HK1223908A1 - 光學活性 -溴- -雙（三氟甲基）苯基 乙烷的製備方法 - Google Patents

光學活性 -溴- -雙（三氟甲基）苯基 乙烷的製備方法

Info

Publication number
HK1223908A1
HK1223908A1 HK16111176.5A HK16111176A HK1223908A1 HK 1223908 A1 HK1223908 A1 HK 1223908A1 HK 16111176 A HK16111176 A HK 16111176A HK 1223908 A1 HK1223908 A1 HK 1223908A1
Authority
HK
Hong Kong
Prior art keywords
ethane
bromo
trifluoromethyl
bis
phenyl
Prior art date
Application number
HK16111176.5A
Other languages
English (en)
Inventor
日下部太
松田健之介
山崎浩市
扇谷忠明
涉谷公幸
Original Assignee
Kowa Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kowa Co filed Critical Kowa Co
Publication of HK1223908A1 publication Critical patent/HK1223908A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/013—Preparation of halogenated hydrocarbons by addition of halogens
    • C07C17/04—Preparation of halogenated hydrocarbons by addition of halogens to unsaturated halogenated hydrocarbons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B53/00—Asymmetric syntheses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
    • C07C17/16—Preparation of halogenated hydrocarbons by replacement by halogens of hydroxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C22/00—Cyclic compounds containing halogen atoms bound to an acyclic carbon atom
    • C07C22/02—Cyclic compounds containing halogen atoms bound to an acyclic carbon atom having unsaturation in the rings
    • C07C22/04—Cyclic compounds containing halogen atoms bound to an acyclic carbon atom having unsaturation in the rings containing six-membered aromatic rings
    • C07C22/08—Cyclic compounds containing halogen atoms bound to an acyclic carbon atom having unsaturation in the rings containing six-membered aromatic rings containing fluorine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HK16111176.5A 2010-07-22 2016-09-23 光學活性 -溴- -雙（三氟甲基）苯基 乙烷的製備方法 HK1223908A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2010164725 2010-07-22
JP2010164726 2010-07-22

Publications (1)

Publication Number Publication Date
HK1223908A1 true HK1223908A1 (zh) 2017-08-11

Family

ID=45496934

Family Applications (1)

Application Number Title Priority Date Filing Date
HK16111176.5A HK1223908A1 (zh) 2010-07-22 2016-09-23 光學活性 -溴- -雙（三氟甲基）苯基 乙烷的製備方法

Country Status (7)

Country Link
US (1) US9272966B2 (zh)
EP (1) EP2597079A4 (zh)
JP (1) JP5793143B2 (zh)
CN (2) CN102985395A (zh)
HK (1) HK1223908A1 (zh)
IN (1) IN2013CN01326A (zh)
WO (1) WO2012011516A1 (zh)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104628584B (zh) * 2013-11-08 2017-03-08 广州朗圣药业有限公司 一种适合工业化的高纯度达泊西汀的制备方法
CN114105796B (zh) * 2021-12-11 2023-11-28 上海化工研究院有限公司 一种稳定性同位素氘标记异亮氨酸的合成方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6750344B1 (en) * 1997-09-05 2004-06-15 Isis Pharmaceuticals, Inc. Amine compounds and combinatorial libraries comprising same
JP3938651B2 (ja) 2000-04-13 2007-06-27 セントラル硝子株式会社 光学活性α−メチル−ビス−３、５−（トリフルオロメチル）ベンジルアミンの製造方法
WO2007044829A2 (en) 2005-10-06 2007-04-19 Dr. Reddy's Laboratories Ltd. Preparation of aprepitant
US7790737B2 (en) * 2007-03-13 2010-09-07 Kowa Company, Ltd. Substituted pyrimidine compounds and their utility as CETP inhibitors
PL2149563T3 (pl) 2007-04-13 2015-06-30 Kowa Co Nowy związek pirymidynowy mający strukturę dibenzyloaminy i lek zawierający ten związek
CN101412711A (zh) 2007-10-15 2009-04-22 上海恒瑞医药有限公司 氨基甲酸酯类衍生物及其在医药上的应用
JP2011506335A (ja) * 2007-12-06 2011-03-03 シェーリング コーポレイション γ−セクレターゼ調節剤
JP5319457B2 (ja) * 2008-08-25 2013-10-16 興和株式会社 新規なジベンジルアミン構造を有するピリミジン化合物及びこれを含有する医薬
KR20170078865A (ko) 2010-06-04 2017-07-07 코와 가부시키가이샤 광학 활성 디벤질아민 유도체 및 그의 제조 방법
EP2626351A4 (en) * 2010-10-04 2014-03-12 Kowa Co AGENT CAPABLE OF INHIBITING THE EXPRESSION OF LIPID METABOLISM-RELATED MRNA

Also Published As

Publication number Publication date
EP2597079A4 (en) 2015-11-11
EP2597079A1 (en) 2013-05-29
US9272966B2 (en) 2016-03-01
IN2013CN01326A (zh) 2015-04-24
CN105837401A (zh) 2016-08-10
CN102985395A (zh) 2013-03-20
US20130190540A1 (en) 2013-07-25
JP5793143B2 (ja) 2015-10-14
WO2012011516A1 (ja) 2012-01-26
JPWO2012011516A1 (ja) 2013-09-09

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