HK1246231A1 - 作為egfr抑制劑的新的嘧啶和治療病症的方法 - Google Patents

作為egfr抑制劑的新的嘧啶和治療病症的方法

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Publication number
HK1246231A1
HK1246231A1 HK18105758.1A HK18105758A HK1246231A1 HK 1246231 A1 HK1246231 A1 HK 1246231A1 HK 18105758 A HK18105758 A HK 18105758A HK 1246231 A1 HK1246231 A1 HK 1246231A1
Authority
HK
Hong Kong
Prior art keywords
methods
treating disorders
egfr inhibitors
novel pyrimidines
pyrimidines
Prior art date
Application number
HK18105758.1A
Other languages
English (en)
Inventor
Nathanael S Gray
Pasi Janne
Hwan Geun Choi
Jaebong Jang
Original Assignee
Dana Farber Cancer Inst Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dana Farber Cancer Inst Inc filed Critical Dana Farber Cancer Inst Inc
Publication of HK1246231A1 publication Critical patent/HK1246231A1/zh

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  • Pain & Pain Management (AREA)
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HK18105758.1A 2014-12-23 2018-05-04 作為egfr抑制劑的新的嘧啶和治療病症的方法 HK1246231A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462096053P 2014-12-23 2014-12-23
PCT/US2015/000286 WO2016105525A2 (en) 2014-12-23 2015-12-23 Novel pyrimidines as egfr inhibitors and methods of treating disorders

Publications (1)

Publication Number Publication Date
HK1246231A1 true HK1246231A1 (zh) 2018-09-07

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HK18105758.1A HK1246231A1 (zh) 2014-12-23 2018-05-04 作為egfr抑制劑的新的嘧啶和治療病症的方法

Country Status (4)

Country Link
US (4) US10266517B2 (zh)
CN (2) CN113563332A (zh)
HK (1) HK1246231A1 (zh)
WO (1) WO2016105525A2 (zh)

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CN111170998B (zh) 2014-11-05 2023-04-11 益方生物科技(上海)股份有限公司 嘧啶或吡啶类化合物、其制备方法和医药用途
WO2016105525A2 (en) * 2014-12-23 2016-06-30 Dana-Farber Cancer Institute, Inc. Novel pyrimidines as egfr inhibitors and methods of treating disorders
CN106117185B (zh) 2015-08-31 2017-11-07 广州必贝特医药技术有限公司 2,4‑二含氮基团取代嘧啶类化合物及其制备方法和应用
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TWI726968B (zh) 2016-01-07 2021-05-11 開曼群島商Ｃｓ醫藥技術公司 Egfr酪胺酸激酶之臨床重要突變體之選擇性抑制劑
JOP20190080A1 (ar) * 2016-10-14 2019-04-11 Bayer Pharma AG مركبات مشتقة من 6-(1h-بيرازول-1-يل) بيريميدين-4- أمين مستبدل واستخداماتها
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WO2022237825A1 (zh) * 2021-05-13 2022-11-17 上海和誉生物医药科技有限公司 具有egfr抑制活性的氮杂芳基衍生物、其制备方法和应用
CN113288899B (zh) * 2021-05-17 2022-10-11 浙江工业大学 一种杂环硫醇类化合物在制备抗肿瘤药物中的应用
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CN115701429B (zh) * 2021-08-02 2024-03-12 上海和誉生物医药科技有限公司 4-(1h-吲哚-1-基)嘧啶-2-氨基衍生物及其制备方法和应用
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US10870636B2 (en) 2020-12-22
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US20170362204A1 (en) 2017-12-21
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