HK1223618A1 - -丙氨酸- -冬淩草甲素 酯三氟乙酸鹽的 型結晶及製備方法 - Google Patents

-丙氨酸- -冬淩草甲素 酯三氟乙酸鹽的 型結晶及製備方法

Info

Publication number
HK1223618A1
HK1223618A1 HK16111954.3A HK16111954A HK1223618A1 HK 1223618 A1 HK1223618 A1 HK 1223618A1 HK 16111954 A HK16111954 A HK 16111954A HK 1223618 A1 HK1223618 A1 HK 1223618A1
Authority
HK
Hong Kong
Prior art keywords
oridonin
alanine
preparation
method therefor
type crystal
Prior art date
Application number
HK16111954.3A
Other languages
English (en)
Inventor
孫飄揚
武乖利
邱振均
陳永江
沈靈佳
Original Assignee
Jiangsu Hengrui Medicine Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jiangsu Hengrui Medicine Co filed Critical Jiangsu Hengrui Medicine Co
Publication of HK1223618A1 publication Critical patent/HK1223618A1/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HK16111954.3A 2014-05-30 2016-10-17 -丙氨酸- -冬淩草甲素 酯三氟乙酸鹽的 型結晶及製備方法 HK1223618A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201410240920.0A CN105131009A (zh) 2014-05-30 2014-05-30 L-丙氨酸-(14-冬凌草甲素)酯三氟乙酸盐的i型结晶及制备方法
PCT/CN2015/077620 WO2015180549A1 (zh) 2014-05-30 2015-04-28 L-丙氨酸-（14-冬凌草甲素）酯三氟乙酸盐的i型结晶及制备方法

Publications (1)

Publication Number Publication Date
HK1223618A1 true HK1223618A1 (zh) 2017-08-04

Family

ID=54698057

Family Applications (1)

Application Number Title Priority Date Filing Date
HK16111954.3A HK1223618A1 (zh) 2014-05-30 2016-10-17 -丙氨酸- -冬淩草甲素 酯三氟乙酸鹽的 型結晶及製備方法

Country Status (3)

Country Link
CN (2) CN105131009A (zh)
HK (1) HK1223618A1 (zh)
WO (1) WO2015180549A1 (zh)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110407848B (zh) * 2019-06-25 2021-10-22 郑州大学 L-氨基酸-14-(7-醚-柔茎香茶菜甲素)酯三氟乙酸盐类化合物及其制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101139350B (zh) * 2007-10-15 2010-06-02 中国药科大学 冬凌草甲素类衍生物、其制备方法及用途
CN102058566A (zh) * 2010-12-24 2011-05-18 中国药科大学 一种冬凌草甲素类成分干粉吸入剂及其制备方法和用途
EP2805955B1 (en) * 2012-01-21 2018-10-31 Bensen Pharmaceutical (Shanghai) Corp. Ltd. 1-oxo/acylation-14-acylated oridonin derivative, preparation method therefor and application thereof
CN104017000B (zh) * 2013-03-01 2017-01-04 江苏恒瑞医药股份有限公司 L-丙氨酸-(14-冬凌草甲素)酯三氟乙酸盐及其制备方法和用途
CN103467474B (zh) * 2013-09-17 2016-06-01 中国药科大学 1,6,7,14-位取代的冬凌草甲素衍生物、制备方法及用途

Also Published As

Publication number Publication date
CN105636964B (zh) 2017-04-12
CN105131009A (zh) 2015-12-09
CN105636964A (zh) 2016-06-01
WO2015180549A1 (zh) 2015-12-03

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20220430