HK1246231A1 - 作為egfr抑制劑的新的嘧啶和治療病症的方法 - Google Patents

作為egfr抑制劑的新的嘧啶和治療病症的方法

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Publication number
HK1246231A1
HK1246231A1 HK18105758.1A HK18105758A HK1246231A1 HK 1246231 A1 HK1246231 A1 HK 1246231A1 HK 18105758 A HK18105758 A HK 18105758A HK 1246231 A1 HK1246231 A1 HK 1246231A1
Authority
HK
Hong Kong
Prior art keywords
methods
treating disorders
egfr inhibitors
novel pyrimidines
pyrimidines
Prior art date
Application number
HK18105758.1A
Other languages
English (en)
Inventor
Nathanael S Gray
Pasi Janne
Hwan Geun Choi
Jaebong Jang
Original Assignee
Dana Farber Cancer Inst Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dana Farber Cancer Inst Inc filed Critical Dana Farber Cancer Inst Inc
Publication of HK1246231A1 publication Critical patent/HK1246231A1/zh

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  • Pain & Pain Management (AREA)
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  • Diabetes (AREA)
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HK18105758.1A 2014-12-23 2018-05-04 作為egfr抑制劑的新的嘧啶和治療病症的方法 HK1246231A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462096053P 2014-12-23 2014-12-23
PCT/US2015/000286 WO2016105525A2 (en) 2014-12-23 2015-12-23 Novel pyrimidines as egfr inhibitors and methods of treating disorders

Publications (1)

Publication Number Publication Date
HK1246231A1 true HK1246231A1 (zh) 2018-09-07

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Application Number Title Priority Date Filing Date
HK18105758.1A HK1246231A1 (zh) 2014-12-23 2018-05-04 作為egfr抑制劑的新的嘧啶和治療病症的方法

Country Status (4)

Country Link
US (4) US10266517B2 (zh)
CN (2) CN113563332A (zh)
HK (1) HK1246231A1 (zh)
WO (1) WO2016105525A2 (zh)

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MX2020008767A (es) * 2018-02-23 2021-01-08 Univ Michigan Regents Disruptores del dímero egfr y uso de estos.
CN110041302B (zh) * 2019-03-01 2021-11-30 南方医科大学 2-氨基-4-取代吡啶衍生物及其合成方法和应用
CN111747931A (zh) * 2019-03-29 2020-10-09 深圳福沃药业有限公司 用于治疗癌症的氮杂芳环酰胺衍生物
KR20220125279A (ko) * 2020-01-07 2022-09-14 다나-파버 캔서 인스티튜트 인크. Ｅｇｆｒ/ｈｅｒ２의 시아노-피리미딘 억제제
WO2022076589A1 (en) * 2020-10-07 2022-04-14 Dana-Farber Cancer Institute, Inc. Covalent egfr inhibitors and methods of use thereof
CN113004246B (zh) * 2021-02-22 2022-02-01 广西医科大学 1，3，5-三嗪-2-胺-4，6取代衍生物或其药学上可接受的盐和用途
CN116670126A (zh) * 2021-05-13 2023-08-29 上海和誉生物医药科技有限公司 具有egfr抑制活性的氮杂芳基衍生物、其制备方法和应用
CN113288899B (zh) * 2021-05-17 2022-10-11 浙江工业大学 一种杂环硫醇类化合物在制备抗肿瘤药物中的应用
AU2022297453A1 (en) 2021-06-22 2024-01-04 Crimson Biopharm Inc. (1h-pyrrolo[2,3-b]pyridin-1-yl)pyrimidin-2-yl-amino-phenyl--acrylamide inhibitors of egfr for use in the treatment of brain tumors
EP4367116A1 (en) * 2021-07-07 2024-05-15 Crimson Biopharm Inc. Crystalline polymorphs of epidermal growth factor receptor inhibitor, and compositions and methods thereof
CN115701429B (zh) * 2021-08-02 2024-03-12 上海和誉生物医药科技有限公司 4-(1h-吲哚-1-基)嘧啶-2-氨基衍生物及其制备方法和应用
WO2023213850A1 (en) * 2022-05-03 2023-11-09 Deutsches Zentrum Für Neurodegenerative Erkrankungen E. V. (Dzne) Inhibitors of tau proteins
WO2024026056A2 (en) * 2022-07-29 2024-02-01 Accutar Biotechnology, Inc. Heteroaryl compounds as egfr inhibitors and their uses

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