3-(1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridine and therapeutic uses thereof |
WO2016040185A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 2-(1h-indazol-3-yl)-3h-imidazo[4,5-b]pyridine and therapeutic uses thereof |
GB201501870D0 (en) | 2015-02-04 | 2015-03-18 | Cancer Rec Tech Ltd | Autotaxin inhibitors |
GB201502020D0 (en) | 2015-02-06 | 2015-03-25 | Cancer Rec Tech Ltd | Autotaxin inhibitory compounds |
EP3302465A1 (en) | 2015-06-05 | 2018-04-11 | Vertex Pharmaceuticals Incorporated | Triazoles for the treatment of demyelinating diseases |
US10206908B2 (en) | 2015-08-03 | 2019-02-19 | Samumed, Llc | 3-(1H-pyrrolo[3,2-C]pyridin-2-YL)-1H-pyrazolo[3,4-C]pyridines and therapeutic uses thereof |
WO2017023986A1 (en) | 2015-08-03 | 2017-02-09 | Samumed, Llc | 3-(1h-indol-2-yl)-1h-indazoles and therapeutic uses thereof |
WO2017024015A1 (en) | 2015-08-03 | 2017-02-09 | Samumed, Llc. | 3-(3h-imidazo[4,5-b]pyridin-2-yl)-1h-pyrazolo[4,3-b]pyridines and therapeutic uses thereof |
WO2017023972A1 (en) | 2015-08-03 | 2017-02-09 | Samumed, Llc. | 3-(1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[4,3-b]pyridines and therapeutic uses thereof |
WO2017024025A1 (en) | 2015-08-03 | 2017-02-09 | Sunil Kumar Kc | 3-(1h-pyrrolo[2,3-c]pyridin-2-yl)-1h-pyrazolo[4,3-b]pyridines and therapeutic uses thereof |
WO2017023993A1 (en) | 2015-08-03 | 2017-02-09 | Samumed, Llc. | 3-(1h-indol-2-yl)-1h-pyrazolo[4,3-b]pyridines and therapeutic uses thereof |
WO2017024003A1 (en) | 2015-08-03 | 2017-02-09 | Samumed, Llc | 3-(1h-pyrrolo[3,2-c]pyridin-2-yl)-1h-pyrazolo[4,3-b]pyridines and therapeutic uses thereof |
US10392383B2 (en) | 2015-08-03 | 2019-08-27 | Samumed, Llc | 3-(1H-benzo[d]imidazol-2-yl)-1H-pyrazolo[4,3-b]pyridines and therapeutic uses thereof |
WO2017023980A1 (en) | 2015-08-03 | 2017-02-09 | Samumed, Llc. | 3-(1h-pyrrolo[2,3-b]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridines and therapeutic uses thereof |
US10350199B2 (en) | 2015-08-03 | 2019-07-16 | Samumed, Llc | 3-(1h-pyrrolo[2,3-b]pyridin-2-yl)-1h-indazoles and therapeutic uses thereof |
US10226448B2 (en) | 2015-08-03 | 2019-03-12 | Samumed, Llc | 3-(1H-pyrrolo[3,2-C]pyridin-2-yl)-1H-pyrazolo[3,4-B]pyridines and therapeutic uses thereof |
WO2017024010A1 (en) | 2015-08-03 | 2017-02-09 | Samumed, Llc. | 3-(1h-pyrrolo[3,2-c]pyridin-2-yl)-1h-indazoles and therapeutic uses thereof |
WO2017024004A1 (en) | 2015-08-03 | 2017-02-09 | Samumed, Llc. | 3-(1h-pyrrolo[2,3-b]pyridin-2-yl)-1h-pyrazolo[4,3-b]pyridines and therapeutic uses thereof |
US10383861B2 (en) | 2015-08-03 | 2019-08-20 | Sammumed, LLC | 3-(1H-pyrrolo[2,3-C]pyridin-2-yl)-1H-pyrazolo[3,4-C]pyridines and therapeutic uses thereof |
US10285983B2 (en) | 2015-08-03 | 2019-05-14 | Samumed, Llc | 3-(1H-pyrrolo[2,3-B]pyridin-2-yl)-1H-pyrazolo[3,4-B] pyridines and therapeutic uses thereof |
BR112018009252A2 (pt) | 2015-11-06 | 2018-11-06 | Samumed Llc | tratamento da osteoartrite |
WO2017192228A1 (en) * | 2016-05-06 | 2017-11-09 | Albert Einstein College Of Medicine, Inc. | Pak1 inhibitors and uses thereof |
SI3464285T1 (sl) | 2016-06-01 | 2023-02-28 | Biosplice Therapeutics, Inc. | Postopek za pripravo N-(5-(3-(7-(3-fluorofenil)-3H-imidazo(4,5-C)piridin-2-il)-1H-indazol-5- il)piridin-3-il)-3-metilbutanamida |
AU2017345699A1 (en) | 2016-10-21 | 2019-05-16 | Samumed, Llc | Methods of using indazole-3-carboxamides and their use as Wnt/B-catenin signaling pathway inhibitors |
US11165073B2 (en) | 2016-10-24 | 2021-11-02 | Precision Combustion, Inc. | Solid oxide electrolysis cell with internal heater |
WO2018085865A1 (en) | 2016-11-07 | 2018-05-11 | Samumed, Llc | Single-dose, ready-to-use injectable formulations |
WO2018106643A1 (en) | 2016-12-06 | 2018-06-14 | Vertex Pharmaceuticals Incorporated | Heterocyclic azoles for the treatment of demyelinating diseases |
WO2018106646A1 (en) | 2016-12-06 | 2018-06-14 | Vertex Pharmaceuticals Incorporated | Aminotriazoles for the treatment of demyelinating diseases |
WO2018106641A1 (en) | 2016-12-06 | 2018-06-14 | Vertex Pharmaceuticals Incorporated | Pyrazoles for the treatment of demyelinating diseases |
GB201710851D0 (en) | 2017-07-06 | 2017-08-23 | Galápagos Nv | Novel compounds and pharmaceutical compositions thereof for the treatment of fibrosis |
CN111033634A (zh) | 2017-08-09 | 2020-04-17 | 加拉帕戈斯股份有限公司 | 用于治疗纤维化疾病的化合物及其药物组合物 |
WO2019029620A1 (zh) * | 2017-08-09 | 2019-02-14 | 广州市恒诺康医药科技有限公司 | Atx抑制剂及其制备方法和应用 |
RU2020119415A (ru) | 2017-11-15 | 2021-12-16 | Галапагос Нв | Соединения и их фармацевтические композиции для применения при лечении фиброзных заболеваний |
CN110156772B (zh) * | 2018-02-14 | 2020-08-07 | 苏州信诺维医药科技有限公司 | 一种杂环化合物、其应用及含其的药物组合物 |
JP7274767B2 (ja) * | 2018-05-24 | 2023-05-17 | ▲広▼州市恒▲諾▼康医▲薬▼科技有限公司 | 芳香族複素環式化合物及びその医薬組成物 |
US10711000B2 (en) | 2018-05-29 | 2020-07-14 | Fronthera U.S. Pharmaceuticals Llc | Autotaxin inhibitors and uses thereof |
EP3728257A4 (en) * | 2018-05-29 | 2021-06-23 | Fronthera U.S. Pharmaceuticals LLC | AUTOTAXIN INHIBITORS AND USES THEREOF |
CN112469699B (zh) | 2018-07-27 | 2024-02-23 | 田边三菱制药株式会社 | 新型3,5-二取代吡啶和3,5-二取代哒嗪衍生物及其医药用途 |
GB201812861D0 (en) | 2018-08-08 | 2018-09-19 | Galapagos Nv | Methods of administering therapy |
MX2021004860A (es) | 2018-10-29 | 2021-06-15 | Boehringer Ingelheim Int | Piridazinas novedosas. |
US11633399B2 (en) | 2018-12-25 | 2023-04-25 | Sol-Gel Technologies Ltd. | Treatment of skin disorders with compositions comprising an EGFR inhibitor |
GB201904375D0 (en) * | 2019-03-29 | 2019-05-15 | Galapagos Nv | Novel compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders |
CN113874354B (zh) * | 2019-06-04 | 2024-02-20 | 江苏恒瑞医药股份有限公司 | 吡啶酮类衍生物、其制备方法及其在医药上的应用 |
US11485727B2 (en) | 2019-07-22 | 2022-11-01 | Boehringer Ingelheim International Gmbh | N-methyl, n-(6-(methoxy)pyridazin-3-yl) amine derivatives as autotaxin (ATX) modulators |
BR112021026267A2 (pt) | 2019-07-22 | 2022-05-31 | Boehringer Ingelheim Int | Derivados de n-metil, n-((6-(metoxi)piridazin-3-il)amina como moduladores de autotaxina (atx) para o tratamento de doenças fibróticas ou inflamatórias das vias aéreas |
US11465982B2 (en) * | 2019-07-22 | 2022-10-11 | Boehringer Ingelheim International Gmbh | Pyridazines |
EP3782997A1 (en) | 2019-08-19 | 2021-02-24 | Galapagos N.V. | Fused pyrimidine compounds and pharmaceutical compositions thereof for the treatment of fibrotic diseases |
BR112022004099A2 (pt) * | 2019-09-06 | 2022-05-31 | Wuhan Humanwell Innovative Drug Res And Development Center Limited Company | Composto, composição farmacêutica, uso do composto, e, método para o tratamento de uma doença relacionada ao atx |
CN112778334B (zh) * | 2019-11-07 | 2022-04-15 | 广州市恒诺康医药科技有限公司 | 芳杂环化合物、其药物组合物及其应用 |
CN111004235A (zh) * | 2019-11-29 | 2020-04-14 | 沈阳药科大学 | 一种ATX抑制剂Ziritaxestat的合成方法 |
CN113493453B (zh) * | 2020-04-07 | 2023-06-16 | 江苏恒瑞医药股份有限公司 | 稠合芳香环类衍生物、其制备方法及其在医药上的应用 |
US20230295159A1 (en) * | 2020-07-09 | 2023-09-21 | Suzhou Ark Biopharmaceutical Co., Ltd. | Atx inhibitor, and preparation method therefor and use thereof |
MX2023004115A (es) | 2020-10-06 | 2023-05-03 | Ildong Pharmaceutical Co Ltd | Compuestos del inhibidor de la autotaxina. |
CN116437917A (zh) * | 2020-11-04 | 2023-07-14 | 四川海思科制药有限公司 | Atx抑制剂氘代衍生物及其应用 |
EP4242211A4 (en) * | 2020-11-16 | 2024-05-22 | Guangzhou Henovcom Bioscience Co., Ltd. | IMIDAZOTHIAZOLE COMPOUND, PHARMACEUTICAL COMPOSITION THEREOF AND USE THEREOF |
US20230091528A1 (en) | 2021-02-02 | 2023-03-23 | Liminal Biosciences Limited | Gpr84 antagonists and uses thereof |
AU2022216810A1 (en) | 2021-02-02 | 2023-08-24 | Liminal Biosciences Limited | Gpr84 antagonists and uses thereof |
WO2023235871A2 (en) * | 2022-06-03 | 2023-12-07 | Seer, Inc. | Systems, compositions, and methods relating to neurodegenerative diseases |
KR102587919B1 (ko) * | 2022-07-22 | 2023-10-11 | 주식회사 넥스트젠바이오사이언스 | 신규한 헤테로사이클릭 화합물 및 이를 포함하는 오토탁신 저해용 약학 조성물 |
WO2024028364A1 (en) | 2022-08-02 | 2024-02-08 | Liminal Biosciences Limited | Aryl-triazolyl and related gpr84 antagonists and uses thereof |
WO2024028365A1 (en) | 2022-08-02 | 2024-02-08 | Liminal Biosciences Limited | Substituted pyridone gpr84 antagonists and uses thereof |
WO2024028363A1 (en) | 2022-08-02 | 2024-02-08 | Liminal Biosciences Limited | Heteroaryl carboxamide and related gpr84 antagonists and uses thereof |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR0014818A (pt) * | 1999-10-08 | 2002-06-18 | Gruenenthal Gmbh | Imidazo-3-il-aminas bicìclicas procedimento de preparação e medicamentos que contém como substância ativa pelo menos uma imidazo-3-il-amina bicìclica |
PT1622912E (pt) * | 2003-04-23 | 2009-08-17 | Schering Corp | Antagonistas 2-alcinil- e 2-alcenilpirazolo-[4,3-b]-1,2,4- triazolo-[1,5-c]-pirimidina do receptor a2a da adenosina |
US20080015193A1 (en) * | 2006-06-20 | 2008-01-17 | Mendoza Jose S | Certain azoles exhibiting ATP-utilizing enzyme inhibitory activity, compositions, and uses thereof |
US8227603B2 (en) * | 2006-08-01 | 2012-07-24 | Cytokinetics, Inc. | Modulating skeletal muscle |
US8148369B2 (en) * | 2007-05-10 | 2012-04-03 | Janssen Pharmaceutica Nv | Fused pyrazine compounds useful for the treatment of degenerative and inflammatory diseases |
DE102008059578A1 (de) | 2008-11-28 | 2010-06-10 | Merck Patent Gmbh | Benzo-Naphtyridin Verbindungen |
JP5697601B2 (ja) * | 2008-12-01 | 2015-04-08 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung | 癌に対するオータキシン阻害剤としての2,5−ジアミノ−置換ピリド[4,3−d]ピリミジン |
EP2414346B1 (en) | 2009-04-02 | 2015-06-24 | Merck Patent GmbH | Autotaxin inhibitors |
TW201120043A (en) * | 2009-11-05 | 2011-06-16 | Galapagos Nv | Fused pyrazine compounds as their salts, useful for the treatment of degenerative and inflammatory diseases |
EP2338888A1 (en) * | 2009-12-24 | 2011-06-29 | Almirall, S.A. | Imidazopyridine derivatives as JAK inhibitors |
CN103201262B (zh) * | 2010-08-20 | 2016-06-01 | 艾米拉医药股份有限公司 | 自分泌运动因子抑制剂及其用途 |
US20130052190A1 (en) * | 2011-02-22 | 2013-02-28 | Oxagen Limited | CRTH2 Antagonists for Treatment of Eosinophilic Diseases and Conditions |
WO2012166415A1 (en) * | 2011-05-27 | 2012-12-06 | Amira Pharmaceuticals, Inc. | Heterocyclic autotaxin inhibitors and uses thereof |
MY170260A (en) * | 2013-03-14 | 2019-07-13 | Galapagos Nv | Novel compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders |
-
2014
- 2014-03-07 MY MYPI2015703027A patent/MY170260A/en unknown
- 2014-03-07 JP JP2015562040A patent/JP6339595B2/ja active Active
- 2014-03-07 LT LTEP17177371.6T patent/LT3269716T/lt unknown
- 2014-03-07 EP EP20189787.3A patent/EP3760630A1/en not_active Withdrawn
- 2014-03-07 WO PCT/EP2014/054440 patent/WO2014139882A1/en active Application Filing
- 2014-03-07 LT LTEP14708291.1T patent/LT2970255T/lt unknown
- 2014-03-07 ES ES14708291.1T patent/ES2638980T3/es active Active
- 2014-03-07 PL PL14708291T patent/PL2970255T3/pl unknown
- 2014-03-07 BR BR112015020998-0A patent/BR112015020998B1/pt active IP Right Grant
- 2014-03-07 SI SI201430403T patent/SI2970255T1/sl unknown
- 2014-03-07 SI SI201431673T patent/SI3269716T1/sl unknown
- 2014-03-07 AU AU2014231009A patent/AU2014231009B2/en active Active
- 2014-03-07 EP EP14708291.1A patent/EP2970255B9/en active Active
- 2014-03-07 CN CN201480014005.8A patent/CN105143221B/zh active Active
- 2014-03-07 SG SG11201507224RA patent/SG11201507224RA/en unknown
- 2014-03-07 HU HUE14708291A patent/HUE035966T2/en unknown
- 2014-03-07 PT PT147082911T patent/PT2970255T/pt unknown
- 2014-03-07 MX MX2015011077A patent/MX358342B/es active IP Right Grant
- 2014-03-07 KR KR1020217008013A patent/KR20210034098A/ko not_active Application Discontinuation
- 2014-03-07 EP EP17177371.6A patent/EP3269716B1/en active Active
- 2014-03-07 PT PT171773716T patent/PT3269716T/pt unknown
- 2014-03-07 NZ NZ711202A patent/NZ711202A/en unknown
- 2014-03-07 ES ES17177371T patent/ES2824723T3/es active Active
- 2014-03-07 DK DK17177371.6T patent/DK3269716T3/da active
- 2014-03-07 DK DK14708291.1T patent/DK2970255T3/en active
- 2014-03-07 RU RU2015143430A patent/RU2675818C2/ru active
- 2014-03-07 PL PL17177371T patent/PL3269716T3/pl unknown
- 2014-03-07 CA CA2902103A patent/CA2902103C/en active Active
- 2014-03-07 HU HUE17177371A patent/HUE051195T2/hu unknown
- 2014-03-07 KR KR1020157029122A patent/KR102231637B1/ko active IP Right Grant
- 2014-03-11 TW TW108104845A patent/TWI749290B/zh active
- 2014-03-11 TW TW103108497A patent/TWI695002B/zh active
- 2014-03-12 AR ARP140100893A patent/AR095280A1/es active IP Right Grant
- 2014-03-12 US US14/205,885 patent/US8993590B2/en active Active
- 2014-03-14 UY UY35437A patent/UY35437A/es not_active Application Discontinuation
- 2014-12-17 US US14/572,870 patent/US9249141B2/en active Active
-
2015
- 2015-08-12 IL IL240531A patent/IL240531B/en active IP Right Grant
- 2015-08-17 ZA ZA2015/05909A patent/ZA201505909B/en unknown
- 2015-09-11 PH PH12015502055A patent/PH12015502055A1/en unknown
- 2015-12-22 US US14/977,918 patent/US9670204B2/en active Active
-
2016
- 2016-07-04 HK HK16107731.1A patent/HK1219730A1/zh unknown
-
2017
- 2017-05-01 US US15/583,161 patent/US10125132B2/en active Active
- 2017-08-09 HR HRP20171219TT patent/HRP20171219T1/hr unknown
- 2017-09-06 CY CY20171100940T patent/CY1119352T1/el unknown
- 2017-12-20 AU AU2017286828A patent/AU2017286828B2/en active Active
- 2017-12-27 IL IL256624A patent/IL256624B/en active IP Right Grant
-
2018
- 2018-04-05 JP JP2018072964A patent/JP6517976B2/ja active Active
- 2018-07-11 HK HK18109028.7A patent/HK1249507A1/zh unknown
- 2018-09-28 US US16/146,450 patent/US10526329B2/en active Active
-
2019
- 2019-06-27 AU AU2019204539A patent/AU2019204539B2/en active Active
- 2019-11-13 US US16/682,553 patent/US11072611B2/en active Active
-
2020
- 2020-10-09 CY CY20201100953T patent/CY1123521T1/el unknown
- 2020-10-13 HR HRP20201641TT patent/HRP20201641T1/hr unknown
-
2021
- 2021-06-18 US US17/351,765 patent/US20230022534A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HK1249507A1 (zh) | 用於治療炎性障礙的新化合物及其藥物組合物 | |
IL257581A (en) | New dihydropyrimidineisoquinolinones and their pharmaceutical preparations for the treatment of inflammatory disorders | |
IL246833A0 (en) | New salts and their pharmaceutical preparations for the treatment of inflammatory disorders | |
IL255109A0 (en) | New dihydropyridoisoquinolinones and their pharmaceutical preparations for the treatment of inflammatory disorders | |
IL241264A0 (en) | Compounds and compositions for the treatment of parasitic diseases | |
GB201402070D0 (en) | Pharmaceutical compositions for the treatment of inflammatory disorders | |
HK1220611A1 (zh) | 用於治療胃腸道病症的組成物 | |
GB201411241D0 (en) | Novel dihydropyridoisoquinolinones and pharmaceutical compositions thereof for the treatment of inflammatory disorders | |
GB201401086D0 (en) | Novel compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders | |
PT2859896T (pt) | Composições farmacêuticas para o tratamento de distúrbios musculares | |
GB201315079D0 (en) | Novel compounds useful for the treatment of degenerative and inflammatory diseases | |
GB201314016D0 (en) | Novel compounds useful for the treatment of degenerative and inflammatory diseases |