SG10201710033PA - Methods and compositions for templated assembly of nucleic acid specific heterocompounds - Google Patents

Methods and compositions for templated assembly of nucleic acid specific heterocompounds

Info

Publication number
SG10201710033PA
SG10201710033PA SG10201710033PA SG10201710033PA SG10201710033PA SG 10201710033P A SG10201710033P A SG 10201710033PA SG 10201710033P A SG10201710033P A SG 10201710033PA SG 10201710033P A SG10201710033P A SG 10201710033PA SG 10201710033P A SG10201710033P A SG 10201710033PA
Authority
SG
Singapore
Prior art keywords
heterocompounds
compositions
methods
nucleic acid
acid specific
Prior art date
Application number
SG10201710033PA
Inventor
Ian Dunn
Matthew Lawler
Original Assignee
Tribiotica Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tribiotica Llc filed Critical Tribiotica Llc
Publication of SG10201710033PA publication Critical patent/SG10201710033PA/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6811—Selection methods for production or design of target specific oligonucleotides or binding molecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6025—Nucleotides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3513—Protein; Peptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3517—Marker; Tag
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
SG10201710033PA 2013-06-04 2014-06-04 Methods and compositions for templated assembly of nucleic acid specific heterocompounds SG10201710033PA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361831133P 2013-06-04 2013-06-04

Publications (1)

Publication Number Publication Date
SG10201710033PA true SG10201710033PA (en) 2018-01-30

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SG10201710033PA SG10201710033PA (en) 2013-06-04 2014-06-04 Methods and compositions for templated assembly of nucleic acid specific heterocompounds

Family Applications Before (1)

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Country Status (12)

Country Link
US (2) US10603385B2 (en)
EP (1) EP3004351B1 (en)
JP (1) JP6710157B2 (en)
CN (1) CN105358691A (en)
AU (2) AU2014275010B2 (en)
CA (1) CA2950117C (en)
HK (1) HK1222201A1 (en)
IL (1) IL242797B (en)
MX (1) MX2015016371A (en)
SG (2) SG11201509882WA (en)
WO (1) WO2014197547A1 (en)
ZA (1) ZA201600024B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6710157B2 (en) 2013-06-04 2020-06-17 トリビオティカ・エルエルシー Methods and compositions for templated assembly of nucleic acid specific hetero compounds
CA2968552A1 (en) 2014-12-02 2016-06-09 Tribiotica Llc Methods and kits for theranostic applications
EP3541415A4 (en) * 2016-11-21 2020-10-14 Tribiotica Llc Methods for split-protein template assembly by proximity-enhanced reactivity
US11186839B2 (en) 2016-11-21 2021-11-30 Tribiotica Llc Methods for preventing titration of bimolecular templated assembly reactions by structurally-determined differential hybridizations
JP2019535281A (en) * 2016-11-21 2019-12-12 トリビオティカ・エルエルシー Method for directed folding assembly or dimerization of proteins by templated assembly reaction
CN110982876B (en) * 2020-03-04 2020-05-26 圣湘生物科技股份有限公司 Pretreatment method, pretreatment liquid, kit and application of virus nucleic acid detection
US20230414764A1 (en) * 2020-11-09 2023-12-28 The General Hospital Corporation Template Assembly by Proximity-Enhanced Reactivity via Metabolic Labeling

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993020096A1 (en) 1991-05-08 1993-10-14 Stratagene Oligonucleotide libraries useful for producing primers
US5514546A (en) 1993-09-01 1996-05-07 Research Corporation Technologies, Inc. Stem-loop oligonucleotides containing parallel and antiparallel binding domains
US5783683A (en) 1995-01-10 1998-07-21 Genta Inc. Antisense oligonucleotides which reduce expression of the FGFRI gene
US20020172965A1 (en) 1996-12-13 2002-11-21 Arcaris, Inc. Methods for measuring relative amounts of nucleic acids in a complex mixture and retrieval of specific sequences therefrom
US6831071B2 (en) 1999-04-08 2004-12-14 Pavel Sergeev Synthesis of biologically active compounds in cells
US7256259B2 (en) 2000-05-12 2007-08-14 Wisconsin Alumni Research Foundation Methods for ligation of molecules to surfaces
US7297494B2 (en) * 2001-06-25 2007-11-20 Georgia Tech Research Corporation Activatable probes and methods for in vivo gene detection
WO2004011486A2 (en) * 2002-07-26 2004-02-05 Pierre Fabre Medicament Method for solubilizing hydrophobic peptides and use thereof for inducing an antitumoral and/or anti-infectious ctl response
ES2368215T3 (en) * 2002-10-30 2011-11-15 Nuevolution A/S ENZYMATIC CODING.
US8420086B2 (en) * 2002-12-13 2013-04-16 Immunomedics, Inc. Camptothecin conjugates of anti-CD22 antibodies for treatment of B cell diseases
US20050026178A1 (en) 2003-03-28 2005-02-03 Marit Nilsen-Hamilton Allosteric probes and methods
EP1828381B1 (en) 2004-11-22 2009-01-07 Peter Birk Rasmussen Template directed split and mix systhesis of small molecule libraries
CN100381460C (en) 2004-11-30 2008-04-16 北京市肿瘤防治研究所 HER-2 analogue antigen epitope and peptide containing said epitope
US20060147963A1 (en) 2004-12-30 2006-07-06 Affymetrix, Inc. Detection of polynucleotides on nucleic acid arrays using azido-modified triphosphate nucleotide analogs
US7795009B2 (en) * 2005-06-15 2010-09-14 Saint Louis University Three-component biosensors for detecting macromolecules and other analytes
US7767421B2 (en) * 2005-10-27 2010-08-03 President And Fellows Of Harvard College Methods and compositions for labeling nucleic acids
EP3438131B1 (en) 2006-02-10 2022-03-16 Life Technologies Corporation Oligosaccharide modification and labeling of proteins
US8114636B2 (en) 2006-02-10 2012-02-14 Life Technologies Corporation Labeling and detection of nucleic acids
US20090074852A1 (en) 2006-04-20 2009-03-19 Silence Therapeutics Ag Lipoplex formulations for specific delivery to vascular endothelium
CA2650668A1 (en) * 2006-04-28 2007-11-08 Centre National De La Recherche Scientifique Method for the synthesis of triazole-containing oligonucleotide deratives
US7674924B2 (en) * 2006-05-22 2010-03-09 Third Wave Technologies, Inc. Compositions, probes, and conjugates and uses thereof
EP2054514A4 (en) * 2006-08-04 2009-11-04 Univ Georgia State Res Found Enzyme sensors, methods for preparing and using such sensors, and methods of detecting protease activity
US8410247B2 (en) 2008-08-22 2013-04-02 Wisconsin Alumni Research Foundation Water-soluble phosphinothiol reagents
FI20095302A0 (en) * 2009-03-24 2009-03-24 Arctic Partners Oy Ab Luminesenssimääritysmenetelmä
US20120209566A1 (en) * 2009-07-13 2012-08-16 Siemens Aktiengesellschaft Method for Checking Plausability of Digital Measurement Signals
GB201001088D0 (en) * 2010-01-23 2010-03-10 Trillion Genomics Ltd Detection
EP2633081B1 (en) 2010-10-29 2017-01-11 Olink Bioscience AB Proximity ligation technology for western blot applications
CA2907050C (en) 2013-03-15 2023-09-26 Prognosys Biosciences, Inc. Methods for detecting peptide/mhc/tcr binding
JP6710157B2 (en) 2013-06-04 2020-06-17 トリビオティカ・エルエルシー Methods and compositions for templated assembly of nucleic acid specific hetero compounds
US9983203B2 (en) 2014-02-13 2018-05-29 Ge Healthcare Bio-Sciences Ab Method for protein analysis
CA2968552A1 (en) 2014-12-02 2016-06-09 Tribiotica Llc Methods and kits for theranostic applications
CN108026145B (en) 2015-09-18 2022-06-10 谷万达公司 Engineered phytases and methods of use thereof

Also Published As

Publication number Publication date
HK1222201A1 (en) 2017-06-23
CN105358691A (en) 2016-02-24
NZ714546A (en) 2021-10-29
IL242797B (en) 2021-12-01
EP3004351B1 (en) 2018-08-08
JP6710157B2 (en) 2020-06-17
US10603385B2 (en) 2020-03-31
US20160106854A1 (en) 2016-04-21
ZA201600024B (en) 2019-04-24
AU2020256386A1 (en) 2020-11-12
CA2950117C (en) 2023-02-14
CA2950117A1 (en) 2014-12-11
EP3004351A1 (en) 2016-04-13
AU2014275010B2 (en) 2020-10-29
AU2014275010A1 (en) 2015-12-17
US20210023227A1 (en) 2021-01-28
EP3004351A4 (en) 2016-12-21
AU2020256386B2 (en) 2023-07-27
SG11201509882WA (en) 2016-01-28
MX2015016371A (en) 2017-02-15
JP2016521714A (en) 2016-07-25
WO2014197547A1 (en) 2014-12-11

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