DK2968379T3 - Etoposid-prodrugs til anvendelse ved målretning mod cancerstamceller - Google Patents

Etoposid-prodrugs til anvendelse ved målretning mod cancerstamceller Download PDF

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Publication number
DK2968379T3
DK2968379T3 DK14709313.2T DK14709313T DK2968379T3 DK 2968379 T3 DK2968379 T3 DK 2968379T3 DK 14709313 T DK14709313 T DK 14709313T DK 2968379 T3 DK2968379 T3 DK 2968379T3
Authority
DK
Denmark
Prior art keywords
etoposid
targeting
product
stem cells
cancer stem
Prior art date
Application number
DK14709313.2T
Other languages
English (en)
Inventor
Nalan Utku
Steven R Gullans
Original Assignee
Mundipharma International Corporation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mundipharma International Corporation Ltd filed Critical Mundipharma International Corporation Ltd
Application granted granted Critical
Publication of DK2968379T3 publication Critical patent/DK2968379T3/da

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK14709313.2T 2013-03-12 2014-03-12 Etoposid-prodrugs til anvendelse ved målretning mod cancerstamceller DK2968379T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB1304417.7A GB2513299A (en) 2013-03-12 2013-03-12 Compounds for targeting cancer stem cells
PCT/EP2014/054785 WO2014140072A1 (en) 2013-03-12 2014-03-12 Etoposide and prodrugs thereof for use in targeting cancer stem cells

Publications (1)

Publication Number Publication Date
DK2968379T3 true DK2968379T3 (da) 2021-08-09

Family

ID=48189766

Family Applications (1)

Application Number Title Priority Date Filing Date
DK14709313.2T DK2968379T3 (da) 2013-03-12 2014-03-12 Etoposid-prodrugs til anvendelse ved målretning mod cancerstamceller

Country Status (7)

Country Link
US (2) US9827261B2 (da)
EP (1) EP2968379B1 (da)
DK (1) DK2968379T3 (da)
ES (1) ES2881928T3 (da)
GB (1) GB2513299A (da)
HK (1) HK1220365A1 (da)
WO (1) WO2014140072A1 (da)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI2912193T1 (sl) 2012-10-29 2019-04-30 Arizona Board Of Regents On Behalf Of University Of Arizona Napovedovalni označevalci za terapije raka z inhibitorjem poliamina
GB2513299A (en) * 2013-03-12 2014-10-29 Cellact Pharma Gmbh Biomedizinzentrum Compounds for targeting cancer stem cells
US10655183B2 (en) 2014-06-18 2020-05-19 Arizona Board Of Regents On Behalf Of University Of Arizona Carcinoma diagnosis and treatment based on ODC1 genotype
US20190046484A1 (en) * 2015-02-12 2019-02-14 Arizona Board Of Regents On Behalf Of The University Of Arizona Methods for treating neuroblastoma
AU2016343851B2 (en) 2015-10-30 2022-04-07 Cancer Prevention Pharmaceuticals, Inc. Eflornithine and sulindac, fixed dose combination formulation
EP3211091A1 (en) * 2016-02-24 2017-08-30 CellAct Pharma GmbH Method for the diagnosis of etoposide prodrug treatable cancer
EP3968971A1 (en) 2019-05-17 2022-03-23 Cancer Prevention Pharmaceuticals, Inc. Methods for treating familial adenomatous polyposis
JP2023539154A (ja) * 2020-08-19 2023-09-13 セラクト ファーマ ジーエムビーエイチ エトポシドトニリベート製剤
EP4233837A1 (en) * 2022-02-24 2023-08-30 CellAct Pharma GmbH Solid and oral etoposide toniribate compositions

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60237915D1 (en) * 2001-12-03 2010-11-18 Universitaetsklinikum Charite Podophyllotoxine als antiproliferative mittel
US6566393B1 (en) * 2002-06-21 2003-05-20 The University Of North Carolina At Chapel Hill Etoposide analogs and methods of use thereof
US7176236B2 (en) * 2002-06-21 2007-02-13 University Of North Carolina At Chapel Hill Water-soluble etoposide analogs and methods of use thereof
WO2009126310A2 (en) 2008-04-10 2009-10-15 Massachusetts Institute Of Technology Methods for identification and use of agents targeting cancer stem cells
US20100298352A1 (en) 2009-05-07 2010-11-25 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Small molecule inhibitors of cancer stem cells
US9889147B2 (en) * 2010-04-16 2018-02-13 Cellact Pharma Gmbh Analogues of etoposide for the treatment of tumours
US8753880B2 (en) 2011-07-08 2014-06-17 University Of Rochester Method of enriching stem and/or progenitor cells
GB2513299A (en) * 2013-03-12 2014-10-29 Cellact Pharma Gmbh Biomedizinzentrum Compounds for targeting cancer stem cells

Also Published As

Publication number Publication date
HK1220365A1 (zh) 2017-05-05
WO2014140072A1 (en) 2014-09-18
US10183035B2 (en) 2019-01-22
EP2968379B1 (en) 2021-05-05
EP2968379A1 (en) 2016-01-20
US20160022721A1 (en) 2016-01-28
US9827261B2 (en) 2017-11-28
US20180042952A1 (en) 2018-02-15
ES2881928T3 (es) 2021-11-30
GB2513299A (en) 2014-10-29
GB201304417D0 (en) 2013-04-24

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