HK1225607A1 - 新型2，4-二硝基苯酚製劑及使用其的方法 - Google Patents

新型2，4-二硝基苯酚製劑及使用其的方法

Info

Publication number
HK1225607A1
HK1225607A1 HK16113846A HK16113846A HK1225607A1 HK 1225607 A1 HK1225607 A1 HK 1225607A1 HK 16113846 A HK16113846 A HK 16113846A HK 16113846 A HK16113846 A HK 16113846A HK 1225607 A1 HK1225607 A1 HK 1225607A1
Authority
HK
Hong Kong
Prior art keywords
dinitrophenol
formulations
novel
methods
same
Prior art date
Application number
HK16113846A
Other languages
English (en)
Inventor
Gerald I Shulman
Rachel Jamison Perry
Original Assignee
Univ Yale
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Yale filed Critical Univ Yale
Publication of HK1225607A1 publication Critical patent/HK1225607A1/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A61K31/06—Phenols the aromatic ring being substituted by nitro groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/501—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nutrition Science (AREA)
  • Inorganic Chemistry (AREA)
  • Physiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Emergency Medicine (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HK16113846A 2013-08-30 2016-12-05 新型2，4-二硝基苯酚製劑及使用其的方法 HK1225607A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361872294P 2013-08-30 2013-08-30
US201361919003P 2013-12-20 2013-12-20

Publications (1)

Publication Number Publication Date
HK1225607A1 true HK1225607A1 (zh) 2017-09-15

Family

ID=52587363

Family Applications (1)

Application Number Title Priority Date Filing Date
HK16113846A HK1225607A1 (zh) 2013-08-30 2016-12-05 新型2，4-二硝基苯酚製劑及使用其的方法

Country Status (6)

Country Link
US (3) US10786466B2 (zh)
EP (1) EP3038611B1 (zh)
JP (4) JP6706204B2 (zh)
CN (2) CN105682653B (zh)
HK (1) HK1225607A1 (zh)
WO (1) WO2015031756A1 (zh)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3038611B1 (en) 2013-08-30 2024-04-17 Yale University Sustained-release pharmaceutical composition comprising 2,4-dinitrophenol
US9763896B2 (en) 2015-01-22 2017-09-19 Mitochon Pharmaceuticals, Inc. Induced expression of brain derived neurotrophic factor (BDNF) for treatment of neuromuscular, neurodegenerative, autoimmune, developmental and/or metabolic diseases
DE102015016801A1 (de) * 2015-12-23 2017-06-29 Christian Windisch Chemotherapeutisches Verfahren zur Behandlung maliger Geschwülste durch "Entkopplung" der oxidativen Phosphorilierung ("Krebsatmung") in aerob glycolysierenden Zellen (Krebszellen)
CA3016465A1 (en) 2016-03-07 2017-09-14 Mitochon Pharmaceuticals, Inc. Dinitrophemol and dinitrophenol prodrug treatment of neuromuscular, neurodegenerative, autoimmune, developmental,traumatic brain injury, concussion, dry eye disease, hearing loss, and/or metabolic diseases______________________
SI3565806T1 (sl) 2017-01-06 2022-07-29 Rivus Pharmaceuticals, Inc. Novi fenilni derivati
WO2019217164A1 (en) * 2018-05-09 2019-11-14 Reyoung Corporation Compositions and methods for treating cancer and other diseases
EP3986420A1 (en) 2019-06-18 2022-04-27 Mitopower LLC Nicotinyl riboside compounds and their uses
CN110302154B (zh) * 2019-07-30 2021-09-10 成都医学院 一种2,4-二硝基苯酚脂肪乳及其制备方法和用途
CN110237033A (zh) * 2019-07-30 2019-09-17 成都医学院 一种2,4二硝基苯酚注射液及其制备方法和用途
CN113045428B (zh) * 2019-12-26 2022-04-22 中国农业大学 化合物及其在减脂中的用途

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US2183589A (en) 1939-12-19 Derivatives of compounds of the
CA774573A (en) 1967-12-26 Sehring Richard Derivatives of 2-hydroxy-3,5-dinitrobenzyl alcohol
US1695656A (en) 1927-03-10 1928-12-18 Firm Gehe & Co A G Method of producing narcotica
US3081224A (en) 1959-01-21 1963-03-12 American Cyanamid Co Methods of removing helminths employing halogenated nitrophenols and their derivatives
NL301998A (zh) 1962-12-27 1900-01-01
DE3313905A1 (de) 1983-04-16 1984-10-25 Henkel KGaA, 4000 Düsseldorf Neue 2.4-diaminophenolether als kuppler fuer oxidationshaarfaerbemittel
DE3515339A1 (de) 1985-04-27 1986-10-30 Cassella Ag, 6000 Frankfurt Verfahren zur herstellung von 2,4-dinitrophenylethern
CN1011660B (zh) * 1986-04-23 1991-02-20 吴佩璇 一种含三硝基苯、田螺的药品合成方法
US5078908A (en) 1989-10-02 1992-01-07 Allergan, Inc. Methods for generating chlorine dioxide and compositions for disinfecting
US5169645A (en) 1989-10-31 1992-12-08 Duquesne University Of The Holy Ghost Directly compressible granules having improved flow properties
IN192400B (zh) * 1995-06-14 2004-04-10 Council Scient Ind Res
CA2180903A1 (en) 1995-07-11 1997-01-12 Kunio Sugisawa Pesticidal composition to noxious organisms
JP2003526694A (ja) * 1998-04-24 2003-09-09 イーストマン ケミカル カンパニー セルロースエステルと機能性添加剤との共沈及びそれによって得られる組成物
DK1098641T3 (en) * 1998-07-27 2016-08-15 St Jude Pharmaceuticals Inc Chemically induced intracellular hyperthermia
US6664297B1 (en) 2000-10-18 2003-12-16 Universidade Federal Do Rio De Janeiro Methods for inhibition and dissolution of amyloidoses by administration of compositions comprising 2,4-dinitrophenol
ATE381924T1 (de) * 2001-09-21 2008-01-15 Egalet As Feste dispersionen mit kontrollierter freisetzung von carvedilol
AU2003275329B2 (en) 2002-09-13 2008-04-03 Cydex Pharmaceuticals, Inc. Capsules containing aqueous fill compositions stabilized with derivatized cyclodextrin
US20040138301A1 (en) 2002-11-08 2004-07-15 Hansen Birgit Sehested Chemical uncouplers for the treatment of obesity
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EP3038611B1 (en) 2013-08-30 2024-04-17 Yale University Sustained-release pharmaceutical composition comprising 2,4-dinitrophenol

Also Published As

Publication number Publication date
US20220339121A1 (en) 2022-10-27
EP3038611B1 (en) 2024-04-17
US11883369B2 (en) 2024-01-30
JP2023133603A (ja) 2023-09-22
JP2021165309A (ja) 2021-10-14
EP3038611A1 (en) 2016-07-06
JP6706204B2 (ja) 2020-06-03
JP6913137B2 (ja) 2021-08-04
CN105682653A (zh) 2016-06-15
CN110302385A (zh) 2019-10-08
EP3038611A4 (en) 2017-03-29
JP7359809B2 (ja) 2023-10-11
US20200352879A1 (en) 2020-11-12
WO2015031756A1 (en) 2015-03-05
JP2020002166A (ja) 2020-01-09
US20160199310A1 (en) 2016-07-14
US11433033B2 (en) 2022-09-06
CN105682653B (zh) 2022-10-21
US10786466B2 (en) 2020-09-29
JP2016530279A (ja) 2016-09-29

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