HK1220365A1 - 用於靶向癌症幹細胞的依託泊苷及其前體藥物 - Google Patents

用於靶向癌症幹細胞的依託泊苷及其前體藥物

Info

Publication number
HK1220365A1
HK1220365A1 HK16108405.4A HK16108405A HK1220365A1 HK 1220365 A1 HK1220365 A1 HK 1220365A1 HK 16108405 A HK16108405 A HK 16108405A HK 1220365 A1 HK1220365 A1 HK 1220365A1
Authority
HK
Hong Kong
Prior art keywords
etoposide
prodrugs
stem cells
cancer stem
targeting cancer
Prior art date
Application number
HK16108405.4A
Other languages
English (en)
Inventor
Nalan Utku
Steven R Gullans
Original Assignee
Cellact Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cellact Pharma Gmbh filed Critical Cellact Pharma Gmbh
Publication of HK1220365A1 publication Critical patent/HK1220365A1/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HK16108405.4A 2013-03-12 2016-07-15 用於靶向癌症幹細胞的依託泊苷及其前體藥物 HK1220365A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB1304417.7A GB2513299A (en) 2013-03-12 2013-03-12 Compounds for targeting cancer stem cells
PCT/EP2014/054785 WO2014140072A1 (en) 2013-03-12 2014-03-12 Etoposide and prodrugs thereof for use in targeting cancer stem cells

Publications (1)

Publication Number Publication Date
HK1220365A1 true HK1220365A1 (zh) 2017-05-05

Family

ID=48189766

Family Applications (1)

Application Number Title Priority Date Filing Date
HK16108405.4A HK1220365A1 (zh) 2013-03-12 2016-07-15 用於靶向癌症幹細胞的依託泊苷及其前體藥物

Country Status (7)

Country Link
US (2) US9827261B2 (zh)
EP (1) EP2968379B1 (zh)
DK (1) DK2968379T3 (zh)
ES (1) ES2881928T3 (zh)
GB (1) GB2513299A (zh)
HK (1) HK1220365A1 (zh)
WO (1) WO2014140072A1 (zh)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2912193T (pt) 2012-10-29 2018-11-29 Arizona Board Of Regents On Behalf Of Univ Of Arizona Marcadores preditivos para terapêuticas de cancro de inibidor de poliamina
GB2513299A (en) * 2013-03-12 2014-10-29 Cellact Pharma Gmbh Biomedizinzentrum Compounds for targeting cancer stem cells
JP2017519770A (ja) 2014-06-18 2017-07-20 アリゾナ ボード オブ リージェンツ オン ビハーフ オブ ザ ユニバーシティ オブ アリゾナ Ｏｄｃ１遺伝子型に基づく癌腫の診断および処置
US20190046484A1 (en) * 2015-02-12 2019-02-14 Arizona Board Of Regents On Behalf Of The University Of Arizona Methods for treating neuroblastoma
EP3368029A1 (en) 2015-10-30 2018-09-05 Cancer Prevention Pharmaceuticals, Inc. Eflornithine and sulindac, fixed dose combination formulation
EP3211091A1 (en) * 2016-02-24 2017-08-30 CellAct Pharma GmbH Method for the diagnosis of etoposide prodrug treatable cancer
TW202110431A (zh) 2019-05-17 2021-03-16 美商癌症預防製藥股份有限公司 治療家族性腺瘤性瘜肉症之方法
KR20230131815A (ko) * 2020-08-19 2023-09-14 셀액트 파마 게엠베하 에토포시드 토니리베이트 제제
EP4233837A1 (en) * 2022-02-24 2023-08-30 CellAct Pharma GmbH Solid and oral etoposide toniribate compositions

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002358086B2 (en) 2001-12-03 2009-06-04 Universitatsklinikum Charite Der Humboldt-Universitat Zu Berlin Technologie Transferstelle Podophyllotoxins as antiproliferative agents
US6566393B1 (en) * 2002-06-21 2003-05-20 The University Of North Carolina At Chapel Hill Etoposide analogs and methods of use thereof
US7176236B2 (en) * 2002-06-21 2007-02-13 University Of North Carolina At Chapel Hill Water-soluble etoposide analogs and methods of use thereof
WO2009126310A2 (en) 2008-04-10 2009-10-15 Massachusetts Institute Of Technology Methods for identification and use of agents targeting cancer stem cells
US20100298352A1 (en) 2009-05-07 2010-11-25 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Small molecule inhibitors of cancer stem cells
JP5727000B2 (ja) * 2010-04-16 2015-06-03 ツェルアクト ファーマ ゲーエムベーハー 腫瘍の処置のためのエポトシドのアナログ
US8753880B2 (en) 2011-07-08 2014-06-17 University Of Rochester Method of enriching stem and/or progenitor cells
GB2513299A (en) * 2013-03-12 2014-10-29 Cellact Pharma Gmbh Biomedizinzentrum Compounds for targeting cancer stem cells

Also Published As

Publication number Publication date
GB2513299A (en) 2014-10-29
GB201304417D0 (en) 2013-04-24
US20180042952A1 (en) 2018-02-15
EP2968379B1 (en) 2021-05-05
EP2968379A1 (en) 2016-01-20
US9827261B2 (en) 2017-11-28
ES2881928T3 (es) 2021-11-30
WO2014140072A1 (en) 2014-09-18
US10183035B2 (en) 2019-01-22
US20160022721A1 (en) 2016-01-28
DK2968379T3 (da) 2021-08-09

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