HK1222201A1 - 用於核酸特異性雜化合物的模板化裝配的方法和組合物 - Google Patents
用於核酸特異性雜化合物的模板化裝配的方法和組合物Info
- Publication number
- HK1222201A1 HK1222201A1 HK16110443.4A HK16110443A HK1222201A1 HK 1222201 A1 HK1222201 A1 HK 1222201A1 HK 16110443 A HK16110443 A HK 16110443A HK 1222201 A1 HK1222201 A1 HK 1222201A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- heterocompounds
- compositions
- methods
- nucleic acid
- acid specific
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title 1
- 150000007523 nucleic acids Chemical class 0.000 title 1
- 102000039446 nucleic acids Human genes 0.000 title 1
- 108020004707 nucleic acids Proteins 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6811—Selection methods for production or design of target specific oligonucleotides or binding molecules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6025—Nucleotides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3513—Protein; Peptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3517—Marker; Tag
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Plant Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Communicable Diseases (AREA)
- Mycology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Bioinformatics & Computational Biology (AREA)
- Analytical Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Cell Biology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361831133P | 2013-06-04 | 2013-06-04 | |
| PCT/US2014/040822 WO2014197547A1 (en) | 2013-06-04 | 2014-06-04 | Methods and compositions for templated assembly of nucleic acid specific heterocompounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1222201A1 true HK1222201A1 (zh) | 2017-06-23 |
Family
ID=52008550
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK16110443.4A HK1222201A1 (zh) | 2013-06-04 | 2016-09-01 | 用於核酸特異性雜化合物的模板化裝配的方法和組合物 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US10603385B2 (zh) |
| EP (1) | EP3004351B1 (zh) |
| JP (1) | JP6710157B2 (zh) |
| CN (1) | CN105358691A (zh) |
| AU (2) | AU2014275010B2 (zh) |
| CA (1) | CA2950117C (zh) |
| HK (1) | HK1222201A1 (zh) |
| IL (1) | IL242797B (zh) |
| MX (1) | MX2015016371A (zh) |
| SG (2) | SG11201509882WA (zh) |
| WO (1) | WO2014197547A1 (zh) |
| ZA (1) | ZA201600024B (zh) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10603385B2 (en) | 2013-06-04 | 2020-03-31 | Tribiotica Llc | Methods and compositions for templated assembly of nucleic acid specific heterocompounds |
| CA2968552A1 (en) | 2014-12-02 | 2016-06-09 | Tribiotica Llc | Methods and kits for theranostic applications |
| US11186839B2 (en) | 2016-11-21 | 2021-11-30 | Tribiotica Llc | Methods for preventing titration of bimolecular templated assembly reactions by structurally-determined differential hybridizations |
| CN110191953A (zh) * | 2016-11-21 | 2019-08-30 | 特里比奥迪卡有限责任公司 | 通过接近增强的反应性实现分裂蛋白模板组装的方法 |
| EP3541940A4 (en) * | 2016-11-21 | 2020-10-14 | Tribiotica Llc | PROCEDURE FOR DIRECTED FOLDING ASSEMBLY OR DIMERIZATION OF PROTEINS BY TEMPLATE REACTIONS |
| CN110982876B (zh) * | 2020-03-04 | 2020-05-26 | 圣湘生物科技股份有限公司 | 病毒核酸检测的预处理方法、预处理液、试剂盒及其用途 |
| US20230414764A1 (en) * | 2020-11-09 | 2023-12-28 | The General Hospital Corporation | Template Assembly by Proximity-Enhanced Reactivity via Metabolic Labeling |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993020096A1 (en) | 1991-05-08 | 1993-10-14 | Stratagene | Oligonucleotide libraries useful for producing primers |
| US5514546A (en) | 1993-09-01 | 1996-05-07 | Research Corporation Technologies, Inc. | Stem-loop oligonucleotides containing parallel and antiparallel binding domains |
| US5783683A (en) | 1995-01-10 | 1998-07-21 | Genta Inc. | Antisense oligonucleotides which reduce expression of the FGFRI gene |
| US20020172965A1 (en) | 1996-12-13 | 2002-11-21 | Arcaris, Inc. | Methods for measuring relative amounts of nucleic acids in a complex mixture and retrieval of specific sequences therefrom |
| US6831071B2 (en) | 1999-04-08 | 2004-12-14 | Pavel Sergeev | Synthesis of biologically active compounds in cells |
| US7256259B2 (en) | 2000-05-12 | 2007-08-14 | Wisconsin Alumni Research Foundation | Methods for ligation of molecules to surfaces |
| US7297494B2 (en) * | 2001-06-25 | 2007-11-20 | Georgia Tech Research Corporation | Activatable probes and methods for in vivo gene detection |
| WO2004011486A2 (fr) * | 2002-07-26 | 2004-02-05 | Pierre Fabre Medicament | Procede de solubilisation de peptides hydrophobes et leur utilisation pour generer une response de type ctl antitumorale ou anti-infectieuse |
| EP1558744B1 (en) * | 2002-10-30 | 2011-06-15 | Nuevolution A/S | Enzymatic encoding |
| US8420086B2 (en) * | 2002-12-13 | 2013-04-16 | Immunomedics, Inc. | Camptothecin conjugates of anti-CD22 antibodies for treatment of B cell diseases |
| US20050026178A1 (en) | 2003-03-28 | 2005-02-03 | Marit Nilsen-Hamilton | Allosteric probes and methods |
| ATE420170T1 (de) | 2004-11-22 | 2009-01-15 | Peter Birk Rasmussen | Matrizengerichtete split-and-mix-synthese von bibliotheken kleiner moleküle |
| CN100381460C (zh) | 2004-11-30 | 2008-04-16 | 北京市肿瘤防治研究所 | Her-2模拟抗原表位及含有该表位的肽 |
| US20060147963A1 (en) * | 2004-12-30 | 2006-07-06 | Affymetrix, Inc. | Detection of polynucleotides on nucleic acid arrays using azido-modified triphosphate nucleotide analogs |
| US7795009B2 (en) * | 2005-06-15 | 2010-09-14 | Saint Louis University | Three-component biosensors for detecting macromolecules and other analytes |
| EP1937849B1 (en) * | 2005-10-27 | 2019-05-29 | The President and Fellows of Harvard College | Methods and compositions for labeling nucleic acids |
| US8716033B2 (en) * | 2006-02-10 | 2014-05-06 | Life Technologies Corporation | Oligosaccharide modification and labeling of proteins |
| US8114636B2 (en) | 2006-02-10 | 2012-02-14 | Life Technologies Corporation | Labeling and detection of nucleic acids |
| JP2009534342A (ja) | 2006-04-20 | 2009-09-24 | サイレンス・セラピューティクス・アーゲー | 血管内皮に特異的に送達するためのリポプレックス処方剤 |
| CA2650668A1 (en) * | 2006-04-28 | 2007-11-08 | Centre National De La Recherche Scientifique | Method for the synthesis of triazole-containing oligonucleotide deratives |
| US7674924B2 (en) * | 2006-05-22 | 2010-03-09 | Third Wave Technologies, Inc. | Compositions, probes, and conjugates and uses thereof |
| EP2054514A4 (en) * | 2006-08-04 | 2009-11-04 | Univ Georgia State Res Found | ENZYME SENSORS, METHODS OF PREPARATION AND USE OF SUCH SENSORS, AND METHODS OF DETECTING PROTEASE ACTIVITY |
| US8410247B2 (en) | 2008-08-22 | 2013-04-02 | Wisconsin Alumni Research Foundation | Water-soluble phosphinothiol reagents |
| FI20095302A0 (fi) * | 2009-03-24 | 2009-03-24 | Arctic Partners Oy Ab | Luminesenssimääritysmenetelmä |
| EP2454559B1 (de) * | 2009-07-13 | 2013-05-01 | Siemens Aktiengesellschaft | Verfahren zur plausibilitätsprüfung von digitalen messsignalen |
| GB201001088D0 (en) | 2010-01-23 | 2010-03-10 | Trillion Genomics Ltd | Detection |
| WO2012057689A1 (en) | 2010-10-29 | 2012-05-03 | Ge Healthcare Bio-Sciences Ab | Proximity ligation technology for western blot applications |
| EP2972366B1 (en) | 2013-03-15 | 2020-06-17 | Prognosys Biosciences, Inc. | Methods for detecting peptide/mhc/tcr binding |
| US10603385B2 (en) | 2013-06-04 | 2020-03-31 | Tribiotica Llc | Methods and compositions for templated assembly of nucleic acid specific heterocompounds |
| US9983203B2 (en) | 2014-02-13 | 2018-05-29 | Ge Healthcare Bio-Sciences Ab | Method for protein analysis |
| CA2968552A1 (en) | 2014-12-02 | 2016-06-09 | Tribiotica Llc | Methods and kits for theranostic applications |
| CN108026145B (zh) | 2015-09-18 | 2022-06-10 | 谷万达公司 | 工程化植酸酶及其使用方法 |
-
2014
- 2014-06-04 US US14/895,398 patent/US10603385B2/en active Active
- 2014-06-04 WO PCT/US2014/040822 patent/WO2014197547A1/en active Application Filing
- 2014-06-04 MX MX2015016371A patent/MX2015016371A/es unknown
- 2014-06-04 AU AU2014275010A patent/AU2014275010B2/en active Active
- 2014-06-04 CA CA2950117A patent/CA2950117C/en active Active
- 2014-06-04 JP JP2016518425A patent/JP6710157B2/ja active Active
- 2014-06-04 CN CN201480038772.2A patent/CN105358691A/zh active Pending
- 2014-06-04 EP EP14807845.4A patent/EP3004351B1/en active Active
- 2014-06-04 SG SG11201509882WA patent/SG11201509882WA/en unknown
- 2014-06-04 SG SG10201710033PA patent/SG10201710033PA/en unknown
-
2015
- 2015-11-26 IL IL242797A patent/IL242797B/en unknown
-
2016
- 2016-01-04 ZA ZA2016/00024A patent/ZA201600024B/en unknown
- 2016-09-01 HK HK16110443.4A patent/HK1222201A1/zh unknown
-
2020
- 2020-02-20 US US16/795,968 patent/US20210023227A1/en not_active Abandoned
- 2020-10-15 AU AU2020256386A patent/AU2020256386B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20160106854A1 (en) | 2016-04-21 |
| WO2014197547A1 (en) | 2014-12-11 |
| MX2015016371A (es) | 2017-02-15 |
| SG11201509882WA (en) | 2016-01-28 |
| IL242797B (en) | 2021-12-01 |
| CN105358691A (zh) | 2016-02-24 |
| NZ714546A (en) | 2021-10-29 |
| US10603385B2 (en) | 2020-03-31 |
| CA2950117C (en) | 2023-02-14 |
| AU2014275010A1 (en) | 2015-12-17 |
| AU2020256386A1 (en) | 2020-11-12 |
| AU2020256386B2 (en) | 2023-07-27 |
| CA2950117A1 (en) | 2014-12-11 |
| EP3004351A4 (en) | 2016-12-21 |
| JP6710157B2 (ja) | 2020-06-17 |
| JP2016521714A (ja) | 2016-07-25 |
| AU2014275010B2 (en) | 2020-10-29 |
| EP3004351A1 (en) | 2016-04-13 |
| SG10201710033PA (en) | 2018-01-30 |
| US20210023227A1 (en) | 2021-01-28 |
| ZA201600024B (en) | 2019-04-24 |
| EP3004351B1 (en) | 2018-08-08 |
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